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The map label for this gene is psmB2

Identifier: 15920692

GI number: 15920692

Start: 477810

End: 478433

Strand: Reverse

Name: psmB2

Synonym: ST0477

Alternate gene names: 15920692

Gene position: 478433-477810 (Counterclockwise)

Preceding gene: 15920693

Following gene: 15920691

Centisome position: 17.75

GC content: 33.49

Gene sequence:

>624_bases
ATGGAGACTAATAATAAGTTAAAGATTTTAAAAACCGGAACTACCACGGTTGGAATAAAAGTAAAAGATGGAGTAGTATT
AGCTGCTGATAGAAGAGCAAGTGCTGGAATGTATGTAGCACATAAGTATGTAAGAAAAGTCCTCTATGTTGCACCAAATA
TAGGTATTACTACAGCCGGTAGTGTAGCTGATTTACAGTTTATATATGATTTGCTAAAGAATATATATCATTATAACCTA
ATAACGGGGATGAGACCAATTACAATCAAAGCGTTAGCTACATATTTAGCTAATATGTTATCATTTTCTAAGTATCTTCC
TTATATAGTTCAAATATTAATAGGTGGTGTAGATGAGCAGCCAAGATTATATAATCTTGATTATGTAGGCGATATAACAG
AAGAGGATTATACTGCGACGGGTTCTGGTTCAGTAGAAGCTATAGGCGTAATTGAAGATGAATATAGGCCAGATATGACA
TTAGATGAAGCTGCTGACTTAGCTAGAAGAGCAATCTTCTCATCTATAAAAAGAGATCCCTATACTGGGACTGGAGTAAT
AGTGAGTAAGATAACTAAAAATGGACATGAGGAAAAAGAATATTATCCTCAAAGAAAAATCTAA

Upstream 100 bases:

>100_bases
ATTAGCGGAGAGCCCTATAAAGATGGAACTGTTTTAGATATTGCAGAGGAAATAATGGGAATTGTTGGTTTTATTAAGTA
GTTTTACACAATTTGTTTTG

Downstream 100 bases:

>100_bases
AAGTTTTTATTCCTTTCTAGGAATTTATAATTATGAATGTAAAGTCCTCAGCTTTTAAGAATGAAGATTTTATTCCAGTA
AGGTACACTTGTGACGGAGA

Product: proteasome subunit beta

Products: NA

Alternate protein names: 20S proteasome beta subunit 2; Proteasome core protein PsmB 2

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
METNNKLKILKTGTTTVGIKVKDGVVLAADRRASAGMYVAHKYVRKVLYVAPNIGITTAGSVADLQFIYDLLKNIYHYNL
ITGMRPITIKALATYLANMLSFSKYLPYIVQILIGGVDEQPRLYNLDYVGDITEEDYTATGSGSVEAIGVIEDEYRPDMT
LDEAADLARRAIFSSIKRDPYTGTGVIVSKITKNGHEEKEYYPQRKI

Sequences:

>Translated_207_residues
METNNKLKILKTGTTTVGIKVKDGVVLAADRRASAGMYVAHKYVRKVLYVAPNIGITTAGSVADLQFIYDLLKNIYHYNL
ITGMRPITIKALATYLANMLSFSKYLPYIVQILIGGVDEQPRLYNLDYVGDITEEDYTATGSGSVEAIGVIEDEYRPDMT
LDEAADLARRAIFSSIKRDPYTGTGVIVSKITKNGHEEKEYYPQRKI
>Mature_207_residues
METNNKLKILKTGTTTVGIKVKDGVVLAADRRASAGMYVAHKYVRKVLYVAPNIGITTAGSVADLQFIYDLLKNIYHYNL
ITGMRPITIKALATYLANMLSFSKYLPYIVQILIGGVDEQPRLYNLDYVGDITEEDYTATGSGSVEAIGVIEDEYRPDMT
LDEAADLARRAIFSSIKRDPYTGTGVIVSKITKNGHEEKEYYPQRKI

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4506203, Length=190, Percent_Identity=38.9473684210526, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI4506201, Length=184, Percent_Identity=36.4130434782609, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI73747875, Length=188, Percent_Identity=36.1702127659575, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI4758970, Length=188, Percent_Identity=36.1702127659575, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI4506191, Length=188, Percent_Identity=34.5744680851064, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI153791216, Length=190, Percent_Identity=32.6315789473684, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI22538465, Length=189, Percent_Identity=26.984126984127, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI23110942, Length=168, Percent_Identity=27.3809523809524, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI23110925, Length=192, Percent_Identity=26.0416666666667, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI195539356, Length=138, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI4506193, Length=203, Percent_Identity=27.0935960591133, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17508495, Length=178, Percent_Identity=35.9550561797753, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17508499, Length=199, Percent_Identity=31.6582914572864, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17541700, Length=201, Percent_Identity=27.8606965174129, Blast_Score=90, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17535357, Length=189, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508493, Length=171, Percent_Identity=27.4853801169591, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325360, Length=192, Percent_Identity=31.25, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324731, Length=189, Percent_Identity=31.7460317460317, Blast_Score=92, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320849, Length=185, Percent_Identity=31.3513513513514, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322459, Length=203, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323547, Length=178, Percent_Identity=28.0898876404494, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319430, Length=215, Percent_Identity=24.6511627906977, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355573, Length=184, Percent_Identity=32.0652173913043, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24652553, Length=184, Percent_Identity=32.0652173913043, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI20130281, Length=184, Percent_Identity=31.5217391304348, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24664391, Length=183, Percent_Identity=33.879781420765, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24653999, Length=197, Percent_Identity=30.9644670050761, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24639979, Length=190, Percent_Identity=31.5789473684211, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24654391, Length=208, Percent_Identity=27.8846153846154, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24654389, Length=208, Percent_Identity=27.8846153846154, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24584895, Length=176, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355629, Length=194, Percent_Identity=23.7113402061856, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17737605, Length=198, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573221, Length=174, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB2_SULTO (Q975D1)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376361.1
- HSSP:   Q9P996
- ProteinModelPortal:   Q975D1
- SMR:   Q975D1
- MEROPS:   T01.002
- GeneID:   1458419
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0477
- NMPDR:   fig|273063.1.peg.529
- HOGENOM:   HBG499923
- OMA:   MAYGVLE
- ProtClustDB:   CLSK802863
- BioCyc:   STOK273063:ST0477-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_02113_A
- InterPro:   IPR019983
- InterPro:   IPR000243
- InterPro:   IPR016050
- InterPro:   IPR001353
- PRINTS:   PR00141
- TIGRFAMs:   TIGR03634

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 23041; Mature: 23041

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METNNKLKILKTGTTTVGIKVKDGVVLAADRRASAGMYVAHKYVRKVLYVAPNIGITTAG
CCCCCEEEEEEECCEEEEEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
SVADLQFIYDLLKNIYHYNLITGMRPITIKALATYLANMLSFSKYLPYIVQILIGGVDEQ
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PRLYNLDYVGDITEEDYTATGSGSVEAIGVIEDEYRPDMTLDEAADLARRAIFSSIKRDP
CCEEECCCCCCCCCCCCEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
YTGTGVIVSKITKNGHEEKEYYPQRKI
CCCCHHHEEHHHCCCCHHHHCCCCCCC
>Mature Secondary Structure
METNNKLKILKTGTTTVGIKVKDGVVLAADRRASAGMYVAHKYVRKVLYVAPNIGITTAG
CCCCCEEEEEEECCEEEEEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
SVADLQFIYDLLKNIYHYNLITGMRPITIKALATYLANMLSFSKYLPYIVQILIGGVDEQ
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PRLYNLDYVGDITEEDYTATGSGSVEAIGVIEDEYRPDMTLDEAADLARRAIFSSIKRDP
CCEEECCCCCCCCCCCCEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
YTGTGVIVSKITKNGHEEKEYYPQRKI
CCCCHHHEEHHHCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479