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The map label for this gene is adh-2 [C]

Identifier: 15897666

GI number: 15897666

Start: 649487

End: 650488

Strand: Reverse

Name: adh-2 [C]

Synonym: SSO0764

Alternate gene names: 15897666

Gene position: 650488-649487 (Counterclockwise)

Preceding gene: 15897672

Following gene: 15897665

Centisome position: 21.74

GC content: 39.12

Gene sequence:

>1002_bases
ATGAAAGCTGTAGTAGTTCCGGGCAAGCAAAAAGGGTATAGAATAGAAGAAGTTTCGGATCCGATTCCAGGAAAAGATGA
AGTTGTAATTAGAGTAAATAGAGCGGCACTCTGCTATAGAGATCTATTGCAACTGCAAGGTTTCTATCCCAGAATGAAAT
ATCCAGTAATTTTAGGACATGAAGTAGTTGGTACGATAGAACAAATTGGAGAAAACGCCAAAGGCTTTAAAGAAGGTGAT
AAGGTTATTTCACTTCTTTATGCACCTGATGGAACTTGTCATTATTGTCAAATGGGTGAGGAAGCATATTGTCACTCTAG
GGTAGGTTATTCAGAGGAATTAGACGGCTTCTTTGCTGAAAAAGCAAAAGTAAAAGTTACAAGCATAGTAAAAGTTGGCA
CTAACGTTCCAGACGAGGGAGCAGTTTTAGTACCTTGTGTAACTGGAATGGTCTATAGAAGTTTGAGAAGGGCAAAGTTG
CAAAAGGGGGAAACAGTTTTAGTTACGGGGGCTAGCGGTGGTGTTGGTATTCATGCCATACAAGTAGCTAAAGCACTTGG
CGCGAAAGTGATAGGAGTAACTACATCAGAGGAAAAAGCAGCTTTCATAAGGAAATTCGCTGATCATGTAATAGTAGGTA
GTAAATTCTCAGAAGAGGCAAAGAAGATAGGTGATGTAAATGTGGTTATCGATACAGTAGGTACACCAACCATAGATGAA
AGTCTGAAAAGTTTGTGGATGGGAGGTAGACTGGTACAAATAGGTAACGTAGATCCAACTCAAATATATCAACTAAGGTT
AGGCTACGTCATATTGAAAGATATAGCGATAATAGGTCATGCCTCTGCAACTAAGAGGGATGCAGAAGAAACTCTCAAGT
TAACTGGAGAAGGGAAAATAAATCCCGTAATAGCAGCAACAGTAGGGTTAGATGAGATAGATAAGGGATATGAAATACTA
AAGGATAAGCATAAGATTGGGAAGGTACTAGTAAAGCCTTAA

Upstream 100 bases:

>100_bases
AATCTCTTATGGGAACACTATATGTATATTATTTTTAAAAATACATCGAACCTACTATGATAGATAATATTTTTTATACA
GTCTAAACACAATCTAACTG

Downstream 100 bases:

>100_bases
ATTTTTAAACCTTTCTATAAGTTACTGTGAAACTTAAAATTTCATGGATAGAGCTTAGTCAAGATTTATTACCACATTCA
GATTTAGACTCCCCAGAAGA

Product: putative alcohol dehydrogenase

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKAVVVPGKQKGYRIEEVSDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGHEVVGTIEQIGENAKGFKEGD
KVISLLYAPDGTCHYCQMGEEAYCHSRVGYSEELDGFFAEKAKVKVTSIVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKL
QKGETVLVTGASGGVGIHAIQVAKALGAKVIGVTTSEEKAAFIRKFADHVIVGSKFSEEAKKIGDVNVVIDTVGTPTIDE
SLKSLWMGGRLVQIGNVDPTQIYQLRLGYVILKDIAIIGHASATKRDAEETLKLTGEGKINPVIAATVGLDEIDKGYEIL
KDKHKIGKVLVKP

Sequences:

>Translated_333_residues
MKAVVVPGKQKGYRIEEVSDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGHEVVGTIEQIGENAKGFKEGD
KVISLLYAPDGTCHYCQMGEEAYCHSRVGYSEELDGFFAEKAKVKVTSIVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKL
QKGETVLVTGASGGVGIHAIQVAKALGAKVIGVTTSEEKAAFIRKFADHVIVGSKFSEEAKKIGDVNVVIDTVGTPTIDE
SLKSLWMGGRLVQIGNVDPTQIYQLRLGYVILKDIAIIGHASATKRDAEETLKLTGEGKINPVIAATVGLDEIDKGYEIL
KDKHKIGKVLVKP
>Mature_333_residues
MKAVVVPGKQKGYRIEEVSDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGHEVVGTIEQIGENAKGFKEGD
KVISLLYAPDGTCHYCQMGEEAYCHSRVGYSEELDGFFAEKAKVKVTSIVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKL
QKGETVLVTGASGGVGIHAIQVAKALGAKVIGVTTSEEKAAFIRKFADHVIVGSKFSEEAKKIGDVNVVIDTVGTPTIDE
SLKSLWMGGRLVQIGNVDPTQIYQLRLGYVILKDIAIIGHASATKRDAEETLKLTGEGKINPVIAATVGLDEIDKGYEIL
KDKHKIGKVLVKP

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=331, Percent_Identity=26.8882175226586, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI13236495, Length=331, Percent_Identity=26.8882175226586, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71565154, Length=366, Percent_Identity=26.775956284153, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI156523966, Length=366, Percent_Identity=26.775956284153, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4501939, Length=367, Percent_Identity=26.7029972752044, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156627571, Length=261, Percent_Identity=32.5670498084291, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4501933, Length=228, Percent_Identity=31.140350877193, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI194239676, Length=202, Percent_Identity=29.7029702970297, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4501929, Length=228, Percent_Identity=31.140350877193, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI71743840, Length=220, Percent_Identity=29.0909090909091, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI262073058, Length=220, Percent_Identity=29.0909090909091, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87081918, Length=288, Percent_Identity=26.0416666666667, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790045, Length=348, Percent_Identity=26.1494252873563, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788407, Length=341, Percent_Identity=26.099706744868, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788075, Length=357, Percent_Identity=26.3305322128852, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI226510992, Length=291, Percent_Identity=27.4914089347079, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786825, Length=390, Percent_Identity=23.8461538461538, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=25.8064516129032, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082125, Length=283, Percent_Identity=27.208480565371, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790485, Length=247, Percent_Identity=26.7206477732794, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786518, Length=310, Percent_Identity=25.1612903225806, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787863, Length=186, Percent_Identity=29.5698924731183, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788073, Length=276, Percent_Identity=26.4492753623188, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082401, Length=326, Percent_Identity=23.3128834355828, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=320, Percent_Identity=26.25, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17562584, Length=343, Percent_Identity=25.6559766763848, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=333, Percent_Identity=24.3243243243243, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=221, Percent_Identity=31.2217194570136, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=218, Percent_Identity=29.8165137614679, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=223, Percent_Identity=30.9417040358744, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=258, Percent_Identity=26.7441860465116, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=191, Percent_Identity=31.413612565445, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=354, Percent_Identity=27.4011299435028, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323729, Length=349, Percent_Identity=29.2263610315186, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6324486, Length=331, Percent_Identity=28.7009063444109, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6323961, Length=331, Percent_Identity=27.7945619335347, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320033, Length=239, Percent_Identity=30.9623430962343, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323980, Length=301, Percent_Identity=27.2425249169435, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=378, Percent_Identity=24.3386243386243, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17737895, Length=228, Percent_Identity=29.8245614035088, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24581345, Length=223, Percent_Identity=27.8026905829596, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330659, Length=215, Percent_Identity=28.8372093023256, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19920632, Length=215, Percent_Identity=28.8372093023256, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 36061; Mature: 36061

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00059 ADH_ZINC ; PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVVPGKQKGYRIEEVSDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGH
CCEEEECCCCCCEEHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCEEECH
EVVGTIEQIGENAKGFKEGDKVISLLYAPDGTCHYCQMGEEAYCHSRVGYSEELDGFFAE
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEHHHCCCHHHHHHCCCCCHHHCCHHHH
KAKVKVTSIVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKLQKGETVLVTGASGGVGIHAI
CCEEEEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
QVAKALGAKVIGVTTSEEKAAFIRKFADHVIVGSKFSEEAKKIGDVNVVIDTVGTPTIDE
HHHHHHCCEEEEEECCHHHHHHHHHHHHHEEECCCHHHHHHHCCCEEEEEECCCCCCHHH
SLKSLWMGGRLVQIGNVDPTQIYQLRLGYVILKDIAIIGHASATKRDAEETLKLTGEGKI
HHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHEEECCCCCC
NPVIAATVGLDEIDKGYEILKDKHKIGKVLVKP
CEEEEEECCHHHHHHHHHHHHHHHHHCCEEECC
>Mature Secondary Structure
MKAVVVPGKQKGYRIEEVSDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGH
CCEEEECCCCCCEEHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCEEECH
EVVGTIEQIGENAKGFKEGDKVISLLYAPDGTCHYCQMGEEAYCHSRVGYSEELDGFFAE
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEHHHCCCHHHHHHCCCCCHHHCCHHHH
KAKVKVTSIVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKLQKGETVLVTGASGGVGIHAI
CCEEEEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
QVAKALGAKVIGVTTSEEKAAFIRKFADHVIVGSKFSEEAKKIGDVNVVIDTVGTPTIDE
HHHHHHCCEEEEEECCHHHHHHHHHHHHHEEECCCHHHHHHHCCCEEEEEECCCCCCHHH
SLKSLWMGGRLVQIGNVDPTQIYQLRLGYVILKDIAIIGHASATKRDAEETLKLTGEGKI
HHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHEEECCCCCC
NPVIAATVGLDEIDKGYEILKDKHKIGKVLVKP
CEEEEEECCHHHHHHHHHHHHHHHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]