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The map label for this gene is mmr [H]

Identifier: 15920936

GI number: 15920936

Start: 692478

End: 694160

Strand: Reverse

Name: mmr [H]

Synonym: ST0707

Alternate gene names: 15920936

Gene position: 694160-692478 (Counterclockwise)

Preceding gene: 15920937

Following gene: 15920933

Centisome position: 25.76

GC content: 36.66

Gene sequence:

>1683_bases
ATGGTTCAGTATAAGTGGATTGCCCTATCTAATACAAGTCTAGGAGTCTTTATGGGATTCATGAATGCTAACATTGTTCT
AATATCATTACCAGCAATATTTAGAGGAATTGACGTCAATCCCTTTACATCATTTCAATACCTATTGTGGGTTCTATTTG
GTTACTCGATAGTATCAGCAATATTAGTAGTTAACATTGGCAGAATCTCAGATATATTTGGAAGAGTTAGAATGTATAAT
TTGGGTTTTGCAATCTTCACTATAGGTTCAATCCTACTTTATATAACACCAGGTACCGGGAGCATAGCTGCTCTTCAGTT
AATAATTTATAGAATTATTCAGGGGATAGGGGGAGCTTTTTTAATGGCAAACAGTGCAGCTGTACTATCTGAAGCGTTCC
CACCAAATCAAAGAGGTTTTGCATTAGGTTTAAACGGTGTAATAGGGATTTTTGGAGGAATTGCTGGAATAATATTAGGC
GGTATTTTAGCCTCAATTTATTGGAGAGATGTGTTCTTAGTTAGCGTCCCAATAGGAATTGCTGGGACTATTTGGTCTTA
TAAATCGTTAAAGCAACTAACTCCTCCTAATAGGAATCAAAGTGTTGATGTAATAGGTAATATATTATATGCAATAGCAT
TAATCCTTATACTAGTAGGAATAACTTATGGAATTTTACCTTACGGTTCTTCGGCTACTGGTTGGACTAATCCATACGTA
ATTGCGAGTATATCTTCTGGTGTAGCACTATTCTTAGTGTTCCTTTATGTGGAAACTAAAGTTAAGGACCCAATGTTTAG
GATCGACCTTTTCAAGGTTAGAGCATTTACTATGGCATCCCTAGCAATATTTTTTGCACAAATTGCTTTTGGAGGACTAC
AACTAATGTTAGTTTTACTTTTACAAGCAATTTGGCTACCATTGCATGGTATACCTTATTCACAAGCACCATTCTGGGCT
GGTGTGTATCTTTTACCCTTATTAGCGGGTTTTGGAATAATGGGAAGTATTGCCGGAAGGCTTTCTGATAAGTATGGGGC
TAGAGTATTAGCAACAGTTGGGTTAGTAATATTAGGGGCTGGATTATTAGGATTAACATCATTGCCCTATGATTTTAACT
ACATAATATTCGCAACAATAATTTTCATAATGGGTGTTGGTAACGGTCTATTTGTATCACCAAATATGGCCTCATTAATA
AATGCAGCACCACCACAGCATAGAGGTTCTGCATCTGGAATTAGAGCAATGTTAACAAATACTGGAAGTACATTAAGTAT
CGGATTATTCTTCACAATAGTTATAGATGTACTTTACCTTAACTTGCCTGGTACTTTGACCTCAGCACTAACTGCTGTTG
GTGCACCACAGTTAGCACCAATAATGGCTAAGATACCACCAACTGCAGCATTATTTGCTGCATTTTTAGGATACAATCCG
GTAAAGACAATATTGTCACAATTACCGGCAAGTATTGTCAATTCAATTCCTTCATCGGTATTAGCAACAATAACCGGCAA
GTATTGGTTCCCCACAGTTATAGCCCCAGCATTTATGGATTCGCTAAAGATAGCATTTTACTTCTCAGCAACTCTTGTGT
TTATTGCAGCTGTTATATCAGCATTGAGAGGAAGAACTGTGATATATGAGAGAGATATGATGAAAACTTCTGATCCAAAG
TAA

Upstream 100 bases:

>100_bases
AAACTCATTTTATTCACTTTCTTCCTTTAATTTTAACTAATAATTATTTAAATCTTCATTAACAAAAGATTTAATAGTTA
ACTATTCACTATTTAACATT

Downstream 100 bases:

>100_bases
ATAGTTTTTTATTTAACTATATATAAATACACCATTTATACAAAGAAAAAGAAGGAAAAGAAAAAATATTATTATACTAT
TTTATCTTCTTCTTAACAAC

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: MMR peptide [H]

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MVQYKWIALSNTSLGVFMGFMNANIVLISLPAIFRGIDVNPFTSFQYLLWVLFGYSIVSAILVVNIGRISDIFGRVRMYN
LGFAIFTIGSILLYITPGTGSIAALQLIIYRIIQGIGGAFLMANSAAVLSEAFPPNQRGFALGLNGVIGIFGGIAGIILG
GILASIYWRDVFLVSVPIGIAGTIWSYKSLKQLTPPNRNQSVDVIGNILYAIALILILVGITYGILPYGSSATGWTNPYV
IASISSGVALFLVFLYVETKVKDPMFRIDLFKVRAFTMASLAIFFAQIAFGGLQLMLVLLLQAIWLPLHGIPYSQAPFWA
GVYLLPLLAGFGIMGSIAGRLSDKYGARVLATVGLVILGAGLLGLTSLPYDFNYIIFATIIFIMGVGNGLFVSPNMASLI
NAAPPQHRGSASGIRAMLTNTGSTLSIGLFFTIVIDVLYLNLPGTLTSALTAVGAPQLAPIMAKIPPTAALFAAFLGYNP
VKTILSQLPASIVNSIPSSVLATITGKYWFPTVIAPAFMDSLKIAFYFSATLVFIAAVISALRGRTVIYERDMMKTSDPK

Sequences:

>Translated_560_residues
MVQYKWIALSNTSLGVFMGFMNANIVLISLPAIFRGIDVNPFTSFQYLLWVLFGYSIVSAILVVNIGRISDIFGRVRMYN
LGFAIFTIGSILLYITPGTGSIAALQLIIYRIIQGIGGAFLMANSAAVLSEAFPPNQRGFALGLNGVIGIFGGIAGIILG
GILASIYWRDVFLVSVPIGIAGTIWSYKSLKQLTPPNRNQSVDVIGNILYAIALILILVGITYGILPYGSSATGWTNPYV
IASISSGVALFLVFLYVETKVKDPMFRIDLFKVRAFTMASLAIFFAQIAFGGLQLMLVLLLQAIWLPLHGIPYSQAPFWA
GVYLLPLLAGFGIMGSIAGRLSDKYGARVLATVGLVILGAGLLGLTSLPYDFNYIIFATIIFIMGVGNGLFVSPNMASLI
NAAPPQHRGSASGIRAMLTNTGSTLSIGLFFTIVIDVLYLNLPGTLTSALTAVGAPQLAPIMAKIPPTAALFAAFLGYNP
VKTILSQLPASIVNSIPSSVLATITGKYWFPTVIAPAFMDSLKIAFYFSATLVFIAAVISALRGRTVIYERDMMKTSDPK
>Mature_560_residues
MVQYKWIALSNTSLGVFMGFMNANIVLISLPAIFRGIDVNPFTSFQYLLWVLFGYSIVSAILVVNIGRISDIFGRVRMYN
LGFAIFTIGSILLYITPGTGSIAALQLIIYRIIQGIGGAFLMANSAAVLSEAFPPNQRGFALGLNGVIGIFGGIAGIILG
GILASIYWRDVFLVSVPIGIAGTIWSYKSLKQLTPPNRNQSVDVIGNILYAIALILILVGITYGILPYGSSATGWTNPYV
IASISSGVALFLVFLYVETKVKDPMFRIDLFKVRAFTMASLAIFFAQIAFGGLQLMLVLLLQAIWLPLHGIPYSQAPFWA
GVYLLPLLAGFGIMGSIAGRLSDKYGARVLATVGLVILGAGLLGLTSLPYDFNYIIFATIIFIMGVGNGLFVSPNMASLI
NAAPPQHRGSASGIRAMLTNTGSTLSIGLFFTIVIDVLYLNLPGTLTSALTAVGAPQLAPIMAKIPPTAALFAAFLGYNP
VKTILSQLPASIVNSIPSSVLATITGKYWFPTVIAPAFMDSLKIAFYFSATLVFIAAVISALRGRTVIYERDMMKTSDPK

Specific function: Resistance to the epoxide antibiotic methylenomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=350, Percent_Identity=27.4285714285714, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI87081983, Length=408, Percent_Identity=27.2058823529412, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1789042, Length=449, Percent_Identity=25.1670378619154, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788710, Length=443, Percent_Identity=25.2821670428894, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788392, Length=423, Percent_Identity=23.6406619385343, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=235, Percent_Identity=25.9574468085106, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 59919; Mature: 59919

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQYKWIALSNTSLGVFMGFMNANIVLISLPAIFRGIDVNPFTSFQYLLWVLFGYSIVSA
CCEEEEEEEECCCHHHHHHHHCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ILVVNIGRISDIFGRVRMYNLGFAIFTIGSILLYITPGTGSIAALQLIIYRIIQGIGGAF
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHCCCHH
LMANSAAVLSEAFPPNQRGFALGLNGVIGIFGGIAGIILGGILASIYWRDVFLVSVPIGI
HHCCCHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCH
AGTIWSYKSLKQLTPPNRNQSVDVIGNILYAIALILILVGITYGILPYGSSATGWTNPYV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
IASISSGVALFLVFLYVETKVKDPMFRIDLFKVRAFTMASLAIFFAQIAFGGLQLMLVLL
EEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQAIWLPLHGIPYSQAPFWAGVYLLPLLAGFGIMGSIAGRLSDKYGARVLATVGLVILGA
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLGLTSLPYDFNYIIFATIIFIMGVGNGLFVSPNMASLINAAPPQHRGSASGIRAMLTN
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCCCCCCCHHHHHHHHCC
TGSTLSIGLFFTIVIDVLYLNLPGTLTSALTAVGAPQLAPIMAKIPPTAALFAAFLGYNP
CCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCCCH
VKTILSQLPASIVNSIPSSVLATITGKYWFPTVIAPAFMDSLKIAFYFSATLVFIAAVIS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRGRTVIYERDMMKTSDPK
HHCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MVQYKWIALSNTSLGVFMGFMNANIVLISLPAIFRGIDVNPFTSFQYLLWVLFGYSIVSA
CCEEEEEEEECCCHHHHHHHHCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ILVVNIGRISDIFGRVRMYNLGFAIFTIGSILLYITPGTGSIAALQLIIYRIIQGIGGAF
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHCCCHH
LMANSAAVLSEAFPPNQRGFALGLNGVIGIFGGIAGIILGGILASIYWRDVFLVSVPIGI
HHCCCHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCH
AGTIWSYKSLKQLTPPNRNQSVDVIGNILYAIALILILVGITYGILPYGSSATGWTNPYV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
IASISSGVALFLVFLYVETKVKDPMFRIDLFKVRAFTMASLAIFFAQIAFGGLQLMLVLL
EEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQAIWLPLHGIPYSQAPFWAGVYLLPLLAGFGIMGSIAGRLSDKYGARVLATVGLVILGA
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLLGLTSLPYDFNYIIFATIIFIMGVGNGLFVSPNMASLINAAPPQHRGSASGIRAMLTN
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCCCCCCCHHHHHHHHCC
TGSTLSIGLFFTIVIDVLYLNLPGTLTSALTAVGAPQLAPIMAKIPPTAALFAAFLGYNP
CCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCCCH
VKTILSQLPASIVNSIPSSVLATITGKYWFPTVIAPAFMDSLKIAFYFSATLVFIAAVIS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRGRTVIYERDMMKTSDPK
HHCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1379177; 9384377 [H]