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The map label for this gene is eif2g

Identifier: 15920584

GI number: 15920584

Start: 397154

End: 398422

Strand: Reverse

Name: eif2g

Synonym: ST0381

Alternate gene names: 15920584

Gene position: 398422-397154 (Counterclockwise)

Preceding gene: 161751100

Following gene: 15920583

Centisome position: 14.79

GC content: 35.22

Gene sequence:

>1269_bases
GTGATTATGCTTTTGTCTTGGCCACAAGTTCAACCAGAAGTTAACATAGGTGTAGTTGGCCATGTAGATCATGGTAAAAC
TACATTAGTCCAAGCGATTACTGGAGTTTGGACTTCAAAGCATAGTGAAGAATTAAAGAGAGGTATGACGATAAAACTTG
GATATGCAGAAGCTAGTATAGGTGTATGCCCCAACTGTAACAAGCCAGAAGCATATGTTACAGAATACTCTTGCAATCAG
TGTGGAAGTGACGAAAAACCACAATTTCTTAGGAAAGTATCTTTTATTGATGCACCAGGGCACGAAATTTTAATGGCTAC
AATGTTATCTGGAGCAGCACTTATGGATGGCGCGTTACTTGTTGTAGCAGCTAATGAACCTTTTCCTCAACCACAAACAA
GAGAGCATTTTGTTGCTTTAGGCATTGTTAATATAAAAAATTTAATTATAGTACAAAATAAGGTAGACGTAGTAAGCAAA
GAAGAAGCGTTAAAACAGTATAAGCAAATAAAAGAATTTCTAAAGGGTACCTGGGCTGAAGACGCTCCAATAATTCCAGT
CAGTGCGTTGCATAAAATTAATATCGATGCGTTAATAGAAGGAATTCAAAAGTATATCCCAACTCCTCAGAGAGATCTTA
GCAAAGATCCAATCATGTTAGTTATTAGAAGTTTTGATGTAAATAAGCCTGGGACTCCTTATAATGAACTGAAAGGAGGA
GTAATTGGAGGTAGTATTATTCAAGGAAAACTAGAAATAGGAGACGAGATAAAAATCTTACCAGGATTAAGGCATGAAAA
ACCTGGCGGTAAAGTAGAGTATGAACCGCTTTACACAACAATTACTTCTATTCGCTTTTCTGATTTAGAAGTAAAAGAGG
CTAAACCGGGTGGTTTAGTAGCTTTAGGAACTGAATTAGATCCTTCCTATGTTAAGGCTGATAGTTTAGTTGGTAGTGTA
GTAGTTAAATCGAGTAACAAAAATGTTTCTGTTTTATGGAATTTAAAAATTGAAAACTATCAATTACTAGAAAGAGTTGT
TGGAGCAAAAGAATTAGTTAAGGTCGAGAATATTAAGAAAGGCGAGGTACTGATGTTAACATTAGGTTCAGCAACTACCT
TAGGTGTAGCAAAAAACATTAAGAATGACGAATTAGAAGTAGAATTAAAAAGGCCTTTAGTAGTATGGGATAAAGATTTA
AGAGTTGTTATAAGTAGACAAGTTAGTGGAAGATGGAGACTAGTAGGTTGGGGAATAATAAAAATTTAG

Upstream 100 bases:

>100_bases
CAGGTTTCTATCCAGAAGAAGACGGAATGAGAAGAAAAAAAACTGTTAGAGGAAATATGATTACACAAGATATAGTTCAG
ATTAACACTATAATTATTAG

Downstream 100 bases:

>100_bases
GAGTATTAGTTGATACTAATATACTTCTTTATATATATCACGGTTTTGATCCTTTTGAGAAGATAATTCAATTTCTAGAT
TATAAGCCAGTTTTCTATAT

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MIMLLSWPQVQPEVNIGVVGHVDHGKTTLVQAITGVWTSKHSEELKRGMTIKLGYAEASIGVCPNCNKPEAYVTEYSCNQ
CGSDEKPQFLRKVSFIDAPGHEILMATMLSGAALMDGALLVVAANEPFPQPQTREHFVALGIVNIKNLIIVQNKVDVVSK
EEALKQYKQIKEFLKGTWAEDAPIIPVSALHKINIDALIEGIQKYIPTPQRDLSKDPIMLVIRSFDVNKPGTPYNELKGG
VIGGSIIQGKLEIGDEIKILPGLRHEKPGGKVEYEPLYTTITSIRFSDLEVKEAKPGGLVALGTELDPSYVKADSLVGSV
VVKSSNKNVSVLWNLKIENYQLLERVVGAKELVKVENIKKGEVLMLTLGSATTLGVAKNIKNDELEVELKRPLVVWDKDL
RVVISRQVSGRWRLVGWGIIKI

Sequences:

>Translated_422_residues
MIMLLSWPQVQPEVNIGVVGHVDHGKTTLVQAITGVWTSKHSEELKRGMTIKLGYAEASIGVCPNCNKPEAYVTEYSCNQ
CGSDEKPQFLRKVSFIDAPGHEILMATMLSGAALMDGALLVVAANEPFPQPQTREHFVALGIVNIKNLIIVQNKVDVVSK
EEALKQYKQIKEFLKGTWAEDAPIIPVSALHKINIDALIEGIQKYIPTPQRDLSKDPIMLVIRSFDVNKPGTPYNELKGG
VIGGSIIQGKLEIGDEIKILPGLRHEKPGGKVEYEPLYTTITSIRFSDLEVKEAKPGGLVALGTELDPSYVKADSLVGSV
VVKSSNKNVSVLWNLKIENYQLLERVVGAKELVKVENIKKGEVLMLTLGSATTLGVAKNIKNDELEVELKRPLVVWDKDL
RVVISRQVSGRWRLVGWGIIKI
>Mature_422_residues
MIMLLSWPQVQPEVNIGVVGHVDHGKTTLVQAITGVWTSKHSEELKRGMTIKLGYAEASIGVCPNCNKPEAYVTEYSCNQ
CGSDEKPQFLRKVSFIDAPGHEILMATMLSGAALMDGALLVVAANEPFPQPQTREHFVALGIVNIKNLIIVQNKVDVVSK
EEALKQYKQIKEFLKGTWAEDAPIIPVSALHKINIDALIEGIQKYIPTPQRDLSKDPIMLVIRSFDVNKPGTPYNELKGG
VIGGSIIQGKLEIGDEIKILPGLRHEKPGGKVEYEPLYTTITSIRFSDLEVKEAKPGGLVALGTELDPSYVKADSLVGSV
VVKSSNKNVSVLWNLKIENYQLLERVVGAKELVKVENIKKGEVLMLTLGSATTLGVAKNIKNDELEVELKRPLVVWDKDL
RVVISRQVSGRWRLVGWGIIKI

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasmic, and membrane-associated [C]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily

Homologues:

Organism=Homo sapiens, GI4503507, Length=428, Percent_Identity=44.392523364486, Blast_Score=354, Evalue=8e-98,
Organism=Homo sapiens, GI34147630, Length=268, Percent_Identity=32.4626865671642, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI54607086, Length=269, Percent_Identity=30.1115241635688, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1790412, Length=266, Percent_Identity=32.3308270676692, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789737, Length=266, Percent_Identity=32.3308270676692, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI2367247, Length=244, Percent_Identity=34.0163934426229, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1789108, Length=386, Percent_Identity=25.9067357512953, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17509919, Length=428, Percent_Identity=41.3551401869159, Blast_Score=341, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI17556456, Length=388, Percent_Identity=28.0927835051546, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI25141371, Length=318, Percent_Identity=29.874213836478, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506081, Length=268, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320863, Length=424, Percent_Identity=44.5754716981132, Blast_Score=356, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6324761, Length=305, Percent_Identity=32.7868852459016, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24647048, Length=424, Percent_Identity=43.8679245283019, Blast_Score=355, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24647046, Length=424, Percent_Identity=43.8679245283019, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI19921738, Length=298, Percent_Identity=31.8791946308725, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281363316, Length=260, Percent_Identity=31.9230769230769, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17864358, Length=260, Percent_Identity=31.9230769230769, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19922690, Length=263, Percent_Identity=32.319391634981, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: 20568 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): IF2G_SULTO (Q975N8)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376253.1
- ProteinModelPortal:   Q975N8
- SMR:   Q975N8
- GeneID:   1458306
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0381
- NMPDR:   fig|273063.1.peg.421
- HOGENOM:   HBG307581
- OMA:   IAANEPC
- ProtClustDB:   PRK04000
- BioCyc:   STOK273063:ST0381-MONOMER
- HAMAP:   MF_00119
- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- PRINTS:   PR00315
- TIGRFAMs:   TIGR03680

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; SSF50465 Elong_init_C; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 46450; Mature: 46450

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMLLSWPQVQPEVNIGVVGHVDHGKTTLVQAITGVWTSKHSEELKRGMTIKLGYAEASI
CEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHCCCEEEEEEEECCC
GVCPNCNKPEAYVTEYSCNQCGSDEKPQFLRKVSFIDAPGHEILMATMLSGAALMDGALL
CCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHEECCEEE
VVAANEPFPQPQTREHFVALGIVNIKNLIIVQNKVDVVSKEEALKQYKQIKEFLKGTWAE
EEECCCCCCCCCCCCEEEEEEEEEECEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
DAPIIPVSALHKINIDALIEGIQKYIPTPQRDLSKDPIMLVIRSFDVNKPGTPYNELKGG
CCCCCCHHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCEEEEEEECCCCCCCCCHHHHCCC
VIGGSIIQGKLEIGDEIKILPGLRHEKPGGKVEYEPLYTTITSIRFSDLEVKEAKPGGLV
EEECCEEEEEEECCCEEEECCCCCCCCCCCCEEECHHHEEEEHEEECCEEEECCCCCCEE
ALGTELDPSYVKADSLVGSVVVKSSNKNVSVLWNLKIENYQLLERVVGAKELVKVENIKK
EEECCCCHHHHHHHHHEEEEEEECCCCCEEEEEEEEECCHHHHHHHHCHHHHHHHCCCCC
GEVLMLTLGSATTLGVAKNIKNDELEVELKRPLVVWDKDLRVVISRQVSGRWRLVGWGII
CCEEEEEECCCEEEHHHHCCCCCCEEEEEECCEEEECCCEEEEEEECCCCEEEEEEEEEE
KI
EC
>Mature Secondary Structure
MIMLLSWPQVQPEVNIGVVGHVDHGKTTLVQAITGVWTSKHSEELKRGMTIKLGYAEASI
CEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHCCCEEEEEEEECCC
GVCPNCNKPEAYVTEYSCNQCGSDEKPQFLRKVSFIDAPGHEILMATMLSGAALMDGALL
CCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHEECCEEE
VVAANEPFPQPQTREHFVALGIVNIKNLIIVQNKVDVVSKEEALKQYKQIKEFLKGTWAE
EEECCCCCCCCCCCCEEEEEEEEEECEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
DAPIIPVSALHKINIDALIEGIQKYIPTPQRDLSKDPIMLVIRSFDVNKPGTPYNELKGG
CCCCCCHHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCEEEEEEECCCCCCCCCHHHHCCC
VIGGSIIQGKLEIGDEIKILPGLRHEKPGGKVEYEPLYTTITSIRFSDLEVKEAKPGGLV
EEECCEEEEEEECCCEEEECCCCCCCCCCCCEEECHHHEEEEHEEECCEEEECCCCCCEE
ALGTELDPSYVKADSLVGSVVVKSSNKNVSVLWNLKIENYQLLERVVGAKELVKVENIKK
EEECCCCHHHHHHHHHEEEEEEECCCCCEEEEEEEEECCHHHHHHHHCHHHHHHHCCCCC
GEVLMLTLGSATTLGVAKNIKNDELEVELKRPLVVWDKDLRVVISRQVSGRWRLVGWGII
CCEEEEEECCCEEEHHHHCCCCCCEEEEEECCEEEECCCEEEEEEECCCCEEEEEEEEEE
KI
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11572479