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The map label for this gene is tmk1

Identifier: 15920677

GI number: 15920677

Start: 466079

End: 466651

Strand: Reverse

Name: tmk1

Synonym: ST0462

Alternate gene names: 15920677

Gene position: 466651-466079 (Counterclockwise)

Preceding gene: 15920678

Following gene: 15920674

Centisome position: 17.32

GC content: 31.76

Gene sequence:

>573_bases
ATGCCCAGATTCATATCATTTGAAGGAATAGACGGAGCCGGTAAAACAACATTAGCTAAAAAAGTATATGAAGTTCTAAA
GAAAAAAGGATATAATGTTATTTTAACACAAGAACCCTTTACGAGAGAAATTACTGAGCTAATAAAGAAAGCTGGTTGGA
ATGATCCAGTATTGTTAACCCTACTATTCTCAGCAGATAGAGCTTTTCACATAAAATGGATAATGGAACAAAAGCCTGAA
ATAGTTTTAATGGATAGGTATTTTCATTCTACGATTGCTTATCAAAGTGTACTTGGTTTAGACGAAAAATGGATAGAAGA
AGTAAATTCTAAATTCCCTAAACCCGATATAGTCTTCTTACTTGATATAAAGGTTAATGAAGCAATAAAGAGGATTAGAA
AAGATGACCAGTTTAATTTTGAGGAAAAGATTGCTACATTGGAAGCCGTTAGGAAAAAGTACCTTGAACTGGCTAGAAAA
TATAATTTTATAGTACTCGATGCCATGTCTAAAATAGAAGAATTAACAGAAAAAACTGTACAAATCATTTGTTCTCTGGT
GAAATGCTCTTAA

Upstream 100 bases:

>100_bases
ACGTTCTAATCAAAACGCCAGAAAAAGATTTTGATGGTGTCCTATTGGGTTATATAAGCTTAAATGATAATTATGAAGAT
ACTGAAGTAAAGATAAGAAA

Downstream 100 bases:

>100_bases
TCTTCCTTATTCTTTCAATAGCGTCTAAGTACCTTATTATTTGTAACAAAGCATCACTATCCATTGGATCAGTCTTTATT
TTTTCAACAACACTATTCAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MPRFISFEGIDGAGKTTLAKKVYEVLKKKGYNVILTQEPFTREITELIKKAGWNDPVLLTLLFSADRAFHIKWIMEQKPE
IVLMDRYFHSTIAYQSVLGLDEKWIEEVNSKFPKPDIVFLLDIKVNEAIKRIRKDDQFNFEEKIATLEAVRKKYLELARK
YNFIVLDAMSKIEELTEKTVQIICSLVKCS

Sequences:

>Translated_190_residues
MPRFISFEGIDGAGKTTLAKKVYEVLKKKGYNVILTQEPFTREITELIKKAGWNDPVLLTLLFSADRAFHIKWIMEQKPE
IVLMDRYFHSTIAYQSVLGLDEKWIEEVNSKFPKPDIVFLLDIKVNEAIKRIRKDDQFNFEEKIATLEAVRKKYLELARK
YNFIVLDAMSKIEELTEKTVQIICSLVKCS
>Mature_189_residues
PRFISFEGIDGAGKTTLAKKVYEVLKKKGYNVILTQEPFTREITELIKKAGWNDPVLLTLLFSADRAFHIKWIMEQKPEI
VLMDRYFHSTIAYQSVLGLDEKWIEEVNSKFPKPDIVFLLDIKVNEAIKRIRKDDQFNFEEKIATLEAVRKKYLELARKY
NFIVLDAMSKIEELTEKTVQIICSLVKCS

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Caenorhabditis elegans, GI17535647, Length=144, Percent_Identity=32.6388888888889, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY1_SULTO (Q975E6)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376346.1
- ProteinModelPortal:   Q975E6
- GeneID:   1458404
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0462
- NMPDR:   fig|273063.1.peg.514
- HOGENOM:   HBG626009
- OMA:   FTFEPTD
- ProtClustDB:   CLSK802872
- BioCyc:   STOK273063:ST0462-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22181; Mature: 22050

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFISFEGIDGAGKTTLAKKVYEVLKKKGYNVILTQEPFTREITELIKKAGWNDPVLLT
CCCEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHH
LLFSADRAFHIKWIMEQKPEIVLMDRYFHSTIAYQSVLGLDEKWIEEVNSKFPKPDIVFL
EEHHCCCEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEE
LDIKVNEAIKRIRKDDQFNFEEKIATLEAVRKKYLELARKYNFIVLDAMSKIEELTEKTV
EECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHH
QIICSLVKCS
HHHHHHHHCC
>Mature Secondary Structure 
PRFISFEGIDGAGKTTLAKKVYEVLKKKGYNVILTQEPFTREITELIKKAGWNDPVLLT
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHH
LLFSADRAFHIKWIMEQKPEIVLMDRYFHSTIAYQSVLGLDEKWIEEVNSKFPKPDIVFL
EEHHCCCEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEE
LDIKVNEAIKRIRKDDQFNFEEKIATLEAVRKKYLELARKYNFIVLDAMSKIEELTEKTV
EECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHH
QIICSLVKCS
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479