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The map label for this gene is fadD-3 [H]

Identifier: 15899770

GI number: 15899770

Start: 2820276

End: 2821817

Strand: Direct

Name: fadD-3 [H]

Synonym: SSO3064

Alternate gene names: 15899770

Gene position: 2820276-2821817 (Clockwise)

Preceding gene: 15899769

Following gene: 15899771

Centisome position: 94.25

GC content: 36.51

Gene sequence:

>1542_bases
ATGAAGATAAAGGGAAAAGAAGAGTTTTGGGAACCTAAAACTCAAATTGATACAATTAATGAAAGTGTAAAGTTATTCAA
GGATAGGATTGCACTAGACTATTTCGGAAACAAAATTACTTTTGAAGAGCTTCGTCATATGGCAAACTCTATTGCTAGCC
AGCTATCAGAGTACGTTAAAAAAGGAAATGTTGTAATTATATCTACACAAAACATTCCCCAATTTATTATAGCAGAATAT
GCAATATGGAAATTGGGAGGAGTTGTATTACCAGTTAATCCTTCCTATACTGAATATGAATTAAAATACTTAATACAAGA
TGCTAATCCAAAAATAGCTATTGCCTCATGTGAATCTAACGTTAGGAAATTAAGTCACATAATAAAAATAATCACAACTA
ATCCCAATACTTTCCATGAATTACCATATGAGTATAAGGAAAAATGGAGAGTCGAAGATTATTGTGAGGAAGAATTGAAC
CTCAAAAGTAATAAATTTAGAATGGATAACGTAAAGGTAAACGTTGATGATTTAGCCTTATTAGTATACACTTCGGGTAC
TACGGGAAAACCTAAAGGCGTTCCAATAACTCACTCTAATATTTACGCCTCCTCGTGGATTTATAAAAATTGGTTCAAGT
ATACTGAAAATGACAAGATACTAGGCATAGCTCCATTTTTCCACATAACTGGCCAAATATTTCACATAACAACTTCAATC
CTAGCCGGCTCATCAATTTATACTTCATTTAGATTTGATCCAGAACTTTCCCTTAGAATTATTGAAGAGAACAAAACTAC
ATTAACAATGGCCGTAGCAACCGTATATAGGGCTATGCTGAACGTATTAGATAAGCAAGATTTGACAAGCATGAGACTTT
GGTCCTCTGGAGGGATGCCCATGCCCAGGGTAATAGAGGAAGAATGGAGGAAGAGAGTAGGGGATTGGGTTTACATGGCG
TGGGGATTAACTGAAACTACTTCGCCTGCAACTTTATGGCCATATCCCTATAACGGTAATTTGCCGGTTGAGCCAGAATA
CGGTATTGTGAGTTCTGGAATTCCAGTATACAATACTGAAATAATGATAGGGGAGGATGGGGAAATATTCGTTAGGGGAC
CTCAAGTTGTTAAGGGGTATTGGGGGATGGGTGAGTTTAAGGATGGTTGGTTGCCAACTGGAGACATAGGAAAAATAATA
AACAATTGGGTTTACATTATCGATAGAAAGAAGGATATAATAAACGCCTCTGGTTTTAAGGTAATGCCTAGAGAGGTTGA
GGAAGTAATATATCAACATTATGCCGTAGATGAGGCTGTAGTTGTTGGAGTGCCAGATGAGTATAGGGGAGAAAATATTG
TGGCTTACGTAAAGCTGAAAAAGGGATATTCGCTTTCAGATGACTTGGCTGCCGATATAATAAATTATTGTAGAATGCAT
TTAGCTCCATATAAGGTTCCCAGGCAAGTTAGATTCGTGAATGATATCCCTAAAACCCCATCTGGAAAAATAATGAGGAG
AGTATTTAGAGATGAAGCTTAG

Upstream 100 bases:

>100_bases
TAGTAAAGACGCAATAATGCTTAGCTTCATTTAAAACCTCTAATTATATTAGAGATGTAAAGGGTTAAGCACTTAATAAG
AAAACGTTTAATTATTAATT

Downstream 100 bases:

>100_bases
AAGATCTTAGATAATCTGAGTTTGATCTTTTATGTGCATTGTGGTCATGTTGAATTTTCACGATCATTTAAGGACTCCCA
TAAACATAAATTATGTATCA

Product: long-chain-fatty-acid--CoA ligase (fadD-3)

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MKIKGKEEFWEPKTQIDTINESVKLFKDRIALDYFGNKITFEELRHMANSIASQLSEYVKKGNVVIISTQNIPQFIIAEY
AIWKLGGVVLPVNPSYTEYELKYLIQDANPKIAIASCESNVRKLSHIIKIITTNPNTFHELPYEYKEKWRVEDYCEEELN
LKSNKFRMDNVKVNVDDLALLVYTSGTTGKPKGVPITHSNIYASSWIYKNWFKYTENDKILGIAPFFHITGQIFHITTSI
LAGSSIYTSFRFDPELSLRIIEENKTTLTMAVATVYRAMLNVLDKQDLTSMRLWSSGGMPMPRVIEEEWRKRVGDWVYMA
WGLTETTSPATLWPYPYNGNLPVEPEYGIVSSGIPVYNTEIMIGEDGEIFVRGPQVVKGYWGMGEFKDGWLPTGDIGKII
NNWVYIIDRKKDIINASGFKVMPREVEEVIYQHYAVDEAVVVGVPDEYRGENIVAYVKLKKGYSLSDDLAADIINYCRMH
LAPYKVPRQVRFVNDIPKTPSGKIMRRVFRDEA

Sequences:

>Translated_513_residues
MKIKGKEEFWEPKTQIDTINESVKLFKDRIALDYFGNKITFEELRHMANSIASQLSEYVKKGNVVIISTQNIPQFIIAEY
AIWKLGGVVLPVNPSYTEYELKYLIQDANPKIAIASCESNVRKLSHIIKIITTNPNTFHELPYEYKEKWRVEDYCEEELN
LKSNKFRMDNVKVNVDDLALLVYTSGTTGKPKGVPITHSNIYASSWIYKNWFKYTENDKILGIAPFFHITGQIFHITTSI
LAGSSIYTSFRFDPELSLRIIEENKTTLTMAVATVYRAMLNVLDKQDLTSMRLWSSGGMPMPRVIEEEWRKRVGDWVYMA
WGLTETTSPATLWPYPYNGNLPVEPEYGIVSSGIPVYNTEIMIGEDGEIFVRGPQVVKGYWGMGEFKDGWLPTGDIGKII
NNWVYIIDRKKDIINASGFKVMPREVEEVIYQHYAVDEAVVVGVPDEYRGENIVAYVKLKKGYSLSDDLAADIINYCRMH
LAPYKVPRQVRFVNDIPKTPSGKIMRRVFRDEA
>Mature_513_residues
MKIKGKEEFWEPKTQIDTINESVKLFKDRIALDYFGNKITFEELRHMANSIASQLSEYVKKGNVVIISTQNIPQFIIAEY
AIWKLGGVVLPVNPSYTEYELKYLIQDANPKIAIASCESNVRKLSHIIKIITTNPNTFHELPYEYKEKWRVEDYCEEELN
LKSNKFRMDNVKVNVDDLALLVYTSGTTGKPKGVPITHSNIYASSWIYKNWFKYTENDKILGIAPFFHITGQIFHITTSI
LAGSSIYTSFRFDPELSLRIIEENKTTLTMAVATVYRAMLNVLDKQDLTSMRLWSSGGMPMPRVIEEEWRKRVGDWVYMA
WGLTETTSPATLWPYPYNGNLPVEPEYGIVSSGIPVYNTEIMIGEDGEIFVRGPQVVKGYWGMGEFKDGWLPTGDIGKII
NNWVYIIDRKKDIINASGFKVMPREVEEVIYQHYAVDEAVVVGVPDEYRGENIVAYVKLKKGYSLSDDLAADIINYCRMH
LAPYKVPRQVRFVNDIPKTPSGKIMRRVFRDEA

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=547, Percent_Identity=26.508226691042, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI187761343, Length=547, Percent_Identity=26.508226691042, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI156151445, Length=520, Percent_Identity=25.7692307692308, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI42544132, Length=504, Percent_Identity=25.3968253968254, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI115511026, Length=517, Percent_Identity=25.1450676982592, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI38505220, Length=512, Percent_Identity=26.171875, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI58082049, Length=517, Percent_Identity=25.1450676982592, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI157311624, Length=516, Percent_Identity=25.1937984496124, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI157311622, Length=516, Percent_Identity=25.1937984496124, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI122937307, Length=508, Percent_Identity=23.8188976377953, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI28416953, Length=551, Percent_Identity=24.5009074410163, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI13375727, Length=529, Percent_Identity=26.2759924385633, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI8923896, Length=569, Percent_Identity=22.8471001757469, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI253970489, Length=374, Percent_Identity=26.2032085561497, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI42544134, Length=296, Percent_Identity=23.3108108108108, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI45580730, Length=347, Percent_Identity=23.6311239193084, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1788107, Length=544, Percent_Identity=31.8014705882353, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI145693145, Length=535, Percent_Identity=27.8504672897196, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI221142682, Length=502, Percent_Identity=24.5019920318725, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790505, Length=553, Percent_Identity=24.4122965641953, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1786810, Length=529, Percent_Identity=22.3062381852552, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1789201, Length=365, Percent_Identity=23.8356164383562, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786529, Length=546, Percent_Identity=25.2747252747253, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788595, Length=500, Percent_Identity=22.8, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1786801, Length=463, Percent_Identity=21.3822894168467, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17557194, Length=519, Percent_Identity=29.2870905587669, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17558820, Length=492, Percent_Identity=27.2357723577236, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17538037, Length=514, Percent_Identity=28.0155642023346, Blast_Score=176, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI32563687, Length=488, Percent_Identity=28.0737704918033, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17559526, Length=543, Percent_Identity=27.8084714548803, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17531443, Length=502, Percent_Identity=28.0876494023904, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71994690, Length=530, Percent_Identity=25.8490566037736, Blast_Score=148, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71994694, Length=530, Percent_Identity=25.8490566037736, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71994703, Length=530, Percent_Identity=25.8490566037736, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17560308, Length=518, Percent_Identity=25.0965250965251, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17560140, Length=526, Percent_Identity=24.9049429657795, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71996755, Length=510, Percent_Identity=24.9019607843137, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25141359, Length=509, Percent_Identity=23.5756385068762, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=354, Percent_Identity=25.9887005649718, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17556552, Length=478, Percent_Identity=25.3138075313808, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71982997, Length=557, Percent_Identity=20.8258527827648, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71983001, Length=557, Percent_Identity=20.8258527827648, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=502, Percent_Identity=27.2908366533865, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323182, Length=527, Percent_Identity=28.4629981024668, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319264, Length=529, Percent_Identity=26.0869565217391, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21355181, Length=476, Percent_Identity=29.4117647058824, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI18859661, Length=510, Percent_Identity=27.6470588235294, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24581924, Length=509, Percent_Identity=26.5225933202358, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI19922652, Length=529, Percent_Identity=24.952741020794, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI21356441, Length=491, Percent_Identity=27.2912423625255, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24648260, Length=505, Percent_Identity=27.7227722772277, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62472339, Length=558, Percent_Identity=22.7598566308244, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24648253, Length=496, Percent_Identity=25.8064516129032, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667955, Length=548, Percent_Identity=22.992700729927, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24648255, Length=355, Percent_Identity=28.7323943661972, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648676, Length=563, Percent_Identity=21.8472468916519, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24667959, Length=377, Percent_Identity=25.1989389920424, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24656500, Length=515, Percent_Identity=22.1359223300971, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21355225, Length=534, Percent_Identity=24.1573033707865, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653035, Length=359, Percent_Identity=25.6267409470752, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21358303, Length=472, Percent_Identity=25, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356947, Length=499, Percent_Identity=24.0480961923848, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648257, Length=358, Percent_Identity=27.0949720670391, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI20130357, Length=353, Percent_Identity=24.6458923512748, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI161076582, Length=365, Percent_Identity=24.3835616438356, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281365686, Length=330, Percent_Identity=25.1515151515152, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 58913; Mature: 58913

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKGKEEFWEPKTQIDTINESVKLFKDRIALDYFGNKITFEELRHMANSIASQLSEYVK
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHH
KGNVVIISTQNIPQFIIAEYAIWKLGGVVLPVNPSYTEYELKYLIQDANPKIAIASCESN
CCCEEEEECCCCCHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEECCCCCEEEEECHHH
VRKLSHIIKIITTNPNTFHELPYEYKEKWRVEDYCEEELNLKSNKFRMDNVKVNVDDLAL
HHHHHHHEEEEECCCCCHHHCCCHHHHCCCHHHHHHHHCCCCCCCEEECCEEEECCCEEE
LVYTSGTTGKPKGVPITHSNIYASSWIYKNWFKYTENDKILGIAPFFHITGQIFHITTSI
EEEECCCCCCCCCCEEECCCEEECHHHHHHHHHCCCCCCEEEEEHHHHHCCCCEEEHHHH
LAGSSIYTSFRFDPELSLRIIEENKTTLTMAVATVYRAMLNVLDKQDLTSMRLWSSGGMP
HCCCCEEEEEEECCCEEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
MPRVIEEEWRKRVGDWVYMAWGLTETTSPATLWPYPYNGNLPVEPEYGIVSSGIPVYNTE
CCHHHHHHHHHHCCCEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCEEECCCCEEEEE
IMIGEDGEIFVRGPQVVKGYWGMGEFKDGWLPTGDIGKIINNWVYIIDRKKDIINASGFK
EEECCCCCEEEECCCEEEECCCCCCCCCCCCCCCHHHHHHCCEEEEEECCCHHCCCCCCE
VMPREVEEVIYQHYAVDEAVVVGVPDEYRGENIVAYVKLKKGYSLSDDLAADIINYCRMH
ECHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
LAPYKVPRQVRFVNDIPKTPSGKIMRRVFRDEA
CCCCCCCCCEEEHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKIKGKEEFWEPKTQIDTINESVKLFKDRIALDYFGNKITFEELRHMANSIASQLSEYVK
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHH
KGNVVIISTQNIPQFIIAEYAIWKLGGVVLPVNPSYTEYELKYLIQDANPKIAIASCESN
CCCEEEEECCCCCHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEECCCCCEEEEECHHH
VRKLSHIIKIITTNPNTFHELPYEYKEKWRVEDYCEEELNLKSNKFRMDNVKVNVDDLAL
HHHHHHHEEEEECCCCCHHHCCCHHHHCCCHHHHHHHHCCCCCCCEEECCEEEECCCEEE
LVYTSGTTGKPKGVPITHSNIYASSWIYKNWFKYTENDKILGIAPFFHITGQIFHITTSI
EEEECCCCCCCCCCEEECCCEEECHHHHHHHHHCCCCCCEEEEEHHHHHCCCCEEEHHHH
LAGSSIYTSFRFDPELSLRIIEENKTTLTMAVATVYRAMLNVLDKQDLTSMRLWSSGGMP
HCCCCEEEEEEECCCEEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
MPRVIEEEWRKRVGDWVYMAWGLTETTSPATLWPYPYNGNLPVEPEYGIVSSGIPVYNTE
CCHHHHHHHHHHCCCEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCEEECCCCEEEEE
IMIGEDGEIFVRGPQVVKGYWGMGEFKDGWLPTGDIGKIINNWVYIIDRKKDIINASGFK
EEECCCCCEEEECCCEEEECCCCCCCCCCCCCCCHHHHHHCCEEEEEECCCHHCCCCCCE
VMPREVEEVIYQHYAVDEAVVVGVPDEYRGENIVAYVKLKKGYSLSDDLAADIINYCRMH
ECHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
LAPYKVPRQVRFVNDIPKTPSGKIMRRVFRDEA
CCCCCCCCCEEEHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]