BacMap

Definition	Sulfolobus solfataricus P2 chromosome, complete genome.
Accession	NC_002754
Length	2,992,245

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The map label for this gene is acsA-4 [H]

Identifier: 15898812

GI number: 15898812

Start: 1834879

End: 1835682

Strand: Direct

Name: acsA-4 [H]

Synonym: SSO2021

Alternate gene names: 15898812

Gene position: 1834879-1835682 (Clockwise)

Preceding gene: 15898811

Following gene: 15898813

Centisome position: 61.32

GC content: 38.43

Gene sequence:

>804_bases
TTGGAGACCATACATAAATACAAGCCTACTATCTTCTTTGGAGTGCCTACTTTATATAACGCAATGCTACATGTAGAGGA
TTGGAAGAATTACAACTTAACTAGTTTAAGATTTTGCGTTTCTGCTGGAGAACCCTTACCCCCGTTAATATATATTAAAT
GGAAAGAGAGATACGGCGTAGAAATTCTAGATGGTATTGGTTCCACTGAGGCACTTCACATATATATCTCTAACATTCCA
AGTAATTCTAAGCCTGGATGTACTGGGAAACCAGTCCCTGGATATGAGGTTAAAATAGTAGATGAAGATGGCAATGAGGT
TCCTCCTAAAACTATAGGGGATCTCTACGTAAAAGGAGATAGTGTAGCCATGTTTTACTGGAATGATTACGAAAGTACTA
GAAAGAACATGATGGGATCTTGGTTTAGAACTGGAGATAAGTTTTACAGAGATGACGAGGGATATTATTACTACGTTGGA
AGGTCTGACGATATGGTTAAGACTGCGGGATTATGGGTTTCTCCAATAGAAGTGGAATCTGCGCTATTATCACATCCTGC
AGTTCTTGAGGCTGCAGTTGTAGGTATTCCAGATGAAGTAGGATTAGTAAGGGTAGTTGGGTTTGTTACGCTAAAACAAG
GGTATTCGCCAAGTAGTGAATTAGCTGAGGAGATAAGGAATTACCTTAGGGAAAAATTAGACCATTATAAGGTTCCTAAA
GAAATAAGGTTTATTACGGAAATTCCTAAGACTGCAACCGGTAAGATACAACGATATAAGTTTAGGCTAGGGGAGATCAA
ATAA

Upstream 100 bases:

>100_bases
AACTATTTTTCGCTTATGGATTAGGAAATGGATCCTACTTCGCCTTTGGTAACGGTGCCTCGACAGTTCTGATGCCAGAT
AGAGTAGAACCAGAAGGGTA

Downstream 100 bases:

>100_bases
TTTATAAGGACAGTTAAAAAAGAAACTAACCCTTTGTAAACATGTCGATGAGCTTTATAACACTTGCTACAACTAAGAAA
ATTTTTTAGTATTAATTTAA

Product: Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment (acsA-4)

Products: NA

Alternate protein names: Benzoyl-CoA synthetase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
METIHKYKPTIFFGVPTLYNAMLHVEDWKNYNLTSLRFCVSAGEPLPPLIYIKWKERYGVEILDGIGSTEALHIYISNIP
SNSKPGCTGKPVPGYEVKIVDEDGNEVPPKTIGDLYVKGDSVAMFYWNDYESTRKNMMGSWFRTGDKFYRDDEGYYYYVG
RSDDMVKTAGLWVSPIEVESALLSHPAVLEAAVVGIPDEVGLVRVVGFVTLKQGYSPSSELAEEIRNYLREKLDHYKVPK
EIRFITEIPKTATGKIQRYKFRLGEIK

Sequences:

>Translated_267_residues
METIHKYKPTIFFGVPTLYNAMLHVEDWKNYNLTSLRFCVSAGEPLPPLIYIKWKERYGVEILDGIGSTEALHIYISNIP
SNSKPGCTGKPVPGYEVKIVDEDGNEVPPKTIGDLYVKGDSVAMFYWNDYESTRKNMMGSWFRTGDKFYRDDEGYYYYVG
RSDDMVKTAGLWVSPIEVESALLSHPAVLEAAVVGIPDEVGLVRVVGFVTLKQGYSPSSELAEEIRNYLREKLDHYKVPK
EIRFITEIPKTATGKIQRYKFRLGEIK
>Mature_267_residues
METIHKYKPTIFFGVPTLYNAMLHVEDWKNYNLTSLRFCVSAGEPLPPLIYIKWKERYGVEILDGIGSTEALHIYISNIP
SNSKPGCTGKPVPGYEVKIVDEDGNEVPPKTIGDLYVKGDSVAMFYWNDYESTRKNMMGSWFRTGDKFYRDDEGYYYYVG
RSDDMVKTAGLWVSPIEVESALLSHPAVLEAAVVGIPDEVGLVRVVGFVTLKQGYSPSSELAEEIRNYLREKLDHYKVPK
EIRFITEIPKTATGKIQRYKFRLGEIK

Specific function: Catalyzes the ligation of benzoate and CoA to form benzoyl-CoA at the expense of ATP. The enzyme also ligates 2- aminobenzoate and CoA. The enzyme shows activity toward a number of benzoate derivates [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=274, Percent_Identity=37.5912408759124, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI38505220, Length=272, Percent_Identity=36.3970588235294, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI122937307, Length=264, Percent_Identity=36.7424242424242, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI115511026, Length=272, Percent_Identity=34.9264705882353, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI58082049, Length=274, Percent_Identity=33.2116788321168, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI157311624, Length=274, Percent_Identity=32.4817518248175, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI157311622, Length=274, Percent_Identity=32.4817518248175, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI187761345, Length=282, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI187761343, Length=282, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI156151445, Length=268, Percent_Identity=30.2238805970149, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI253970489, Length=271, Percent_Identity=33.210332103321, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI8923896, Length=271, Percent_Identity=33.210332103321, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI28416953, Length=278, Percent_Identity=30.2158273381295, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI195947378, Length=178, Percent_Identity=30.8988764044944, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI13375727, Length=243, Percent_Identity=30.0411522633745, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI42544134, Length=100, Percent_Identity=40, Blast_Score=78, Evalue=8e-15,
Organism=Escherichia coli, GI1788107, Length=263, Percent_Identity=34.9809885931559, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1790505, Length=277, Percent_Identity=31.7689530685921, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI145693145, Length=265, Percent_Identity=29.0566037735849, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI221142682, Length=269, Percent_Identity=26.7657992565056, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789201, Length=264, Percent_Identity=26.5151515151515, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786810, Length=268, Percent_Identity=26.865671641791, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786529, Length=283, Percent_Identity=24.7349823321555, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786801, Length=252, Percent_Identity=27.3809523809524, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788595, Length=268, Percent_Identity=25, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994694, Length=269, Percent_Identity=30.4832713754647, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71994690, Length=269, Percent_Identity=30.4832713754647, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71994703, Length=269, Percent_Identity=30.4832713754647, Blast_Score=126, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17531443, Length=265, Percent_Identity=31.3207547169811, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17558820, Length=259, Percent_Identity=29.3436293436293, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17560140, Length=260, Percent_Identity=29.2307692307692, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=254, Percent_Identity=28.740157480315, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17560308, Length=268, Percent_Identity=30.2238805970149, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=267, Percent_Identity=26.9662921348315, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17538037, Length=205, Percent_Identity=32.1951219512195, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17557194, Length=179, Percent_Identity=33.5195530726257, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=269, Percent_Identity=28.6245353159851, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=269, Percent_Identity=28.996282527881, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982997, Length=273, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71996755, Length=177, Percent_Identity=29.3785310734463, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319699, Length=257, Percent_Identity=34.2412451361868, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323182, Length=290, Percent_Identity=31.7241379310345, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319264, Length=283, Percent_Identity=29.3286219081272, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24581924, Length=266, Percent_Identity=31.5789473684211, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI18859661, Length=268, Percent_Identity=31.7164179104478, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI62472339, Length=271, Percent_Identity=30.9963099630996, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667959, Length=271, Percent_Identity=30.9963099630996, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667955, Length=271, Percent_Identity=30.9963099630996, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24648260, Length=274, Percent_Identity=29.9270072992701, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21355181, Length=269, Percent_Identity=31.5985130111524, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21356441, Length=262, Percent_Identity=27.0992366412214, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653035, Length=205, Percent_Identity=31.219512195122, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922652, Length=270, Percent_Identity=27.4074074074074, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21358303, Length=232, Percent_Identity=27.1551724137931, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355225, Length=271, Percent_Identity=25.4612546125461, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24648253, Length=267, Percent_Identity=25.4681647940075, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648255, Length=267, Percent_Identity=25.8426966292135, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281365686, Length=234, Percent_Identity=25.2136752136752, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24656500, Length=179, Percent_Identity=27.9329608938547, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21356947, Length=181, Percent_Identity=30.3867403314917, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076582, Length=212, Percent_Identity=29.7169811320755, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648257, Length=213, Percent_Identity=27.2300469483568, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR011957 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.25 [H]

Molecular weight: Translated: 30431; Mature: 30431

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00024 HEMOPEXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIHKYKPTIFFGVPTLYNAMLHVEDWKNYNLTSLRFCVSAGEPLPPLIYIKWKERYGV
CCCCHHHCCEEEEECHHHHHHEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCC
EILDGIGSTEALHIYISNIPSNSKPGCTGKPVPGYEVKIVDEDGNEVPPKTIGDLYVKGD
EEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECC
SVAMFYWNDYESTRKNMMGSWFRTGDKFYRDDEGYYYYVGRSDDMVKTAGLWVSPIEVES
CEEEEEECCHHHHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCEEECCCEECHHHHHH
ALLSHPAVLEAAVVGIPDEVGLVRVVGFVTLKQGYSPSSELAEEIRNYLREKLDHYKVPK
HHHCCCHHHHHHEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCH
EIRFITEIPKTATGKIQRYKFRLGEIK
HHHHHHHCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure
METIHKYKPTIFFGVPTLYNAMLHVEDWKNYNLTSLRFCVSAGEPLPPLIYIKWKERYGV
CCCCHHHCCEEEEECHHHHHHEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCC
EILDGIGSTEALHIYISNIPSNSKPGCTGKPVPGYEVKIVDEDGNEVPPKTIGDLYVKGD
EEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECC
SVAMFYWNDYESTRKNMMGSWFRTGDKFYRDDEGYYYYVGRSDDMVKTAGLWVSPIEVES
CEEEEEECCHHHHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCEEECCCEECHHHHHH
ALLSHPAVLEAAVVGIPDEVGLVRVVGFVTLKQGYSPSSELAEEIRNYLREKLDHYKVPK
HHHCCCHHHHHHEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCH
EIRFITEIPKTATGKIQRYKFRLGEIK
HHHHHHHCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12897012 [H]