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The map label for this gene is trxB [H]

Identifier: 15920649

GI number: 15920649

Start: 446222

End: 447229

Strand: Direct

Name: trxB [H]

Synonym: ST0438

Alternate gene names: 15920649

Gene position: 446222-447229 (Clockwise)

Preceding gene: 15920646

Following gene: 15920663

Centisome position: 16.56

GC content: 34.62

Gene sequence:

>1008_bases
ATGCAACAATTGAATCAACATAATGAAATATATGATGTAATCATAGTAGGAGCAGGAATTGCTGGGCTAAGTGCCGCTTT
ATATACCTCAAGGCAAAGAATGAAAACGTTAGTTGTCTCAAAAGATTTAGGAGGACAACTAACATTAACTGATCTCATAG
AGAATTATCCTGTAGTTGAGCCTTTAAGTGGACTTAGTTTAGCGCGAAAGGTAGAGTCGCAGGCAAAGAGGTTTGGAGCT
AAATTCATCTATGGAGAAGAAATATACAAGATAGATAAAAAAGGCGATATTTTTGAACTTCAAGGTATTTTAGGAAGTTA
TAAGGCTAAGACTGTTATTTTAGCGTTCGGTAAGACACCTAGAGAACTTAATGTGCCGGGTGAGAAAGAATTTAAAGGTA
AAGGTGTATCGTATTGTGCAATTTGTGATGCTGCATTTTTTAAAGATAAGCCAGCTGCAGTTGTAGGAGAAGGAGAGCCT
GGCGTAGAAGCTATAGAACTTCTTTCAAAATATGCAAGACCTGCTTATTATATTTCTATGTCTACTCAGTTGGTTGGAGG
AGATGAGGGCACATTAAAGTCAATATTGAACAATGAAAATATAAAAATGTTTTTAGGATATAAAGTGATTAGAATTATTG
GAAATTCTAAAGTTGAGGGAATAGTTATACAAAATTCTAAGACAAAAGAAGATAAAATTCTAAATGTAGATGGAGTAATA
ATAGAAATGGGTTATGTTTTACGAACAGAGTTCTTAAAAGATTTTATAAAACTCAATGAAAAAGGAGAAATAATAGTAGA
TGAATTAGGAAGAACTAATGTAGAAGGAATATTCGCTGCTGGTGATGTTACAAATACTCCATACAAGCAAGCTGTTGTAG
CTGCTGCAGAAGGAGTGAAAGCTGCACTTTCTGCGTACAACTATTTAAGGAGCAAGTCTGGCTTACCTCCAGTAAATGTT
GATTGGAAAGCAGAAAAACAGAAAGCTGTAGTTTCATTTAGGCTCTAA

Upstream 100 bases:

>100_bases
TAACTTCAGAATATTAAAGTGTAATGGATATCCTACATCAATAATTGATACAATCTTTTTAATAAACAACTTTTTATCAT
AAGATTTAAAATAAGTAAAT

Downstream 100 bases:

>100_bases
GAAGTCAAGCAAAGAAGTTTTATTATTTCTTTCCTCCTTTTTATTCGTATATGTTGTATGTATAACTTTATATATTTCCT
CAGCTTTCTTTCTACTCTCC

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MQQLNQHNEIYDVIIVGAGIAGLSAALYTSRQRMKTLVVSKDLGGQLTLTDLIENYPVVEPLSGLSLARKVESQAKRFGA
KFIYGEEIYKIDKKGDIFELQGILGSYKAKTVILAFGKTPRELNVPGEKEFKGKGVSYCAICDAAFFKDKPAAVVGEGEP
GVEAIELLSKYARPAYYISMSTQLVGGDEGTLKSILNNENIKMFLGYKVIRIIGNSKVEGIVIQNSKTKEDKILNVDGVI
IEMGYVLRTEFLKDFIKLNEKGEIIVDELGRTNVEGIFAAGDVTNTPYKQAVVAAAEGVKAALSAYNYLRSKSGLPPVNV
DWKAEKQKAVVSFRL

Sequences:

>Translated_335_residues
MQQLNQHNEIYDVIIVGAGIAGLSAALYTSRQRMKTLVVSKDLGGQLTLTDLIENYPVVEPLSGLSLARKVESQAKRFGA
KFIYGEEIYKIDKKGDIFELQGILGSYKAKTVILAFGKTPRELNVPGEKEFKGKGVSYCAICDAAFFKDKPAAVVGEGEP
GVEAIELLSKYARPAYYISMSTQLVGGDEGTLKSILNNENIKMFLGYKVIRIIGNSKVEGIVIQNSKTKEDKILNVDGVI
IEMGYVLRTEFLKDFIKLNEKGEIIVDELGRTNVEGIFAAGDVTNTPYKQAVVAAAEGVKAALSAYNYLRSKSGLPPVNV
DWKAEKQKAVVSFRL
>Mature_335_residues
MQQLNQHNEIYDVIIVGAGIAGLSAALYTSRQRMKTLVVSKDLGGQLTLTDLIENYPVVEPLSGLSLARKVESQAKRFGA
KFIYGEEIYKIDKKGDIFELQGILGSYKAKTVILAFGKTPRELNVPGEKEFKGKGVSYCAICDAAFFKDKPAAVVGEGEP
GVEAIELLSKYARPAYYISMSTQLVGGDEGTLKSILNNENIKMFLGYKVIRIIGNSKVEGIVIQNSKTKEDKILNVDGVI
IEMGYVLRTEFLKDFIKLNEKGEIIVDELGRTNVEGIFAAGDVTNTPYKQAVVAAAEGVKAALSAYNYLRSKSGLPPVNV
DWKAEKQKAVVSFRL

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081763, Length=318, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1787114, Length=310, Percent_Identity=31.6129032258064, Blast_Score=144, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6321898, Length=322, Percent_Identity=32.9192546583851, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320560, Length=325, Percent_Identity=31.6923076923077, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 36661; Mature: 36661

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQLNQHNEIYDVIIVGAGIAGLSAALYTSRQRMKTLVVSKDLGGQLTLTDLIENYPVVE
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHHHCCCCCC
PLSGLSLARKVESQAKRFGAKFIYGEEIYKIDKKGDIFELQGILGSYKAKTVILAFGKTP
CCCHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCCEEEEHHHHCCCCCEEEEEEECCCC
RELNVPGEKEFKGKGVSYCAICDAAFFKDKPAAVVGEGEPGVEAIELLSKYARPAYYISM
CCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCEEEEEE
STQLVGGDEGTLKSILNNENIKMFLGYKVIRIIGNSKVEGIVIQNSKTKEDKILNVDGVI
EEEEECCCCHHHHHHHCCCCEEEEECEEEEEEECCCCEEEEEEECCCCCCCCEEECCCEE
IEMGYVLRTEFLKDFIKLNEKGEIIVDELGRTNVEGIFAAGDVTNTPYKQAVVAAAEGVK
EEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
AALSAYNYLRSKSGLPPVNVDWKAEKQKAVVSFRL
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MQQLNQHNEIYDVIIVGAGIAGLSAALYTSRQRMKTLVVSKDLGGQLTLTDLIENYPVVE
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHHHCCCCCC
PLSGLSLARKVESQAKRFGAKFIYGEEIYKIDKKGDIFELQGILGSYKAKTVILAFGKTP
CCCHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCCEEEEHHHHCCCCCEEEEEEECCCC
RELNVPGEKEFKGKGVSYCAICDAAFFKDKPAAVVGEGEPGVEAIELLSKYARPAYYISM
CCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCEEEEEE
STQLVGGDEGTLKSILNNENIKMFLGYKVIRIIGNSKVEGIVIQNSKTKEDKILNVDGVI
EEEEECCCCHHHHHHHCCCCEEEEECEEEEEEECCCCEEEEEEECCCCCCCCEEECCCEE
IEMGYVLRTEFLKDFIKLNEKGEIIVDELGRTNVEGIFAAGDVTNTPYKQAVVAAAEGVK
EEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
AALSAYNYLRSKSGLPPVNVDWKAEKQKAVVSFRL
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]