Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 15920713

GI number: 15920713

Start: 495426

End: 497126

Strand: Direct

Name: sdhA [H]

Synonym: ST0497

Alternate gene names: 15920713

Gene position: 495426-497126 (Clockwise)

Preceding gene: 15920712

Following gene: 15920714

Centisome position: 18.38

GC content: 37.62

Gene sequence:

>1701_bases
GTGGAGAAAGTTTCATACGATGTTGTAATCGTAGGAGCTGGGTTAGCTGGATTAATGGCAGCACACGAGATAGCTTCAGC
AGGTTATAACGTAGCAGTAATCTCTAAAGTATTCCCTACCAGATCACATTCAGCGGCTGCTGAAGGAGGAATTGCGGCCT
ACATTCAAGGCAATTCAGATCCAAATGATAATCCAGATTATATGGCTTATGATACTATCAAAGGAGGCGATTATTTAGTC
GATCAAGATGCTGCTGAACTCTTAGCATATAAGTCTGGAGAGATAGTGATGCTTCTAGAAAGATGGGGAACTTTATTTAA
TAGGCAACCAGATGGACGAGTTGCTGTGAGATATTTTGGTGGGCAAACTTATCCTAGAACTAGATTTGTTGGAGATAAGA
CTGGAATGGCACTATTGCATACAGTATATGAAAGAACTTCTGGTTTAGGTAGTGTAGATTTCTATTTTGAATGGTTTGCA
TGGGAATTAGTTAGAGATGAGAACAGGGTTAGAGGTATTATAGCTTTTGATATGAGGAATATGGTTCCAGTATTTTTCAA
AGCAAAAGCTGTTGTGATAGCTTCCGGAGGTATGGGAATGTTATATAGGCATTCAACCAATAGTTATATCAATACTGGTG
ACGGTTATGCTATGGCATTAAGAGCAAGGGTCGCATTAAAAGATCCAGAATTTGTTCAATTCCATCCTACAGCATTGTAT
CCCTCAGATATCTTAATTAGTGAAGCTGCAAGAGGTGAGGGGGCAGTACTAAGAAACGTTAAAGGAGAAAGATTTATGGC
AAGATACGCCCCTAAAAAACTGGATCTTGCCCCCAGGGATATAGTTTCTAGAGCAATACTTACTGAAGTAAAAGAAGGAA
GAGGATTTCCGGGAGGGTATGTAGGCTTAGATCTTACTCATTTAGGTGAGGATTATATTAAGGAGAGATTAGCCCTAGCT
TATGAAGCAGCAAAGAGCTTTGCAGGGTTAGATGCAACCAAAGAGATGATTCCAGTAAGGCCTGCTCAACATTATTATAT
GGGAGGTATTGATGTAGATATAACTGGTAGAAATCCAGATTTGATAGGATTATTTGCAGCAGGAGAAGCAGCATGTGTTT
CAGTACATGGTGCCAACAGATTAGGTTCTAACTCTTTGTTAGAAACTTTAGTATTTGGTAGAGAAACAGGAAGGGCTGTA
GTCGAATTTCTTAAAAGTTACACTGAACCTTCTTCCGATATTGATAAAGAAGCTGAAAAAATGATTGACTCAGCTTATGA
CGTAGTAAAAAGTGAAAGCGGTATTCATTTTGGAGAAATATTAGAAAAATTGAGAGATACTATGTGGGATTACGTTGGTG
TGTTTAGGGATGAAAATGGATTAAAAACTGCTCTTTCAGAAATTATGAAACTAAGAGAAGATATGAAAAAAATGTATGTA
TTAGATAAGAGTAAGGTCTATAACACAGAATTTTATAATGCTCTTGAGCTTAAGAACATGTTAGATCTAGCCCTTGTAAT
AGCTACTTCTGCTTTAAACAGAAAAGAATCAAGAGGAGCCCACTATAGGTTAGATTTCCCAGAAAGAGATGATCAGAACT
GGCTCAAACATACGATAGCATATCTGAGAGGTAATAGTGTAGAGATTACATATAAACCTGTAAAAATGACAAAATGGAAA
CCAGAAGCTAGGGTGTATTAA

Upstream 100 bases:

>100_bases
AAGATATTGAGAGAACAAATATTAAACCTAAGTTTGTAGTAAACTCTCTAAATGAAATTGTGAAATAAAGGTTTTTTAGT
CAAAATACACATTTACTCAT

Downstream 100 bases:

>100_bases
AATGTCTCTACAAAATGAAGAGATGGATGTAGTACTTAAGATAAAGAGATATTCTCCTGAAAAAGGATATTGGTGGCAAG
AATATAAATTAAAAGTTGAT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MEKVSYDVVIVGAGLAGLMAAHEIASAGYNVAVISKVFPTRSHSAAAEGGIAAYIQGNSDPNDNPDYMAYDTIKGGDYLV
DQDAAELLAYKSGEIVMLLERWGTLFNRQPDGRVAVRYFGGQTYPRTRFVGDKTGMALLHTVYERTSGLGSVDFYFEWFA
WELVRDENRVRGIIAFDMRNMVPVFFKAKAVVIASGGMGMLYRHSTNSYINTGDGYAMALRARVALKDPEFVQFHPTALY
PSDILISEAARGEGAVLRNVKGERFMARYAPKKLDLAPRDIVSRAILTEVKEGRGFPGGYVGLDLTHLGEDYIKERLALA
YEAAKSFAGLDATKEMIPVRPAQHYYMGGIDVDITGRNPDLIGLFAAGEAACVSVHGANRLGSNSLLETLVFGRETGRAV
VEFLKSYTEPSSDIDKEAEKMIDSAYDVVKSESGIHFGEILEKLRDTMWDYVGVFRDENGLKTALSEIMKLREDMKKMYV
LDKSKVYNTEFYNALELKNMLDLALVIATSALNRKESRGAHYRLDFPERDDQNWLKHTIAYLRGNSVEITYKPVKMTKWK
PEARVY

Sequences:

>Translated_566_residues
MEKVSYDVVIVGAGLAGLMAAHEIASAGYNVAVISKVFPTRSHSAAAEGGIAAYIQGNSDPNDNPDYMAYDTIKGGDYLV
DQDAAELLAYKSGEIVMLLERWGTLFNRQPDGRVAVRYFGGQTYPRTRFVGDKTGMALLHTVYERTSGLGSVDFYFEWFA
WELVRDENRVRGIIAFDMRNMVPVFFKAKAVVIASGGMGMLYRHSTNSYINTGDGYAMALRARVALKDPEFVQFHPTALY
PSDILISEAARGEGAVLRNVKGERFMARYAPKKLDLAPRDIVSRAILTEVKEGRGFPGGYVGLDLTHLGEDYIKERLALA
YEAAKSFAGLDATKEMIPVRPAQHYYMGGIDVDITGRNPDLIGLFAAGEAACVSVHGANRLGSNSLLETLVFGRETGRAV
VEFLKSYTEPSSDIDKEAEKMIDSAYDVVKSESGIHFGEILEKLRDTMWDYVGVFRDENGLKTALSEIMKLREDMKKMYV
LDKSKVYNTEFYNALELKNMLDLALVIATSALNRKESRGAHYRLDFPERDDQNWLKHTIAYLRGNSVEITYKPVKMTKWK
PEARVY
>Mature_566_residues
MEKVSYDVVIVGAGLAGLMAAHEIASAGYNVAVISKVFPTRSHSAAAEGGIAAYIQGNSDPNDNPDYMAYDTIKGGDYLV
DQDAAELLAYKSGEIVMLLERWGTLFNRQPDGRVAVRYFGGQTYPRTRFVGDKTGMALLHTVYERTSGLGSVDFYFEWFA
WELVRDENRVRGIIAFDMRNMVPVFFKAKAVVIASGGMGMLYRHSTNSYINTGDGYAMALRARVALKDPEFVQFHPTALY
PSDILISEAARGEGAVLRNVKGERFMARYAPKKLDLAPRDIVSRAILTEVKEGRGFPGGYVGLDLTHLGEDYIKERLALA
YEAAKSFAGLDATKEMIPVRPAQHYYMGGIDVDITGRNPDLIGLFAAGEAACVSVHGANRLGSNSLLETLVFGRETGRAV
VEFLKSYTEPSSDIDKEAEKMIDSAYDVVKSESGIHFGEILEKLRDTMWDYVGVFRDENGLKTALSEIMKLREDMKKMYV
LDKSKVYNTEFYNALELKNMLDLALVIATSALNRKESRGAHYRLDFPERDDQNWLKHTIAYLRGNSVEITYKPVKMTKWK
PEARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=568, Percent_Identity=38.7323943661972, Blast_Score=379, Evalue=1e-105,
Organism=Escherichia coli, GI1786942, Length=587, Percent_Identity=40.2044293015332, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1790597, Length=554, Percent_Identity=40.4332129963899, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1788928, Length=538, Percent_Identity=35.3159851301115, Blast_Score=266, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17505833, Length=593, Percent_Identity=39.6290050590219, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17550100, Length=592, Percent_Identity=38.1756756756757, Blast_Score=366, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322416, Length=574, Percent_Identity=43.5540069686411, Blast_Score=420, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322701, Length=570, Percent_Identity=43.1578947368421, Blast_Score=419, Evalue=1e-118,
Organism=Drosophila melanogaster, GI17137288, Length=583, Percent_Identity=39.7941680960549, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24655642, Length=583, Percent_Identity=39.7941680960549, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24655647, Length=583, Percent_Identity=39.7941680960549, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24663005, Length=588, Percent_Identity=38.6054421768707, Blast_Score=374, Evalue=1e-104,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63128; Mature: 63128

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVSYDVVIVGAGLAGLMAAHEIASAGYNVAVISKVFPTRSHSAAAEGGIAAYIQGNSD
CCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCEEEEEECCCC
PNDNPDYMAYDTIKGGDYLVDQDAAELLAYKSGEIVMLLERWGTLFNRQPDGRVAVRYFG
CCCCCCEEEEEEECCCCEEECCHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCEEEEEEC
GQTYPRTRFVGDKTGMALLHTVYERTSGLGSVDFYFEWFAWELVRDENRVRGIIAFDMRN
CCCCCCEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCC
MVPVFFKAKAVVIASGGMGMLYRHSTNSYINTGDGYAMALRARVALKDPEFVQFHPTALY
CCCEEEEEEEEEEECCCCEEEEEECCCCEEECCCCEEEEEEEEEEECCCCEEEECCCEEC
PSDILISEAARGEGAVLRNVKGERFMARYAPKKLDLAPRDIVSRAILTEVKEGRGFPGGY
CCHHHHHHCCCCCCCEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
VGLDLTHLGEDYIKERLALAYEAAKSFAGLDATKEMIPVRPAQHYYMGGIDVDITGRNPD
EEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEECCEEEEEECCCCC
LIGLFAAGEAACVSVHGANRLGSNSLLETLVFGRETGRAVVEFLKSYTEPSSDIDKEAEK
EEEEEECCCEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHH
MIDSAYDVVKSESGIHFGEILEKLRDTMWDYVGVFRDENGLKTALSEIMKLREDMKKMYV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHE
LDKSKVYNTEFYNALELKNMLDLALVIATSALNRKESRGAHYRLDFPERDDQNWLKHTIA
ECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEECCCCCCCHHHHHHHHH
YLRGNSVEITYKPVKMTKWKPEARVY
HHCCCEEEEEEECEEEECCCCCCCCC
>Mature Secondary Structure
MEKVSYDVVIVGAGLAGLMAAHEIASAGYNVAVISKVFPTRSHSAAAEGGIAAYIQGNSD
CCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCEEEEEECCCC
PNDNPDYMAYDTIKGGDYLVDQDAAELLAYKSGEIVMLLERWGTLFNRQPDGRVAVRYFG
CCCCCCEEEEEEECCCCEEECCHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCEEEEEEC
GQTYPRTRFVGDKTGMALLHTVYERTSGLGSVDFYFEWFAWELVRDENRVRGIIAFDMRN
CCCCCCEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCC
MVPVFFKAKAVVIASGGMGMLYRHSTNSYINTGDGYAMALRARVALKDPEFVQFHPTALY
CCCEEEEEEEEEEECCCCEEEEEECCCCEEECCCCEEEEEEEEEEECCCCEEEECCCEEC
PSDILISEAARGEGAVLRNVKGERFMARYAPKKLDLAPRDIVSRAILTEVKEGRGFPGGY
CCHHHHHHCCCCCCCEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
VGLDLTHLGEDYIKERLALAYEAAKSFAGLDATKEMIPVRPAQHYYMGGIDVDITGRNPD
EEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEECCEEEEEECCCCC
LIGLFAAGEAACVSVHGANRLGSNSLLETLVFGRETGRAVVEFLKSYTEPSSDIDKEAEK
EEEEEECCCEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHH
MIDSAYDVVKSESGIHFGEILEKLRDTMWDYVGVFRDENGLKTALSEIMKLREDMKKMYV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHE
LDKSKVYNTEFYNALELKNMLDLALVIATSALNRKESRGAHYRLDFPERDDQNWLKHTIA
ECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEECCCCCCCHHHHHHHHH
YLRGNSVEITYKPVKMTKWKPEARVY
HHCCCEEEEEEECEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA