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The map label for this gene is serS [H]

Identifier: 15897519

GI number: 15897519

Start: 526402

End: 527775

Strand: Direct

Name: serS [H]

Synonym: SSO0602

Alternate gene names: 15897519

Gene position: 526402-527775 (Clockwise)

Preceding gene: 15897518

Following gene: 15897531

Centisome position: 17.59

GC content: 34.79

Gene sequence:

>1374_bases
ATGTCGTGGAGTATCCTAGAGCTTTTGCGAAAAAATCCGGAGGATTTGAAAAATAATTTGAAAAGACGGGCTATAGATGT
TTCTTTAGTAGATAAAGCAGTAGAATTGGACAAAAAATGGAGACAAGTATTACAAGAAGTTGAAAAATTAAGGCATCAAC
ATAATGTTTTAAGTTCACAGATTTCTAAGCTCTCTGGAGAAGAGAGAAAAAAGAAAATTGAGGAAAGCAAAAACTTATTG
AAAATCCTAGAAGAAAAAGAAAAAGAACTAGAAGAAATAGAGAATGAAAGAGATAGATTACTATCATCTCTACCGAACCT
TGTAGCTGACGACGTCCCAAACGGTCCGGACGATAGCTATAACGTTCCTATTAAGTTTTGGGGGAAGTTTAAAGTATATG
AGGGAGACGTTCAAGAATTTCTAAAGCAGATCAAGGATGCTAAAGTAAACTATGAAGTAATTAAATGGAAACCGAAAGGG
CATGCGGAAATGCTAGAAGATGTATTACATTTAGGAAATACGCTGAAAGCAGCTGAAATTGCGGGTTCTAGATTTTACTA
TTTATTTAATGATATAGTTTGGCTAGACTTCTCTCTACTACTTTTCGCAATCGATTACATTACTCAGCAAGGGTATACTT
TAGTTCTCCCTCCTTATATGCTAAGGGGAGAGGTTATACAATCAGTAATAGACCTAGACACGTTTAAGGATGCTATATAT
AAGATAGAAAACGAGGATTTATATCTGATTGCAACCGCAGAACACCCTATAGCAGCTATGTTCTTTAAAGAAGAAATTGA
GAAAGATAAATTACCCTTAAAATTCGCCGGAATTAGTCCAGCTTTTAGAAAAGAAGCAAGTGCTGCAAATAAGGATTTAA
AGGGAATTTTCAGAGTTCATCAATTTCATAAAGTTGAACAGTTTATATTTTCAACTCCAGAAGATAGTTGGAAATATCAT
AGTGAATTGATAACGAATGCTGAAAGTATATTTCAGCAACTCGAATTGCCATACAGAATTGTAAATATAGCGTCAGGTGA
TTTAGGTGCATGCGCTGCAAAGAAATTCGATTTAGAGGTATGGATGCCAGCTCAGGCCAAATTTAGAGAAATGGTAAGTT
GTAGCAATTGTACGGATTGGCAAGCTTTCAGAATGAAGATAAGATATGTGGATAGAAAAAATAATAGAAGGGGCTACGTA
CATACATTAAATAGTACTGCAATAGCTAGCACAAGAACTATAACAGCTATTCTAGAAAATTATCAGAGAGAAGATGGTGT
TGTCGAGGTACCAAAAGTACTAAGAAAATATCTTGAGGCGTTTCCGAAGGCTCCTAAAGATTATATATACCCGCTAAAAA
ATAAGATAATTTAG

Upstream 100 bases:

>100_bases
CAGTTATATGGTTACGATATAGTTGAGATGTGGGTACAGACTTATGGACTACCTGCTGATGAACAGAAGTCATAAAATTG
TCTAATAATTATGTTATTCA

Downstream 100 bases:

>100_bases
TTTTATGCTTTTAATTGATTCTCCAACCATTTTTCTACTTCTCTCATTTTCTTCTTTGCGAATCTTAAGAATAGCTTCAG
TGCGAATCTTACTGGCATAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSWSILELLRKNPEDLKNNLKRRAIDVSLVDKAVELDKKWRQVLQEVEKLRHQHNVLSSQISKLSGEERKKKIEESKNLL
KILEEKEKELEEIENERDRLLSSLPNLVADDVPNGPDDSYNVPIKFWGKFKVYEGDVQEFLKQIKDAKVNYEVIKWKPKG
HAEMLEDVLHLGNTLKAAEIAGSRFYYLFNDIVWLDFSLLLFAIDYITQQGYTLVLPPYMLRGEVIQSVIDLDTFKDAIY
KIENEDLYLIATAEHPIAAMFFKEEIEKDKLPLKFAGISPAFRKEASAANKDLKGIFRVHQFHKVEQFIFSTPEDSWKYH
SELITNAESIFQQLELPYRIVNIASGDLGACAAKKFDLEVWMPAQAKFREMVSCSNCTDWQAFRMKIRYVDRKNNRRGYV
HTLNSTAIASTRTITAILENYQREDGVVEVPKVLRKYLEAFPKAPKDYIYPLKNKII

Sequences:

>Translated_457_residues
MSWSILELLRKNPEDLKNNLKRRAIDVSLVDKAVELDKKWRQVLQEVEKLRHQHNVLSSQISKLSGEERKKKIEESKNLL
KILEEKEKELEEIENERDRLLSSLPNLVADDVPNGPDDSYNVPIKFWGKFKVYEGDVQEFLKQIKDAKVNYEVIKWKPKG
HAEMLEDVLHLGNTLKAAEIAGSRFYYLFNDIVWLDFSLLLFAIDYITQQGYTLVLPPYMLRGEVIQSVIDLDTFKDAIY
KIENEDLYLIATAEHPIAAMFFKEEIEKDKLPLKFAGISPAFRKEASAANKDLKGIFRVHQFHKVEQFIFSTPEDSWKYH
SELITNAESIFQQLELPYRIVNIASGDLGACAAKKFDLEVWMPAQAKFREMVSCSNCTDWQAFRMKIRYVDRKNNRRGYV
HTLNSTAIASTRTITAILENYQREDGVVEVPKVLRKYLEAFPKAPKDYIYPLKNKII
>Mature_456_residues
SWSILELLRKNPEDLKNNLKRRAIDVSLVDKAVELDKKWRQVLQEVEKLRHQHNVLSSQISKLSGEERKKKIEESKNLLK
ILEEKEKELEEIENERDRLLSSLPNLVADDVPNGPDDSYNVPIKFWGKFKVYEGDVQEFLKQIKDAKVNYEVIKWKPKGH
AEMLEDVLHLGNTLKAAEIAGSRFYYLFNDIVWLDFSLLLFAIDYITQQGYTLVLPPYMLRGEVIQSVIDLDTFKDAIYK
IENEDLYLIATAEHPIAAMFFKEEIEKDKLPLKFAGISPAFRKEASAANKDLKGIFRVHQFHKVEQFIFSTPEDSWKYHS
ELITNAESIFQQLELPYRIVNIASGDLGACAAKKFDLEVWMPAQAKFREMVSCSNCTDWQAFRMKIRYVDRKNNRRGYVH
TLNSTAIASTRTITAILENYQREDGVVEVPKVLRKYLEAFPKAPKDYIYPLKNKII

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=475, Percent_Identity=34.7368421052632, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI8923421, Length=359, Percent_Identity=30.6406685236769, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI225579074, Length=359, Percent_Identity=30.6406685236769, Blast_Score=165, Evalue=9e-41,
Organism=Escherichia coli, GI1787120, Length=446, Percent_Identity=34.304932735426, Blast_Score=241, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17539260, Length=476, Percent_Identity=34.0336134453782, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17542084, Length=337, Percent_Identity=32.3442136498516, Blast_Score=171, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6320226, Length=453, Percent_Identity=35.0993377483444, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6321799, Length=453, Percent_Identity=30.0220750551876, Blast_Score=199, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24581334, Length=488, Percent_Identity=34.4262295081967, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17737985, Length=271, Percent_Identity=36.5313653136531, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 53188; Mature: 53057

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWSILELLRKNPEDLKNNLKRRAIDVSLVDKAVELDKKWRQVLQEVEKLRHQHNVLSSQ
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISKLSGEERKKKIEESKNLLKILEEKEKELEEIENERDRLLSSLPNLVADDVPNGPDDSY
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NVPIKFWGKFKVYEGDVQEFLKQIKDAKVNYEVIKWKPKGHAEMLEDVLHLGNTLKAAEI
CCCEEEEEEEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHH
AGSRFYYLFNDIVWLDFSLLLFAIDYITQQGYTLVLPPYMLRGEVIQSVIDLDTFKDAIY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
KIENEDLYLIATAEHPIAAMFFKEEIEKDKLPLKFAGISPAFRKEASAANKDLKGIFRVH
EECCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHH
QFHKVEQFIFSTPEDSWKYHSELITNAESIFQQLELPYRIVNIASGDLGACAAKKFDLEV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCCEEE
WMPAQAKFREMVSCSNCTDWQAFRMKIRYVDRKNNRRGYVHTLNSTAIASTRTITAILEN
ECCCHHHHHHHHHCCCCCCHHHHHHHHHEECCCCCCCCEEEECCCCHHHHHHHHHHHHHH
YQREDGVVEVPKVLRKYLEAFPKAPKDYIYPLKNKII
HHHCCCCCHHHHHHHHHHHHCCCCCHHHHCCHHHCCC
>Mature Secondary Structure 
SWSILELLRKNPEDLKNNLKRRAIDVSLVDKAVELDKKWRQVLQEVEKLRHQHNVLSSQ
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISKLSGEERKKKIEESKNLLKILEEKEKELEEIENERDRLLSSLPNLVADDVPNGPDDSY
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NVPIKFWGKFKVYEGDVQEFLKQIKDAKVNYEVIKWKPKGHAEMLEDVLHLGNTLKAAEI
CCCEEEEEEEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHH
AGSRFYYLFNDIVWLDFSLLLFAIDYITQQGYTLVLPPYMLRGEVIQSVIDLDTFKDAIY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
KIENEDLYLIATAEHPIAAMFFKEEIEKDKLPLKFAGISPAFRKEASAANKDLKGIFRVH
EECCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHH
QFHKVEQFIFSTPEDSWKYHSELITNAESIFQQLELPYRIVNIASGDLGACAAKKFDLEV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCCEEE
WMPAQAKFREMVSCSNCTDWQAFRMKIRYVDRKNNRRGYVHTLNSTAIASTRTITAILEN
ECCCHHHHHHHHHCCCCCCHHHHHHHHHEECCCCCCCCEEEECCCCHHHHHHHHHHHHHH
YQREDGVVEVPKVLRKYLEAFPKAPKDYIYPLKNKII
HHHCCCCCHHHHHHHHHHHHCCCCCHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA