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The map label for this gene is ilvC

Identifier: 159041733

GI number: 159041733

Start: 1226291

End: 1227277

Strand: Reverse

Name: ilvC

Synonym: Cmaq_1168

Alternate gene names: 159041733

Gene position: 1227277-1226291 (Counterclockwise)

Preceding gene: 159041734

Following gene: 159041732

Centisome position: 59.07

GC content: 47.01

Gene sequence:

>987_bases
ATGGCTAAAATATATAGGGAAACGGACGCCGACCTATCTGAATTAAAGGGAAAGGTAATTGCAGTGTTAGGCTACGGTAT
ACAGGGGAGGTCATGGGCACTTAACATGAGGGATAGTGGGTTAAGGGTTATTGTGGGTGTAAGGCCAGGTAAGAGCCGTG
ACCTAGCTAAGGAGGAGGGGTTTGAGACATATGATGTAGCCGAGGCCACTAAAATGGCTGATGTAGTTGCTGTGCTACTC
CCAGACATGGTTCAACCAAAGGTTTGGACCAGTGAAATAGGGCCTAACCTAAAACCCGGTGCATTAGTCATATTCGCCCA
TGGTTTCAACATACGCTACAACTTAATTAAACCACCCAGCAATATTGATGTAACCCTAGTGGCCCCTAAGGCGCCAGGTA
AGGCTGTTAGAGACGAGTACCTTAGAGGATGGGGTGTGCCTGCTCTTGTTGCGGTTCACCAGGATTACACTGGTAAGGCC
TTGAGGAGGGCCTTGGCTGTGGCTAAGGCGAATGGCTTCACTAGGGTTGGTGTTATTGAAACAACATTCGCGGAGGAGAC
TGAAACAGACCTAATTGGTGAGCAAACAGTGCTTGTGGGTGGTTTAATGGAGTTAATTAAGAAGGGGTTTGAGACAATGA
TTGAACTCGGCTACCAACCTGAGGTAGCCTACTTCGAGGTGCTTAATGAGGCTAAGTTAATAATGGATTTAATATGGGAG
AGGGGCGTTTACGGAATGCTTAATGGCGTTAGTGAAACAGCAAGGTACGGAGGATTAACAGTGGGTCCTTATGTTCTTGA
TAATTCAGTTAAGGAGAGGATGAGGAAGGCCGCGGAGAGGGTTAGGAATGGTGAATTCGCCAGGGAGTGGTTGAATGAGT
ATGAGGGGGGTATGAAGAACCTCAGTAGAATGCTGAATGAGGTTAAGAACCATAGATTAGAGGTTGTTGGGGAGGATTTG
AGGAGACTAATGAGGAGCGGTAGGTAA

Upstream 100 bases:

>100_bases
GTTTGCAATAAATTGAATAAACTGTACGATGTAGTTAACGTAAGCTATACAACAAGTATAAGTATACCTAAAGTGCAGTC
CCTACAGGTAGGTGAGAGGA

Downstream 100 bases:

>100_bases
TACCACGTATTTATTTTAGTAAAACATGAAATATTTAATGTTAGTTTTACAAATATTAAAACTAAGTTAAGTAGAATTCT
TGGTAAAATTAATAAACCCA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MAKIYRETDADLSELKGKVIAVLGYGIQGRSWALNMRDSGLRVIVGVRPGKSRDLAKEEGFETYDVAEATKMADVVAVLL
PDMVQPKVWTSEIGPNLKPGALVIFAHGFNIRYNLIKPPSNIDVTLVAPKAPGKAVRDEYLRGWGVPALVAVHQDYTGKA
LRRALAVAKANGFTRVGVIETTFAEETETDLIGEQTVLVGGLMELIKKGFETMIELGYQPEVAYFEVLNEAKLIMDLIWE
RGVYGMLNGVSETARYGGLTVGPYVLDNSVKERMRKAAERVRNGEFAREWLNEYEGGMKNLSRMLNEVKNHRLEVVGEDL
RRLMRSGR

Sequences:

>Translated_328_residues
MAKIYRETDADLSELKGKVIAVLGYGIQGRSWALNMRDSGLRVIVGVRPGKSRDLAKEEGFETYDVAEATKMADVVAVLL
PDMVQPKVWTSEIGPNLKPGALVIFAHGFNIRYNLIKPPSNIDVTLVAPKAPGKAVRDEYLRGWGVPALVAVHQDYTGKA
LRRALAVAKANGFTRVGVIETTFAEETETDLIGEQTVLVGGLMELIKKGFETMIELGYQPEVAYFEVLNEAKLIMDLIWE
RGVYGMLNGVSETARYGGLTVGPYVLDNSVKERMRKAAERVRNGEFAREWLNEYEGGMKNLSRMLNEVKNHRLEVVGEDL
RRLMRSGR
>Mature_327_residues
AKIYRETDADLSELKGKVIAVLGYGIQGRSWALNMRDSGLRVIVGVRPGKSRDLAKEEGFETYDVAEATKMADVVAVLLP
DMVQPKVWTSEIGPNLKPGALVIFAHGFNIRYNLIKPPSNIDVTLVAPKAPGKAVRDEYLRGWGVPALVAVHQDYTGKAL
RRALAVAKANGFTRVGVIETTFAEETETDLIGEQTVLVGGLMELIKKGFETMIELGYQPEVAYFEVLNEAKLIMDLIWER
GVYGMLNGVSETARYGGLTVGPYVLDNSVKERMRKAAERVRNGEFAREWLNEYEGGMKNLSRMLNEVKNHRLEVVGEDLR
RLMRSGR

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=299, Percent_Identity=35.4515050167224, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323387, Length=325, Percent_Identity=34.4615384615385, Blast_Score=145, Evalue=8e-36,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_CALMQ (A8MDY9)

Other databases:

- EMBL:   CP000852
- RefSeq:   YP_001540985.1
- ProteinModelPortal:   A8MDY9
- SMR:   A8MDY9
- GeneID:   5709431
- GenomeReviews:   CP000852_GR
- KEGG:   cma:Cmaq_1168
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- BioCyc:   CMAQ397948:CMAQ_1168-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36490; Mature: 36359

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIYRETDADLSELKGKVIAVLGYGIQGRSWALNMRDSGLRVIVGVRPGKSRDLAKEEG
CCCCCCCCCCCHHHHCCCEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHCC
FETYDVAEATKMADVVAVLLPDMVQPKVWTSEIGPNLKPGALVIFAHGFNIRYNLIKPPS
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCEEEEEEECCEEEEEEECCCC
NIDVTLVAPKAPGKAVRDEYLRGWGVPALVAVHQDYTGKALRRALAVAKANGFTRVGVIE
CCEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEE
TTFAEETETDLIGEQTVLVGGLMELIKKGFETMIELGYQPEVAYFEVLNEAKLIMDLIWE
EHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
RGVYGMLNGVSETARYGGLTVGPYVLDNSVKERMRKAAERVRNGEFAREWLNEYEGGMKN
CCHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHH
LSRMLNEVKNHRLEVVGEDLRRLMRSGR
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKIYRETDADLSELKGKVIAVLGYGIQGRSWALNMRDSGLRVIVGVRPGKSRDLAKEEG
CCCCCCCCCCHHHHCCCEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHCC
FETYDVAEATKMADVVAVLLPDMVQPKVWTSEIGPNLKPGALVIFAHGFNIRYNLIKPPS
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCEEEEEEECCEEEEEEECCCC
NIDVTLVAPKAPGKAVRDEYLRGWGVPALVAVHQDYTGKALRRALAVAKANGFTRVGVIE
CCEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEE
TTFAEETETDLIGEQTVLVGGLMELIKKGFETMIELGYQPEVAYFEVLNEAKLIMDLIWE
EHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
RGVYGMLNGVSETARYGGLTVGPYVLDNSVKERMRKAAERVRNGEFAREWLNEYEGGMKN
CCHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHH
LSRMLNEVKNHRLEVVGEDLRRLMRSGR
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA