Click here to switch to the map view.

The map label for this gene is merA [H]

Identifier: 15899410

GI number: 15899410

Start: 2445401

End: 2446762

Strand: Direct

Name: merA [H]

Synonym: SSO2689

Alternate gene names: 15899410

Gene position: 2445401-2446762 (Clockwise)

Preceding gene: 15899408

Following gene: 15899411

Centisome position: 81.72

GC content: 37.52

Gene sequence:

>1362_bases
GTGGAAGATCTGGTGATCATAGGATACGGCGCAGCTGGATTTGCGGCGTTAATTAGGGCAAATGAACTCGGAATAAAGCC
AGTGGTTGTAGGTTATGGAGAAATAGGCGGAACTTGCGTTAATGTAGGATGTGTTCCATCGAAGAGAATGTTGAGAATAG
GTGAATTGTACAATTACTCTTCAAAAGTAATAGGAAAAAAGTTGTTTCCAGAATTTTTCCAAGCCTTTCAAGACAAGGCT
GAAATCGTAAATTCCCTGCGAAAGGAAAAATACGAGGATGTGATAAATTCATATGATATCAAATTAAAAATTGGTAAAGC
ATATTTTACTTCACCTAATGCAGTTAAAGTAAATGGTGAGATAATAGAGGCTAAAAAGTTTATAATAGCCACAGGCTCTT
CTCCCAATATACCTAACATAAAGGGTTTAACTGAAGTTGGATTTTGGACTAATGTGGAAGCCTTATCACCAGACAAGACA
ATATCATCCTTGGCTATTATAGGCGGAAGGGCATTGGCGTTAGAGTTCGCACAAATGTATAAGAGACTAGGAGTTGATAC
TACAATTCTTCAAAGGAGCGGAAGAATATTACCGGATTGGGAGCCTGAAATTTCCCTTTCCGTTAAAAACTATTTAGAGG
AGAATGATAGTATTCCAATTTTTACAAATGTGAGAGTTAAGGAGGTTAGAAAAGGAAACGGGGGAAAGATAATAGTTACT
GATAAGGGTGAAGTTGAGGCTGATGAAATTCTGTTAGCTACCGGAAGAAAGCCCAATGTAGATTTAAATTTAGATGCAGC
AGGAATCGAATTAAACGATAAGGGAGGCATAAAAGTTAATGAAGAACTAAGAACCTCAAATCCTAATGTATTTGCCGCAG
GAGATGTAATTGGCGGTCCTATGTTGGAAGCTCTAGCTGGCAGACAAGGTTCAATTGCGGCAGAGAACGCAATAATGAAT
GTGCATAGAAAGATTGATATGTTAAGTGTACCTCAAGTTGTGTTTATAGAGCCGAATGTAGCTAAAGTTGGTCTCACTGC
ACTTGAAGCAGTAAAAGAAGGCTATGATATAGACCAAAGGGTAGTAAAAATGGATAATATAGCTAAAGCGAGGATATTAA
GGGAAAATTACGGATTAATAAAAATGGTTATAGATAAGAAGTTTAGGAACATTTTAGGTGTCCAGATGTTTGGTAAATAC
GCAGCTGAAGTGATAAATGAGGCAGCATTAGCACTTAGATTTAGGGCTACAATAGATGACTTGATCGATACAATACATGT
CTTTCCCACAATGGGAGAAAGTTTAAGAATAGCAGCGTTAGCTTTTACCGGTGACGTTAGTAAAATGAGTTGTTGTGTAT
AG

Upstream 100 bases:

>100_bases
AATGGTAAAGAACATTACTTCTGTTGCTCTCATTGTGCCGATAAATATGAGGCAAGATTTAAGGAAGGAGTATCATCGTG
TTGCTAGAGAGGGATAGATA

Downstream 100 bases:

>100_bases
CTCGATTTCATTTCTTTTTATATAATTAGTTGTTCTATTGGTTAAGCGATAAAGAAAAATTCTCTGTATAGTAACGCGCT
TATTTCTATGAAAGTTATGA

Product: mercuric reductase (Hg(II) reductase) (merA)

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MEDLVIIGYGAAGFAALIRANELGIKPVVVGYGEIGGTCVNVGCVPSKRMLRIGELYNYSSKVIGKKLFPEFFQAFQDKA
EIVNSLRKEKYEDVINSYDIKLKIGKAYFTSPNAVKVNGEIIEAKKFIIATGSSPNIPNIKGLTEVGFWTNVEALSPDKT
ISSLAIIGGRALALEFAQMYKRLGVDTTILQRSGRILPDWEPEISLSVKNYLEENDSIPIFTNVRVKEVRKGNGGKIIVT
DKGEVEADEILLATGRKPNVDLNLDAAGIELNDKGGIKVNEELRTSNPNVFAAGDVIGGPMLEALAGRQGSIAAENAIMN
VHRKIDMLSVPQVVFIEPNVAKVGLTALEAVKEGYDIDQRVVKMDNIAKARILRENYGLIKMVIDKKFRNILGVQMFGKY
AAEVINEAALALRFRATIDDLIDTIHVFPTMGESLRIAALAFTGDVSKMSCCV

Sequences:

>Translated_453_residues
MEDLVIIGYGAAGFAALIRANELGIKPVVVGYGEIGGTCVNVGCVPSKRMLRIGELYNYSSKVIGKKLFPEFFQAFQDKA
EIVNSLRKEKYEDVINSYDIKLKIGKAYFTSPNAVKVNGEIIEAKKFIIATGSSPNIPNIKGLTEVGFWTNVEALSPDKT
ISSLAIIGGRALALEFAQMYKRLGVDTTILQRSGRILPDWEPEISLSVKNYLEENDSIPIFTNVRVKEVRKGNGGKIIVT
DKGEVEADEILLATGRKPNVDLNLDAAGIELNDKGGIKVNEELRTSNPNVFAAGDVIGGPMLEALAGRQGSIAAENAIMN
VHRKIDMLSVPQVVFIEPNVAKVGLTALEAVKEGYDIDQRVVKMDNIAKARILRENYGLIKMVIDKKFRNILGVQMFGKY
AAEVINEAALALRFRATIDDLIDTIHVFPTMGESLRIAALAFTGDVSKMSCCV
>Mature_453_residues
MEDLVIIGYGAAGFAALIRANELGIKPVVVGYGEIGGTCVNVGCVPSKRMLRIGELYNYSSKVIGKKLFPEFFQAFQDKA
EIVNSLRKEKYEDVINSYDIKLKIGKAYFTSPNAVKVNGEIIEAKKFIIATGSSPNIPNIKGLTEVGFWTNVEALSPDKT
ISSLAIIGGRALALEFAQMYKRLGVDTTILQRSGRILPDWEPEISLSVKNYLEENDSIPIFTNVRVKEVRKGNGGKIIVT
DKGEVEADEILLATGRKPNVDLNLDAAGIELNDKGGIKVNEELRTSNPNVFAAGDVIGGPMLEALAGRQGSIAAENAIMN
VHRKIDMLSVPQVVFIEPNVAKVGLTALEAVKEGYDIDQRVVKMDNIAKARILRENYGLIKMVIDKKFRNILGVQMFGKY
AAEVINEAALALRFRATIDDLIDTIHVFPTMGESLRIAALAFTGDVSKMSCCV

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=470, Percent_Identity=32.7659574468085, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=30.1724137931034, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI291045266, Length=462, Percent_Identity=27.4891774891775, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI22035672, Length=468, Percent_Identity=28.6324786324786, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI148277071, Length=448, Percent_Identity=26.3392857142857, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI148277065, Length=440, Percent_Identity=26.3636363636364, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI33519430, Length=440, Percent_Identity=26.3636363636364, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI33519428, Length=440, Percent_Identity=26.3636363636364, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI33519426, Length=440, Percent_Identity=26.3636363636364, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI291045268, Length=454, Percent_Identity=27.0925110132159, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1786307, Length=473, Percent_Identity=30.0211416490486, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI87081717, Length=440, Percent_Identity=27.2727272727273, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=27.1739130434783, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=29.5612009237875, Blast_Score=138, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=30.6034482758621, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71983419, Length=448, Percent_Identity=30.1339285714286, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=448, Percent_Identity=30.1339285714286, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17557007, Length=496, Percent_Identity=27.2177419354839, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71982272, Length=494, Percent_Identity=25.7085020242915, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=29.3617021276596, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=26.9473684210526, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=25.7510729613734, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=31.0344827586207, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24640549, Length=485, Percent_Identity=29.0721649484536, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24640553, Length=485, Percent_Identity=29.0721649484536, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24640551, Length=498, Percent_Identity=29.1164658634538, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17737741, Length=493, Percent_Identity=28.3975659229209, Blast_Score=132, Evalue=7e-31,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 49416; Mature: 49416

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLVIIGYGAAGFAALIRANELGIKPVVVGYGEIGGTCVNVGCVPSKRMLRIGELYNYS
CCCEEEEEECHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHCCH
SKVIGKKLFPEFFQAFQDKAEIVNSLRKEKYEDVINSYDIKLKIGKAYFTSPNAVKVNGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECCCCEEEECCE
IIEAKKFIIATGSSPNIPNIKGLTEVGFWTNVEALSPDKTISSLAIIGGRALALEFAQMY
EEEEEEEEEEECCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHH
KRLGVDTTILQRSGRILPDWEPEISLSVKNYLEENDSIPIFTNVRVKEVRKGNGGKIIVT
HHHCCCHHHHHHCCCCCCCCCCCEEEEHHHHHCCCCCCEEEECCEEEEECCCCCCEEEEE
DKGEVEADEILLATGRKPNVDLNLDAAGIELNDKGGIKVNEELRTSNPNVFAAGDVIGGP
CCCCCCCCEEEEECCCCCCCEEEEEECCEEECCCCCEEECHHHHCCCCCEEEECCCCCCH
MLEALAGRQGSIAAENAIMNVHRKIDMLSVPQVVFIEPNVAKVGLTALEAVKEGYDIDQR
HHHHHCCCCCCCHHHHHHHHHHHHCCEECCCEEEEECCCCHHHHHHHHHHHHCCCCHHHH
VVKMDNIAKARILRENYGLIKMVIDKKFRNILGVQMFGKYAAEVINEAALALRFRATIDD
HHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIDTIHVFPTMGESLRIAALAFTGDVSKMSCCV
HHHHHHHHCCCCCCEEEEEEEEECCCCHHHCCC
>Mature Secondary Structure
MEDLVIIGYGAAGFAALIRANELGIKPVVVGYGEIGGTCVNVGCVPSKRMLRIGELYNYS
CCCEEEEEECHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHCCH
SKVIGKKLFPEFFQAFQDKAEIVNSLRKEKYEDVINSYDIKLKIGKAYFTSPNAVKVNGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECCCCEEEECCE
IIEAKKFIIATGSSPNIPNIKGLTEVGFWTNVEALSPDKTISSLAIIGGRALALEFAQMY
EEEEEEEEEEECCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHH
KRLGVDTTILQRSGRILPDWEPEISLSVKNYLEENDSIPIFTNVRVKEVRKGNGGKIIVT
HHHCCCHHHHHHCCCCCCCCCCCEEEEHHHHHCCCCCCEEEECCEEEEECCCCCCEEEEE
DKGEVEADEILLATGRKPNVDLNLDAAGIELNDKGGIKVNEELRTSNPNVFAAGDVIGGP
CCCCCCCCEEEEECCCCCCCEEEEEECCEEECCCCCEEECHHHHCCCCCEEEECCCCCCH
MLEALAGRQGSIAAENAIMNVHRKIDMLSVPQVVFIEPNVAKVGLTALEAVKEGYDIDQR
HHHHHCCCCCCCHHHHHHHHHHHHCCEECCCEEEEECCCCHHHHHHHHHHHHCCCCHHHH
VVKMDNIAKARILRENYGLIKMVIDKKFRNILGVQMFGKYAAEVINEAALALRFRATIDD
HHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIDTIHVFPTMGESLRIAALAFTGDVSKMSCCV
HHHHHHHHCCCCCCEEEEEEEEECCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]