Click here to switch to the map view.

The map label for this gene is serS [H]

Identifier: 159041457

GI number: 159041457

Start: 927235

End: 928659

Strand: Reverse

Name: serS [H]

Synonym: Cmaq_0885

Alternate gene names: 159041457

Gene position: 928659-927235 (Counterclockwise)

Preceding gene: 159041458

Following gene: 159041453

Centisome position: 44.7

GC content: 45.89

Gene sequence:

>1425_bases
ATGCTTGAAGCAGTTAACGTGAGTTGGAGCCTACTCACCGCCCTTAGGGAGAGGCCTGGGGAGGTTAGAAGAATGCTTAA
GTGGAGGGGTTATGAAGAATCAATGGTTGATCAATTCATTGCACTTGATAACCAGTGGAAGAGCATTAAGGTTAAGGCTG
ATGAACTTAGGCATAGGAGGAATAGCCTAAGTAGTCAAATATCTAAGGCTCCCCCTGAGGCAAGGGGGTTAATGATTGAG
GAGGCTAATAAGGTTCTTAAGGAGCTTGAGAACCTTAACGCTGAGCTTAAGAGAATTGAGGATGAGAGGGATAGGCTACT
TAGGAGGTTTCCAAATCTACTTCATGAGTCAGTCTACTCAACATGCCCAAATGAATCCGCTGAGTCAGTGGCCTTAAAGT
ACTTTGGGAAACCGAAGGCTTGGAGGGGGTACTTGAGTGAATTAAGCGGCTTCAATGGTCTTGAATTCAATGTTATTGAC
TGGCAGCCGATTGGTCATGCTGATATGCTTGAGCGTGTCCTTGGCCTTGGTGACACCGCTAAGGCTGGGGAGGTGGCTGG
GAGTAGGTTCTTCTACCTCTTTGATGATGTGGCTTGGCTTAACCTAGCCCTATCCCTATATGCAGTGGATTTCCTAACCC
AGAGGGGGTTTAGGCTTGTTATGCCGCCCCACATGCTTAACTACGATGTTATAAGCTCAGTAATAGACTTCGATGCATTT
AAGGATGCAATATACAGTGTGGATAATGAACAGCTTTACCTAATAGGCACCGCTGAGCATCCATTAGCTGCATTATACCG
CGGCAGTGAATTACTGGAGAAGGATCTACCAATACTCCTAGCCGGCTTCTCACCATCATATAGGAAGGAGGCTGGGGCCG
GTAACAGGGATTTGAAGGGCATATTTAGGGTTCATCAATTCTATAAGGTTGAGCAATTCGCCTTCACGCTACCTGAGGAT
AGTTGGAGTTGGCACGAGAAGCTGTTAGGTAATCTAATTGACATATGGAGTAGCCTTGAATTACCCTTCAGGGTGGTTTT
AGTGTGTCCTAGGGAAATGTCTAGAACAGCCGCTAAGCAATATGACTTAGAGGCTTGGATGCCTGCCCAGGGAATGTTCA
GGGAAATGGCCTCCTGCAGTAATGTGACTGATTGGCAATCATATAGGCTTGGGATTAGGGTGATTAGGAAGGGTATGAGG
AGGGAGTACGTGCACACTCTAAATAGTACTGCCATAGCCGTGGAGAGAACCATAACAGCTATTCTTGAGAATAACCAGGA
GGAGGATGGCACAGTGAGGATACCTAAGGTACTCAACAAGTATCTTGAAGCCTTCCCAAAGGCTCCGAGGGATTACATAC
ACCCTAGGGCTAAGATAATTAGGGATAGTGAAGGTAAAATAGTGGATATTGTTAAGATTAGCTAA

Upstream 100 bases:

>100_bases
GCATTATAGGGAGCTTAATGGATTCATCAATTGATCAACTCCTATCAACAATAGGTAAACTCTACTCCTAGCCGCTGTTA
AGGATAAGCGTTATTAAGGT

Downstream 100 bases:

>100_bases
AAACGCTTAAAGGGATCACATACTCACTGCACGCTAATGTTTAAAGCATTAAGAACAGTAATCATTATACTCACAGCTCT
CTTAGCCATATCCAAGGCCC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MLEAVNVSWSLLTALRERPGEVRRMLKWRGYEESMVDQFIALDNQWKSIKVKADELRHRRNSLSSQISKAPPEARGLMIE
EANKVLKELENLNAELKRIEDERDRLLRRFPNLLHESVYSTCPNESAESVALKYFGKPKAWRGYLSELSGFNGLEFNVID
WQPIGHADMLERVLGLGDTAKAGEVAGSRFFYLFDDVAWLNLALSLYAVDFLTQRGFRLVMPPHMLNYDVISSVIDFDAF
KDAIYSVDNEQLYLIGTAEHPLAALYRGSELLEKDLPILLAGFSPSYRKEAGAGNRDLKGIFRVHQFYKVEQFAFTLPED
SWSWHEKLLGNLIDIWSSLELPFRVVLVCPREMSRTAAKQYDLEAWMPAQGMFREMASCSNVTDWQSYRLGIRVIRKGMR
REYVHTLNSTAIAVERTITAILENNQEEDGTVRIPKVLNKYLEAFPKAPRDYIHPRAKIIRDSEGKIVDIVKIS

Sequences:

>Translated_474_residues
MLEAVNVSWSLLTALRERPGEVRRMLKWRGYEESMVDQFIALDNQWKSIKVKADELRHRRNSLSSQISKAPPEARGLMIE
EANKVLKELENLNAELKRIEDERDRLLRRFPNLLHESVYSTCPNESAESVALKYFGKPKAWRGYLSELSGFNGLEFNVID
WQPIGHADMLERVLGLGDTAKAGEVAGSRFFYLFDDVAWLNLALSLYAVDFLTQRGFRLVMPPHMLNYDVISSVIDFDAF
KDAIYSVDNEQLYLIGTAEHPLAALYRGSELLEKDLPILLAGFSPSYRKEAGAGNRDLKGIFRVHQFYKVEQFAFTLPED
SWSWHEKLLGNLIDIWSSLELPFRVVLVCPREMSRTAAKQYDLEAWMPAQGMFREMASCSNVTDWQSYRLGIRVIRKGMR
REYVHTLNSTAIAVERTITAILENNQEEDGTVRIPKVLNKYLEAFPKAPRDYIHPRAKIIRDSEGKIVDIVKIS
>Mature_474_residues
MLEAVNVSWSLLTALRERPGEVRRMLKWRGYEESMVDQFIALDNQWKSIKVKADELRHRRNSLSSQISKAPPEARGLMIE
EANKVLKELENLNAELKRIEDERDRLLRRFPNLLHESVYSTCPNESAESVALKYFGKPKAWRGYLSELSGFNGLEFNVID
WQPIGHADMLERVLGLGDTAKAGEVAGSRFFYLFDDVAWLNLALSLYAVDFLTQRGFRLVMPPHMLNYDVISSVIDFDAF
KDAIYSVDNEQLYLIGTAEHPLAALYRGSELLEKDLPILLAGFSPSYRKEAGAGNRDLKGIFRVHQFYKVEQFAFTLPED
SWSWHEKLLGNLIDIWSSLELPFRVVLVCPREMSRTAAKQYDLEAWMPAQGMFREMASCSNVTDWQSYRLGIRVIRKGMR
REYVHTLNSTAIAVERTITAILENNQEEDGTVRIPKVLNKYLEAFPKAPRDYIHPRAKIIRDSEGKIVDIVKIS

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=468, Percent_Identity=32.6923076923077, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI8923421, Length=309, Percent_Identity=35.2750809061489, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI225579074, Length=309, Percent_Identity=35.2750809061489, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1787120, Length=444, Percent_Identity=34.2342342342342, Blast_Score=229, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17539260, Length=464, Percent_Identity=32.3275862068966, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=261, Percent_Identity=31.8007662835249, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320226, Length=445, Percent_Identity=34.1573033707865, Blast_Score=233, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6321799, Length=288, Percent_Identity=35.0694444444444, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24581334, Length=472, Percent_Identity=31.9915254237288, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17737985, Length=294, Percent_Identity=36.0544217687075, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 54501; Mature: 54501

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAVNVSWSLLTALRERPGEVRRMLKWRGYEESMVDQFIALDNQWKSIKVKADELRHRR
CCCEECCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
NSLSSQISKAPPEARGLMIEEANKVLKELENLNAELKRIEDERDRLLRRFPNLLHESVYS
HHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TCPNESAESVALKYFGKPKAWRGYLSELSGFNGLEFNVIDWQPIGHADMLERVLGLGDTA
CCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCC
KAGEVAGSRFFYLFDDVAWLNLALSLYAVDFLTQRGFRLVMPPHMLNYDVISSVIDFDAF
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHH
KDAIYSVDNEQLYLIGTAEHPLAALYRGSELLEKDLPILLAGFSPSYRKEAGAGNRDLKG
HHHHHCCCCCEEEEEECCCCHHHHHHCCHHHHHCCCCEEEECCCCHHHHHCCCCCCHHHH
IFRVHQFYKVEQFAFTLPEDSWSWHEKLLGNLIDIWSSLELPFRVVLVCPREMSRTAAKQ
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHH
YDLEAWMPAQGMFREMASCSNVTDWQSYRLGIRVIRKGMRREYVHTLNSTAIAVERTITA
CCCHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ILENNQEEDGTVRIPKVLNKYLEAFPKAPRDYIHPRAKIIRDSEGKIVDIVKIS
HHHCCCCCCCEEEHHHHHHHHHHHCCCCCHHHHCCHHHHEECCCCCEEEEEEEC
>Mature Secondary Structure
MLEAVNVSWSLLTALRERPGEVRRMLKWRGYEESMVDQFIALDNQWKSIKVKADELRHRR
CCCEECCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
NSLSSQISKAPPEARGLMIEEANKVLKELENLNAELKRIEDERDRLLRRFPNLLHESVYS
HHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TCPNESAESVALKYFGKPKAWRGYLSELSGFNGLEFNVIDWQPIGHADMLERVLGLGDTA
CCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCC
KAGEVAGSRFFYLFDDVAWLNLALSLYAVDFLTQRGFRLVMPPHMLNYDVISSVIDFDAF
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHH
KDAIYSVDNEQLYLIGTAEHPLAALYRGSELLEKDLPILLAGFSPSYRKEAGAGNRDLKG
HHHHHCCCCCEEEEEECCCCHHHHHHCCHHHHHCCCCEEEECCCCHHHHHCCCCCCHHHH
IFRVHQFYKVEQFAFTLPEDSWSWHEKLLGNLIDIWSSLELPFRVVLVCPREMSRTAAKQ
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHH
YDLEAWMPAQGMFREMASCSNVTDWQSYRLGIRVIRKGMRREYVHTLNSTAIAVERTITA
CCCHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ILENNQEEDGTVRIPKVLNKYLEAFPKAPRDYIHPRAKIIRDSEGKIVDIVKIS
HHHCCCCCCCEEEHHHHHHHHHHHCCCCCHHHHCCHHHHEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA