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The map label for this gene is trpA

Identifier: 15897777

GI number: 15897777

Start: 757372

End: 758109

Strand: Direct

Name: trpA

Synonym: SSO0889

Alternate gene names: 15897777

Gene position: 757372-758109 (Clockwise)

Preceding gene: 15897776

Following gene: 15897778

Centisome position: 25.31

GC content: 32.93

Gene sequence:

>738_bases
ATGGAAATGGGTAAGATGCTTGTAGTCTATATGACGTTAGGTTATCCAAATGTTCAAAGTTTTAAGGATTTTATTATTGG
GGCAGTTGAAAATGGAGCTGATATATTAGAGCTTGGAATCCCCCCTAAGTATGCTAAGTATGATGGTCCAGTTATAAGGA
AGAGTTATGATAAAGTAAAAGGGCTAGATATTTGGCCCTTAATAGAAGATATTAGGAAAGATGTGGGTGTTCCCATAATT
GCACTTACTTATTTAGAAGATTGGGTTGATCAGCTAGAGAATTTTCTAAATATGATAAAAGACGTCAAACTGGACGGAAT
TCTATTTCCAGATTTACTTATTGATTATATAGATGATTTGGATAAAATTGATGGGATAATAAAAAATAAAGGATTAAAAA
ACGTTATTTTTACATCTCCTTCAGTACCAGATCTTCTAATCCACAAAGTCTCTAAGATTAGCGATTTATTCTTATATTAT
GGTGTCAGACCAACTACTGGCGTACCTATACCAGTATCAGTTAAGCAATTGATTAATAGAGTTAGAAATCTAGTTGAGAA
TAAGCTAATAGTAGGATTTGGCTTATCAAGCGAGTCAGATTTAAGAGATGCTCTAAGTGCTGGTGCTGACGGAATAGCAA
TTGGAACTGTGTTCATAGAGGAAATTGAGAGGAATGGTGTAAAATCTGCAATAAATTTAGTTAAAAAATTTAGGGCGATA
TTAGATGAATATAAATGA

Upstream 100 bases:

>100_bases
GAGGCAAGAAAGAATAATGAGCGAAAGGTCATCGTCTTTAATCTAAGTGGACATGGATTGTTAGATCTGTCAAATTACGA
ATCCATGATGAAAAGGTTGA

Downstream 100 bases:

>100_bases
GATTCTTAAAAAACTCATAAATAAATCAGATTTAGAAATTAATGAGGCTGAAGAATTAGCTAAAGCTATAATTAGAGGAG
AAGTTCCAGAGATTTTAGTA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MEMGKMLVVYMTLGYPNVQSFKDFIIGAVENGADILELGIPPKYAKYDGPVIRKSYDKVKGLDIWPLIEDIRKDVGVPII
ALTYLEDWVDQLENFLNMIKDVKLDGILFPDLLIDYIDDLDKIDGIIKNKGLKNVIFTSPSVPDLLIHKVSKISDLFLYY
GVRPTTGVPIPVSVKQLINRVRNLVENKLIVGFGLSSESDLRDALSAGADGIAIGTVFIEEIERNGVKSAINLVKKFRAI
LDEYK

Sequences:

>Translated_245_residues
MEMGKMLVVYMTLGYPNVQSFKDFIIGAVENGADILELGIPPKYAKYDGPVIRKSYDKVKGLDIWPLIEDIRKDVGVPII
ALTYLEDWVDQLENFLNMIKDVKLDGILFPDLLIDYIDDLDKIDGIIKNKGLKNVIFTSPSVPDLLIHKVSKISDLFLYY
GVRPTTGVPIPVSVKQLINRVRNLVENKLIVGFGLSSESDLRDALSAGADGIAIGTVFIEEIERNGVKSAINLVKKFRAI
LDEYK
>Mature_245_residues
MEMGKMLVVYMTLGYPNVQSFKDFIIGAVENGADILELGIPPKYAKYDGPVIRKSYDKVKGLDIWPLIEDIRKDVGVPII
ALTYLEDWVDQLENFLNMIKDVKLDGILFPDLLIDYIDDLDKIDGIIKNKGLKNVIFTSPSVPDLLIHKVSKISDLFLYY
GVRPTTGVPIPVSVKQLINRVRNLVENKLIVGFGLSSESDLRDALSAGADGIAIGTVFIEEIERNGVKSAINLVKKFRAI
LDEYK

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Saccharomyces cerevisiae, GI6321412, Length=226, Percent_Identity=30.9734513274336, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPA_SULSO (P50382)

Other databases:

- EMBL:   Z50014
- EMBL:   AE006641
- PIR:   E90239
- RefSeq:   NP_342382.1
- ProteinModelPortal:   P50382
- SMR:   P50382
- GeneID:   1455139
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0889
- NMPDR:   fig|273057.1.peg.805
- HOGENOM:   HBG508952
- OMA:   NPKYDGP
- ProtClustDB:   PRK13125
- BioCyc:   SSOL273057:SSO0889-MONOMER
- BRENDA:   4.2.1.20
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 27387; Mature: 27387

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 37-37 ACT_SITE 48-48

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMGKMLVVYMTLGYPNVQSFKDFIIGAVENGADILELGIPPKYAKYDGPVIRKSYDKVK
CCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHC
GLDIWPLIEDIRKDVGVPIIALTYLEDWVDQLENFLNMIKDVKLDGILFPDLLIDYIDDL
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHH
DKIDGIIKNKGLKNVIFTSPSVPDLLIHKVSKISDLFLYYGVRPTTGVPIPVSVKQLINR
HHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
VRNLVENKLIVGFGLSSESDLRDALSAGADGIAIGTVFIEEIERNGVKSAINLVKKFRAI
HHHHHHCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LDEYK
HHCCC
>Mature Secondary Structure
MEMGKMLVVYMTLGYPNVQSFKDFIIGAVENGADILELGIPPKYAKYDGPVIRKSYDKVK
CCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHC
GLDIWPLIEDIRKDVGVPIIALTYLEDWVDQLENFLNMIKDVKLDGILFPDLLIDYIDDL
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHH
DKIDGIIKNKGLKNVIFTSPSVPDLLIHKVSKISDLFLYYGVRPTTGVPIPVSVKQLINR
HHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
VRNLVENKLIVGFGLSSESDLRDALSAGADGIAIGTVFIEEIERNGVKSAINLVKKFRAI
HHHHHHCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LDEYK
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726