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The map label for this gene is acd-3 [H]

Identifier: 15898849

GI number: 15898849

Start: 1878836

End: 1879951

Strand: Direct

Name: acd-3 [H]

Synonym: SSO2060

Alternate gene names: 15898849

Gene position: 1878836-1879951 (Clockwise)

Preceding gene: 15898847

Following gene: 15898850

Centisome position: 62.79

GC content: 38.44

Gene sequence:

>1116_bases
ATGAGCGAAAAAGAGCTCTTTATACAATCATTAAGGGAGTTTCTAAACAGAGATGTTGAGAAGATAGTGAATAAAATAGA
CAAAGAAGATTACTACCCCAGAGATTTAGTTAGAAAGCTTGGAGAGTTAGGCTTTCTAATCCCTTTAACTAGTGGTCTAT
CAAACTACGACATGATGATTATTTTAGAAGAGATTGCAAAGGTTAGCGGGTCTTTAGCATTAATTGCTGATGCTCAAGGA
GAGTTAGCCGGTGAGATGATTAGATTGTATGCAAATGAAAGGCAAAAGAAGGAGTTTATGGAACCATTGAGTAAGGGAGA
AATTATAGGTAGTTTTGCCTTAACTGAACCTTCAGGTGGAAGCGATATAGGTTCCATGAAGACTCTCGCTGAGAAAAGAA
ATGGATCGTGGATAATAAAGGGACATAAGATGTGGATAACTCAAGGGCTTTACGCTGACGTTTTCATCACAGTAGCGAAA
ACGGGTTCATCTAGACGTGATTTATCAGTTTTTATAGTGCCCAGAAGTAATTGCGTTGAGACTAGAAAAATAGAAGTCAT
GGGTAATAGGGGAACTGGGACCGCTGAGGTAATCTTTCATAATTGCGAAGTGTCAAACGATTACGTTGTTGGGGAGGTGA
ATAATGGGTGGAACATGGTCAACTCAGTATTAGAAATAGGTAGGCTTGCTATCTCAGGTATTGCAATAGGTTTGGCTGAG
GCGGCTTTGGAAGAAGCTTTTAAGTGGGCTAAATCAAGATTTGCATTTGGGAATTCGATTTATGATTTTCAAGGGATAAG
ATGGTATTTCGCAGATGCCATAGCTAAACTTAACGCAGTTAAGTCAATGGCTAAGGATGTCAGTAGTAAGTTCGATGAGA
ATTCAAAGGATAAGGGAGTTTACGTCTCAATGTTAAAGTTATTATCTGCAAATATTGCTAACGAAGTAATAGACATCTCC
TTACAAGTATTCGGTGGTATGGGTTACGCTAAGGGAACTAACATAGAACGAATATATCGTGATGCTAGACTACTTAGGAT
AGGTGAGGGAACTGATGAAGTACAGAGGCACATTATAGCTAAATATATTGAACAGTATGGAATACCGTATATCTAG

Upstream 100 bases:

>100_bases
GTTATCATATATATTTGTAAATTAAAAATTATATATACCTTTCGTTCAACAATGATAGATTTGTATAAGATTTAAAAGTT
ATTTAATGTAAGATAAATAT

Downstream 100 bases:

>100_bases
TTACTTTTGATCCTTTCTGACATTAGGCTAAAAAGTTTTAATAGGATGAGAAGAGAATATTTTTGGGGACTTTTTTGAAT
CGAATCGCAATAATAGGCTT

Product: Acyl-CoA dehydrogenase (acd-3)

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSEKELFIQSLREFLNRDVEKIVNKIDKEDYYPRDLVRKLGELGFLIPLTSGLSNYDMMIILEEIAKVSGSLALIADAQG
ELAGEMIRLYANERQKKEFMEPLSKGEIIGSFALTEPSGGSDIGSMKTLAEKRNGSWIIKGHKMWITQGLYADVFITVAK
TGSSRRDLSVFIVPRSNCVETRKIEVMGNRGTGTAEVIFHNCEVSNDYVVGEVNNGWNMVNSVLEIGRLAISGIAIGLAE
AALEEAFKWAKSRFAFGNSIYDFQGIRWYFADAIAKLNAVKSMAKDVSSKFDENSKDKGVYVSMLKLLSANIANEVIDIS
LQVFGGMGYAKGTNIERIYRDARLLRIGEGTDEVQRHIIAKYIEQYGIPYI

Sequences:

>Translated_371_residues
MSEKELFIQSLREFLNRDVEKIVNKIDKEDYYPRDLVRKLGELGFLIPLTSGLSNYDMMIILEEIAKVSGSLALIADAQG
ELAGEMIRLYANERQKKEFMEPLSKGEIIGSFALTEPSGGSDIGSMKTLAEKRNGSWIIKGHKMWITQGLYADVFITVAK
TGSSRRDLSVFIVPRSNCVETRKIEVMGNRGTGTAEVIFHNCEVSNDYVVGEVNNGWNMVNSVLEIGRLAISGIAIGLAE
AALEEAFKWAKSRFAFGNSIYDFQGIRWYFADAIAKLNAVKSMAKDVSSKFDENSKDKGVYVSMLKLLSANIANEVIDIS
LQVFGGMGYAKGTNIERIYRDARLLRIGEGTDEVQRHIIAKYIEQYGIPYI
>Mature_370_residues
SEKELFIQSLREFLNRDVEKIVNKIDKEDYYPRDLVRKLGELGFLIPLTSGLSNYDMMIILEEIAKVSGSLALIADAQGE
LAGEMIRLYANERQKKEFMEPLSKGEIIGSFALTEPSGGSDIGSMKTLAEKRNGSWIIKGHKMWITQGLYADVFITVAKT
GSSRRDLSVFIVPRSNCVETRKIEVMGNRGTGTAEVIFHNCEVSNDYVVGEVNNGWNMVNSVLEIGRLAISGIAIGLAEA
ALEEAFKWAKSRFAFGNSIYDFQGIRWYFADAIAKLNAVKSMAKDVSSKFDENSKDKGVYVSMLKLLSANIANEVIDISL
QVFGGMGYAKGTNIERIYRDARLLRIGEGTDEVQRHIIAKYIEQYGIPYI

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=369, Percent_Identity=31.9783197831978, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=32.9787234042553, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI226958414, Length=358, Percent_Identity=33.5195530726257, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI21361497, Length=378, Percent_Identity=31.2169312169312, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI4557231, Length=383, Percent_Identity=28.1984334203655, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI187960098, Length=383, Percent_Identity=28.1984334203655, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=27.2, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI76496475, Length=378, Percent_Identity=28.5714285714286, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4557235, Length=378, Percent_Identity=28.5714285714286, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=27.8820375335121, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=28.3422459893048, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI38505218, Length=343, Percent_Identity=25.6559766763848, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI4503943, Length=381, Percent_Identity=25.7217847769029, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=27.0833333333333, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=27.0833333333333, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI7669494, Length=346, Percent_Identity=26.5895953757225, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1786223, Length=385, Percent_Identity=29.3506493506493, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI87081958, Length=372, Percent_Identity=29.0322580645161, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87082384, Length=267, Percent_Identity=24.3445692883895, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=372, Percent_Identity=32.7956989247312, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=30.6068601583113, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=27.4193548387097, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71985184, Length=354, Percent_Identity=30.5084745762712, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17506239, Length=379, Percent_Identity=29.5514511873351, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17570075, Length=375, Percent_Identity=28.5333333333333, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=28.4960422163588, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17533517, Length=368, Percent_Identity=25.8152173913043, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17551932, Length=366, Percent_Identity=27.3224043715847, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17505929, Length=367, Percent_Identity=26.9754768392371, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI71985192, Length=291, Percent_Identity=28.5223367697594, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI32563615, Length=220, Percent_Identity=31.8181818181818, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=27.9411764705882, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71990804, Length=235, Percent_Identity=28.5106382978723, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17534353, Length=370, Percent_Identity=25.1351351351351, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=325, Percent_Identity=27.0769230769231, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356377, Length=380, Percent_Identity=32.6315789473684, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=31.7333333333333, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=30.5851063829787, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24660351, Length=375, Percent_Identity=28.8, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=26.8096514745308, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281363737, Length=345, Percent_Identity=29.2753623188406, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=25.065963060686, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41395; Mature: 41264

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKELFIQSLREFLNRDVEKIVNKIDKEDYYPRDLVRKLGELGFLIPLTSGLSNYDMMI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHH
ILEEIAKVSGSLALIADAQGELAGEMIRLYANERQKKEFMEPLSKGEIIGSFALTEPSGG
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
SDIGSMKTLAEKRNGSWIIKGHKMWITQGLYADVFITVAKTGSSRRDLSVFIVPRSNCVE
CCCHHHHHHHHHCCCCEEEECCEEEEECCCCEEEEEEEECCCCCCCCEEEEEEECCCCCC
TRKIEVMGNRGTGTAEVIFHNCEVSNDYVVGEVNNGWNMVNSVLEIGRLAISGIAIGLAE
CEEEEEEECCCCCEEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AALEEAFKWAKSRFAFGNSIYDFQGIRWYFADAIAKLNAVKSMAKDVSSKFDENSKDKGV
HHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
YVSMLKLLSANIANEVIDISLQVFGGMGYAKGTNIERIYRDARLLRIGEGTDEVQRHIIA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEEECCCHHHHHHHHHH
KYIEQYGIPYI
HHHHHCCCCCC
>Mature Secondary Structure 
SEKELFIQSLREFLNRDVEKIVNKIDKEDYYPRDLVRKLGELGFLIPLTSGLSNYDMMI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHH
ILEEIAKVSGSLALIADAQGELAGEMIRLYANERQKKEFMEPLSKGEIIGSFALTEPSGG
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
SDIGSMKTLAEKRNGSWIIKGHKMWITQGLYADVFITVAKTGSSRRDLSVFIVPRSNCVE
CCCHHHHHHHHHCCCCEEEECCEEEEECCCCEEEEEEEECCCCCCCCEEEEEEECCCCCC
TRKIEVMGNRGTGTAEVIFHNCEVSNDYVVGEVNNGWNMVNSVLEIGRLAISGIAIGLAE
CEEEEEEECCCCCEEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AALEEAFKWAKSRFAFGNSIYDFQGIRWYFADAIAKLNAVKSMAKDVSSKFDENSKDKGV
HHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
YVSMLKLLSANIANEVIDISLQVFGGMGYAKGTNIERIYRDARLLRIGEGTDEVQRHIIA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEEECCCHHHHHHHHHH
KYIEQYGIPYI
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]