Click here to switch to the map view.

The map label for this gene is malA

Identifier: 15899756

GI number: 15899756

Start: 2802789

End: 2804870

Strand: Reverse

Name: malA

Synonym: SSO3051

Alternate gene names: 15899756

Gene position: 2804870-2802789 (Counterclockwise)

Preceding gene: 15899758

Following gene: 15899753

Centisome position: 93.74

GC content: 38.76

Gene sequence:

>2082_bases
ATGCAGACAATAAAAATATACGAGAACAAAGGCGTTTACAAAGTAGTTATAGGAGAACCATTTCCCCCCATAGAATTCCC
ACTTGAGCAAAAGATATCATCGAATAAATCTTTATCAGAGTTGGGTTTAACAATAGTTCAACAAGGTAACAAGGTTATTG
TCGAGAAATCATTGGATTTGAAAGAGCACATTATAGGATTGGGAGAGAAGGCGTTTGAGTTGGATAGAAAGAGGAAAAGG
TATGTGATGTATAACGTTGACGCTGGGGCTTATAAGAAATATCAAGATCCACTTTACGTTAGTATACCCTTATTTATATC
AGTGAAAGACGGCGTTGCAACTGGTTACTTCTTCAACTCAGCTTCTAAAGTGATCTTCGACGTGGGACTTGAGGAATACG
ATAAAGTAATTGTTACAATTCCAGAGGACTCAGTAGAGTTTTACGTGATTGAAGGGCCAAGAATTGAGGACGTTCTAGAG
AAATACACGGAGCTTACCGGAAAACCTTTCCTACCTCCCATGTGGGCTTTCGGTTACATGATATCACGCTACTCTTACTA
CCCCCAGGATAAGGTTGTTGAGTTAGTAGATATAATGCAAAAGGAGGGTTTTAGAGTAGCTGGAGTATTCTTAGATATAC
ACTACATGGACTCCTATAAGTTATTTACATGGCATCCTTATAGGTTCCCAGAACCTAAAAAGCTAATTGACGAATTACAC
AAGAGAAACGTTAAGCTAATTACAATAGTTGACCACGGAATAAGGGTTGATCAGAATTATTCACCATTTCTTTCCGGAAT
GGGAAAATTCTGTGAGATTGAAAGTGGTGAACTATTCGTAGGTAAAATGTGGCCTGGTACTACTGTCTATCCAGACTTCT
TCAGGGAGGATACTAGAGAATGGTGGGCTGGGTTAATCTCCGAATGGCTTTCACAAGGAGTTGATGGTATTTGGCTAGAC
ATGAATGAACCAACTGACTTCTCTAGGGCTATTGAGATCAGAGACGTTTTATCTTCGTTACCCGTACAGTTCAGAGATGA
TAGACTTGTTACCACTTTTCCAGATAACGTAGTTCACTACTTGAGGGGAAAGAGGGTTAAACACGAAAAAGTTAGAAATG
CTTATCCTTTATATGAGGCTATGGCAACGTTTAAGGGGTTTAGGACAAGCCATAGGAATGAAATATTTATCTTGAGTAGA
GCCGGTTATGCCGGAATACAAAGATACGCATTCATCTGGACTGGTGATAATACCCCTTCATGGGATGATTTGAAGCTTCA
ACTACAATTGGTTCTCGGCTTATCGATTTCTGGTGTACCATTTGTAGGTTGTGATATAGGTGGATTTCAAGGCAGGAACT
TCGCGGAAATTGACAACTCTATGGATTTATTAGTCAAATATTATGCTTTAGCCTTGTTCTTCCCCTTCTATAGGTCACAC
AAGGCAACTGATGGTATAGATACGGAACCAGTTTTCCTGCCAGATTACTATAAGGAGAAAGTAAAGGAAATCGTGGAGTT
GAGGTATAAGTTCTTACCCTATATTTATTCCTTAGCTTTAGAGGCTAGTGAGAAGGGACATCCGGTAATTAGACCTCTAT
TTTACGAATTCCAGGATGATGACGACATGTATAGAATAGAAGACGAGTATATGGTTGGTAAGTATTTGCTTTACGCTCCA
ATTGTAAGTAAAGAGGAGAGTAGGTTAGTAACATTACCTAGAGGTAAGTGGTACAATTACTGGAATGGCGAGATAATAAA
CGGTAAGAGTGTTGTTAAGTCTACTCATGAGTTGCCAATTTACTTGAGAGAAGGATCAATAATCCCGTTGGAGGGTGACG
AGTTAATAGTTTACGGTGAGACCTCGTTCAAGCGTTACGATAATGCTGAAATTACCTCCTCAAGTAATGAAATTAAGTTT
TCAAGGGAGATTTATGTATCTAAGCTAACTATCACATCAGAGAAACCAGTGAGCAAGATAATAGTTGACGATAGTAAGGA
AATTCAAGTAGAGAAGACAATGCAAAACACTTACGTTGCTAAGATTAATCAAAAAATTAGGGGAAAGATTAACCTAGAGT
AG

Upstream 100 bases:

>100_bases
TTATTGTCATAATCCGAAAAAAGGATAACAATCTAGTTGTTAGATAAACTAGATAAAGAAAGCTTTATATTTTGAAGAGA
ATTGTATACGGTGATAAGGG

Downstream 100 bases:

>100_bases
TTTTTTCACGTACTCCAAGGACTTAACTATTCCCGGAAGAGGGTTTTCTGGTTCTGGCTCATATTCTATCATTAGCGGTA
TGTCTAGATTCAACTCCTTT

Product: Alpha-glucosidase (malA)

Products: NA

Alternate protein names: Maltase

Number of amino acids: Translated: 693; Mature: 693

Protein sequence:

>693_residues
MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDLKEHIIGLGEKAFELDRKRKR
YVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVATGYFFNSASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLE
KYTELTGKPFLPPMWAFGYMISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELH
KRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTREWWAGLISEWLSQGVDGIWLD
MNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHYLRGKRVKHEKVRNAYPLYEAMATFKGFRTSHRNEIFILSR
AGYAGIQRYAFIWTGDNTPSWDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSH
KATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDDDDMYRIEDEYMVGKYLLYAP
IVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPIYLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKF
SREIYVSKLTITSEKPVSKIIVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE

Sequences:

>Translated_693_residues
MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDLKEHIIGLGEKAFELDRKRKR
YVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVATGYFFNSASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLE
KYTELTGKPFLPPMWAFGYMISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELH
KRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTREWWAGLISEWLSQGVDGIWLD
MNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHYLRGKRVKHEKVRNAYPLYEAMATFKGFRTSHRNEIFILSR
AGYAGIQRYAFIWTGDNTPSWDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSH
KATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDDDDMYRIEDEYMVGKYLLYAP
IVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPIYLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKF
SREIYVSKLTITSEKPVSKIIVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE
>Mature_693_residues
MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDLKEHIIGLGEKAFELDRKRKR
YVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVATGYFFNSASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLE
KYTELTGKPFLPPMWAFGYMISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELH
KRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTREWWAGLISEWLSQGVDGIWLD
MNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHYLRGKRVKHEKVRNAYPLYEAMATFKGFRTSHRNEIFILSR
AGYAGIQRYAFIWTGDNTPSWDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSH
KATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDDDDMYRIEDEYMVGKYLLYAP
IVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPIYLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKF
SREIYVSKLTITSEKPVSKIIVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE

Specific function: Major soluble alpha-glucosidase

COG id: COG1501

COG function: function code G; Alpha-glucosidases, family 31 of glycosyl hydrolases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 31 family

Homologues:

Organism=Homo sapiens, GI66346737, Length=593, Percent_Identity=30.5227655986509, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI88900491, Length=597, Percent_Identity=30.4857621440536, Blast_Score=277, Evalue=3e-74,
Organism=Homo sapiens, GI38202257, Length=597, Percent_Identity=30.4857621440536, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI119393895, Length=597, Percent_Identity=27.6381909547739, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI119393893, Length=597, Percent_Identity=27.6381909547739, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI119393891, Length=597, Percent_Identity=27.6381909547739, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI221316699, Length=578, Percent_Identity=29.757785467128, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI157364974, Length=586, Percent_Identity=26.6211604095563, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI310115361, Length=502, Percent_Identity=26.2948207171315, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI2367256, Length=581, Percent_Identity=25.1290877796902, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI2367323, Length=604, Percent_Identity=20.8609271523179, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17560800, Length=567, Percent_Identity=32.9805996472663, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17560798, Length=567, Percent_Identity=32.9805996472663, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71991189, Length=613, Percent_Identity=29.6900489396411, Blast_Score=259, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71985706, Length=648, Percent_Identity=26.0802469135802, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32563849, Length=531, Percent_Identity=27.683615819209, Blast_Score=201, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319706, Length=572, Percent_Identity=28.3216783216783, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24643749, Length=565, Percent_Identity=28.4955752212389, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24643753, Length=565, Percent_Identity=28.4955752212389, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24643751, Length=565, Percent_Identity=28.4955752212389, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24643746, Length=565, Percent_Identity=28.4955752212389, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI21357605, Length=565, Percent_Identity=28.4955752212389, Blast_Score=230, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AGLU_SULS9 (D0KQM8)

Other databases:

- EMBL:   AF042494
- EMBL:   CP001800
- GenomeReviews:   CP001800_GR
- NMPDR:   fig|273057.1.peg.2784
- OMA:   WEHLEMS
- PhylomeDB:   O59645
- BRENDA:   3.2.1.20
- GO:   GO:0005737
- InterPro:   IPR013785
- InterPro:   IPR011013
- InterPro:   IPR000322
- InterPro:   IPR017853
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR22762

Pfam domain/function: PF01055 Glyco_hydro_31; SSF74650 Gal_mut_like; SSF51445 Glyco_hydro_cat

EC number: =3.2.1.20

Molecular weight: Translated: 80442; Mature: 80442

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00129 GLYCOSYL_HYDROL_F31_1; PS00707 GLYCOSYL_HYDROL_F31_2

Important sites: ACT_SITE 320-320 ACT_SITE 323-323 ACT_SITE 416-416

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDL
CCEEEEEECCCEEEEEECCCCCCCCCCHHHHHCCCCCHHHHCHHHEECCCEEEEEECCCH
KEHIIGLGEKAFELDRKRKRYVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVATGYFFNS
HHHHHCCCHHHHHHHHCCCEEEEEECCCCCCHHCCCCEEEEEEEEEEEECCCEEEEEECC
ASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLEKYTELTGKPFLPPMWAFGYM
CCEEEEECCHHHCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHH
ISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELH
HHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEEECCCCCCCHHHHHHHHH
KRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTRE
HCCEEEEEEEECCEEECCCCCHHHHCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHH
WWAGLISEWLSQGVDGIWLDMNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHY
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEECCCEEEEECCHHHHHH
LRGKRVKHEKVRNAYPLYEAMATFKGFRTSHRNEIFILSRAGYAGIQRYAFIWTGDNTPS
HCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCC
WDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSH
CCCCEEEEEEEEECCCCCCCEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
KATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDD
CCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCC
DDMYRIEDEYMVGKYLLYAPIVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPI
CCEEEEECCHHHCEEEEEECCCCCCCCCEEEECCCCEECCCCCEEECCHHHHCCCCCCEE
YLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKFSREIYVSKLTITSEKPVSKI
EEECCCEEEECCCEEEEECCCCCCCCCCCEEECCCCCEEEEEEEEEEEEEEECCCCCEEE
IVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE
EECCCCCEEEEHHHHHHHHEEECHHHCCEEECC
>Mature Secondary Structure
MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDL
CCEEEEEECCCEEEEEECCCCCCCCCCHHHHHCCCCCHHHHCHHHEECCCEEEEEECCCH
KEHIIGLGEKAFELDRKRKRYVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVATGYFFNS
HHHHHCCCHHHHHHHHCCCEEEEEECCCCCCHHCCCCEEEEEEEEEEEECCCEEEEEECC
ASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLEKYTELTGKPFLPPMWAFGYM
CCEEEEECCHHHCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHH
ISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELH
HHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEEECCCCCCCHHHHHHHHH
KRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTRE
HCCEEEEEEEECCEEECCCCCHHHHCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHH
WWAGLISEWLSQGVDGIWLDMNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHY
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEECCCEEEEECCHHHHHH
LRGKRVKHEKVRNAYPLYEAMATFKGFRTSHRNEIFILSRAGYAGIQRYAFIWTGDNTPS
HCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCC
WDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSH
CCCCEEEEEEEEECCCCCCCEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
KATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDD
CCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCC
DDMYRIEDEYMVGKYLLYAPIVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPI
CCEEEEECCHHHCEEEEEECCCCCCCCCEEEECCCCEECCCCCEEECCHHHHCCCCCCEE
YLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKFSREIYVSKLTITSEKPVSKI
EEECCCEEEECCCEEEEECCCCCCCCCCCEEECCCCCEEEEEEEEEEEEEEECCCCCEEE
IVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE
EECCCCCEEEEHHHHHHHHEEECHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9495770