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The map label for this gene is alkK-2 [H]

Identifier: 15899248

GI number: 15899248

Start: 2278488

End: 2280146

Strand: Direct

Name: alkK-2 [H]

Synonym: SSO2510

Alternate gene names: 15899248

Gene position: 2278488-2280146 (Clockwise)

Preceding gene: 15899247

Following gene: 15899249

Centisome position: 76.15

GC content: 37.97

Gene sequence:

>1659_bases
GTGGAGATAATAAAAGGTTTTCCTTCAACTATGATGGATGACTATCAACTAAACGTCACACAAATATTAGAACATGCAGG
GAAATGGATTGGGGAGCAAGAAATAATCTCTAGGAAAAAGGATGGTACAATCTTTAGATACAATTATGGGGAAGCGTTTA
GAAGAGTTAAGAAACTCGCAAGTTCTCTTAAATCTTTAGGTGTTAAAGTAGGTGATAGAGTAGGAGTACTAGAATGGAAC
ACGCATAGGTTTTACGAATTATACTTCGCAATCCCTGCTACTGGTGCTGTAATGTTAGAGTTGAATCCTAGACTTCACCC
ACTTCAATTGGCAAAGATAATTAACCACTCTAAAGTATCATTTCTTTTCTTAAATGAGGACTTCATTCCTCTAGTTGAGA
GTATATCAAACAATATACCATTAGTTAAGAAATTCATATTGATTTCCGATATCGAGAAAACACCCCAAACTAATTATTAT
AATTATGAGAGTCTAGTGGAGGAGGGCAATGAGGAATATGAGATACCAATGTTTGATGAGAGGACATCGTGCTACGCAGC
ATATACTACTGGTACAACTGGAGACCCTAAAGGCATATACTATTCACACAGGTCAATTGTATTAAATACATTGGTAATTT
CACGTAATATTACAATAGATGATACTTTTATGCAGTTAGTACCCATGTTCCACGTAAATGGTTGGTTAGGATTTATGGCT
GCTACGTTAGTGGGGGCGAAGTTAGTGTTACCGGGTAGATATACTGTTGATAATCCGAAACCTTTAGTTGACTTAATGAT
TAATGAGAAGGTTACCGTTACGGCTGGTGTTCCAGAGGTGTTTAGCTCTATCTTAAACTATTTAAGGAGTATGGAAAACA
AACCACTATTTGTGAATTCTAGAATACTTATAGGAGGAAGTGAGCCTCCTCTGAGTCTGGTAATAGGTCTAATGGAGTTT
GGATTTCAAGTTGGACAAGGATATGGCGCTACAGAAACCACTCCATCAGTTGCGGGTAGTGTTGTTAAACCCAGGATAAG
AGAAAAATATTCTGACAAGGACATGTTGGATTTGCTGAGAAAACAAGGTATACCAACTTTTGGAGTTGACATAAGGGTTA
TTGATCCCTCAACCGGTAAAGACGTACCCCATGATGGTAAAACTATAGGAGAGTTATGGATCAGAGGACCATGGATTGCT
TCCGCATACTATAATGATCCCAGAACTGTGGAATCTTTTGTTGGTGATGGTGTAGATAGGTGGTGGAGAAGTGGTGATCT
AGCTGTAGTAGATGAACTAGGTTATATTAAAATAGTAGATAGAATAAAGGATGTTATAAAAAGCGGAGGAGAATGGATAA
GTACAGTAGATTTAGAGAATCATTTAATGGCCCATCCCGCTGTGGCAGAGGCTACAGTTATAGGCGTTCCTCATCCCAAG
TGGGGGGAGAGACCATTAGCTTTTGTTGTGTTAAGGCAAGGATTTGAAAATAAGGTTAGCAAGGAGGAACTATTGGGGCA
TTTAGGTCAGAGGTTTGCTAGATGGCAATTACCTGACGATATAATATTCGTTAAGGAGATTCCTAAGACTAGTGTAGGGA
AATTCGATAAGAAGGTTTTAAGGGAAAAATATAGAGATTTCTTTATTAGCAGTAGATAA

Upstream 100 bases:

>100_bases
GCAGAAGTTACGCCACGGGTAAACACTCTCTAAACCTGAGTTTCATTTTTTATCCATAGAGGTAAAAAAGCTTAAATATA
GAAAAGATTACATCTTACAT

Downstream 100 bases:

>100_bases
GAAAATATTTAAAGTAATAAGGAGGTATTAAAAGTATGAGTAAAAATGAGGATGAATTAGAAGAGTACAGAATAAAGGTG
AGGGAGTGGATAAGGAATAA

Product: medium-chain-fatty-acid--CoA ligase (alkK-2)

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MEIIKGFPSTMMDDYQLNVTQILEHAGKWIGEQEIISRKKDGTIFRYNYGEAFRRVKKLASSLKSLGVKVGDRVGVLEWN
THRFYELYFAIPATGAVMLELNPRLHPLQLAKIINHSKVSFLFLNEDFIPLVESISNNIPLVKKFILISDIEKTPQTNYY
NYESLVEEGNEEYEIPMFDERTSCYAAYTTGTTGDPKGIYYSHRSIVLNTLVISRNITIDDTFMQLVPMFHVNGWLGFMA
ATLVGAKLVLPGRYTVDNPKPLVDLMINEKVTVTAGVPEVFSSILNYLRSMENKPLFVNSRILIGGSEPPLSLVIGLMEF
GFQVGQGYGATETTPSVAGSVVKPRIREKYSDKDMLDLLRKQGIPTFGVDIRVIDPSTGKDVPHDGKTIGELWIRGPWIA
SAYYNDPRTVESFVGDGVDRWWRSGDLAVVDELGYIKIVDRIKDVIKSGGEWISTVDLENHLMAHPAVAEATVIGVPHPK
WGERPLAFVVLRQGFENKVSKEELLGHLGQRFARWQLPDDIIFVKEIPKTSVGKFDKKVLREKYRDFFISSR

Sequences:

>Translated_552_residues
MEIIKGFPSTMMDDYQLNVTQILEHAGKWIGEQEIISRKKDGTIFRYNYGEAFRRVKKLASSLKSLGVKVGDRVGVLEWN
THRFYELYFAIPATGAVMLELNPRLHPLQLAKIINHSKVSFLFLNEDFIPLVESISNNIPLVKKFILISDIEKTPQTNYY
NYESLVEEGNEEYEIPMFDERTSCYAAYTTGTTGDPKGIYYSHRSIVLNTLVISRNITIDDTFMQLVPMFHVNGWLGFMA
ATLVGAKLVLPGRYTVDNPKPLVDLMINEKVTVTAGVPEVFSSILNYLRSMENKPLFVNSRILIGGSEPPLSLVIGLMEF
GFQVGQGYGATETTPSVAGSVVKPRIREKYSDKDMLDLLRKQGIPTFGVDIRVIDPSTGKDVPHDGKTIGELWIRGPWIA
SAYYNDPRTVESFVGDGVDRWWRSGDLAVVDELGYIKIVDRIKDVIKSGGEWISTVDLENHLMAHPAVAEATVIGVPHPK
WGERPLAFVVLRQGFENKVSKEELLGHLGQRFARWQLPDDIIFVKEIPKTSVGKFDKKVLREKYRDFFISSR
>Mature_552_residues
MEIIKGFPSTMMDDYQLNVTQILEHAGKWIGEQEIISRKKDGTIFRYNYGEAFRRVKKLASSLKSLGVKVGDRVGVLEWN
THRFYELYFAIPATGAVMLELNPRLHPLQLAKIINHSKVSFLFLNEDFIPLVESISNNIPLVKKFILISDIEKTPQTNYY
NYESLVEEGNEEYEIPMFDERTSCYAAYTTGTTGDPKGIYYSHRSIVLNTLVISRNITIDDTFMQLVPMFHVNGWLGFMA
ATLVGAKLVLPGRYTVDNPKPLVDLMINEKVTVTAGVPEVFSSILNYLRSMENKPLFVNSRILIGGSEPPLSLVIGLMEF
GFQVGQGYGATETTPSVAGSVVKPRIREKYSDKDMLDLLRKQGIPTFGVDIRVIDPSTGKDVPHDGKTIGELWIRGPWIA
SAYYNDPRTVESFVGDGVDRWWRSGDLAVVDELGYIKIVDRIKDVIKSGGEWISTVDLENHLMAHPAVAEATVIGVPHPK
WGERPLAFVVLRQGFENKVSKEELLGHLGQRFARWQLPDDIIFVKEIPKTSVGKFDKKVLREKYRDFFISSR

Specific function: Unknown

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=563, Percent_Identity=26.1101243339254, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI187761345, Length=542, Percent_Identity=27.1217712177122, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI187761343, Length=542, Percent_Identity=27.1217712177122, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI58082049, Length=546, Percent_Identity=25.4578754578755, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI122937307, Length=520, Percent_Identity=25.7692307692308, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI157311624, Length=547, Percent_Identity=25.7769652650823, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI157311622, Length=547, Percent_Identity=25.7769652650823, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI38505220, Length=540, Percent_Identity=24.2592592592593, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI42544132, Length=537, Percent_Identity=22.9050279329609, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI115511026, Length=513, Percent_Identity=23.9766081871345, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI28416953, Length=552, Percent_Identity=25.1811594202899, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI8923896, Length=155, Percent_Identity=34.1935483870968, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI253970489, Length=155, Percent_Identity=34.1935483870968, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI13375727, Length=117, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI145693145, Length=506, Percent_Identity=27.4703557312253, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI221142682, Length=517, Percent_Identity=24.1779497098646, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788107, Length=555, Percent_Identity=24.5045045045045, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1786810, Length=514, Percent_Identity=26.6536964980545, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789201, Length=380, Percent_Identity=27.3684210526316, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788595, Length=500, Percent_Identity=23.8, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790505, Length=181, Percent_Identity=31.4917127071823, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786801, Length=437, Percent_Identity=23.5697940503432, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17558820, Length=517, Percent_Identity=28.6266924564797, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI32563687, Length=514, Percent_Identity=27.6264591439689, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71994703, Length=563, Percent_Identity=25.7548845470693, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71994694, Length=563, Percent_Identity=25.7548845470693, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71994690, Length=563, Percent_Identity=25.9325044404973, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17560308, Length=531, Percent_Identity=26.7419962335217, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17531443, Length=506, Percent_Identity=23.7154150197628, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17559526, Length=515, Percent_Identity=24.2718446601942, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17560140, Length=526, Percent_Identity=22.8136882129278, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71996755, Length=547, Percent_Identity=24.1316270566728, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17557194, Length=526, Percent_Identity=22.4334600760456, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17538037, Length=531, Percent_Identity=21.8455743879473, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71985884, Length=378, Percent_Identity=24.6031746031746, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319699, Length=363, Percent_Identity=28.6501377410468, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319264, Length=403, Percent_Identity=25.5583126550869, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=196, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320852, Length=351, Percent_Identity=25.0712250712251, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24581924, Length=553, Percent_Identity=27.6672694394213, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI18859661, Length=477, Percent_Identity=28.0922431865828, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21355181, Length=537, Percent_Identity=27.1880819366853, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24648260, Length=513, Percent_Identity=23.7816764132554, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI62471681, Length=558, Percent_Identity=23.6559139784946, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI62471687, Length=558, Percent_Identity=23.6559139784946, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24586634, Length=558, Percent_Identity=23.6559139784946, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22026970, Length=558, Percent_Identity=23.6559139784946, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI62471679, Length=559, Percent_Identity=23.613595706619, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI62471683, Length=559, Percent_Identity=23.613595706619, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI62471685, Length=559, Percent_Identity=23.613595706619, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24586636, Length=559, Percent_Identity=23.613595706619, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI62471689, Length=559, Percent_Identity=23.613595706619, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656500, Length=505, Percent_Identity=22.1782178217822, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24653035, Length=516, Percent_Identity=21.7054263565891, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922652, Length=503, Percent_Identity=21.6699801192843, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356947, Length=534, Percent_Identity=22.2846441947566, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI161076582, Length=516, Percent_Identity=22.093023255814, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI62472339, Length=185, Percent_Identity=30.8108108108108, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667955, Length=185, Percent_Identity=30.8108108108108, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24667959, Length=185, Percent_Identity=30.8108108108108, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648255, Length=570, Percent_Identity=22.6315789473684, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21358303, Length=513, Percent_Identity=19.6881091617934, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 62392; Mature: 62392

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIKGFPSTMMDDYQLNVTQILEHAGKWIGEQEIISRKKDGTIFRYNYGEAFRRVKKLA
CCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCEEEECHHHHHHHHHHHH
SSLKSLGVKVGDRVGVLEWNTHRFYELYFAIPATGAVMLELNPRLHPLQLAKIINHSKVS
HHHHHCCCCCCCEEEEEEECCCEEEEEEEEECCCCEEEEEECCCCCHHHHHHHHCCCCEE
FLFLNEDFIPLVESISNNIPLVKKFILISDIEKTPQTNYYNYESLVEEGNEEYEIPMFDE
EEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCC
RTSCYAAYTTGTTGDPKGIYYSHRSIVLNTLVISRNITIDDTFMQLVPMFHVNGWLGFMA
CCCEEEEEECCCCCCCCCEEEECHHEEEEEEEEECCCEECHHHHHHHHHHHCCHHHHHHH
ATLVGAKLVLPGRYTVDNPKPLVDLMINEKVTVTAGVPEVFSSILNYLRSMENKPLFVNS
HHHHCCEEEECCCEECCCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEC
RILIGGSEPPLSLVIGLMEFGFQVGQGYGATETTPSVAGSVVKPRIREKYSDKDMLDLLR
EEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHCCCHHHHHHHH
KQGIPTFGVDIRVIDPSTGKDVPHDGKTIGELWIRGPWIASAYYNDPRTVESFVGDGVDR
HCCCCEECEEEEEECCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHCCCHHH
WWRSGDLAVVDELGYIKIVDRIKDVIKSGGEWISTVDLENHLMAHPAVAEATVIGVPHPK
HHCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCHHCEEEEECCCCC
WGERPLAFVVLRQGFENKVSKEELLGHLGQRFARWQLPDDIIFVKEIPKTSVGKFDKKVL
CCCCCHHHHHHHHCHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
REKYRDFFISSR
HHHHHHHHCCCC
>Mature Secondary Structure
MEIIKGFPSTMMDDYQLNVTQILEHAGKWIGEQEIISRKKDGTIFRYNYGEAFRRVKKLA
CCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCEEEECHHHHHHHHHHHH
SSLKSLGVKVGDRVGVLEWNTHRFYELYFAIPATGAVMLELNPRLHPLQLAKIINHSKVS
HHHHHCCCCCCCEEEEEEECCCEEEEEEEEECCCCEEEEEECCCCCHHHHHHHHCCCCEE
FLFLNEDFIPLVESISNNIPLVKKFILISDIEKTPQTNYYNYESLVEEGNEEYEIPMFDE
EEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCC
RTSCYAAYTTGTTGDPKGIYYSHRSIVLNTLVISRNITIDDTFMQLVPMFHVNGWLGFMA
CCCEEEEEECCCCCCCCCEEEECHHEEEEEEEEECCCEECHHHHHHHHHHHCCHHHHHHH
ATLVGAKLVLPGRYTVDNPKPLVDLMINEKVTVTAGVPEVFSSILNYLRSMENKPLFVNS
HHHHCCEEEECCCEECCCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEC
RILIGGSEPPLSLVIGLMEFGFQVGQGYGATETTPSVAGSVVKPRIREKYSDKDMLDLLR
EEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHCCCHHHHHHHH
KQGIPTFGVDIRVIDPSTGKDVPHDGKTIGELWIRGPWIASAYYNDPRTVESFVGDGVDR
HCCCCEECEEEEEECCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHCCCHHH
WWRSGDLAVVDELGYIKIVDRIKDVIKSGGEWISTVDLENHLMAHPAVAEATVIGVPHPK
HHCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCHHCEEEEECCCCC
WGERPLAFVVLRQGFENKVSKEELLGHLGQRFARWQLPDDIIFVKEIPKTSVGKFDKKVL
CCCCCHHHHHHHHCHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
REKYRDFFISSR
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]