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The map label for this gene is guaA

Identifier: 15899931

GI number: 15899931

Start: 2976437

End: 2977540

Strand: Reverse

Name: guaA

Synonym: SSO3232

Alternate gene names: 15899931

Gene position: 2977540-2976437 (Counterclockwise)

Preceding gene: 15899932

Following gene: 15899929

Centisome position: 99.51

GC content: 35.6

Gene sequence:

>1104_bases
ATGTTTGATCCTGCTTCATTTGTCGAGGAAATAGGGCCGCAGTTGAGACAGAAGCTTGGCAATGAGAAAGTTTTAGCTGC
GGTAAGTGGTGGTGTTGATAGTACTACAGCTGCAGTTCTCGCTTATAATTTGTTAGGCGATAAAGTAATTCCCGTTTTAG
TAGATACCGGCTTTTTAAGGAAAAACGAAGCTGAGAAAATTAAAGATTATTTAAGTAATATTTTACCTAACCTTATTATA
GTAGACAAGAAGGAGACATTTATCTCTGAAATTGAGGGAATTGACGATGCCGAAATGAAAAGGAAGAGATTCAGAGAACT
TTTTTACTCTACTATTTCATCATTAATGAAAAAGTTCAACGCAAGATATTTAATGCAAGGTACCATAGCCGCTGACTGGG
TAGAGACTCAAGGTGGAATAAAGACACAACATAATGTCTTAGTTCAAATAGGTATAGACACTGAGAAAGAATGGGGATTT
ACATTAATCGAACCATTGGCAGACCTTTATAAGAATGAGGTCAGGGAACTAGCTAGATATCTTAAACTACCTAAGGAAAT
TTCTGAAAGGCAGCCATTTCCTGGCCCTGGTCTCCTAGTTAGGGCGGTGGGGAAACTGACTAGGGAAAAGTTGGAAGTAG
TGAGAGAAGCTAATGATATAGTTGAAAAGTATTTAGATCCTTTTAACTACTCGCAATATTTTGCAGTATCCTTTGAATCC
TATGGTAATCTTGTAAATTTAGACGGTATTGATGCTTTTCTATACAAAGCTAGGGCTACTGGAGTTAAGGGTGACGTTAG
GGCTTATGGGAATATAGCAAAGATTGAGTGCAGTAATATTAATAATGTGAAAAACATTATAGATACTTTAGTTAAATATG
ACATTACTCATGTATTATGTACCTTGGACGAAAGGAATAGCGGAAAATACAGTGTCGCAATAAGGGCAGTCACTACTGAG
GATTTCATGACAGCTGATTATGTTAGAATACCTAAAGAAATTTTAAGTAAAATTAGTTCTGAAATATTACAAAAAATACC
TAATGTTAAAGAAGTACTTTATGATGTTACTTCTAAACCACCTGCAACTATAGAGTTCGAATAA

Upstream 100 bases:

>100_bases
CAAACAGCAAGCAATTCGTGTAGAGCAATTTTTAAGGAAATATTTACATATTGACGAAATAGTCGAAATTTATAAGCAAT
GAATTTTTAGTCTTAACTAA

Downstream 100 bases:

>100_bases
TTAATATTTTGAAACTTTATCTAGTAACTGTATCCTTTTGGCAGGATGTGGATGATCCATAAATATATCAGCATACCATG
GAACCTTTGTAGTTTTCCAA

Product: GMP synthase PP-ATPase subunit

Products: NA

Alternate protein names: GMP synthetase

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MFDPASFVEEIGPQLRQKLGNEKVLAAVSGGVDSTTAAVLAYNLLGDKVIPVLVDTGFLRKNEAEKIKDYLSNILPNLII
VDKKETFISEIEGIDDAEMKRKRFRELFYSTISSLMKKFNARYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGF
TLIEPLADLYKNEVRELARYLKLPKEISERQPFPGPGLLVRAVGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFES
YGNLVNLDGIDAFLYKARATGVKGDVRAYGNIAKIECSNINNVKNIIDTLVKYDITHVLCTLDERNSGKYSVAIRAVTTE
DFMTADYVRIPKEILSKISSEILQKIPNVKEVLYDVTSKPPATIEFE

Sequences:

>Translated_367_residues
MFDPASFVEEIGPQLRQKLGNEKVLAAVSGGVDSTTAAVLAYNLLGDKVIPVLVDTGFLRKNEAEKIKDYLSNILPNLII
VDKKETFISEIEGIDDAEMKRKRFRELFYSTISSLMKKFNARYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGF
TLIEPLADLYKNEVRELARYLKLPKEISERQPFPGPGLLVRAVGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFES
YGNLVNLDGIDAFLYKARATGVKGDVRAYGNIAKIECSNINNVKNIIDTLVKYDITHVLCTLDERNSGKYSVAIRAVTTE
DFMTADYVRIPKEILSKISSEILQKIPNVKEVLYDVTSKPPATIEFE
>Mature_367_residues
MFDPASFVEEIGPQLRQKLGNEKVLAAVSGGVDSTTAAVLAYNLLGDKVIPVLVDTGFLRKNEAEKIKDYLSNILPNLII
VDKKETFISEIEGIDDAEMKRKRFRELFYSTISSLMKKFNARYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGF
TLIEPLADLYKNEVRELARYLKLPKEISERQPFPGPGLLVRAVGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFES
YGNLVNLDGIDAFLYKARATGVKGDVRAYGNIAKIECSNINNVKNIIDTLVKYDITHVLCTLDERNSGKYSVAIRAVTTE
DFMTADYVRIPKEILSKISSEILQKIPNVKEVLYDVTSKPPATIEFE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=474, Percent_Identity=28.2700421940928, Blast_Score=145, Evalue=8e-35,
Organism=Escherichia coli, GI1788854, Length=376, Percent_Identity=30.8510638297872, Blast_Score=181, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71992710, Length=303, Percent_Identity=32.013201320132, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71992717, Length=303, Percent_Identity=32.013201320132, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI133901714, Length=303, Percent_Identity=32.013201320132, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323873, Length=368, Percent_Identity=32.3369565217391, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI281365319, Length=479, Percent_Identity=28.8100208768267, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAB_SULSO (Q97TZ8)

Other databases:

- EMBL:   AE006641
- PIR:   G90508
- RefSeq:   NP_344536.1
- ProteinModelPortal:   Q97TZ8
- SMR:   Q97TZ8
- GeneID:   1453245
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO3232
- NMPDR:   fig|273057.1.peg.2959
- HOGENOM:   HBG391775
- OMA:   QGTIAPD
- ProtClustDB:   CLSK883887
- BioCyc:   SSOL273057:SSO2451-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_00345
- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 41383; Mature: 41383

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDPASFVEEIGPQLRQKLGNEKVLAAVSGGVDSTTAAVLAYNLLGDKVIPVLVDTGFLR
CCCHHHHHHHHCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCC
KNEAEKIKDYLSNILPNLIIVDKKETFISEIEGIDDAEMKRKRFRELFYSTISSLMKKFN
CCHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
ARYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGFTLIEPLADLYKNEVRELARY
CCEEEECCHHHHHHHCCCCCEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LKLPKEISERQPFPGPGLLVRAVGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFES
HHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHH
YGNLVNLDGIDAFLYKARATGVKGDVRAYGNIAKIECSNINNVKNIIDTLVKYDITHVLC
CCCEEECCCHHHHHHHHHHCCCCCCHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEE
TLDERNSGKYSVAIRAVTTEDFMTADYVRIPKEILSKISSEILQKIPNVKEVLYDVTSKP
ECCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PATIEFE
CCEEECC
>Mature Secondary Structure
MFDPASFVEEIGPQLRQKLGNEKVLAAVSGGVDSTTAAVLAYNLLGDKVIPVLVDTGFLR
CCCHHHHHHHHCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCC
KNEAEKIKDYLSNILPNLIIVDKKETFISEIEGIDDAEMKRKRFRELFYSTISSLMKKFN
CCHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
ARYLMQGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGFTLIEPLADLYKNEVRELARY
CCEEEECCHHHHHHHCCCCCEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LKLPKEISERQPFPGPGLLVRAVGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFES
HHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHH
YGNLVNLDGIDAFLYKARATGVKGDVRAYGNIAKIECSNINNVKNIIDTLVKYDITHVLC
CCCEEECCCHHHHHHHHHHCCCCCCHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEE
TLDERNSGKYSVAIRAVTTEDFMTADYVRIPKEILSKISSEILQKIPNVKEVLYDVTSKP
ECCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PATIEFE
CCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726