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The map label for this gene is trpE [H]

Identifier: 159041610

GI number: 159041610

Start: 1093572

End: 1094825

Strand: Reverse

Name: trpE [H]

Synonym: Cmaq_1043

Alternate gene names: 159041610

Gene position: 1094825-1093572 (Counterclockwise)

Preceding gene: 159041611

Following gene: 159041609

Centisome position: 52.7

GC content: 46.09

Gene sequence:

>1254_bases
GTGAAGGTGCCCCTTGAGGAGTTACCTAAGCCTAGGGAATTAGTTAGGGTTCTTATTGAGAATGGTGAGGATCACGTTAC
ACTACTTGAGAGTGGGCCAGGATTCCCTGAGAGGGCTAGGTTCACCATAGTGGCCTGGGGGGTTAAGGACTTAGTGACTA
TTAATGATAACTTATATGATGAGCTTAAGTCCCTTTACAGGGGACTGGGTAGGTTTGAGGATGGTAATATCGCTGTGGGT
TACTTATCCTATGAGGCCATTGCATCAATAGAGCCTCACTTAGCTGGTTTAATTAAGATGAGTGATTGGCCTCAGGCTGA
ATTCATGATACCCAGTAACGTGGTTATCTACGATTACTTCCTGGGGAGGGCCTACGTTAAGGGTGAGTTACCTAGGAGTA
AGCCTGGTGATGAGGGTGATTTCAAGGTCACTGGGTTAGTGACCGCCACGGATCCCGTTGAGTACATGAAGTGGGTTTCA
GAGGCCATTGAGGATATTAAGAATGGTGAGGTCTTCCAAGTGGTTTTATCAAGGTATGAGGAGTATGGGTTCACGGGGGA
TTTAATGACTCTTTACGGGAAGTTAGCTGACCTTAACCCATCACCATACATGTACTTCATGAGGATGAGTGATAAGTACA
TAATAGGCACAAGCCCTGAACTACTGGTTAAGGTTGATGGACTCAGGGTTGAGACACACCCAATAGCTGGAACAAGACCT
AGGGGGAGGGATTCATGGAGTGATATTAGGCTTGAGGAGGAATTACTCTCAAGCATTAAGGATAGGGCTGAACACGTAAT
GCTCGTTGACTTAGCTAGGAACGATATAGGTAAGGTATGCGTATACGGTAGTGTTAAGGTTAAGGAACTATACGCCATTG
AGAAGTATCAAAGCGTCCAACACCTTGTTTCCAGGGTTGAGGGAATGCTGAGTAAGGGTAATGATATTGTCGACGCCTTA
GTCTCAACATTCCCAGCAGGCACAGTGAGTGGTGCACCTAAGCCAAGGGCAATGGAGCTAATAGCCAAGTACGAGAATTC
ACCAAGAGGACCCTACGCAGGTGCATTGGGCATTATGCATAGTGGTGGTGGGGAATTCGCCATAATAATAAGAAGCCTAT
TCTCAATGAACGATAAAGTAAGGATTCAGGCAGGCGCCGGCATAGTTTACGATTCAATACCTGAAGCCGAGCTTCAGGAA
ACTGAGGATAAGCTTGGAAGCATTAAGAGGGTGTTAGGTGTATGGCGGACATAA

Upstream 100 bases:

>100_bases
AAGTATAATCCATTTTTAATAGATGTTAATTCAGGGGTTGAATCAAGCCCCGGTGTTAAGGATTGGAGACTAATCATGGA
GGTTGTTAAGGTGATTAAGG

Downstream 100 bases:

>100_bases
CAGTGATAATAGATAACTACGATTCATTCGTGTACAATATCGCCCAGTACGTGGGTGAATTAGACAGTAGACCACTGGTC
TTTAGGAATGATGAAGTAAG

Product: anthranilate synthase

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKVPLEELPKPRELVRVLIENGEDHVTLLESGPGFPERARFTIVAWGVKDLVTINDNLYDELKSLYRGLGRFEDGNIAVG
YLSYEAIASIEPHLAGLIKMSDWPQAEFMIPSNVVIYDYFLGRAYVKGELPRSKPGDEGDFKVTGLVTATDPVEYMKWVS
EAIEDIKNGEVFQVVLSRYEEYGFTGDLMTLYGKLADLNPSPYMYFMRMSDKYIIGTSPELLVKVDGLRVETHPIAGTRP
RGRDSWSDIRLEEELLSSIKDRAEHVMLVDLARNDIGKVCVYGSVKVKELYAIEKYQSVQHLVSRVEGMLSKGNDIVDAL
VSTFPAGTVSGAPKPRAMELIAKYENSPRGPYAGALGIMHSGGGEFAIIIRSLFSMNDKVRIQAGAGIVYDSIPEAELQE
TEDKLGSIKRVLGVWRT

Sequences:

>Translated_417_residues
MKVPLEELPKPRELVRVLIENGEDHVTLLESGPGFPERARFTIVAWGVKDLVTINDNLYDELKSLYRGLGRFEDGNIAVG
YLSYEAIASIEPHLAGLIKMSDWPQAEFMIPSNVVIYDYFLGRAYVKGELPRSKPGDEGDFKVTGLVTATDPVEYMKWVS
EAIEDIKNGEVFQVVLSRYEEYGFTGDLMTLYGKLADLNPSPYMYFMRMSDKYIIGTSPELLVKVDGLRVETHPIAGTRP
RGRDSWSDIRLEEELLSSIKDRAEHVMLVDLARNDIGKVCVYGSVKVKELYAIEKYQSVQHLVSRVEGMLSKGNDIVDAL
VSTFPAGTVSGAPKPRAMELIAKYENSPRGPYAGALGIMHSGGGEFAIIIRSLFSMNDKVRIQAGAGIVYDSIPEAELQE
TEDKLGSIKRVLGVWRT
>Mature_417_residues
MKVPLEELPKPRELVRVLIENGEDHVTLLESGPGFPERARFTIVAWGVKDLVTINDNLYDELKSLYRGLGRFEDGNIAVG
YLSYEAIASIEPHLAGLIKMSDWPQAEFMIPSNVVIYDYFLGRAYVKGELPRSKPGDEGDFKVTGLVTATDPVEYMKWVS
EAIEDIKNGEVFQVVLSRYEEYGFTGDLMTLYGKLADLNPSPYMYFMRMSDKYIIGTSPELLVKVDGLRVETHPIAGTRP
RGRDSWSDIRLEEELLSSIKDRAEHVMLVDLARNDIGKVCVYGSVKVKELYAIEKYQSVQHLVSRVEGMLSKGNDIVDAL
VSTFPAGTVSGAPKPRAMELIAKYENSPRGPYAGALGIMHSGGGEFAIIIRSLFSMNDKVRIQAGAGIVYDSIPEAELQE
TEDKLGSIKRVLGVWRT

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=369, Percent_Identity=35.5013550135501, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1788114, Length=260, Percent_Identity=38.4615384615385, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI87082077, Length=269, Percent_Identity=27.5092936802974, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786809, Length=269, Percent_Identity=29.368029739777, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320935, Length=372, Percent_Identity=37.0967741935484, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324361, Length=323, Percent_Identity=26.3157894736842, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR015890 [H]

Pfam domain/function: PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 46455; Mature: 46455

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVPLEELPKPRELVRVLIENGEDHVTLLESGPGFPERARFTIVAWGVKDLVTINDNLYD
CCCCHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEECCEEEEEECCHHHH
ELKSLYRGLGRFEDGNIAVGYLSYEAIASIEPHLAGLIKMSDWPQAEFMIPSNVVIYDYF
HHHHHHHHHCCCCCCCEEEEEEEHHHHHCCCHHHHHEEEECCCCCCEEECCCCEEEEEEH
LGRAYVKGELPRSKPGDEGDFKVTGLVTATDPVEYMKWVSEAIEDIKNGEVFQVVLSRYE
HCCEEEECCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EYGFTGDLMTLYGKLADLNPSPYMYFMRMSDKYIIGTSPELLVKVDGLRVETHPIAGTRP
HCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCEEEECCCCEEEEECCEEEEECCCCCCCC
RGRDSWSDIRLEEELLSSIKDRAEHVMLVDLARNDIGKVCVYGSVKVKELYAIEKYQSVQ
CCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCEEEECCEEHHHHHHHHHHHHHH
HLVSRVEGMLSKGNDIVDALVSTFPAGTVSGAPKPRAMELIAKYENSPRGPYAGALGIMH
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEE
SGGGEFAIIIRSLFSMNDKVRIQAGAGIVYDSIPEAELQETEDKLGSIKRVLGVWRT
CCCCCHHHHHHHHHCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVPLEELPKPRELVRVLIENGEDHVTLLESGPGFPERARFTIVAWGVKDLVTINDNLYD
CCCCHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEECCEEEEEECCHHHH
ELKSLYRGLGRFEDGNIAVGYLSYEAIASIEPHLAGLIKMSDWPQAEFMIPSNVVIYDYF
HHHHHHHHHCCCCCCCEEEEEEEHHHHHCCCHHHHHEEEECCCCCCEEECCCCEEEEEEH
LGRAYVKGELPRSKPGDEGDFKVTGLVTATDPVEYMKWVSEAIEDIKNGEVFQVVLSRYE
HCCEEEECCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EYGFTGDLMTLYGKLADLNPSPYMYFMRMSDKYIIGTSPELLVKVDGLRVETHPIAGTRP
HCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCEEEECCCCEEEEECCEEEEECCCCCCCC
RGRDSWSDIRLEEELLSSIKDRAEHVMLVDLARNDIGKVCVYGSVKVKELYAIEKYQSVQ
CCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCEEEECCEEHHHHHHHHHHHHHH
HLVSRVEGMLSKGNDIVDALVSTFPAGTVSGAPKPRAMELIAKYENSPRGPYAGALGIMH
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEE
SGGGEFAIIIRSLFSMNDKVRIQAGAGIVYDSIPEAELQETEDKLGSIKRVLGVWRT
CCCCCHHHHHHHHHCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]