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The map label for this gene is adh-7 [H]

Identifier: 15899189

GI number: 15899189

Start: 2217271

End: 2218257

Strand: Direct

Name: adh-7 [H]

Synonym: SSO2441

Alternate gene names: 15899189

Gene position: 2217271-2218257 (Clockwise)

Preceding gene: 15899188

Following gene: 15899192

Centisome position: 74.1

GC content: 36.37

Gene sequence:

>987_bases
ATGCTAGGTGCTATTCTGAAAAATTTCGGTGAGGAGCTAAGTCTTGAAGACGTAAGAGAACCTTCTAACGGAATTGTTCT
AAAAGTTCTAGCCACTGGACTTTGTCATGGAGACTTACATGTCATAAATGGCGATTGGAGATACGAAATTAAGGTGGAAT
TGCCGAAGATATTAGGGCATGAGATAGTTGGTGAAGTCGTCAAAGGTAATGGTACATTTAAAGAGGGAGATAAGGTATTA
GTTTATAATAGTATTGGTTGCGGAAAATGTAAGTATTGTGCATCAAAAAAGTATCAATACTGCGAAAAAGTGAAAATTAT
TGGGCTTAATATTAACGGTGGTTTCGCGGAATATGTAAGTGTTCCTTCTGATAATATCCTCTTAAGAGTAGATGGTGAGC
CCGTTAAACTGGCACCTCTAGCAGACGCTGGAATCACAGCTTATAGTTCAGCCAAGGGTATAACCAATGAAGATAGTGTA
TTGATTATAGGAACTGGGGCTGTCGCATTATTAGCACTACAAATTTTGAAACTAAAAGGAGCTAGAGTTACTGTTATTGG
GCATAATAAAAATAAGCTTGAAAAAGCTAAAGAACTAGGAGCTGATGAGGTGATTAATATAAAGTATGATAGTACGATAG
CGAGTGAGGTTAAAGAATCCAAGTTTGATTACATTATAGATTATGTGGGCAGCGATTATACACTGTCTGATTCCATGTGG
TTGCTAAATAGGGAAGGGGAGTTAAGAATTATTGGGGAATTTGGTGGTACTATAACTGTACCGGAACAATTACTAGTGTT
AAAGGGGTTAAAAGTAAGGGGTATATTATACGGTAGCTTTGATGATTTGATAAGTGTTTACAAACTATATAATGAGGGAA
AAATTAGACCTATAGTAAATACGTATAAATTAAGGGATATTAACAAGGCGATTAGGGATTTAAGAGATGGTAGAGTGATA
GGTCGTGCAGTAATAGTACCTCCTTAA

Upstream 100 bases:

>100_bases
GATTTCCATCTACATTAATATTAAAAATATAGAGATAGAAGAATACGAATCACAAATAACTGAATGGGAAAGAGACTACT
ATCTAAAGGCAGGATGGTAA

Downstream 100 bases:

>100_bases
GGTTTTTGGTTTGAAAGCTGTTCTGAAAACTTCTTAAGCGTTTCCACATTTTCTTCATGAACTGACTTCCTTCTTATATC
CACGAATATTCCTAGCTTCC

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MLGAILKNFGEELSLEDVREPSNGIVLKVLATGLCHGDLHVINGDWRYEIKVELPKILGHEIVGEVVKGNGTFKEGDKVL
VYNSIGCGKCKYCASKKYQYCEKVKIIGLNINGGFAEYVSVPSDNILLRVDGEPVKLAPLADAGITAYSSAKGITNEDSV
LIIGTGAVALLALQILKLKGARVTVIGHNKNKLEKAKELGADEVINIKYDSTIASEVKESKFDYIIDYVGSDYTLSDSMW
LLNREGELRIIGEFGGTITVPEQLLVLKGLKVRGILYGSFDDLISVYKLYNEGKIRPIVNTYKLRDINKAIRDLRDGRVI
GRAVIVPP

Sequences:

>Translated_328_residues
MLGAILKNFGEELSLEDVREPSNGIVLKVLATGLCHGDLHVINGDWRYEIKVELPKILGHEIVGEVVKGNGTFKEGDKVL
VYNSIGCGKCKYCASKKYQYCEKVKIIGLNINGGFAEYVSVPSDNILLRVDGEPVKLAPLADAGITAYSSAKGITNEDSV
LIIGTGAVALLALQILKLKGARVTVIGHNKNKLEKAKELGADEVINIKYDSTIASEVKESKFDYIIDYVGSDYTLSDSMW
LLNREGELRIIGEFGGTITVPEQLLVLKGLKVRGILYGSFDDLISVYKLYNEGKIRPIVNTYKLRDINKAIRDLRDGRVI
GRAVIVPP
>Mature_328_residues
MLGAILKNFGEELSLEDVREPSNGIVLKVLATGLCHGDLHVINGDWRYEIKVELPKILGHEIVGEVVKGNGTFKEGDKVL
VYNSIGCGKCKYCASKKYQYCEKVKIIGLNINGGFAEYVSVPSDNILLRVDGEPVKLAPLADAGITAYSSAKGITNEDSV
LIIGTGAVALLALQILKLKGARVTVIGHNKNKLEKAKELGADEVINIKYDSTIASEVKESKFDYIIDYVGSDYTLSDSMW
LLNREGELRIIGEFGGTITVPEQLLVLKGLKVRGILYGSFDDLISVYKLYNEGKIRPIVNTYKLRDINKAIRDLRDGRVI
GRAVIVPP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=27.6422764227642, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI34577061, Length=363, Percent_Identity=28.3746556473829, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4501929, Length=372, Percent_Identity=26.8817204301075, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI71565154, Length=372, Percent_Identity=26.8817204301075, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156523966, Length=363, Percent_Identity=25.3443526170799, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=25.207756232687, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI71743840, Length=328, Percent_Identity=25.9146341463415, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI262073058, Length=328, Percent_Identity=25.9146341463415, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI156627571, Length=332, Percent_Identity=24.0963855421687, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1790045, Length=325, Percent_Identity=28, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI226510992, Length=280, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI87081918, Length=331, Percent_Identity=30.8157099697885, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1786518, Length=326, Percent_Identity=27.9141104294479, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI87082401, Length=323, Percent_Identity=26.0061919504644, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790718, Length=305, Percent_Identity=25.2459016393443, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786825, Length=335, Percent_Identity=28.6567164179104, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788407, Length=326, Percent_Identity=27.3006134969325, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787863, Length=312, Percent_Identity=27.5641025641026, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788073, Length=244, Percent_Identity=27.4590163934426, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082125, Length=254, Percent_Identity=29.5275590551181, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788075, Length=283, Percent_Identity=27.9151943462898, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786552, Length=357, Percent_Identity=27.1708683473389, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=24.4837758112094, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17565904, Length=348, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=331, Percent_Identity=24.4712990936556, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=333, Percent_Identity=23.4234234234234, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=336, Percent_Identity=24.1071428571429, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=314, Percent_Identity=23.5668789808917, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=321, Percent_Identity=25.5451713395639, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=339, Percent_Identity=24.7787610619469, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=332, Percent_Identity=25.9036144578313, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=24.8484848484848, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=326, Percent_Identity=29.4478527607362, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=328, Percent_Identity=27.4390243902439, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=277, Percent_Identity=26.3537906137184, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=302, Percent_Identity=27.8145695364238, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=321, Percent_Identity=24.2990654205607, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=321, Percent_Identity=24.2990654205607, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17137530, Length=337, Percent_Identity=24.3323442136499, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=25.7617728531856, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737897, Length=337, Percent_Identity=23.7388724035608, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35928; Mature: 35928

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGAILKNFGEELSLEDVREPSNGIVLKVLATGLCHGDLHVINGDWRYEIKVELPKILGH
CCCHHHHHHCCCCCHHHHCCCCCCEEEEEEEHHCCCCCEEEECCCEEEEEEEECHHHHCH
EIVGEVVKGNGTFKEGDKVLVYNSIGCGKCKYCASKKYQYCEKVKIIGLNINGGFAEYVS
HHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHCCCHHCCCEEEEEEEEECCCCCEEEE
VPSDNILLRVDGEPVKLAPLADAGITAYSSAKGITNEDSVLIIGTGAVALLALQILKLKG
CCCCCEEEEECCCCEEEEECCCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHCCC
ARVTVIGHNKNKLEKAKELGADEVINIKYDSTIASEVKESKFDYIIDYVGSDYTLSDSMW
CEEEEEECCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCHHEEEEECCCCEEECCCEE
LLNREGELRIIGEFGGTITVPEQLLVLKGLKVRGILYGSFDDLISVYKLYNEGKIRPIVN
EEECCCCEEEEEECCCEEECCHHHHHHCCCEEEEEEEECHHHHHHHHHHHCCCCEEEEEE
TYKLRDINKAIRDLRDGRVIGRAVIVPP
EEEHHHHHHHHHHHHCCEEEEEEEEECC
>Mature Secondary Structure
MLGAILKNFGEELSLEDVREPSNGIVLKVLATGLCHGDLHVINGDWRYEIKVELPKILGH
CCCHHHHHHCCCCCHHHHCCCCCCEEEEEEEHHCCCCCEEEECCCEEEEEEEECHHHHCH
EIVGEVVKGNGTFKEGDKVLVYNSIGCGKCKYCASKKYQYCEKVKIIGLNINGGFAEYVS
HHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHCCCHHCCCEEEEEEEEECCCCCEEEE
VPSDNILLRVDGEPVKLAPLADAGITAYSSAKGITNEDSVLIIGTGAVALLALQILKLKG
CCCCCEEEEECCCCEEEEECCCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHCCC
ARVTVIGHNKNKLEKAKELGADEVINIKYDSTIASEVKESKFDYIIDYVGSDYTLSDSMW
CEEEEEECCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCHHEEEEECCCCEEECCCEE
LLNREGELRIIGEFGGTITVPEQLLVLKGLKVRGILYGSFDDLISVYKLYNEGKIRPIVN
EEECCCCEEEEEECCCEEECCHHHHHHCCCEEEEEEEECHHHHHHHHHHHCCCCEEEEEE
TYKLRDINKAIRDLRDGRVIGRAVIVPP
EEEHHHHHHHHHHHHCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA