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The map label for this gene is gds [H]

Identifier: 159041083

GI number: 159041083

Start: 536846

End: 537745

Strand: Reverse

Name: gds [H]

Synonym: Cmaq_0500

Alternate gene names: 159041083

Gene position: 537745-536846 (Counterclockwise)

Preceding gene: 159041084

Following gene: 159041080

Centisome position: 25.88

GC content: 43.89

Gene sequence:

>900_bases
ATGGCTTTCATTTTTGAGCTACCTAAGGAAATAAACGACGTGTTGAGCCTTATCATTAATGAGCTTGGTAATCTACTTAA
TGGAGTCAACATGCCTCCTAACTTAAGGGAATCAGCAATGCATTACATTCATAATAAGGGTAAGATGATTAGGCCACTCC
TAACCCTGATAACAACACACACCCTGGGCGGTAACCTAATGGATGCCGTTAACCCAGCTATTGCAGTGGAGCTGGTTCAT
GTAGCTACCCTGCTTCAAGACGATATAATCGATGGGCACTTAATGAGGAGGGGCTCTGAAACACCCTTCAAGAGGTATGG
AACCGAGTACACTATATTAGCCAGTGACTTATTGATTGCTAAGGCAATTGAGTACTCGTTGAAATCCAAGACTAGGAGGA
TAACAATGGAGTTAACCAGCGCAGCCTTAAGACTAGCCATAGGGCAATCCTATGAACTTGAGTATAAACTGAACGGTAAA
GTGGATATGAATATTTACATGAGGATCATTGAGAATAAGACAGCATCCCTAATCTCAGCCGCAATAGTGCTGGGTGGTTA
CGTGGCTGACGCCGATAGCAACACGATTAATCTACTTAGGTCCCTTGGGGAGAAGCTTGGCGCAGCGTACCAGATAAGGG
ACGACATAATAGATTACCTCAATTTAGATAAGGATAATCCAAAGGGCTTAAGGAGCGTTGACGTTAACGTAATTGATGCA
CTTAAAGCGGAGGGCTTCAGTGACCCGCTTAAGGAGGCTTATAGATTATTCATGGGCTACATGAGTGAAGCGAGGGCAAT
AACGGCATCAATAAGGGGTGGTGAAGTCTTCGCAGGCATTATCGACTTCCTGCAGGATCCCTTAACTAAGCTCATTGAGG
GGAATAAGAACCAAGTTTAA

Upstream 100 bases:

>100_bases
ATAGGTCAGGCTATAGGGTGTATTAGTGGTTAAATTAGTTAAAATGATTCGTGGAAAAACTATAAAAATGGTTAACCCAC
GGTGATTAGTGAAGTTAACT

Downstream 100 bases:

>100_bases
GAATAAGAATTCTTTAACGGGTTAGTACTCAGCAACCTTAGGTGCCCTACCAAGTATCTTAAGTGACTCCTGGGCAGTCA
CAAGCCTAGCTACTGGAACC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MAFIFELPKEINDVLSLIINELGNLLNGVNMPPNLRESAMHYIHNKGKMIRPLLTLITTHTLGGNLMDAVNPAIAVELVH
VATLLQDDIIDGHLMRRGSETPFKRYGTEYTILASDLLIAKAIEYSLKSKTRRITMELTSAALRLAIGQSYELEYKLNGK
VDMNIYMRIIENKTASLISAAIVLGGYVADADSNTINLLRSLGEKLGAAYQIRDDIIDYLNLDKDNPKGLRSVDVNVIDA
LKAEGFSDPLKEAYRLFMGYMSEARAITASIRGGEVFAGIIDFLQDPLTKLIEGNKNQV

Sequences:

>Translated_299_residues
MAFIFELPKEINDVLSLIINELGNLLNGVNMPPNLRESAMHYIHNKGKMIRPLLTLITTHTLGGNLMDAVNPAIAVELVH
VATLLQDDIIDGHLMRRGSETPFKRYGTEYTILASDLLIAKAIEYSLKSKTRRITMELTSAALRLAIGQSYELEYKLNGK
VDMNIYMRIIENKTASLISAAIVLGGYVADADSNTINLLRSLGEKLGAAYQIRDDIIDYLNLDKDNPKGLRSVDVNVIDA
LKAEGFSDPLKEAYRLFMGYMSEARAITASIRGGEVFAGIIDFLQDPLTKLIEGNKNQV
>Mature_298_residues
AFIFELPKEINDVLSLIINELGNLLNGVNMPPNLRESAMHYIHNKGKMIRPLLTLITTHTLGGNLMDAVNPAIAVELVHV
ATLLQDDIIDGHLMRRGSETPFKRYGTEYTILASDLLIAKAIEYSLKSKTRRITMELTSAALRLAIGQSYELEYKLNGKV
DMNIYMRIIENKTASLISAAIVLGGYVADADSNTINLLRSLGEKLGAAYQIRDDIIDYLNLDKDNPKGLRSVDVNVIDAL
KAEGFSDPLKEAYRLFMGYMSEARAITASIRGGEVFAGIIDFLQDPLTKLIEGNKNQV

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=196, Percent_Identity=29.0816326530612, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1789578, Length=232, Percent_Identity=28.448275862069, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786623, Length=191, Percent_Identity=32.9842931937173, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24651612, Length=219, Percent_Identity=24.6575342465753, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 33116; Mature: 32985

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFIFELPKEINDVLSLIINELGNLLNGVNMPPNLRESAMHYIHNKGKMIRPLLTLITTH
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
TLGGNLMDAVNPAIAVELVHVATLLQDDIIDGHLMRRGSETPFKRYGTEYTILASDLLIA
HCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCHHHCCCCEEEHHHHHHHH
KAIEYSLKSKTRRITMELTSAALRLAIGQSYELEYKLNGKVDMNIYMRIIENKTASLISA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEHHHHHHHHHCHHHHHHHH
AIVLGGYVADADSNTINLLRSLGEKLGAAYQIRDDIIDYLNLDKDNPKGLRSVDVNVIDA
HHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
LKAEGFSDPLKEAYRLFMGYMSEARAITASIRGGEVFAGIIDFLQDPLTKLIEGNKNQV
HHHCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AFIFELPKEINDVLSLIINELGNLLNGVNMPPNLRESAMHYIHNKGKMIRPLLTLITTH
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
TLGGNLMDAVNPAIAVELVHVATLLQDDIIDGHLMRRGSETPFKRYGTEYTILASDLLIA
HCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCHHHCCCCEEEHHHHHHHH
KAIEYSLKSKTRRITMELTSAALRLAIGQSYELEYKLNGKVDMNIYMRIIENKTASLISA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEHHHHHHHHHCHHHHHHHH
AIVLGGYVADADSNTINLLRSLGEKLGAAYQIRDDIIDYLNLDKDNPKGLRSVDVNVIDA
HHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
LKAEGFSDPLKEAYRLFMGYMSEARAITASIRGGEVFAGIIDFLQDPLTKLIEGNKNQV
HHHCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8182085 [H]