Click here to switch to the map view.

The map label for this gene is secY [H]

Identifier: 15920619

GI number: 15920619

Start: 423274

End: 424665

Strand: Reverse

Name: secY [H]

Synonym: ST0411

Alternate gene names: 15920619

Gene position: 424665-423274 (Counterclockwise)

Preceding gene: 15920620

Following gene: 15920618

Centisome position: 15.76

GC content: 33.84

Gene sequence:

>1392_bases
ATGGGTTTTGTTGATTTTCTTGCTACACTAGGAGAATATTTACCAGCTGTAACTAAACCTAAAGATAGACCTTCTTTGGC
AACTAAACTCCTTTGGTCGTTTATAGCTGTTATTGTTTATCTAGTAATGGCGTCAATACCACTTTATGGAGTTACCTCAG
CAAATTCGTTCTTAAGCAATTTTTTGGCTGAAGAAATTATTTTTGCCTCAACTCAAGGTACATTAGCTCAACTAGGAATA
GGTCCTATCATTACTTCTGGTTTAATTATGCAAATATTAGTAGGTTCAAAACTAATTCAAATGGATTTAGCTAAAGAAGA
AGATCAAGCTAGATTTACTGAAGCAGAAAAAGGATTAGCTTTCGTTTTCATTCTAGTAGAATCTGCCTTATTTGGTTACG
TGTTTACAAGAACTGCTGGTAATATTGAACTATCAGCTATTGTAACAATACAATTAATTGTTGCTACATATATAATTTTA
CTTCTAGATGAAATGATTCAAAAAGGATGGGGATTAGGATCTGGAATAAGTCTGTTTATATTAGCTGGTGTAACTAAAAT
TATGTTTTGGGATATGTTTGGTATTGCAGCAGTTAGTAATCAAAACTTACCAGTAGGTTTCTTCCCCGTGTTAATATCTG
ACATAGTAAGTGGAAAGAACATACTATCATTAATAGTAAATACGAGCACAACTACACCATTTCAACCAGATCTAGTAGGA
CTTATTTCTACCATTGGACTAATTATATTAATAATATATCTAACTAACATAAATATACAAATCCCAGTAACTACACAGCG
ATTAAGAGGGATAAAGACTACAATTCCATTAAACTTCTTATATGTTAGTAGCATCCCAGTAATATTTGTAAGTGTTTTAG
GTGCTGATTTCCAATTATTTGCATCGTTAGCTTCCTATATATCATCTCCTGCCTCTACAGTCTTAACAGATATTGCAAAT
GCGTTTTTCTTCCCTCCAGCTAATGTCCCACATAGTGTGTTTGCTTTAGTAGTTGACCCAATAGGAGCAGTAATCTATGC
AGTCGTATTTATTGTATTATCCATTATATTCGGTATTCTGTGGATTGATGTCGCTGGTCTTGATCCAGCAACACAAGCGC
AACAAATGGTTGAAGCTGGGATGGAAATACCGGGAATGAGAAATAGTCCTAAAGTAATAGAAGGAATTCTGGCTAGGTAT
ATATATCCGTTAGGTTTCTATAGTTCTCTTATAGTAGGAGTAATTGCTGTGTTAGCAACTTTTCTAGGAGTATATGGAAC
TGGTGTAGGAATTTTGCTAGCAGTAACTATAGCTATTCAGTACTATAATTTATTAGCTTATGAGAGAACGTTAGAAATGT
ACCCACTATTAAAGAGAATAATCGGTGAGTAA

Upstream 100 bases:

>100_bases
ATTAAGGTGAATATGGCCAGTAAAAAAGCAATTGAAAAAGTTAAGGAATTAGGAGGACAAATTATATTAACCACAAGTGA
ATAGGCTTTTTTAGAGTAGT

Downstream 100 bases:

>100_bases
AATGAAAATTGGAATAGTAACTGGAATACCTGGTGTGGGAAAAACTACTGTTCTTTCTAAAGTTAAAGAAATACTAGAAG
AAAAAAAGATAAATAATAAG

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MGFVDFLATLGEYLPAVTKPKDRPSLATKLLWSFIAVIVYLVMASIPLYGVTSANSFLSNFLAEEIIFASTQGTLAQLGI
GPIITSGLIMQILVGSKLIQMDLAKEEDQARFTEAEKGLAFVFILVESALFGYVFTRTAGNIELSAIVTIQLIVATYIIL
LLDEMIQKGWGLGSGISLFILAGVTKIMFWDMFGIAAVSNQNLPVGFFPVLISDIVSGKNILSLIVNTSTTTPFQPDLVG
LISTIGLIILIIYLTNINIQIPVTTQRLRGIKTTIPLNFLYVSSIPVIFVSVLGADFQLFASLASYISSPASTVLTDIAN
AFFFPPANVPHSVFALVVDPIGAVIYAVVFIVLSIIFGILWIDVAGLDPATQAQQMVEAGMEIPGMRNSPKVIEGILARY
IYPLGFYSSLIVGVIAVLATFLGVYGTGVGILLAVTIAIQYYNLLAYERTLEMYPLLKRIIGE

Sequences:

>Translated_463_residues
MGFVDFLATLGEYLPAVTKPKDRPSLATKLLWSFIAVIVYLVMASIPLYGVTSANSFLSNFLAEEIIFASTQGTLAQLGI
GPIITSGLIMQILVGSKLIQMDLAKEEDQARFTEAEKGLAFVFILVESALFGYVFTRTAGNIELSAIVTIQLIVATYIIL
LLDEMIQKGWGLGSGISLFILAGVTKIMFWDMFGIAAVSNQNLPVGFFPVLISDIVSGKNILSLIVNTSTTTPFQPDLVG
LISTIGLIILIIYLTNINIQIPVTTQRLRGIKTTIPLNFLYVSSIPVIFVSVLGADFQLFASLASYISSPASTVLTDIAN
AFFFPPANVPHSVFALVVDPIGAVIYAVVFIVLSIIFGILWIDVAGLDPATQAQQMVEAGMEIPGMRNSPKVIEGILARY
IYPLGFYSSLIVGVIAVLATFLGVYGTGVGILLAVTIAIQYYNLLAYERTLEMYPLLKRIIGE
>Mature_462_residues
GFVDFLATLGEYLPAVTKPKDRPSLATKLLWSFIAVIVYLVMASIPLYGVTSANSFLSNFLAEEIIFASTQGTLAQLGIG
PIITSGLIMQILVGSKLIQMDLAKEEDQARFTEAEKGLAFVFILVESALFGYVFTRTAGNIELSAIVTIQLIVATYIILL
LDEMIQKGWGLGSGISLFILAGVTKIMFWDMFGIAAVSNQNLPVGFFPVLISDIVSGKNILSLIVNTSTTTPFQPDLVGL
ISTIGLIILIIYLTNINIQIPVTTQRLRGIKTTIPLNFLYVSSIPVIFVSVLGADFQLFASLASYISSPASTVLTDIANA
FFFPPANVPHSVFALVVDPIGAVIYAVVFIVLSIIFGILWIDVAGLDPATQAQQMVEAGMEIPGMRNSPKVIEGILARYI
YPLGFYSSLIVGVIAVLATFLGVYGTGVGILLAVTIAIQYYNLLAYERTLEMYPLLKRIIGE

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel [H]

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family [H]

Homologues:

Organism=Homo sapiens, GI7019415, Length=462, Percent_Identity=34.1991341991342, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI14589847, Length=476, Percent_Identity=31.5126050420168, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI217330618, Length=431, Percent_Identity=32.2505800464037, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI217330616, Length=421, Percent_Identity=29.6912114014252, Blast_Score=165, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17543770, Length=478, Percent_Identity=32.0083682008368, Blast_Score=207, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323411, Length=470, Percent_Identity=25.9574468085106, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319760, Length=449, Percent_Identity=23.8307349665924, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI19920826, Length=473, Percent_Identity=31.5010570824524, Blast_Score=204, Evalue=9e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561 [H]

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY [H]

EC number: NA

Molecular weight: Translated: 50022; Mature: 49891

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00755 SECY_1 ; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFVDFLATLGEYLPAVTKPKDRPSLATKLLWSFIAVIVYLVMASIPLYGVTSANSFLSN
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FLAEEIIFASTQGTLAQLGIGPIITSGLIMQILVGSKLIQMDLAKEEDQARFTEAEKGLA
HHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCHH
FVFILVESALFGYVFTRTAGNIELSAIVTIQLIVATYIILLLDEMIQKGWGLGSGISLFI
HHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LAGVTKIMFWDMFGIAAVSNQNLPVGFFPVLISDIVSGKNILSLIVNTSTTTPFQPDLVG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHEEECCCCCCCCHHHHH
LISTIGLIILIIYLTNINIQIPVTTQRLRGIKTTIPLNFLYVSSIPVIFVSVLGADFQLF
HHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
ASLASYISSPASTVLTDIANAFFFPPANVPHSVFALVVDPIGAVIYAVVFIVLSIIFGIL
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIDVAGLDPATQAQQMVEAGMEIPGMRNSPKVIEGILARYIYPLGFYSSLIVGVIAVLAT
HHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVYGTGVGILLAVTIAIQYYNLLAYERTLEMYPLLKRIIGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GFVDFLATLGEYLPAVTKPKDRPSLATKLLWSFIAVIVYLVMASIPLYGVTSANSFLSN
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FLAEEIIFASTQGTLAQLGIGPIITSGLIMQILVGSKLIQMDLAKEEDQARFTEAEKGLA
HHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCHH
FVFILVESALFGYVFTRTAGNIELSAIVTIQLIVATYIILLLDEMIQKGWGLGSGISLFI
HHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LAGVTKIMFWDMFGIAAVSNQNLPVGFFPVLISDIVSGKNILSLIVNTSTTTPFQPDLVG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHEEECCCCCCCCHHHHH
LISTIGLIILIIYLTNINIQIPVTTQRLRGIKTTIPLNFLYVSSIPVIFVSVLGADFQLF
HHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
ASLASYISSPASTVLTDIANAFFFPPANVPHSVFALVVDPIGAVIYAVVFIVLSIIFGIL
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIDVAGLDPATQAQQMVEAGMEIPGMRNSPKVIEGILARYIYPLGFYSSLIVGVIAVLAT
HHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVYGTGVGILLAVTIAIQYYNLLAYERTLEMYPLLKRIIGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7495856; 10381320 [H]