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The map label for this gene is glmS-2 [H]

Identifier: 15898110

GI number: 15898110

Start: 1091187

End: 1092941

Strand: Reverse

Name: glmS-2 [H]

Synonym: SSO1268

Alternate gene names: 15898110

Gene position: 1092941-1091187 (Counterclockwise)

Preceding gene: 15898111

Following gene: 15898109

Centisome position: 36.53

GC content: 38.29

Gene sequence:

>1755_bases
ATGGGAGGAATTTTCGCTTTCGTATGCAAGGATTCCATTGATGTTTCAATTATTAACAAGGGTTTAAAGAAGTTGATTTA
TAGGGGATATGATAGCGCTGGTATTGCTTACCTTGAAGACGATAGCTTAGTAATAAAGAAAATTTTAGGTAATATCTCAA
AGAATGAGATAAGCGTTAGTGACAAGGCAAGAGTTGCAATAGGTCACACTAGATATGCGAGTAGGGGTTGGCCAACTTTG
GAAAACGCTCACCCACTGACTGATTGTAATGGGAAGATAGCAGTTGTAATGGACGGTATTCTTGACGATTACGAAAAAAT
TAGGGAAGATCTGATTGCGAAGGGACATAAATTCGTCTCTACAACTGACGCTGAGGTGATTCCCCACTTACTTGAGAATT
CAACAAACTATCTAAACTCATCATTAAACGTTATGAAAAGGGTAAAGGGCATTTACTCTCTGGTTTTTGTAACCATAGAC
ATTGATAAAATATTCGCAATTAACTCTGGCCAACCCTTGATGATAGGTATCACACAAGAGTGTAAATACGTTTCTAGCGA
TTTACCCTCTTTGAGCGGTTTTGCTGAGAATGCGATAATAATGCCAGAAAATACTGTGGCAGTAATCTCTTGGAATGATG
TGCAAGTGTATAATATTGAAGGTAATGAGGTAAAACCGGAAATTAAGAGAGTTAAATATAAGGAGGAGATCGCTGAAAAG
GGTGGATTTCCACACTTCATGTTAAAGGAGATATACGATATCCCACAAGCGTTAATAAACTCATTTAACTCTCTAATGGA
AAAGTACCTTTCCTTAGCCTCAATGATAGTATATGGTGCCAAGAACGTCTATATAATAGGTAATGGGACTAGTCTTCACG
CTGGATTTATCTCATCATATTACTTTTCTGAAATTAGCCTAAATGTTAATGTTGTAAGTGCAGCGGAGTTTCCCTATTAC
GCCTTGAAAAACGTGACTACTGGTTCGGTAATTATTGCTATAAGTCAAAGTGGGGAGACAAGTGATGTTATAAGGAGTAT
TAAAATGGCTAAGCAAAGAGGGGCTGTAATATTAGGTATAACCAACTCTGTAGGTTCAAGATTAGCCTTAGAATCTAACG
TGTACTTACCAATAACTGCTGGGCCAGAGATGGCTGTACCAGCGACAAAAACTTTCACTTCAACTATTGTAGTATTAAAA
GTGCTTTCGCTATACACTGGACTTCACTCTGGTAAAAACGATAGGAGTGAGATCAGTTCGTTAAAAAGTGAGATTGAAGA
ATTGGCTAAACAGTTAATGGTAAGGTTACCGGAGATGGAGAAAGAGGCAGAGAAATTGGCTCCTAAATTAGACAAGGAAA
GCTTATACATTTCGAGTAGTGGTATAAATTACCCCATAGCCTTAGAAGGAGCTTTGAAGTTTAAGGAAGCTTCGATGACT
CACGCAGAGGGGATTCAGCTGGGAGAACTCCTCCACGGTCCCATTGTTCTAACAAATAAAGGTTACCCCGTAATTTTAAT
AAAACCTGTGGAGGCTGAGGATTTATATAACAAGGTTATTAGATCTATAAAGGAAAGAGGAGATGTAATTGTGACCGTTG
CTGAAGATGGTGATATGAAAAGTATAAAGGCTACTAGGGATTTAACTCCCATAAGCAATGTAATACCGTTACACTTATTG
GCCTATAAACTGGGAGTTAGGAAAGGGTTGCCGATAGATACTCCTCCAGGGTTAGTGAAAGCTGTGATAGTTTAA

Upstream 100 bases:

>100_bases
CACCCAGAAGTGTATAGTCTGATTTTAGGTGTATTTACCTCGATTAAGCAGGGAAATGAGGGTTAGAATTCCTTTTTATA
ACCAAAACTAAAATTTAAGT

Downstream 100 bases:

>100_bases
AATAAATAATAAATTATCCTTTTTCTTCTATTTATATTACATGACTATTGAAGTTGAGGATTTAAGGAAAAAGTTTGCTG
GTAAAGAAGTACTTAAGGGC

Product: glutamine-fructose-6-phosphate transaminase (isomerizing) (glmS-2)

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 584; Mature: 583

Protein sequence:

>584_residues
MGGIFAFVCKDSIDVSIINKGLKKLIYRGYDSAGIAYLEDDSLVIKKILGNISKNEISVSDKARVAIGHTRYASRGWPTL
ENAHPLTDCNGKIAVVMDGILDDYEKIREDLIAKGHKFVSTTDAEVIPHLLENSTNYLNSSLNVMKRVKGIYSLVFVTID
IDKIFAINSGQPLMIGITQECKYVSSDLPSLSGFAENAIIMPENTVAVISWNDVQVYNIEGNEVKPEIKRVKYKEEIAEK
GGFPHFMLKEIYDIPQALINSFNSLMEKYLSLASMIVYGAKNVYIIGNGTSLHAGFISSYYFSEISLNVNVVSAAEFPYY
ALKNVTTGSVIIAISQSGETSDVIRSIKMAKQRGAVILGITNSVGSRLALESNVYLPITAGPEMAVPATKTFTSTIVVLK
VLSLYTGLHSGKNDRSEISSLKSEIEELAKQLMVRLPEMEKEAEKLAPKLDKESLYISSSGINYPIALEGALKFKEASMT
HAEGIQLGELLHGPIVLTNKGYPVILIKPVEAEDLYNKVIRSIKERGDVIVTVAEDGDMKSIKATRDLTPISNVIPLHLL
AYKLGVRKGLPIDTPPGLVKAVIV

Sequences:

>Translated_584_residues
MGGIFAFVCKDSIDVSIINKGLKKLIYRGYDSAGIAYLEDDSLVIKKILGNISKNEISVSDKARVAIGHTRYASRGWPTL
ENAHPLTDCNGKIAVVMDGILDDYEKIREDLIAKGHKFVSTTDAEVIPHLLENSTNYLNSSLNVMKRVKGIYSLVFVTID
IDKIFAINSGQPLMIGITQECKYVSSDLPSLSGFAENAIIMPENTVAVISWNDVQVYNIEGNEVKPEIKRVKYKEEIAEK
GGFPHFMLKEIYDIPQALINSFNSLMEKYLSLASMIVYGAKNVYIIGNGTSLHAGFISSYYFSEISLNVNVVSAAEFPYY
ALKNVTTGSVIIAISQSGETSDVIRSIKMAKQRGAVILGITNSVGSRLALESNVYLPITAGPEMAVPATKTFTSTIVVLK
VLSLYTGLHSGKNDRSEISSLKSEIEELAKQLMVRLPEMEKEAEKLAPKLDKESLYISSSGINYPIALEGALKFKEASMT
HAEGIQLGELLHGPIVLTNKGYPVILIKPVEAEDLYNKVIRSIKERGDVIVTVAEDGDMKSIKATRDLTPISNVIPLHLL
AYKLGVRKGLPIDTPPGLVKAVIV
>Mature_583_residues
GGIFAFVCKDSIDVSIINKGLKKLIYRGYDSAGIAYLEDDSLVIKKILGNISKNEISVSDKARVAIGHTRYASRGWPTLE
NAHPLTDCNGKIAVVMDGILDDYEKIREDLIAKGHKFVSTTDAEVIPHLLENSTNYLNSSLNVMKRVKGIYSLVFVTIDI
DKIFAINSGQPLMIGITQECKYVSSDLPSLSGFAENAIIMPENTVAVISWNDVQVYNIEGNEVKPEIKRVKYKEEIAEKG
GFPHFMLKEIYDIPQALINSFNSLMEKYLSLASMIVYGAKNVYIIGNGTSLHAGFISSYYFSEISLNVNVVSAAEFPYYA
LKNVTTGSVIIAISQSGETSDVIRSIKMAKQRGAVILGITNSVGSRLALESNVYLPITAGPEMAVPATKTFTSTIVVLKV
LSLYTGLHSGKNDRSEISSLKSEIEELAKQLMVRLPEMEKEAEKLAPKLDKESLYISSSGINYPIALEGALKFKEASMTH
AEGIQLGELLHGPIVLTNKGYPVILIKPVEAEDLYNKVIRSIKERGDVIVTVAEDGDMKSIKATRDLTPISNVIPLHLLA
YKLGVRKGLPIDTPPGLVKAVIV

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=691, Percent_Identity=28.6541244573082, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI4826742, Length=692, Percent_Identity=29.3352601156069, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI29570798, Length=180, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790167, Length=624, Percent_Identity=31.7307692307692, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI87082251, Length=300, Percent_Identity=22, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532899, Length=434, Percent_Identity=28.8018433179723, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17532897, Length=434, Percent_Identity=28.8018433179723, Blast_Score=164, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17539970, Length=435, Percent_Identity=27.816091954023, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322745, Length=441, Percent_Identity=30.3854875283447, Blast_Score=167, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6323731, Length=436, Percent_Identity=24.5412844036697, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=31.5533980582524, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357745, Length=693, Percent_Identity=28.8600288600289, Blast_Score=245, Evalue=7e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 63915; Mature: 63784

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGIFAFVCKDSIDVSIINKGLKKLIYRGYDSAGIAYLEDDSLVIKKILGNISKNEISVS
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHCCCCCCEEECC
DKARVAIGHTRYASRGWPTLENAHPLTDCNGKIAVVMDGILDDYEKIREDLIAKGHKFVS
CCCEEEEECCEECCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCEEE
TTDAEVIPHLLENSTNYLNSSLNVMKRVKGIYSLVFVTIDIDKIFAINSGQPLMIGITQE
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEHHEEEECCCCEEEEEECHH
CKYVSSDLPSLSGFAENAIIMPENTVAVISWNDVQVYNIEGNEVKPEIKRVKYKEEIAEK
HHHHHCCCCCCCCCCCCEEEECCCEEEEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHC
GGFPHFMLKEIYDIPQALINSFNSLMEKYLSLASMIVYGAKNVYIIGNGTSLHAGFISSY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEECHHHHHHH
YFSEISLNVNVVSAAEFPYYALKNVTTGSVIIAISQSGETSDVIRSIKMAKQRGAVILGI
EEEEEEEEEEEEEECCCCHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEE
TNSVGSRLALESNVYLPITAGPEMAVPATKTFTSTIVVLKVLSLYTGLHSGKNDRSEISS
CCCCCCEEEEECCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LKSEIEELAKQLMVRLPEMEKEAEKLAPKLDKESLYISSSGINYPIALEGALKFKEASMT
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCCCCCCEEECCCEEEHHHCCC
HAEGIQLGELLHGPIVLTNKGYPVILIKPVEAEDLYNKVIRSIKERGDVIVTVAEDGDMK
HHCCCHHHHHCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCC
SIKATRDLTPISNVIPLHLLAYKLGVRKGLPIDTPPGLVKAVIV
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEEC
>Mature Secondary Structure 
GGIFAFVCKDSIDVSIINKGLKKLIYRGYDSAGIAYLEDDSLVIKKILGNISKNEISVS
CCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHCCCCCCEEECC
DKARVAIGHTRYASRGWPTLENAHPLTDCNGKIAVVMDGILDDYEKIREDLIAKGHKFVS
CCCEEEEECCEECCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCEEE
TTDAEVIPHLLENSTNYLNSSLNVMKRVKGIYSLVFVTIDIDKIFAINSGQPLMIGITQE
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEHHEEEECCCCEEEEEECHH
CKYVSSDLPSLSGFAENAIIMPENTVAVISWNDVQVYNIEGNEVKPEIKRVKYKEEIAEK
HHHHHCCCCCCCCCCCCEEEECCCEEEEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHC
GGFPHFMLKEIYDIPQALINSFNSLMEKYLSLASMIVYGAKNVYIIGNGTSLHAGFISSY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEECHHHHHHH
YFSEISLNVNVVSAAEFPYYALKNVTTGSVIIAISQSGETSDVIRSIKMAKQRGAVILGI
EEEEEEEEEEEEEECCCCHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEE
TNSVGSRLALESNVYLPITAGPEMAVPATKTFTSTIVVLKVLSLYTGLHSGKNDRSEISS
CCCCCCEEEEECCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LKSEIEELAKQLMVRLPEMEKEAEKLAPKLDKESLYISSSGINYPIALEGALKFKEASMT
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCCCCCCEEECCCEEEHHHCCC
HAEGIQLGELLHGPIVLTNKGYPVILIKPVEAEDLYNKVIRSIKERGDVIVTVAEDGDMK
HHCCCHHHHHCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCC
SIKATRDLTPISNVIPLHLLAYKLGVRKGLPIDTPPGLVKAVIV
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]