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The map label for this gene is psmA

Identifier: 15920658

GI number: 15920658

Start: 452276

End: 452983

Strand: Reverse

Name: psmA

Synonym: ST0446

Alternate gene names: 15920658

Gene position: 452983-452276 (Counterclockwise)

Preceding gene: 15920659

Following gene: 15920657

Centisome position: 16.81

GC content: 35.03

Gene sequence:

>708_bases
ATGGGATATGATAGAGCTATAACAATATTTTCTCCAGATGGATCATTATATCAAGTAGATTATGCCTTTGAGGCAGTAAA
GAAAGGTTGGACTACTTTAGGGGTAAAAACAAAAGCTGGAGTTGTTCTCATTGGAGAAAAAAGAAAAGCCACCCAACTTC
TTGATGTTGATAGCATAGAAAAAGTCTTTATCCTTGATGACCATGTAGGATGTAGCTTTGCTGGATTAGCCTCAGACGGA
AGAATATTAATTGATTATGCTAGATCTCAAGCACTTCAGCATAGGTTAATATATGATGAACCTATCAATATTGACTATCT
TACAAAATTAGTTTCAGATGTAAAACAAATGTATACCCAACACGGTGGAGTAAGACCCTTTGGTGTTGCTTTAATTATAG
GTGGTATTGATAGAGGAAAAACTCCAAAATTATTAATGACAGAGCCAAGCGGTCAGTTTATGCCTTACTATGCTGTAGCT
ATTGGACAAGGTGGGTATACCGCAACAGAATACTTTGAGAAAAACTATAGAGAAGATCTCAATATGCAAGATACAATATT
ACTAGGAATTAGAGCCTTAGCATCTACTCTTAAACCCGGAGAAAAACTTGCACCTTCTAATATTGAAGTTGGATTTGCAG
ATGTAGATTCCGGAATGTTTAGAAAGATGAGTTTCGAAGAAAGAGCATCAATATTACAAAAATTATAA

Upstream 100 bases:

>100_bases
ACTGTATCATGATGAACACGCGACGAACTGATAACACTTTTTAACACTTATTATATCTACTGATATTGGGAGAAGAAATT
TGGCATTTGGACCAGCAGCA

Downstream 100 bases:

>100_bases
TTGGGGTGAAAATAATTTCATGACCAAGAAAGAAGAATATGTTATCGCTAGATATGAGCATGGTGGTGAAAGATTTGAAA
TACTAGTAAAACCTAAAGAA

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MGYDRAITIFSPDGSLYQVDYAFEAVKKGWTTLGVKTKAGVVLIGEKRKATQLLDVDSIEKVFILDDHVGCSFAGLASDG
RILIDYARSQALQHRLIYDEPINIDYLTKLVSDVKQMYTQHGGVRPFGVALIIGGIDRGKTPKLLMTEPSGQFMPYYAVA
IGQGGYTATEYFEKNYREDLNMQDTILLGIRALASTLKPGEKLAPSNIEVGFADVDSGMFRKMSFEERASILQKL

Sequences:

>Translated_235_residues
MGYDRAITIFSPDGSLYQVDYAFEAVKKGWTTLGVKTKAGVVLIGEKRKATQLLDVDSIEKVFILDDHVGCSFAGLASDG
RILIDYARSQALQHRLIYDEPINIDYLTKLVSDVKQMYTQHGGVRPFGVALIIGGIDRGKTPKLLMTEPSGQFMPYYAVA
IGQGGYTATEYFEKNYREDLNMQDTILLGIRALASTLKPGEKLAPSNIEVGFADVDSGMFRKMSFEERASILQKL
>Mature_234_residues
GYDRAITIFSPDGSLYQVDYAFEAVKKGWTTLGVKTKAGVVLIGEKRKATQLLDVDSIEKVFILDDHVGCSFAGLASDGR
ILIDYARSQALQHRLIYDEPINIDYLTKLVSDVKQMYTQHGGVRPFGVALIIGGIDRGKTPKLLMTEPSGQFMPYYAVAI
GQGGYTATEYFEKNYREDLNMQDTILLGIRALASTLKPGEKLAPSNIEVGFADVDSGMFRKMSFEERASILQKL

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family

Homologues:

Organism=Homo sapiens, GI4506189, Length=221, Percent_Identity=43.8914027149321, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI68303563, Length=212, Percent_Identity=43.3962264150943, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI68303561, Length=218, Percent_Identity=42.2018348623853, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI4506181, Length=226, Percent_Identity=38.9380530973451, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI23110942, Length=234, Percent_Identity=37.1794871794872, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI23110944, Length=229, Percent_Identity=34.061135371179, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI23110935, Length=216, Percent_Identity=34.7222222222222, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI4506179, Length=216, Percent_Identity=34.7222222222222, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI156713442, Length=218, Percent_Identity=36.697247706422, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI4506185, Length=218, Percent_Identity=36.697247706422, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI68303565, Length=212, Percent_Identity=36.3207547169811, Blast_Score=140, Evalue=7e-34,
Organism=Homo sapiens, GI4506183, Length=185, Percent_Identity=34.5945945945946, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI23110939, Length=185, Percent_Identity=34.5945945945946, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI221316716, Length=109, Percent_Identity=37.6146788990826, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI156713444, Length=151, Percent_Identity=32.4503311258278, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17508491, Length=235, Percent_Identity=41.2765957446808, Blast_Score=188, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17508493, Length=244, Percent_Identity=34.0163934426229, Blast_Score=144, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25143215, Length=211, Percent_Identity=37.4407582938389, Blast_Score=143, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17562790, Length=226, Percent_Identity=33.6283185840708, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17562792, Length=217, Percent_Identity=34.5622119815668, Blast_Score=126, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17562788, Length=231, Percent_Identity=31.1688311688312, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71998965, Length=211, Percent_Identity=30.3317535545024, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324535, Length=231, Percent_Identity=45.021645021645, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321692, Length=239, Percent_Identity=38.4937238493724, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6321574, Length=195, Percent_Identity=38.4615384615385, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323547, Length=197, Percent_Identity=37.0558375634518, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324938, Length=188, Percent_Identity=36.7021276595745, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323974, Length=219, Percent_Identity=34.2465753424658, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321427, Length=222, Percent_Identity=30.1801801801802, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17933602, Length=214, Percent_Identity=43.4579439252336, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21356137, Length=193, Percent_Identity=44.559585492228, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI19922898, Length=209, Percent_Identity=39.7129186602871, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24654391, Length=215, Percent_Identity=37.2093023255814, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24654389, Length=215, Percent_Identity=37.2093023255814, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17737927, Length=214, Percent_Identity=36.9158878504673, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI281360341, Length=235, Percent_Identity=31.063829787234, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24586406, Length=235, Percent_Identity=31.063829787234, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24586400, Length=235, Percent_Identity=31.063829787234, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24586402, Length=235, Percent_Identity=31.063829787234, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI17136420, Length=214, Percent_Identity=36.4485981308411, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17737405, Length=202, Percent_Identity=36.6336633663366, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24652204, Length=173, Percent_Identity=35.8381502890173, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24651571, Length=216, Percent_Identity=32.8703703703704, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19921232, Length=198, Percent_Identity=33.8383838383838, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSA_SULTO (Q975G5)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376327.1
- ProteinModelPortal:   Q975G5
- SMR:   Q975G5
- GeneID:   1458383
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0446
- NMPDR:   fig|273063.1.peg.495
- HOGENOM:   HBG499923
- ProtClustDB:   PRK03996
- BioCyc:   STOK273063:ST0446-MONOMER
- BRENDA:   3.4.25.1
- GO:   GO:0005737
- HAMAP:   MF_00289_A
- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353
- SMART:   SM00948
- TIGRFAMs:   TIGR03633

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N

EC number: =3.4.25.1

Molecular weight: Translated: 26021; Mature: 25890

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00388 PROTEASOME_A_1; PS51475 PROTEASOME_A_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYDRAITIFSPDGSLYQVDYAFEAVKKGWTTLGVKTKAGVVLIGEKRKATQLLDVDSIE
CCCCCEEEEECCCCCEEEEHHHHHHHHCCCEEECEEECCCEEEEECCCCHHHEECCCCCC
KVFILDDHVGCSFAGLASDGRILIDYARSQALQHRLIYDEPINIDYLTKLVSDVKQMYTQ
EEEEEECCCCCEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
HGGVRPFGVALIIGGIDRGKTPKLLMTEPSGQFMPYYAVAIGQGGYTATEYFEKNYREDL
CCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCC
NMQDTILLGIRALASTLKPGEKLAPSNIEVGFADVDSGMFRKMSFEERASILQKL
CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
GYDRAITIFSPDGSLYQVDYAFEAVKKGWTTLGVKTKAGVVLIGEKRKATQLLDVDSIE
CCCCEEEEECCCCCEEEEHHHHHHHHCCCEEECEEECCCEEEEECCCCHHHEECCCCCC
KVFILDDHVGCSFAGLASDGRILIDYARSQALQHRLIYDEPINIDYLTKLVSDVKQMYTQ
EEEEEECCCCCEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
HGGVRPFGVALIIGGIDRGKTPKLLMTEPSGQFMPYYAVAIGQGGYTATEYFEKNYREDL
CCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCC
NMQDTILLGIRALASTLKPGEKLAPSNIEVGFADVDSGMFRKMSFEERASILQKL
CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479