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The map label for this gene is apeH-1

Identifier: 15898258

GI number: 15898258

Start: 1271424

End: 1273034

Strand: Reverse

Name: apeH-1

Synonym: SSO1419

Alternate gene names: NA

Gene position: 1273034-1271424 (Counterclockwise)

Preceding gene: 15898273

Following gene: 15898256

Centisome position: 42.54

GC content: 35.26

Gene sequence:

>1611_bases
ATGAAATATGAAGATTTATTTAAGATAAAACCTGTACTCGATTACGACGTATATAACGGAAAAATAGCAACAATTATAAG
AGATGAAAAACCCGTCCTTTACGTCAACAAGGAAAAAGTCCAACTCGAAGGATATGCCAAAGAAGTAGACTGGATAAATA
GAAACAAAATGTTTATCACAGTAGACCCTAACGGTAGTGAAATTAGGAAAATTTACCTTTACGATAACGGGAAGATAGAG
AAAATTATTGATAATGAGTTTGATAATTTATCTCCTCGCGAGACAAACGAAGGGATTCTAGTAATCTCAAACTATGATAA
AAAGACATTACATCTTTACCTCTACAATGAAGGAAAATATATTAAGCTAAGCAAGGGTGAAGGACCGGTAAACAATTACT
GTTTTAATGGCAAATACATAGTTTACTCGACTGGGATTTATGATAATAACATTCACGTGATGGATCTCAGTGGTAATGAA
ATTAATGTAATTAATATCCCAAACTCAGAGCAAGAGCTTGCAAATGAGAATTGTTTTACTTCTCCTTCATCATTCATCTT
TCTCTCAAATCACGAGGATTTATCTAAGGTTTATGAGTTTAATATTTTAAAGGGAGAGATCAGAAAAATAAGGGAAAGCG
ATTACGAAATCTTTGAGGCTATTCCATATAAGGGTTCTATCGCTTATGTTGAGGATAGACACGGCAACTTTGTCTTAATT
CACGAAAAAGAGATAGTTAATGAAGGCTTTACCTACTCCTTAAAGGTTGATGGAGATTATATTTATTTTGTAAACTCTAA
ACATGATAGATCAGCAGACCTATACAGATATGGGAAAAAGGTAGAGAGGTTAACTGACTCAATGAACGATGCTAAAGGGA
ATTTCATAAAACCTAAGGTTGTCTCTTACGACTCCAATGGGTTGAGGATTTACGCCTTACTCTATGAAAAAGGTGGTGAG
GATAAGGGTATAGTTTATATTCACGGAGGTCCAGATTGGGAATGCGTAAACTCATTCAACCCAGAAATTCAGTTCTTTAT
GGAGAGAGGATTTAAGGTTATTTGTCCCAATTACAGAGGATCTATAGGTTATGGAAGGAGGTTTAACCATTTGAACGATA
AAGACCCAGGAGGAGGTGAGTTGTTAGATGTTATAAATTCAGTGAAGGTCTTAGGAGTTAAAAAGATTGCAATAACTGGT
GCAAGTTATGGTGGCTATTTGACCATGATGGCTACTACTAAGTTCTCGGACCTTTGGTGTTCGGCTGTGGCTGTAGTACC
TTTTGTTAATTGGTTTACCGAAAAGAAGCTTGAAAGGGAAATACTTCAACTATATGACGAAATAAAGGTTGGTAATGATG
AAAATTTATTGAGGGATAGATCACCTATATTCTTTATTGATAGGATAAAAACTTCATTGCTTCTCTTAGCTGGTGAAAAT
GACCCAAGATGTCCAGCTGAGGAAACTTTGCAAGTAGTTGAAGAACTTAGAAAGTTGGGTAGAGAAGTGAAATATAAGAT
ATACAAAGATGAGGGACACGGATTTGCAAAAATAGAAAACTATGTTGACTCGATAAAAGAGGCTGTGGAGTTTATTACTA
GTCACTGCTGA

Upstream 100 bases:

>100_bases
ATTTATACCATATTCTGTTGATGAACTCGAATGGGAGCGATTAGTGATATGAGGCCTGCTATCTGAATAACTTTTTATTT
CTACTCCTCTTTTATTATTT

Downstream 100 bases:

>100_bases
AGTCGATTTCCAAATGACGGATTTTCTGACAATTGATTATTTGTACAAAAGTCAATATTACTAAAAAAGAGTCGAAGTAA
ATGAAAATTTCTTAAAAGAT

Product: acylaminoacyl-peptidase

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MKYEDLFKIKPVLDYDVYNGKIATIIRDEKPVLYVNKEKVQLEGYAKEVDWINRNKMFITVDPNGSEIRKIYLYDNGKIE
KIIDNEFDNLSPRETNEGILVISNYDKKTLHLYLYNEGKYIKLSKGEGPVNNYCFNGKYIVYSTGIYDNNIHVMDLSGNE
INVINIPNSEQELANENCFTSPSSFIFLSNHEDLSKVYEFNILKGEIRKIRESDYEIFEAIPYKGSIAYVEDRHGNFVLI
HEKEIVNEGFTYSLKVDGDYIYFVNSKHDRSADLYRYGKKVERLTDSMNDAKGNFIKPKVVSYDSNGLRIYALLYEKGGE
DKGIVYIHGGPDWECVNSFNPEIQFFMERGFKVICPNYRGSIGYGRRFNHLNDKDPGGGELLDVINSVKVLGVKKIAITG
ASYGGYLTMMATTKFSDLWCSAVAVVPFVNWFTEKKLEREILQLYDEIKVGNDENLLRDRSPIFFIDRIKTSLLLLAGEN
DPRCPAEETLQVVEELRKLGREVKYKIYKDEGHGFAKIENYVDSIKEAVEFITSHC

Sequences:

>Translated_536_residues
MKYEDLFKIKPVLDYDVYNGKIATIIRDEKPVLYVNKEKVQLEGYAKEVDWINRNKMFITVDPNGSEIRKIYLYDNGKIE
KIIDNEFDNLSPRETNEGILVISNYDKKTLHLYLYNEGKYIKLSKGEGPVNNYCFNGKYIVYSTGIYDNNIHVMDLSGNE
INVINIPNSEQELANENCFTSPSSFIFLSNHEDLSKVYEFNILKGEIRKIRESDYEIFEAIPYKGSIAYVEDRHGNFVLI
HEKEIVNEGFTYSLKVDGDYIYFVNSKHDRSADLYRYGKKVERLTDSMNDAKGNFIKPKVVSYDSNGLRIYALLYEKGGE
DKGIVYIHGGPDWECVNSFNPEIQFFMERGFKVICPNYRGSIGYGRRFNHLNDKDPGGGELLDVINSVKVLGVKKIAITG
ASYGGYLTMMATTKFSDLWCSAVAVVPFVNWFTEKKLEREILQLYDEIKVGNDENLLRDRSPIFFIDRIKTSLLLLAGEN
DPRCPAEETLQVVEELRKLGREVKYKIYKDEGHGFAKIENYVDSIKEAVEFITSHC
>Mature_536_residues
MKYEDLFKIKPVLDYDVYNGKIATIIRDEKPVLYVNKEKVQLEGYAKEVDWINRNKMFITVDPNGSEIRKIYLYDNGKIE
KIIDNEFDNLSPRETNEGILVISNYDKKTLHLYLYNEGKYIKLSKGEGPVNNYCFNGKYIVYSTGIYDNNIHVMDLSGNE
INVINIPNSEQELANENCFTSPSSFIFLSNHEDLSKVYEFNILKGEIRKIRESDYEIFEAIPYKGSIAYVEDRHGNFVLI
HEKEIVNEGFTYSLKVDGDYIYFVNSKHDRSADLYRYGKKVERLTDSMNDAKGNFIKPKVVSYDSNGLRIYALLYEKGGE
DKGIVYIHGGPDWECVNSFNPEIQFFMERGFKVICPNYRGSIGYGRRFNHLNDKDPGGGELLDVINSVKVLGVKKIAITG
ASYGGYLTMMATTKFSDLWCSAVAVVPFVNWFTEKKLEREILQLYDEIKVGNDENLLRDRSPIFFIDRIKTSLLLLAGEN
DPRCPAEETLQVVEELRKLGREVKYKIYKDEGHGFAKIENYVDSIKEAVEFITSHC

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=251, Percent_Identity=25.8964143426295, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI18450280, Length=219, Percent_Identity=23.7442922374429, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI37577089, Length=219, Percent_Identity=23.7442922374429, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144537, Length=221, Percent_Identity=32.1266968325792, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25144540, Length=222, Percent_Identity=31.981981981982, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17552908, Length=293, Percent_Identity=26.962457337884, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI45550825, Length=238, Percent_Identity=24.7899159663866, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45553511, Length=238, Percent_Identity=24.7899159663866, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45551969, Length=238, Percent_Identity=24.7899159663866, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 61785; Mature: 61785

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYEDLFKIKPVLDYDVYNGKIATIIRDEKPVLYVNKEKVQLEGYAKEVDWINRNKMFIT
CCCCCCEEECEEEEEEECCCEEEEEEECCCCEEEEECCEEEEECCHHHCCEECCCEEEEE
VDPNGSEIRKIYLYDNGKIEKIIDNEFDNLSPRETNEGILVISNYDKKTLHLYLYNEGKY
ECCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCE
IKLSKGEGPVNNYCFNGKYIVYSTGIYDNNIHVMDLSGNEINVINIPNSEQELANENCFT
EEEECCCCCCCCEEECCEEEEEECCEECCCEEEEEECCCEEEEEECCCCHHHHCCCCCCC
SPSSFIFLSNHEDLSKVYEFNILKGEIRKIRESDYEIFEAIPYKGSIAYVEDRHGNFVLI
CCCCEEEEECCHHHHHHHHEEEHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCEEEE
HEKEIVNEGFTYSLKVDGDYIYFVNSKHDRSADLYRYGKKVERLTDSMNDAKGNFIKPKV
ECHHHHCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEECCEE
VSYDSNGLRIYALLYEKGGEDKGIVYIHGGPDWECVNSFNPEIQFFMERGFKVICPNYRG
EEECCCCEEEEEEEEECCCCCCCEEEEECCCCCHHHCCCCCHHHHHHHCCCEEECCCCCC
SIGYGRRFNHLNDKDPGGGELLDVINSVKVLGVKKIAITGASYGGYLTMMATTKFSDLWC
CCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEEEEEEEECCCCCCEEEEEEECCHHHHHH
SAVAVVPFVNWFTEKKLEREILQLYDEIKVGNDENLLRDRSPIFFIDRIKTSLLLLAGEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEEECCEEEEEEECCC
DPRCPAEETLQVVEELRKLGREVKYKIYKDEGHGFAKIENYVDSIKEAVEFITSHC
CCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYEDLFKIKPVLDYDVYNGKIATIIRDEKPVLYVNKEKVQLEGYAKEVDWINRNKMFIT
CCCCCCEEECEEEEEEECCCEEEEEEECCCCEEEEECCEEEEECCHHHCCEECCCEEEEE
VDPNGSEIRKIYLYDNGKIEKIIDNEFDNLSPRETNEGILVISNYDKKTLHLYLYNEGKY
ECCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCE
IKLSKGEGPVNNYCFNGKYIVYSTGIYDNNIHVMDLSGNEINVINIPNSEQELANENCFT
EEEECCCCCCCCEEECCEEEEEECCEECCCEEEEEECCCEEEEEECCCCHHHHCCCCCCC
SPSSFIFLSNHEDLSKVYEFNILKGEIRKIRESDYEIFEAIPYKGSIAYVEDRHGNFVLI
CCCCEEEEECCHHHHHHHHEEEHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCEEEE
HEKEIVNEGFTYSLKVDGDYIYFVNSKHDRSADLYRYGKKVERLTDSMNDAKGNFIKPKV
ECHHHHCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEECCEE
VSYDSNGLRIYALLYEKGGEDKGIVYIHGGPDWECVNSFNPEIQFFMERGFKVICPNYRG
EEECCCCEEEEEEEEECCCCCCCEEEEECCCCCHHHCCCCCHHHHHHHCCCEEECCCCCC
SIGYGRRFNHLNDKDPGGGELLDVINSVKVLGVKKIAITGASYGGYLTMMATTKFSDLWC
CCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEEEEEEEECCCCCCEEEEEEECCHHHHHH
SAVAVVPFVNWFTEKKLEREILQLYDEIKVGNDENLLRDRSPIFFIDRIKTSLLLLAGEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEEECCEEEEEEECCC
DPRCPAEETLQVVEELRKLGREVKYKIYKDEGHGFAKIENYVDSIKEAVEFITSHC
CCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]