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The map label for this gene is tfb

Identifier: 159041370

GI number: 159041370

Start: 830694

End: 831704

Strand: Reverse

Name: tfb

Synonym: Cmaq_0797

Alternate gene names: 159041370

Gene position: 831704-830694 (Counterclockwise)

Preceding gene: 159041377

Following gene: 159041369

Centisome position: 40.03

GC content: 47.77

Gene sequence:

>1011_bases
ATGAGCACCACACAGGGGGGTTCTAACCAACAGGATGAAACCAGGAGGGAATTAATAATACAGAAGTTTAAATTATTTAG
GAGGGAGGGCAATAACCTGGAGTTTGTTGATCAGAGCGGTCAGAAGTTAAGGTGCCCAATATGCGGTAACACCGTGTTTA
TTGAGGATGCTGAGCGAGGACAGATAGTGTGCGCCTCCTGCGGTTACGTACTCATGGAGCATATTCTTGACACTGGGCCT
GAGTGGAGGGCATTCACCCCGGAGGAGAAGGAGGATAGGGCTAGGACTGGTGGGCCATTGGAGAGGGTTACCAGTGAGGA
GCTTGTAACTAGGATTGAAACAACCTTAAAGTCCCCTGATTTGAAGAAGAAGCTTGAGATTCTTAAGTATAAGAAATGGC
AGCAGAGGATTAGGGTTCAGACTAGTTACGAGAGGAACCTTGTTCAAGCCACTCATGAGTTAAATAGGATTGCCCACCAG
TTAGGTGTCCCTAAGTCCTGCATGGATGAGGCCCTAGCCGTATATAAGCAGGTCCTTAAGAGCGGCTTAGTTAAGGGTAG
GAGCGTTGAGGCTATTATAGCTGCCTGCCTACACATGGCCTGTAGAATGCAGGGGATGCCTAGGAGTCTTGATGAGATTT
CACAGTACACTAGGGCGCCTAGGAAGGAGATTGCGAGGTGCTTTAGGTTAATTGCAAGGGAGCTTAGGATTAGGTTACCG
TTAAGTGACCCAAGGCAGTATGTACCTAAGATAGTTGAGCAACTTAAACTCCCAGGGGATATTGCTAAGGAGGCCATTAG
GGTTCTTGAGGAGGCTAAGGATAAGGGCTTAACCGCTGGTAAGGACCCAGCCGGCTTAGCTGCAGCGGCCGTCTACATTG
CGTCATTACTTAAGGGTGAGGTTAGGACTCAGAAGGAGATTGCCCAAGCAGCCCAAGTCACTGAGGTTACTGTTAGGAAT
AGGTATAAGGAGCTTGCTAAGGAGTTAAACATAAAGATACCGATTAAGTAA

Upstream 100 bases:

>100_bases
ACCCGGTCATCACGTTGGATAATACTTAAGTTAATGTAGTTTATTTTATGCGAAAAGTTTATAAATGAGTAAAATTTTAA
TTAGGTGGAAAGGAGATAAC

Downstream 100 bases:

>100_bases
CTTACTCATGAAAATACCTGGTGTTGAGTATAAGACCCTATGCAGATACTGTAGCCTGAGTAATGAATTACTGATAGCGG
AGGAGAGCGGCTACGGTATC

Product: transcription initiation factor IIB

Products: NA

Alternate protein names: TFIIB

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSTTQGGSNQQDETRRELIIQKFKLFRREGNNLEFVDQSGQKLRCPICGNTVFIEDAERGQIVCASCGYVLMEHILDTGP
EWRAFTPEEKEDRARTGGPLERVTSEELVTRIETTLKSPDLKKKLEILKYKKWQQRIRVQTSYERNLVQATHELNRIAHQ
LGVPKSCMDEALAVYKQVLKSGLVKGRSVEAIIAACLHMACRMQGMPRSLDEISQYTRAPRKEIARCFRLIARELRIRLP
LSDPRQYVPKIVEQLKLPGDIAKEAIRVLEEAKDKGLTAGKDPAGLAAAAVYIASLLKGEVRTQKEIAQAAQVTEVTVRN
RYKELAKELNIKIPIK

Sequences:

>Translated_336_residues
MSTTQGGSNQQDETRRELIIQKFKLFRREGNNLEFVDQSGQKLRCPICGNTVFIEDAERGQIVCASCGYVLMEHILDTGP
EWRAFTPEEKEDRARTGGPLERVTSEELVTRIETTLKSPDLKKKLEILKYKKWQQRIRVQTSYERNLVQATHELNRIAHQ
LGVPKSCMDEALAVYKQVLKSGLVKGRSVEAIIAACLHMACRMQGMPRSLDEISQYTRAPRKEIARCFRLIARELRIRLP
LSDPRQYVPKIVEQLKLPGDIAKEAIRVLEEAKDKGLTAGKDPAGLAAAAVYIASLLKGEVRTQKEIAQAAQVTEVTVRN
RYKELAKELNIKIPIK
>Mature_335_residues
STTQGGSNQQDETRRELIIQKFKLFRREGNNLEFVDQSGQKLRCPICGNTVFIEDAERGQIVCASCGYVLMEHILDTGPE
WRAFTPEEKEDRARTGGPLERVTSEELVTRIETTLKSPDLKKKLEILKYKKWQQRIRVQTSYERNLVQATHELNRIAHQL
GVPKSCMDEALAVYKQVLKSGLVKGRSVEAIIAACLHMACRMQGMPRSLDEISQYTRAPRKEIARCFRLIARELRIRLPL
SDPRQYVPKIVEQLKLPGDIAKEAIRVLEEAKDKGLTAGKDPAGLAAAAVYIASLLKGEVRTQKEIAQAAQVTEVTVRNR
YKELAKELNIKIPIK

Specific function: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)

COG id: COG1405

COG function: function code K; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TFIIB-type zinc finger

Homologues:

Organism=Homo sapiens, GI4504193, Length=284, Percent_Identity=32.0422535211268, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI22035556, Length=284, Percent_Identity=27.8169014084507, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17564892, Length=285, Percent_Identity=34.0350877192982, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17531397, Length=287, Percent_Identity=25.4355400696864, Blast_Score=103, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6325343, Length=322, Percent_Identity=27.9503105590062, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321685, Length=199, Percent_Identity=27.6381909547739, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136758, Length=273, Percent_Identity=34.0659340659341, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI281361961, Length=288, Percent_Identity=26.3888888888889, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24647658, Length=288, Percent_Identity=26.3888888888889, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TF2B_CALMQ (A8MCX6)

Other databases:

- EMBL:   CP000852
- RefSeq:   YP_001540622.1
- ProteinModelPortal:   A8MCX6
- GeneID:   5710362
- GenomeReviews:   CP000852_GR
- KEGG:   cma:Cmaq_0797
- HOGENOM:   HBG646536
- OMA:   HDYERAE
- ProtClustDB:   PRK00423
- BioCyc:   CMAQ397948:CMAQ_0797-MONOMER
- HAMAP:   MF_00383
- InterPro:   IPR006670
- InterPro:   IPR011028
- InterPro:   IPR013763
- InterPro:   IPR000812
- InterPro:   IPR013150
- InterPro:   IPR013137
- Gene3D:   G3DSA:1.10.472.10
- PANTHER:   PTHR11618
- PRINTS:   PR00685
- SMART:   SM00385

Pfam domain/function: PF00382 TFIIB; PF08271 TFIIB_Zn_Ribbon; SSF47954 Cyclin_like

EC number: NA

Molecular weight: Translated: 38079; Mature: 37948

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00782 TFIIB; PS51134 ZF_TFIIB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTQGGSNQQDETRRELIIQKFKLFRREGNNLEFVDQSGQKLRCPICGNTVFIEDAERG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEECEECCCEEEEEECCCC
QIVCASCGYVLMEHILDTGPEWRAFTPEEKEDRARTGGPLERVTSEELVTRIETTLKSPD
CEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
LKKKLEILKYKKWQQRIRVQTSYERNLVQATHELNRIAHQLGVPKSCMDEALAVYKQVLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SGLVKGRSVEAIIAACLHMACRMQGMPRSLDEISQYTRAPRKEIARCFRLIARELRIRLP
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
LSDPRQYVPKIVEQLKLPGDIAKEAIRVLEEAKDKGLTAGKDPAGLAAAAVYIASLLKGE
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VRTQKEIAQAAQVTEVTVRNRYKELAKELNIKIPIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STTQGGSNQQDETRRELIIQKFKLFRREGNNLEFVDQSGQKLRCPICGNTVFIEDAERG
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEECEECCCEEEEEECCCC
QIVCASCGYVLMEHILDTGPEWRAFTPEEKEDRARTGGPLERVTSEELVTRIETTLKSPD
CEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
LKKKLEILKYKKWQQRIRVQTSYERNLVQATHELNRIAHQLGVPKSCMDEALAVYKQVLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SGLVKGRSVEAIIAACLHMACRMQGMPRSLDEISQYTRAPRKEIARCFRLIARELRIRLP
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
LSDPRQYVPKIVEQLKLPGDIAKEAIRVLEEAKDKGLTAGKDPAGLAAAAVYIASLLKGE
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VRTQKEIAQAAQVTEVTVRNRYKELAKELNIKIPIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA