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The map label for this gene is pyrF

Identifier: 15897532

GI number: 15897532

Start: 536506

End: 537174

Strand: Direct

Name: pyrF

Synonym: SSO0616

Alternate gene names: 15897532

Gene position: 536506-537174 (Clockwise)

Preceding gene: 15897531

Following gene: 15897533

Centisome position: 17.93

GC content: 34.23

Gene sequence:

>669_bases
ATGTTGAAAAGTAGAGTAATATTAGCAATGGATAAACCTCTCTCATATCAAGTTCTTAAAGAGATGGAAAATGAGTTATA
TGGGATAAAAGTTGGTTTACCTTTAGTTTTAGATCTAGGAGTGGATAAAACTAGAGAGCTCTTAATTGGTTTAGACGTGG
AGGAAATTATTGTTGATTTTAAGCTTGCAGATATCGGATACATAATGAAAAGCATAGTTGAAAGATTATCTTTCGCCAAC
TCGTTCATAGCACATTCCTTTATAGGCGTTAAGGGATCTCTAGATGAATTAAAAAGATATCTTGATGCAAACTCTAAAAA
TTTATACTTAGTTGCCGTAATGTCACATGAAGGATGGAGTACGTTATTCGCAGACTATATTAAAAACGTTATAAGAGAGA
TAAGCCCAAAAGGAATAGTAGTTGGAGGGACTAAATTAGATCATATAACGCAGTATAGGAGAGACTTCGAAAAAATGACC
ATAGTCTCTCCGGGTATGGGTAGTCAAGGTGGAAGTTATGGCGATGCAGTATGTGCTGGAGCGGATTATGAAATCATTGG
AAGAAGTATTTATAATGCAGGGAATCCATTAACAGCATTAAGAACTATAAATAAGATTATCGAGGATAAGGTGATGAAAT
GTAAAGGAGCAATTTTTAGGAAAAAATGA

Upstream 100 bases:

>100_bases
CACTCTCTATTTAAAATTTCAGAAATTCTAGATGAATTGTTGAAGAGTGATAAACTTAAGGATAATGAAAAGAAGTCAAT
TCTAGATTATTTGGTGAAGA

Downstream 100 bases:

>100_bases
AATTAGTGAAAAAATAGCCGGTCTTTATAAACTAACATTAATAGGGGAAAATCTACACGAGGAATATGGCGTAATTCCAA
CAACAGATTTAACTTATATT

Product: orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (pyrF)

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MLKSRVILAMDKPLSYQVLKEMENELYGIKVGLPLVLDLGVDKTRELLIGLDVEEIIVDFKLADIGYIMKSIVERLSFAN
SFIAHSFIGVKGSLDELKRYLDANSKNLYLVAVMSHEGWSTLFADYIKNVIREISPKGIVVGGTKLDHITQYRRDFEKMT
IVSPGMGSQGGSYGDAVCAGADYEIIGRSIYNAGNPLTALRTINKIIEDKVMKCKGAIFRKK

Sequences:

>Translated_222_residues
MLKSRVILAMDKPLSYQVLKEMENELYGIKVGLPLVLDLGVDKTRELLIGLDVEEIIVDFKLADIGYIMKSIVERLSFAN
SFIAHSFIGVKGSLDELKRYLDANSKNLYLVAVMSHEGWSTLFADYIKNVIREISPKGIVVGGTKLDHITQYRRDFEKMT
IVSPGMGSQGGSYGDAVCAGADYEIIGRSIYNAGNPLTALRTINKIIEDKVMKCKGAIFRKK
>Mature_222_residues
MLKSRVILAMDKPLSYQVLKEMENELYGIKVGLPLVLDLGVDKTRELLIGLDVEEIIVDFKLADIGYIMKSIVERLSFAN
SFIAHSFIGVKGSLDELKRYLDANSKNLYLVAVMSHEGWSTLFADYIKNVIREISPKGIVVGGTKLDHITQYRRDFEKMT
IVSPGMGSQGGSYGDAVCAGADYEIIGRSIYNAGNPLTALRTINKIIEDKVMKCKGAIFRKK

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRF_SULSO (Q9UX10)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   H90208
- RefSeq:   NP_342137.1
- ProteinModelPortal:   Q9UX10
- SMR:   Q9UX10
- GeneID:   1454894
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0616
- NMPDR:   fig|273057.1.peg.560
- HOGENOM:   HBG625253
- OMA:   TEMSHPG
- ProtClustDB:   CLSK802793
- BioCyc:   SSOL273057:SSO0616-MONOMER
- BRENDA:   4.1.1.23
- HAMAP:   MF_01200_A
- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR001754
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00934
- TIGRFAMs:   TIGR01740

Pfam domain/function: PF00215 OMPdecase; SSF51366 RibP_bind_barrel

EC number: =4.1.1.23

Molecular weight: Translated: 24701; Mature: 24701

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00156 OMPDECASE

Important sites: ACT_SITE 61-61 BINDING 11-11 BINDING 30-30 BINDING 115-115 BINDING 187-187 BINDING 188-188

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSRVILAMDKPLSYQVLKEMENELYGIKVGLPLVLDLGVDKTRELLIGLDVEEIIVDF
CCCCCEEEEECCCCHHHHHHHHHHHHEEEEECCCEEEECCCCHHHHHEECCCHHHHHHHH
KLADIGYIMKSIVERLSFANSFIAHSFIGVKGSLDELKRYLDANSKNLYLVAVMSHEGWS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEECCCCHH
TLFADYIKNVIREISPKGIVVGGTKLDHITQYRRDFEKMTIVSPGMGSQGGSYGDAVCAG
HHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEECC
ADYEIIGRSIYNAGNPLTALRTINKIIEDKVMKCKGAIFRKK
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKSRVILAMDKPLSYQVLKEMENELYGIKVGLPLVLDLGVDKTRELLIGLDVEEIIVDF
CCCCCEEEEECCCCHHHHHHHHHHHHEEEEECCCEEEECCCCHHHHHEECCCHHHHHHHH
KLADIGYIMKSIVERLSFANSFIAHSFIGVKGSLDELKRYLDANSKNLYLVAVMSHEGWS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEECCCCHH
TLFADYIKNVIREISPKGIVVGGTKLDHITQYRRDFEKMTIVSPGMGSQGGSYGDAVCAG
HHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEECC
ADYEIIGRSIYNAGNPLTALRTINKIIEDKVMKCKGAIFRKK
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726