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The map label for this gene is cysG [H]

Identifier: 15899622

GI number: 15899622

Start: 2659249

End: 2659944

Strand: Reverse

Name: cysG [H]

Synonym: SSO2908

Alternate gene names: 15899622

Gene position: 2659944-2659249 (Counterclockwise)

Preceding gene: 15899623

Following gene: 15899619

Centisome position: 88.89

GC content: 38.36

Gene sequence:

>696_bases
ATGGGTAAGGTAGTTTTAGTAGGTGCTGGTCCTGGTGATCCTGAACTAATAACGTTAAAGGGTATTAAATATTTACAAAT
GGCTGATGTAATAGTCTACGATAAGTTAGTGTCCAGAGAACTCATTAATTACGCTAAGCCGTCGAGTTTTGTAATATTCC
TCAGTAATGATGATATTGAAGTTGATTTATTGAGAAAGTACGCTTTGGAAGATAAGCTTGTGATTAGGCTAAAAAACGGA
GATCCCTACATATTTGGAAGGGGAGGGAAAATTTGTCAAGAGTTAATTAAAGACGGTATAGAGTGTGAGGTAATACCCGG
AGTTTCGTCAGTTAACTCAGTCCCTGCGTATGCTGGGATACCACTCACTTTCAACGGAGTCTCCGATATGGTAACAATCG
TAAGTGCAGTTTCACAAGGTGGGAAGCTCTTTAACTTTCAAAAAATTCCAGATTATGGTACTCTAGTAGTTTTAATGGGA
GGCAGGAGATTAGAGGAGGTGAGTAAATGGTTGATGGCTAAGAGAGATCCTTCAGAAGACGTAGCAGTTATAGAAAGAGG
GACTTATCTGGATCAGAAGGTACACGTCAACAAATTGGAGAAACTAGCTGAAGTTGGTAATAATTTAGCTACTCCTTCTT
TGTTGGTTTTAGGAAACGTTGTGAGATTGAGAGAAATTCTATGGAAATTTAGATAA

Upstream 100 bases:

>100_bases
ACTAAAGACCTCATGAAACCTCACAAGTTTGATAGAAAGATTGAGGGCTATAGGGAGTATCACGATCTGCTAAGAAAACG
TTTAGAGGAGGTGAGTAGAT

Downstream 100 bases:

>100_bases
TGCATTTATTTGGAATACAATGAGAACATTTGGATTTAATTGGGGAAAATATATGAATATTACACATAGGGTACTTATTT
TAACTACATGTACCTTGTAA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MGKVVLVGAGPGDPELITLKGIKYLQMADVIVYDKLVSRELINYAKPSSFVIFLSNDDIEVDLLRKYALEDKLVIRLKNG
DPYIFGRGGKICQELIKDGIECEVIPGVSSVNSVPAYAGIPLTFNGVSDMVTIVSAVSQGGKLFNFQKIPDYGTLVVLMG
GRRLEEVSKWLMAKRDPSEDVAVIERGTYLDQKVHVNKLEKLAEVGNNLATPSLLVLGNVVRLREILWKFR

Sequences:

>Translated_231_residues
MGKVVLVGAGPGDPELITLKGIKYLQMADVIVYDKLVSRELINYAKPSSFVIFLSNDDIEVDLLRKYALEDKLVIRLKNG
DPYIFGRGGKICQELIKDGIECEVIPGVSSVNSVPAYAGIPLTFNGVSDMVTIVSAVSQGGKLFNFQKIPDYGTLVVLMG
GRRLEEVSKWLMAKRDPSEDVAVIERGTYLDQKVHVNKLEKLAEVGNNLATPSLLVLGNVVRLREILWKFR
>Mature_230_residues
GKVVLVGAGPGDPELITLKGIKYLQMADVIVYDKLVSRELINYAKPSSFVIFLSNDDIEVDLLRKYALEDKLVIRLKNGD
PYIFGRGGKICQELIKDGIECEVIPGVSSVNSVPAYAGIPLTFNGVSDMVTIVSAVSQGGKLFNFQKIPDYGTLVVLMGG
RRLEEVSKWLMAKRDPSEDVAVIERGTYLDQKVHVNKLEKLAEVGNNLATPSLLVLGNVVRLREILWKFR

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=240, Percent_Identity=37.5, Blast_Score=151, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322922, Length=232, Percent_Identity=32.3275862068966, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 25509; Mature: 25378

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVVLVGAGPGDPELITLKGIKYLQMADVIVYDKLVSRELINYAKPSSFVIFLSNDDIE
CCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
VDLLRKYALEDKLVIRLKNGDPYIFGRGGKICQELIKDGIECEVIPGVSSVNSVPAYAGI
HHHHHHHCCCCEEEEEEECCCCEEEECCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
PLTFNGVSDMVTIVSAVSQGGKLFNFQKIPDYGTLVVLMGGRRLEEVSKWLMAKRDPSED
CEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCCCCC
VAVIERGTYLDQKVHVNKLEKLAEVGNNLATPSLLVLGNVVRLREILWKFR
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKVVLVGAGPGDPELITLKGIKYLQMADVIVYDKLVSRELINYAKPSSFVIFLSNDDIE
CCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
VDLLRKYALEDKLVIRLKNGDPYIFGRGGKICQELIKDGIECEVIPGVSSVNSVPAYAGI
HHHHHHHCCCCEEEEEEECCCCEEEECCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
PLTFNGVSDMVTIVSAVSQGGKLFNFQKIPDYGTLVVLMGGRRLEEVSKWLMAKRDPSED
CEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCCCCC
VAVIERGTYLDQKVHVNKLEKLAEVGNNLATPSLLVLGNVVRLREILWKFR
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA