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The map label for this gene is thsA [H]

Identifier: 159040599

GI number: 159040599

Start: 19499

End: 21175

Strand: Reverse

Name: thsA [H]

Synonym: Cmaq_0007

Alternate gene names: 159040599

Gene position: 21175-19499 (Counterclockwise)

Preceding gene: 159040600

Following gene: 159040597

Centisome position: 1.02

GC content: 49.14

Gene sequence:

>1677_bases
ATGTCAACAGCTCAACAACCTAAGAGTGGTGTTCCAGTAGCCATACTTAAGGAGGGTAGTTCAAGGACAACTGGTGCGGA
TGCCAGGAGGAGTAACATAATGGCTGCTAAGGTTATAACAGAGGTTCTTCAAACAAGCCTTGGACCCAGGGGAATGGATA
AGTTACTCATTGACGCCTTCGGTGACGTGACAATAACCGGTGATGGTGCAACAATACTCAAGGAAATGGAGGTCCAGCAC
CCTGCCGCTAAGCTACTTGTTGAGGTGGCTAAGGCACAGGACGCTGAGGTTGGTGACGGTACAACAACCGTGGTTGTACT
GGCGGGTAAGCTCCTTGAGCAGGCTGAGATACTGCTGGATGAGGGTATTCACCCAACTATAATAATTGACGGATTTAAGA
AGGCGTTAGACTTCATAAACTCAACCATAACCGAGGTACCGAACCTAATATACCCTGTTAACTTAAGTAATAGGGATGAG
GTTGCTAAGATTGTTGCCAACTCACTGAGCAGTAAGGTTGTTGCTGAGGCTAGGGATTACTTAGCCAAGATAGTTGTTGA
CGCCTCCTACATTGCCGCTGAGCAAACCAACGGTAAGTACAACCTGGATTTAGATTGGGTTAAGGTTGAGAAGAAGAAGG
GCCAGAGCCTATACGAGACTCAATTCATCCAGGGTATTGTACTGGATAAGGAGGTTGTTCACCCAGGGATGCCTAAGAGG
ATTGAGAAGGCTAAGATAGCTGTCTTAGATGCGCCACTTGAGATTGAGAAGCCTGAGTGGACCACTAAGATATCGGTTTC
ATCACCGCAGCAGATTAAGGCCTACCTTGAGGAGGAGGCTAACATACTTAAGGGTTACGTTGATAAGCTTAAGGAGATAG
GGGCCAACGTAGTTATTACGCAGAAGGGTATTGATGAGACTGCTCAACACTTCCTGGCTAAGGCCGGTATTATGGCTGTT
AGGAGGGTTAAGAGGAGTGACATTGAGAAGCTGGCTAAGGCAACTGGGGCTAGGATAGCCACCAGTATTAAGGATCTTAA
GCCCGAGGACCTCGGTACAGCTGGGTTAGTTGAGGAGAGGAAGGTTGGTGAGGAGAAGATGGTGTTCGTTGAGCAATGCC
CCAACCCAAGGGCAGTCACAATACTCATTAGGGGTGCCGCGGACAGGGTGCTTGATGAGGCTGAGAGGTCGATAAACGAT
GCACTACACGTCACAAGGGACCTATTCAGGGATCCGAGAATAGTCCCAGGCGGTGGGGCATTTGAGATTGAGGTTGCTAG
GAGGCTTAGGGAGTGGGGTAGGAAGCTTCCAGGTAAGGAGCAGTTAGCGGTAATGAGGTACGCCGAGGCCGTGGAGAAGG
TTCCTGAAATACTAGCCCTAACCGCGGGCCTAGACCCAGTGGATGCAATAGCTGAATTAAGGAGTAGGCATGATAAGGGT
GAGCTTGACGCCGGTGTGGATGTGCTTGGAGGCAGGATAACAAGGATGAGTGAATTAAACATATGGGACCCATTAATAGT
TAAGATGCAGGTACTGAGAAGCGCCACTGAGGCAGCGATAATGGTGCTTAGGATAGATGACATAATAGCAGCCGGCCAGA
CAAAGTCATCCACAGGTAAGGGTAAGGCCGGTGAGGAGTCAAAGACCGGTGAGGAAGGCGGAACCAGTAGTGATTAA

Upstream 100 bases:

>100_bases
TGAGGCTTATTTAAGCACTCAATACTGTTTATTCCAGTGTCCTAGGTTTCTATGGTTACTTAGGGAAAGGTTTATATAGA
AGCGGCTTCTGGGGATGCAT

Downstream 100 bases:

>100_bases
TTAAAAACAGTTAACTCCGGCTTAGATTTAATTCCCTCTTCTTCCCTCACTACGTTATCTTAATCCCTACGCATTAAACC
ACCGTTAATAGTCTCAGTAA

Product: thermosome

Products: NA

Alternate protein names: Chaperonin subunit alpha; Thermosome subunit 1 [H]

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MSTAQQPKSGVPVAILKEGSSRTTGADARRSNIMAAKVITEVLQTSLGPRGMDKLLIDAFGDVTITGDGATILKEMEVQH
PAAKLLVEVAKAQDAEVGDGTTTVVVLAGKLLEQAEILLDEGIHPTIIIDGFKKALDFINSTITEVPNLIYPVNLSNRDE
VAKIVANSLSSKVVAEARDYLAKIVVDASYIAAEQTNGKYNLDLDWVKVEKKKGQSLYETQFIQGIVLDKEVVHPGMPKR
IEKAKIAVLDAPLEIEKPEWTTKISVSSPQQIKAYLEEEANILKGYVDKLKEIGANVVITQKGIDETAQHFLAKAGIMAV
RRVKRSDIEKLAKATGARIATSIKDLKPEDLGTAGLVEERKVGEEKMVFVEQCPNPRAVTILIRGAADRVLDEAERSIND
ALHVTRDLFRDPRIVPGGGAFEIEVARRLREWGRKLPGKEQLAVMRYAEAVEKVPEILALTAGLDPVDAIAELRSRHDKG
ELDAGVDVLGGRITRMSELNIWDPLIVKMQVLRSATEAAIMVLRIDDIIAAGQTKSSTGKGKAGEESKTGEEGGTSSD

Sequences:

>Translated_558_residues
MSTAQQPKSGVPVAILKEGSSRTTGADARRSNIMAAKVITEVLQTSLGPRGMDKLLIDAFGDVTITGDGATILKEMEVQH
PAAKLLVEVAKAQDAEVGDGTTTVVVLAGKLLEQAEILLDEGIHPTIIIDGFKKALDFINSTITEVPNLIYPVNLSNRDE
VAKIVANSLSSKVVAEARDYLAKIVVDASYIAAEQTNGKYNLDLDWVKVEKKKGQSLYETQFIQGIVLDKEVVHPGMPKR
IEKAKIAVLDAPLEIEKPEWTTKISVSSPQQIKAYLEEEANILKGYVDKLKEIGANVVITQKGIDETAQHFLAKAGIMAV
RRVKRSDIEKLAKATGARIATSIKDLKPEDLGTAGLVEERKVGEEKMVFVEQCPNPRAVTILIRGAADRVLDEAERSIND
ALHVTRDLFRDPRIVPGGGAFEIEVARRLREWGRKLPGKEQLAVMRYAEAVEKVPEILALTAGLDPVDAIAELRSRHDKG
ELDAGVDVLGGRITRMSELNIWDPLIVKMQVLRSATEAAIMVLRIDDIIAAGQTKSSTGKGKAGEESKTGEEGGTSSD
>Mature_557_residues
STAQQPKSGVPVAILKEGSSRTTGADARRSNIMAAKVITEVLQTSLGPRGMDKLLIDAFGDVTITGDGATILKEMEVQHP
AAKLLVEVAKAQDAEVGDGTTTVVVLAGKLLEQAEILLDEGIHPTIIIDGFKKALDFINSTITEVPNLIYPVNLSNRDEV
AKIVANSLSSKVVAEARDYLAKIVVDASYIAAEQTNGKYNLDLDWVKVEKKKGQSLYETQFIQGIVLDKEVVHPGMPKRI
EKAKIAVLDAPLEIEKPEWTTKISVSSPQQIKAYLEEEANILKGYVDKLKEIGANVVITQKGIDETAQHFLAKAGIMAVR
RVKRSDIEKLAKATGARIATSIKDLKPEDLGTAGLVEERKVGEEKMVFVEQCPNPRAVTILIRGAADRVLDEAERSINDA
LHVTRDLFRDPRIVPGGGAFEIEVARRLREWGRKLPGKEQLAVMRYAEAVEKVPEILALTAGLDPVDAIAELRSRHDKGE
LDAGVDVLGGRITRMSELNIWDPLIVKMQVLRSATEAAIMVLRIDDIIAAGQTKSSTGKGKAGEESKTGEEGGTSSD

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI63162572, Length=544, Percent_Identity=36.9485294117647, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI24307939, Length=541, Percent_Identity=41.0351201478743, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI38455427, Length=515, Percent_Identity=40.9708737864078, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI57863257, Length=528, Percent_Identity=37.6893939393939, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI5453607, Length=522, Percent_Identity=36.0153256704981, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI58761484, Length=544, Percent_Identity=34.0073529411765, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI261399877, Length=482, Percent_Identity=34.8547717842324, Blast_Score=315, Evalue=1e-85,
Organism=Homo sapiens, GI4502643, Length=519, Percent_Identity=36.0308285163777, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI58331173, Length=512, Percent_Identity=35.9375, Blast_Score=312, Evalue=5e-85,
Organism=Homo sapiens, GI5453603, Length=532, Percent_Identity=35.3383458646617, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI302058290, Length=508, Percent_Identity=34.0551181102362, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI261399875, Length=437, Percent_Identity=31.8077803203661, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI48762932, Length=546, Percent_Identity=33.6996336996337, Blast_Score=256, Evalue=5e-68,
Organism=Homo sapiens, GI302058292, Length=513, Percent_Identity=31.7738791423002, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI58331171, Length=520, Percent_Identity=31.7307692307692, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI57863259, Length=377, Percent_Identity=33.42175066313, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI58331185, Length=316, Percent_Identity=31.6455696202532, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI7657253, Length=507, Percent_Identity=27.2189349112426, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI25914754, Length=408, Percent_Identity=23.0392156862745, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI9055272, Length=408, Percent_Identity=23.0392156862745, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1790586, Length=167, Percent_Identity=33.5329341317365, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25144674, Length=530, Percent_Identity=41.3207547169811, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI25148561, Length=533, Percent_Identity=36.3977485928705, Blast_Score=367, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17532601, Length=530, Percent_Identity=38.3018867924528, Blast_Score=360, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17532603, Length=510, Percent_Identity=40.9803921568627, Blast_Score=348, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI17564182, Length=530, Percent_Identity=34.7169811320755, Blast_Score=338, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI25147750, Length=533, Percent_Identity=33.9587242026266, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI32566944, Length=446, Percent_Identity=34.0807174887892, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI25144678, Length=530, Percent_Identity=33.5849056603774, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI25144680, Length=388, Percent_Identity=35.8247422680412, Blast_Score=235, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI71981457, Length=325, Percent_Identity=38.7692307692308, Blast_Score=228, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI71998178, Length=564, Percent_Identity=27.6595744680851, Blast_Score=217, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322446, Length=528, Percent_Identity=36.9318181818182, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6322524, Length=540, Percent_Identity=37.2222222222222, Blast_Score=352, Evalue=8e-98,
Organism=Saccharomyces cerevisiae, GI6320058, Length=511, Percent_Identity=38.747553816047, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6322350, Length=533, Percent_Identity=33.5834896810507, Blast_Score=326, Evalue=7e-90,
Organism=Saccharomyces cerevisiae, GI6320418, Length=532, Percent_Identity=35.3383458646617, Blast_Score=322, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6320393, Length=531, Percent_Identity=35.5932203389831, Blast_Score=285, Evalue=9e-78,
Organism=Saccharomyces cerevisiae, GI6322049, Length=508, Percent_Identity=33.4645669291339, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6322452, Length=551, Percent_Identity=30.4900181488203, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24647512, Length=530, Percent_Identity=37.3584905660377, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24647510, Length=530, Percent_Identity=37.3584905660377, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI17647245, Length=526, Percent_Identity=39.7338403041825, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI24645179, Length=521, Percent_Identity=37.236084452975, Blast_Score=351, Evalue=7e-97,
Organism=Drosophila melanogaster, GI24652903, Length=503, Percent_Identity=39.5626242544732, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24649027, Length=544, Percent_Identity=35.8455882352941, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24649029, Length=544, Percent_Identity=35.8455882352941, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24583944, Length=509, Percent_Identity=39.6856581532416, Blast_Score=343, Evalue=3e-94,
Organism=Drosophila melanogaster, GI18859933, Length=531, Percent_Identity=35.7815442561205, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI28571140, Length=524, Percent_Identity=34.3511450381679, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI18858175, Length=524, Percent_Identity=34.3511450381679, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI19921848, Length=550, Percent_Identity=31.2727272727273, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI45550936, Length=541, Percent_Identity=24.0295748613678, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45550132, Length=541, Percent_Identity=24.0295748613678, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45550935, Length=541, Percent_Identity=24.0295748613678, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 60507; Mature: 60376

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAQQPKSGVPVAILKEGSSRTTGADARRSNIMAAKVITEVLQTSLGPRGMDKLLIDAF
CCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
GDVTITGDGATILKEMEVQHPAAKLLVEVAKAQDAEVGDGTTTVVVLAGKLLEQAEILLD
CCEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
EGIHPTIIIDGFKKALDFINSTITEVPNLIYPVNLSNRDEVAKIVANSLSSKVVAEARDY
CCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAKIVVDASYIAAEQTNGKYNLDLDWVKVEKKKGQSLYETQFIQGIVLDKEVVHPGMPKR
HHHHHHHHHHHHHCCCCCEEEECCCEEEEEHHCCCHHHHHHHHHHHHCCHHHHCCCCCHH
IEKAKIAVLDAPLEIEKPEWTTKISVSSPQQIKAYLEEEANILKGYVDKLKEIGANVVIT
HHHCEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
QKGIDETAQHFLAKAGIMAVRRVKRSDIEKLAKATGARIATSIKDLKPEDLGTAGLVEER
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCHHHH
KVGEEKMVFVEQCPNPRAVTILIRGAADRVLDEAERSINDALHVTRDLFRDPRIVPGGGA
HCCHHHEEEHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
FEIEVARRLREWGRKLPGKEQLAVMRYAEAVEKVPEILALTAGLDPVDAIAELRSRHDKG
EEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
ELDAGVDVLGGRITRMSELNIWDPLIVKMQVLRSATEAAIMVLRIDDIIAAGQTKSSTGK
CCCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHEEEEEEEHHHHHCCCCCCCCCC
GKAGEESKTGEEGGTSSD
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STAQQPKSGVPVAILKEGSSRTTGADARRSNIMAAKVITEVLQTSLGPRGMDKLLIDAF
CCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
GDVTITGDGATILKEMEVQHPAAKLLVEVAKAQDAEVGDGTTTVVVLAGKLLEQAEILLD
CCEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
EGIHPTIIIDGFKKALDFINSTITEVPNLIYPVNLSNRDEVAKIVANSLSSKVVAEARDY
CCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAKIVVDASYIAAEQTNGKYNLDLDWVKVEKKKGQSLYETQFIQGIVLDKEVVHPGMPKR
HHHHHHHHHHHHHCCCCCEEEECCCEEEEEHHCCCHHHHHHHHHHHHCCHHHHCCCCCHH
IEKAKIAVLDAPLEIEKPEWTTKISVSSPQQIKAYLEEEANILKGYVDKLKEIGANVVIT
HHHCEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
QKGIDETAQHFLAKAGIMAVRRVKRSDIEKLAKATGARIATSIKDLKPEDLGTAGLVEER
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCHHHH
KVGEEKMVFVEQCPNPRAVTILIRGAADRVLDEAERSINDALHVTRDLFRDPRIVPGGGA
HCCHHHEEEHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
FEIEVARRLREWGRKLPGKEQLAVMRYAEAVEKVPEILALTAGLDPVDAIAELRSRHDKG
EEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
ELDAGVDVLGGRITRMSELNIWDPLIVKMQVLRSATEAAIMVLRIDDIIAAGQTKSSTGK
CCCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHEEEEEEEHHHHHCCCCCCCCCC
GKAGEESKTGEEGGTSSD
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]