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The map label for this gene is thyX [H]

Identifier: 159041713

GI number: 159041713

Start: 1203720

End: 1204523

Strand: Reverse

Name: thyX [H]

Synonym: Cmaq_1148

Alternate gene names: 159041713

Gene position: 1204523-1203720 (Counterclockwise)

Preceding gene: 159041714

Following gene: 159041711

Centisome position: 57.98

GC content: 43.78

Gene sequence:

>804_bases
GTGAAACTAATCAACGTGGAGTACTCCTTAATTAAACCAACAGTGACCTTATTATCCACCTGGGGTAGTGAGGATGTTAC
GGCGGCTATGGCTGATGTAATATATAGGGGTTACTCCATTGATAAGGCTCTTGAAAGGGTTAAGGGTGATCAAGGTATTG
TTAAGAGGAGGATCCTGAGCTTCCTTAGGGATGGGCATTCAAGCGTCTTCGAGTTCATGGGTGCTCAATGGCTTATTGAG
GGTAGTAGGGCCTTAACCCATGAGCTTATTAGACATAGGTTAGCCTCATACTGGCAGGAGAGTCAGAGGTATGTTGATTA
CGCTAAGGGTCAGTTAAGATTCATTACACCACCAGGTGAATTAAGCGCAGTAAGTAGGTTAATTGAGTTCACGGCTAAGG
AGTATGTTAACCTAAGGAGTAGTCAAGTACCTGAGGATGCAAGGTACATTCTACCCAATGCCATGGCTAGTAGGATTTGG
GTTCAAATGAATGCTAGGGAATTCTTCCTAAACTTCATACCACTTAGAACAGGCCTAGGGGCATTTCATGAGATTAGGCT
AGTAGCATGGTTAATGTTCACCACAGTCATTGATAAATTCCCAATAACAGCAAGGTGGATTTGGATAAACCTCACTAAAC
TCCACCCAGACTACTGCAGGGGTGTTGAGAAGCTTAGCGAGTATTACGGAACCAGTGACTGCAGGATTATTAGTATTAGG
CAGGCCTTTGAGAAATGGGGATTAAGCATACCCATTAGCCTAGGGGAATTAATGAATGAGGAGCAGGGTAGGGTTAGTGC
TTAA

Upstream 100 bases:

>100_bases
GAAATGGTTAGGGTACTTAGATCACTTGGTTAACCCGCTACATTGAGATACCTACTAGTGGATTATTAATTCGAAATAAC
TTAGGGGGTTTTAAATCACA

Downstream 100 bases:

>100_bases
ACCTCTTCGGCCTTAAATCCTTACTACCGCATCTTCTACACTTCTCAGCCCCAATGGGGTTCCTTGCACCACATCTCCTA
CATATCCAGTAACCGAACCT

Product: thymidylate synthase, flavin-dependent

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MKLINVEYSLIKPTVTLLSTWGSEDVTAAMADVIYRGYSIDKALERVKGDQGIVKRRILSFLRDGHSSVFEFMGAQWLIE
GSRALTHELIRHRLASYWQESQRYVDYAKGQLRFITPPGELSAVSRLIEFTAKEYVNLRSSQVPEDARYILPNAMASRIW
VQMNAREFFLNFIPLRTGLGAFHEIRLVAWLMFTTVIDKFPITARWIWINLTKLHPDYCRGVEKLSEYYGTSDCRIISIR
QAFEKWGLSIPISLGELMNEEQGRVSA

Sequences:

>Translated_267_residues
MKLINVEYSLIKPTVTLLSTWGSEDVTAAMADVIYRGYSIDKALERVKGDQGIVKRRILSFLRDGHSSVFEFMGAQWLIE
GSRALTHELIRHRLASYWQESQRYVDYAKGQLRFITPPGELSAVSRLIEFTAKEYVNLRSSQVPEDARYILPNAMASRIW
VQMNAREFFLNFIPLRTGLGAFHEIRLVAWLMFTTVIDKFPITARWIWINLTKLHPDYCRGVEKLSEYYGTSDCRIISIR
QAFEKWGLSIPISLGELMNEEQGRVSA
>Mature_267_residues
MKLINVEYSLIKPTVTLLSTWGSEDVTAAMADVIYRGYSIDKALERVKGDQGIVKRRILSFLRDGHSSVFEFMGAQWLIE
GSRALTHELIRHRLASYWQESQRYVDYAKGQLRFITPPGELSAVSRLIEFTAKEYVNLRSSQVPEDARYILPNAMASRIW
VQMNAREFFLNFIPLRTGLGAFHEIRLVAWLMFTTVIDKFPITARWIWINLTKLHPDYCRGVEKLSEYYGTSDCRIISIR
QAFEKWGLSIPISLGELMNEEQGRVSA

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 30806; Mature: 30806

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLINVEYSLIKPTVTLLSTWGSEDVTAAMADVIYRGYSIDKALERVKGDQGIVKRRILS
CEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
FLRDGHSSVFEFMGAQWLIEGSRALTHELIRHRLASYWQESQRYVDYAKGQLRFITPPGE
HHHCCHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCH
LSAVSRLIEFTAKEYVNLRSSQVPEDARYILPNAMASRIWVQMNAREFFLNFIPLRTGLG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHEEECHHHHHHHHHHHHHCCC
AFHEIRLVAWLMFTTVIDKFPITARWIWINLTKLHPDYCRGVEKLSEYYGTSDCRIISIR
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEHHH
QAFEKWGLSIPISLGELMNEEQGRVSA
HHHHHCCCCCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKLINVEYSLIKPTVTLLSTWGSEDVTAAMADVIYRGYSIDKALERVKGDQGIVKRRILS
CEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
FLRDGHSSVFEFMGAQWLIEGSRALTHELIRHRLASYWQESQRYVDYAKGQLRFITPPGE
HHHCCHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCH
LSAVSRLIEFTAKEYVNLRSSQVPEDARYILPNAMASRIWVQMNAREFFLNFIPLRTGLG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHEEECHHHHHHHHHHHHHCCC
AFHEIRLVAWLMFTTVIDKFPITARWIWINLTKLHPDYCRGVEKLSEYYGTSDCRIISIR
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEHHH
QAFEKWGLSIPISLGELMNEEQGRVSA
HHHHHCCCCCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]