BacMap

Definition	Sulfolobus solfataricus P2 chromosome, complete genome.
Accession	NC_002754
Length	2,992,245

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The map label for this gene is psmA [H]

Identifier: 15897639

GI number: 15897639

Start: 627926

End: 628651

Strand: Reverse

Name: psmA [H]

Synonym: SSO0738

Alternate gene names: 15897639

Gene position: 628651-627926 (Counterclockwise)

Preceding gene: 15897640

Following gene: 15897638

Centisome position: 21.01

GC content: 36.91

Gene sequence:

>726_bases
ATGGCGTTCGGACCAGCCGCTATGGGATATGATAGGGCAATAACCATATTCTCGCCCGACGGATCACTATATCAAGTAGA
CTATGCATTTGAAGCTGTAAAAAAGGGATGGACAGCAATTGGTATTAAATCAAAGTCTAGTGTTGTTATTGCAAGTGAGA
AAAGGAAAGCTCAATCTTTACTAGATGTAGATAGCATAGAGAAAGTATTTTTAATCGACGATCACGTAGGGTGCAGTTTT
GCTGGATTAGCTTCTGATGGAAGAGTTTTAATAGACTATGCAAGGAATATAGCATTACAACACAGGTTAATATATGATGA
ACCAGTTAGCATTGATTATCTAACCAAATCAGTTGCTGATGTTAAGCAAATGTATACACAACATGGAGGAGTTAGACCAT
TTGGCGTTGCCCTAGTAATTGCGGGAATAGATAAATCAGTTCCTAAATTATTTATGACTGAACCTAGTGGGCAATATATG
CCATATCAAGCTGTTGCAATAGGGCAGGGTTACTATACAGCTACTGAGTTTTTAGAGAAGAATTATAAGGAGGATTTGAA
TGTGGAAGAGACTATATTGCTTGCTTTAAAGGCCTTATCGGCTACTCTAAAGCCTAATGAAAAGTTAACTCCAAATACTG
TGGAAATAGGATATGCCTCAACCCAGACTGGGTTATTTCTGAAAATGACTAATGAAGATAAGAATATGTATTTACAGAAG
TTATAA

Upstream 100 bases:

>100_bases
GATGAAGCCGCTCCGGACTGTATCGATGATGTTCTCTGCGACGAGCTGAACGATATTTTTAAAATTAGGGATTACTCAGT
ATTTCATGAGTGAATAGTAT

Downstream 100 bases:

>100_bases
TAAGGTGGATTTTTTTCATGACGAAGGAGCGTGATTATGTAATAGTTAAATATGAGTCACATGGAGAGAGGTTTGAGATA
TTAGCTAAGCCAAAAGAAGC

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MAFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSSVVIASEKRKAQSLLDVDSIEKVFLIDDHVGCSF
AGLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVADVKQMYTQHGGVRPFGVALVIAGIDKSVPKLFMTEPSGQYM
PYQAVAIGQGYYTATEFLEKNYKEDLNVEETILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTNEDKNMYLQK
L

Sequences:

>Translated_241_residues
MAFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSSVVIASEKRKAQSLLDVDSIEKVFLIDDHVGCSF
AGLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVADVKQMYTQHGGVRPFGVALVIAGIDKSVPKLFMTEPSGQYM
PYQAVAIGQGYYTATEFLEKNYKEDLNVEETILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTNEDKNMYLQK
L
>Mature_240_residues
AFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSSVVIASEKRKAQSLLDVDSIEKVFLIDDHVGCSFA
GLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVADVKQMYTQHGGVRPFGVALVIAGIDKSVPKLFMTEPSGQYMP
YQAVAIGQGYYTATEFLEKNYKEDLNVEETILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTNEDKNMYLQKL

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation [H]

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family [H]

Homologues:

Organism=Homo sapiens, GI68303563, Length=196, Percent_Identity=48.469387755102, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI4506189, Length=195, Percent_Identity=47.1794871794872, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI68303561, Length=202, Percent_Identity=47.029702970297, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI4506181, Length=233, Percent_Identity=40.343347639485, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI156713442, Length=218, Percent_Identity=39.4495412844037, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4506185, Length=218, Percent_Identity=39.4495412844037, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI23110944, Length=245, Percent_Identity=34.2857142857143, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI23110942, Length=225, Percent_Identity=36.8888888888889, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI4506179, Length=210, Percent_Identity=38.0952380952381, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI23110935, Length=210, Percent_Identity=38.0952380952381, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI68303565, Length=196, Percent_Identity=41.8367346938776, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI4506183, Length=173, Percent_Identity=36.9942196531792, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI23110939, Length=172, Percent_Identity=37.2093023255814, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI156713444, Length=151, Percent_Identity=37.7483443708609, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI221316716, Length=106, Percent_Identity=39.622641509434, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17508491, Length=199, Percent_Identity=47.2361809045226, Blast_Score=191, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25143215, Length=221, Percent_Identity=39.3665158371041, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17562790, Length=234, Percent_Identity=38.034188034188, Blast_Score=153, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17508493, Length=243, Percent_Identity=34.9794238683128, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562792, Length=210, Percent_Identity=40, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17562788, Length=247, Percent_Identity=34.0080971659919, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71998965, Length=216, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324535, Length=239, Percent_Identity=43.9330543933054, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321692, Length=223, Percent_Identity=42.152466367713, Blast_Score=174, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6321574, Length=195, Percent_Identity=41.025641025641, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6323547, Length=248, Percent_Identity=37.5, Blast_Score=154, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6324938, Length=194, Percent_Identity=38.1443298969072, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323974, Length=218, Percent_Identity=34.8623853211009, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6321427, Length=236, Percent_Identity=30.0847457627119, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324731, Length=180, Percent_Identity=29.4444444444444, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17933602, Length=227, Percent_Identity=40.5286343612335, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21356137, Length=193, Percent_Identity=43.0051813471503, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI19922898, Length=212, Percent_Identity=37.2641509433962, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI17737927, Length=208, Percent_Identity=38.9423076923077, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24654391, Length=239, Percent_Identity=35.5648535564854, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24654389, Length=239, Percent_Identity=35.5648535564854, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI281360341, Length=243, Percent_Identity=33.7448559670782, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24586406, Length=243, Percent_Identity=33.7448559670782, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24586400, Length=243, Percent_Identity=33.7448559670782, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24586402, Length=243, Percent_Identity=33.7448559670782, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17136420, Length=217, Percent_Identity=39.1705069124424, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24651571, Length=215, Percent_Identity=34.8837209302326, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19921232, Length=213, Percent_Identity=34.2723004694836, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17737405, Length=201, Percent_Identity=35.3233830845771, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24652204, Length=185, Percent_Identity=36.7567567567568, Blast_Score=123, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24639979, Length=174, Percent_Identity=28.1609195402299, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353 [H]

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N [H]

EC number: =3.4.25.1 [H]

Molecular weight: Translated: 26589; Mature: 26458

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00388 PROTEASOME_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSSVVIASEKRKAQSL
CCCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHCCCEEEEECCCCCEEEECCHHHHHHH
LDVDSIEKVFLIDDHVGCSFAGLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVAD
CCCCCCCEEEEEECCCCCEEECCCCCCEEEEEHHHHHHHHEEEEECCCCCHHHHHHHHHH
VKQMYTQHGGVRPFGVALVIAGIDKSVPKLFMTEPSGQYMPYQAVAIGQGYYTATEFLEK
HHHHHHHCCCCCCHHEEEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHH
NYKEDLNVEETILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTNEDKNMYLQK
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEC
L
C
>Mature Secondary Structure 
AFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSSVVIASEKRKAQSL
CCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHCCCEEEEECCCCCEEEECCHHHHHHH
LDVDSIEKVFLIDDHVGCSFAGLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVAD
CCCCCCCEEEEEECCCCCEEECCCCCCEEEEEHHHHHHHHEEEEECCCCCHHHHHHHHHH
VKQMYTQHGGVRPFGVALVIAGIDKSVPKLFMTEPSGQYMPYQAVAIGQGYYTATEFLEK
HHHHHHHCCCCCCHHEEEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHH
NYKEDLNVEETILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTNEDKNMYLQK
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA