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The map label for this gene is aroE

Identifier: 159041378

GI number: 159041378

Start: 840614

End: 841423

Strand: Reverse

Name: aroE

Synonym: Cmaq_0805

Alternate gene names: 159041378

Gene position: 841423-840614 (Counterclockwise)

Preceding gene: 159041379

Following gene: 159041377

Centisome position: 40.5

GC content: 41.73

Gene sequence:

>810_bases
ATGCATGTATTTGGCTTAATAGGTTATCCACTGAACTATACCCTATCACCTCAGATTCATAACTACGTCTTCAAGAGACT
AAGAATTGATGCAGCGTATGTACCATTAAGGGTAGCGTCGAAGAGATTACTACACTTCATTGAGTTCTCAAGGGATGCCT
TAAGCGGATTCAACGTAACTATACCGCATAAGGTTGCAGTGGCTAAACTAATTGATGAACTTAATGATGATGCAGACACT
ATTAAGAGCGTGAACACTGTTGTTAACAGTAACCAGAAATTAATAGGCTATAATACCGACTATGTGGCTGTTGAGGAATC
TTTAATTGAAAGAGGATATAAGGGTGAGGAAGCATTACTAATTGGTGCTGGGGGAGCTGCTAGGGCTGTGGTTCTGGCTT
TATCGAAAACTGGGTGCAGGGCAATTAAAGTACTTAATAGAAGTAGGGAGAGGGCAGTGGAGTTATGTGGATTAGCCAAT
GGATTAGGCTTAGACTGCAGTGTGGTGGATATTGGTGGGAATTATGGTAAACCCCACGTTATTATTAACGCCACCCCACT
GAGCAGTGAGGAGTATTGGTTACTTAACCTAGGTGAGCTGGGGACTATGCTGCTCCTTGACATGGCTTATAAACCCAATA
CTGAAACAGACTTAATCAAGAGGGCTAGGGAGCTAGGTATTCAAGTTATTGATGGTGTTGAAATACTGGTTAGGCAAGCC
CTGGCTGCTGATAAACTATGGCTAGGTGACTTTAATGAACCAAGTGCTAGTGAAGTAATTAAGTATATTAAGGGTATTAA
TCCCTCCTGA

Upstream 100 bases:

>100_bases
GAAACGGTGGCTTCCTTAACTTACCCATTGTTACTGAATTAGGTGATTGGGTTAAGGTTAGGGTTAAGGTTGATGAGTAC
CTTAGGCTGGTGAAGGAGTC

Downstream 100 bases:

>100_bases
GAAGCTTATTAATAATCCTCACCTTAACCGGTAATGATGCCCACTGGCAGGGCGTTATTAATAGCATCGGATAGGAGTGG
ATCAGGAAAGACCACGGTTA

Product: shikimate dehydrogenase substrate binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MHVFGLIGYPLNYTLSPQIHNYVFKRLRIDAAYVPLRVASKRLLHFIEFSRDALSGFNVTIPHKVAVAKLIDELNDDADT
IKSVNTVVNSNQKLIGYNTDYVAVEESLIERGYKGEEALLIGAGGAARAVVLALSKTGCRAIKVLNRSRERAVELCGLAN
GLGLDCSVVDIGGNYGKPHVIINATPLSSEEYWLLNLGELGTMLLLDMAYKPNTETDLIKRARELGIQVIDGVEILVRQA
LAADKLWLGDFNEPSASEVIKYIKGINPS

Sequences:

>Translated_269_residues
MHVFGLIGYPLNYTLSPQIHNYVFKRLRIDAAYVPLRVASKRLLHFIEFSRDALSGFNVTIPHKVAVAKLIDELNDDADT
IKSVNTVVNSNQKLIGYNTDYVAVEESLIERGYKGEEALLIGAGGAARAVVLALSKTGCRAIKVLNRSRERAVELCGLAN
GLGLDCSVVDIGGNYGKPHVIINATPLSSEEYWLLNLGELGTMLLLDMAYKPNTETDLIKRARELGIQVIDGVEILVRQA
LAADKLWLGDFNEPSASEVIKYIKGINPS
>Mature_269_residues
MHVFGLIGYPLNYTLSPQIHNYVFKRLRIDAAYVPLRVASKRLLHFIEFSRDALSGFNVTIPHKVAVAKLIDELNDDADT
IKSVNTVVNSNQKLIGYNTDYVAVEESLIERGYKGEEALLIGAGGAARAVVLALSKTGCRAIKVLNRSRERAVELCGLAN
GLGLDCSVVDIGGNYGKPHVIINATPLSSEEYWLLNLGELGTMLLLDMAYKPNTETDLIKRARELGIQVIDGVEILVRQA
LAADKLWLGDFNEPSASEVIKYIKGINPS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=284, Percent_Identity=27.4647887323944, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789675, Length=277, Percent_Identity=29.2418772563177, Blast_Score=75, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320332, Length=272, Percent_Identity=29.4117647058824, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_CALMQ (A8MCY4)

Other databases:

- EMBL:   CP000852
- RefSeq:   YP_001540630.1
- ProteinModelPortal:   A8MCY4
- SMR:   A8MCY4
- GeneID:   5708718
- GenomeReviews:   CP000852_GR
- KEGG:   cma:Cmaq_0805
- HOGENOM:   HBG553408
- OMA:   GYNTDAS
- BioCyc:   CMAQ397948:CMAQ_0805-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29480; Mature: 29480

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: ACT_SITE 64-64

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVFGLIGYPLNYTLSPQIHNYVFKRLRIDAAYVPLRVASKRLLHFIEFSRDALSGFNVT
CEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IPHKVAVAKLIDELNDDADTIKSVNTVVNSNQKLIGYNTDYVAVEESLIERGYKGEEALL
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCCEEE
IGAGGAARAVVLALSKTGCRAIKVLNRSRERAVELCGLANGLGLDCSVVDIGGNYGKPHV
EECCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEE
IINATPLSSEEYWLLNLGELGTMLLLDMAYKPNTETDLIKRARELGIQVIDGVEILVRQA
EEEECCCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHH
LAADKLWLGDFNEPSASEVIKYIKGINPS
HHHCCEEECCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MHVFGLIGYPLNYTLSPQIHNYVFKRLRIDAAYVPLRVASKRLLHFIEFSRDALSGFNVT
CEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IPHKVAVAKLIDELNDDADTIKSVNTVVNSNQKLIGYNTDYVAVEESLIERGYKGEEALL
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCCEEE
IGAGGAARAVVLALSKTGCRAIKVLNRSRERAVELCGLANGLGLDCSVVDIGGNYGKPHV
EECCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEE
IINATPLSSEEYWLLNLGELGTMLLLDMAYKPNTETDLIKRARELGIQVIDGVEILVRQA
EEEECCCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHH
LAADKLWLGDFNEPSASEVIKYIKGINPS
HHHCCEEECCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA