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The map label for this gene is acd-6 [H]

Identifier: 15899587

GI number: 15899587

Start: 2629414

End: 2630616

Strand: Reverse

Name: acd-6 [H]

Synonym: SSO2877

Alternate gene names: 15899587

Gene position: 2630616-2629414 (Counterclockwise)

Preceding gene: 15899588

Following gene: 15899586

Centisome position: 87.91

GC content: 41.4

Gene sequence:

>1203_bases
ATGGTCTTACCTTTCAGTAGTGTGGAAGCATTTTCTATAAACATTTCCGAGAAACATGAACTATTTAGGAGAGCTGTAAG
GGAATTCATGGAGAGAGACGTTGCGCCTTATGTGGAAAAGGGTGAAAAAGAAGGTACAGTACCAAAGGAAGTATTGGAAA
AAGCTAAGGAAATTGGTCTATATGGTGTTGCAGTACCAGAACAATACGGTGGTCAAGGTGGAGATACGCTAATGACTGCC
ATAGCTCAAGAAGAGATATCTAGAGTCTGGGCCTCACTTTCTACGAGAATATCTGTTGGAGGGTTATTCATGACTCCAAT
ATTGCTTTTCGGTAATGAAGAACAGAAGAAAAAGTACGTTACTCCAGTAGCTAGGGGAGATAAAGTTGCAGCTTTTGCTA
ATACTGAACCAGTAGCGGGATCAGACGTTGCTGGAATACAGACGGTGGCTAAAAAGATAAATGGTAAATACGTTATTAAT
GGTAGGAAAATCTTTATCACTAATGGTGGGATAGCTGACTATTACGTGGTTACAGCTAGGACATCACCCCCAGAGCCCAA
TGCTAGATGGAAGGGGATATCGATGTTCATAGTAGAAAGGGAATGGAAGGGAGTTAAGGTATTGAATAGAATTGAGACTA
TGGGATTAAGGGCTTCAAATACTGCAGAGTTAGCCTTTGAAGACGTAGAGGTCCCTGCAGAAAACCTTTTGGGAGAAGAA
GGGAATGGATTCAAGTACGCAATGGCCACTTTCGATAGGACAAGGGTTGGTGTTGCAGCCCAAGGAGTTGGTGTTGCCCA
GGCTGCGTTAGAGAGAATGGTCACATATTCAACTCAGAGGTTTGCTTTCCAGAGTCCATTAATAGGATTTCAAATGGTTC
AAGAGAAGATAGCCGAATCACTTACTGAAGTAAATACTGCAAGATTACTCACGTACTGGGCAGCTAATTTATTTGACCGT
GGTCTTGAGAATGAAGCTATAGTAGCTGCCTCAATGGCTAAATTGTACGCAACAGATATTGCAGAGAAGGTTGCGATTAG
GGCAATAACTGTTCATGGTGGATACGGTGTAGCTACTTCTACTGGTGTAGAGAGATTGTTAAGAGATGTTGAGGTAATGA
GAATATACGAAGGTGCTAATGATATTCAAAAACTTGTTATATTAAGGGAAACTGCGAGAAGACTTCTCGGAATTAAGATG
TAA

Upstream 100 bases:

>100_bases
AATATATTACTTTTCGGTACCAATATGTGCTAAATTAAAGGCTGAAATTGCATCTAATGATAGAAAGAGTTATAATTAGT
CTATTGGTTCAGTAAATTAT

Downstream 100 bases:

>100_bases
AATTTTTTATAGTTGTTTTTCAAAGTATTATAACATGAATAGCGAATATTACGAATACCAATTAACAATAGATAAGATAT
TAGATTCTGGTTCTAGAAGT

Product: Acyl-CoA dehydrogenase (acd-6)

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MVLPFSSVEAFSINISEKHELFRRAVREFMERDVAPYVEKGEKEGTVPKEVLEKAKEIGLYGVAVPEQYGGQGGDTLMTA
IAQEEISRVWASLSTRISVGGLFMTPILLFGNEEQKKKYVTPVARGDKVAAFANTEPVAGSDVAGIQTVAKKINGKYVIN
GRKIFITNGGIADYYVVTARTSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRASNTAELAFEDVEVPAENLLGEE
GNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTYSTQRFAFQSPLIGFQMVQEKIAESLTEVNTARLLTYWAANLFDR
GLENEAIVAASMAKLYATDIAEKVAIRAITVHGGYGVATSTGVERLLRDVEVMRIYEGANDIQKLVILRETARRLLGIKM

Sequences:

>Translated_400_residues
MVLPFSSVEAFSINISEKHELFRRAVREFMERDVAPYVEKGEKEGTVPKEVLEKAKEIGLYGVAVPEQYGGQGGDTLMTA
IAQEEISRVWASLSTRISVGGLFMTPILLFGNEEQKKKYVTPVARGDKVAAFANTEPVAGSDVAGIQTVAKKINGKYVIN
GRKIFITNGGIADYYVVTARTSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRASNTAELAFEDVEVPAENLLGEE
GNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTYSTQRFAFQSPLIGFQMVQEKIAESLTEVNTARLLTYWAANLFDR
GLENEAIVAASMAKLYATDIAEKVAIRAITVHGGYGVATSTGVERLLRDVEVMRIYEGANDIQKLVILRETARRLLGIKM
>Mature_400_residues
MVLPFSSVEAFSINISEKHELFRRAVREFMERDVAPYVEKGEKEGTVPKEVLEKAKEIGLYGVAVPEQYGGQGGDTLMTA
IAQEEISRVWASLSTRISVGGLFMTPILLFGNEEQKKKYVTPVARGDKVAAFANTEPVAGSDVAGIQTVAKKINGKYVIN
GRKIFITNGGIADYYVVTARTSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRASNTAELAFEDVEVPAENLLGEE
GNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTYSTQRFAFQSPLIGFQMVQEKIAESLTEVNTARLLTYWAANLFDR
GLENEAIVAASMAKLYATDIAEKVAIRAITVHGGYGVATSTGVERLLRDVEVMRIYEGANDIQKLVILRETARRLLGIKM

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=40.8488063660477, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=38.4210526315789, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=38.4210526315789, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=36.968085106383, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI4501859, Length=382, Percent_Identity=35.0785340314136, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI21361497, Length=392, Percent_Identity=34.4387755102041, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=32.8042328042328, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI4557235, Length=341, Percent_Identity=37.2434017595308, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI76496475, Length=341, Percent_Identity=37.2434017595308, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=33.1578947368421, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI226958414, Length=344, Percent_Identity=34.8837209302326, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI4503943, Length=373, Percent_Identity=28.686327077748, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=28.2548476454294, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI38505218, Length=397, Percent_Identity=29.7229219143577, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI48976061, Length=391, Percent_Identity=27.3657289002558, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI211971008, Length=391, Percent_Identity=27.3657289002558, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=30.9711286089239, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI87081958, Length=386, Percent_Identity=31.0880829015544, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI87082384, Length=265, Percent_Identity=24.9056603773585, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=37.8238341968912, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17570075, Length=374, Percent_Identity=37.9679144385027, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=38.2585751978892, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=35.9249329758713, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI71985184, Length=359, Percent_Identity=37.6044568245125, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=33.9622641509434, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=373, Percent_Identity=32.9758713136729, Blast_Score=207, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=32.5136612021858, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71990804, Length=289, Percent_Identity=38.0622837370242, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17505929, Length=383, Percent_Identity=31.5926892950392, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=383, Percent_Identity=30.8093994778068, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=305, Percent_Identity=31.4754098360656, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=302, Percent_Identity=35.7615894039735, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=235, Percent_Identity=37.4468085106383, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17534353, Length=387, Percent_Identity=29.7157622739018, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17562446, Length=398, Percent_Identity=28.894472361809, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=32.6359832635983, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531913, Length=173, Percent_Identity=31.2138728323699, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17540912, Length=352, Percent_Identity=23.2954545454545, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=307, Percent_Identity=26.3843648208469, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI86563383, Length=307, Percent_Identity=26.3843648208469, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=40.3743315508021, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=40.2116402116402, Blast_Score=267, Evalue=8e-72,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=37.5328083989501, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=34.0425531914894, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI281363737, Length=343, Percent_Identity=37.3177842565598, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=32.5520833333333, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI19920834, Length=380, Percent_Identity=29.4736842105263, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24652780, Length=340, Percent_Identity=22.6470588235294, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 43963; Mature: 43963

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLPFSSVEAFSINISEKHELFRRAVREFMERDVAPYVEKGEKEGTVPKEVLEKAKEIGL
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHCCE
YGVAVPEQYGGQGGDTLMTAIAQEEISRVWASLSTRISVGGLFMTPILLFGNEEQKKKYV
EEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHEECCCHHHHHHC
TPVARGDKVAAFANTEPVAGSDVAGIQTVAKKINGKYVINGRKIFITNGGIADYYVVTAR
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEECCCCEEEEEEEEE
TSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRASNTAELAFEDVEVPAENLLGEE
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHEEHHCCCCHHHHCCCC
GNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTYSTQRFAFQSPLIGFQMVQEKIAES
CCCEEEEEEECCHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LTEVNTARLLTYWAANLFDRGLENEAIVAASMAKLYATDIAEKVAIRAITVHGGYGVATS
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHH
TGVERLLRDVEVMRIYEGANDIQKLVILRETARRLLGIKM
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLPFSSVEAFSINISEKHELFRRAVREFMERDVAPYVEKGEKEGTVPKEVLEKAKEIGL
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHCCE
YGVAVPEQYGGQGGDTLMTAIAQEEISRVWASLSTRISVGGLFMTPILLFGNEEQKKKYV
EEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHEECCCHHHHHHC
TPVARGDKVAAFANTEPVAGSDVAGIQTVAKKINGKYVINGRKIFITNGGIADYYVVTAR
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEECCCCEEEEEEEEE
TSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRASNTAELAFEDVEVPAENLLGEE
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHEEHHCCCCHHHHCCCC
GNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTYSTQRFAFQSPLIGFQMVQEKIAES
CCCEEEEEEECCHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LTEVNTARLLTYWAANLFDRGLENEAIVAASMAKLYATDIAEKVAIRAITVHGGYGVATS
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHH
TGVERLLRDVEVMRIYEGANDIQKLVILRETARRLLGIKM
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]