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The map label for this gene is purM

Identifier: 15897549

GI number: 15897549

Start: 550574

End: 551545

Strand: Direct

Name: purM

Synonym: SSO0636

Alternate gene names: 15897549

Gene position: 550574-551545 (Clockwise)

Preceding gene: 15897548

Following gene: 15897550

Centisome position: 18.4

GC content: 34.88

Gene sequence:

>972_bases
ATGGTGAGTGAGGAGTATAAAAAAGCAGGAGTTGATTTAGAAAAATTACGTAATTATCATAATATGATTTCTCAAATAAT
CTCATCTACTTATAAAAATACTATTATAGGAGCGGGACATTATTCTGGAGTAATAAAAATAGGTAGTCTTAACATAGCGA
TGCATACTGATGGCGTAGGAACAAAGACTTTTCTAGCATTGCAAACTAGAATAATAAAGCCCGTAGGAATAGACTGCGTT
GCCATGAATGTTAATGATCTGATATGTGTTGGAGCAAAACCAGTTGCCTTAGTGGATTATATTGCGTTAGAAAGGCCGAT
GGATAATGTGGTAAATGAGATCATTGATGGTATTGTTCAGGGTGCTAAAGAGGCTGATGTTGAGGTTATTGGTGGAGAGA
CTGCTATTATGCCTGATGTGATTAGAGGATTTGATCTTTCTTGTACTGCAATAGGGGTTGTAGATAAACTGAAAACGGGC
GCTGAAATAAGGCCAGGAGATTATGTATTGGGACTAGAAAGCAGTGGTATACATGCTAACGGTTATTCCCTAGTTAGAAA
ATTAATAGAAGAAGGTAAGCTTTCGCTAGATGAATATAAAAATGAATTGTTAAAACCAACTAAAATTTATGTCAAACCAA
TTTTGGAAGTTATGAATATGATAAAGGGAGCGGCTCACGTAACTGGAGGTGCATTTAGTAAGCTTAAAAGACTTACTAGT
TATAAGATTGTCTTAAATATGCCAGATCCACCACAGATTTTTAAGACTATCGAAAAAGCAGGGGTCGCTCACGAGGAGAT
GTATAAAGTTTTCAATATGGGTATAGGAATTGTCTTATTTGTTTCAGAAGAACTTATGAAGGAAGTAAAAACAAAACTAG
AAGGATATGGAACTGTATATGAACTTGGCAGAGTATATAATGGAAATGGAATCACTATAAAGACTTATAAGAACGAAATT
CTCAGATTATAG

Upstream 100 bases:

>100_bases
CTCAAATTGAAAAGGCTGAAATCATAAGATATTCTTATAAAAATAGAGAAAAAAGAGGGATTCTTGGAGTTTCTGCAGAT
TGGTCTCCTAATGGTGGGTT

Downstream 100 bases:

>100_bases
AATTATGTATATACCTTTTAAACTCTAAAGAATATAGAGGGTTCCAGTGGCTCTATATGAAACAAACTGATATAAAGTCT
TTAGTAAATTATGTAGCTTT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MVSEEYKKAGVDLEKLRNYHNMISQIISSTYKNTIIGAGHYSGVIKIGSLNIAMHTDGVGTKTFLALQTRIIKPVGIDCV
AMNVNDLICVGAKPVALVDYIALERPMDNVVNEIIDGIVQGAKEADVEVIGGETAIMPDVIRGFDLSCTAIGVVDKLKTG
AEIRPGDYVLGLESSGIHANGYSLVRKLIEEGKLSLDEYKNELLKPTKIYVKPILEVMNMIKGAAHVTGGAFSKLKRLTS
YKIVLNMPDPPQIFKTIEKAGVAHEEMYKVFNMGIGIVLFVSEELMKEVKTKLEGYGTVYELGRVYNGNGITIKTYKNEI
LRL

Sequences:

>Translated_323_residues
MVSEEYKKAGVDLEKLRNYHNMISQIISSTYKNTIIGAGHYSGVIKIGSLNIAMHTDGVGTKTFLALQTRIIKPVGIDCV
AMNVNDLICVGAKPVALVDYIALERPMDNVVNEIIDGIVQGAKEADVEVIGGETAIMPDVIRGFDLSCTAIGVVDKLKTG
AEIRPGDYVLGLESSGIHANGYSLVRKLIEEGKLSLDEYKNELLKPTKIYVKPILEVMNMIKGAAHVTGGAFSKLKRLTS
YKIVLNMPDPPQIFKTIEKAGVAHEEMYKVFNMGIGIVLFVSEELMKEVKTKLEGYGTVYELGRVYNGNGITIKTYKNEI
LRL
>Mature_323_residues
MVSEEYKKAGVDLEKLRNYHNMISQIISSTYKNTIIGAGHYSGVIKIGSLNIAMHTDGVGTKTFLALQTRIIKPVGIDCV
AMNVNDLICVGAKPVALVDYIALERPMDNVVNEIIDGIVQGAKEADVEVIGGETAIMPDVIRGFDLSCTAIGVVDKLKTG
AEIRPGDYVLGLESSGIHANGYSLVRKLIEEGKLSLDEYKNELLKPTKIYVKPILEVMNMIKGAAHVTGGAFSKLKRLTS
YKIVLNMPDPPQIFKTIEKAGVAHEEMYKVFNMGIGIVLFVSEELMKEVKTKLEGYGTVYELGRVYNGNGITIKTYKNEI
LRL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=320, Percent_Identity=31.5625, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI209869995, Length=320, Percent_Identity=31.5625, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI209869993, Length=320, Percent_Identity=31.5625, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1788845, Length=301, Percent_Identity=34.5514950166113, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17567511, Length=350, Percent_Identity=34, Blast_Score=157, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6321203, Length=334, Percent_Identity=33.8323353293413, Blast_Score=162, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24582400, Length=266, Percent_Identity=34.2105263157895, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_SULSO (Q9UX29)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   A99211
- RefSeq:   NP_342154.1
- ProteinModelPortal:   Q9UX29
- SMR:   Q9UX29
- GeneID:   1454911
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0636
- NMPDR:   fig|273057.1.peg.577
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   SSOL273057:SSO0636-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_A
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 35401; Mature: 35401

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSEEYKKAGVDLEKLRNYHNMISQIISSTYKNTIIGAGHYSGVIKIGSLNIAMHTDGVG
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEEEEEEECCCCC
TKTFLALQTRIIKPVGIDCVAMNVNDLICVGAKPVALVDYIALERPMDNVVNEIIDGIVQ
HHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHC
GAKEADVEVIGGETAIMPDVIRGFDLSCTAIGVVDKLKTGAEIRPGDYVLGLESSGIHAN
CCCCCCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCC
GYSLVRKLIEEGKLSLDEYKNELLKPTKIYVKPILEVMNMIKGAAHVTGGAFSKLKRLTS
HHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YKIVLNMPDPPQIFKTIEKAGVAHEEMYKVFNMGIGIVLFVSEELMKEVKTKLEGYGTVY
EEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCHHH
ELGRVYNGNGITIKTYKNEILRL
HHCEEECCCCEEEEEECHHHHCC
>Mature Secondary Structure
MVSEEYKKAGVDLEKLRNYHNMISQIISSTYKNTIIGAGHYSGVIKIGSLNIAMHTDGVG
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEEEEEEECCCCC
TKTFLALQTRIIKPVGIDCVAMNVNDLICVGAKPVALVDYIALERPMDNVVNEIIDGIVQ
HHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHC
GAKEADVEVIGGETAIMPDVIRGFDLSCTAIGVVDKLKTGAEIRPGDYVLGLESSGIHAN
CCCCCCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCC
GYSLVRKLIEEGKLSLDEYKNELLKPTKIYVKPILEVMNMIKGAAHVTGGAFSKLKRLTS
HHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YKIVLNMPDPPQIFKTIEKAGVAHEEMYKVFNMGIGIVLFVSEELMKEVKTKLEGYGTVY
EEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCHHH
ELGRVYNGNGITIKTYKNEILRL
HHCEEECCCCEEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726