Click here to switch to the map view.

The map label for this gene is hisI

Identifier: 15897517

GI number: 15897517

Start: 525694

End: 525951

Strand: Direct

Name: hisI

Synonym: SSO6227

Alternate gene names: 15897517

Gene position: 525694-525951 (Clockwise)

Preceding gene: 15897516

Following gene: 15897518

Centisome position: 17.57

GC content: 31.4

Gene sequence:

>258_bases
ATGGTGGGAAATATGAATAGAGAAGCGTTATTTAAAACATTAACAACTGGTTACCTCCATTTTTGGTCTTTAAGTAGAAA
GAAATTATGGTTGAAGGGGGAAACTAGTGGAAATTTTCAAATAATTGAAGAATTTAAAGTGGATTGTGATGCAGACGCTG
TACTTTTTAAAGTAACATCATTAGGACCTATTTGTCACACTGGTAACTACACTTGTTTTTATAGAAGTTATGATGAGCTT
GTTAATAGTAAGAGTTAA

Upstream 100 bases:

>100_bases
TGAAATAGAAGCACAGAAGATCGCCTCTTTATTAAATTTTAAACATGAGGAAAATACAGTAATTGCCGTAATTCAAGACT
ATAAGAGTAAAGAGATATTA

Downstream 100 bases:

>100_bases
AATTTACTTTAACATAGTTAAAGAATATGAGTTCGCAACAACAAAAAGTAGACAAGGAAGAATGGAAGAAAAAAATAATG
GAAGCGTTAAAAGACGTTTA

Product: phosphoribosyl-AMP cyclohydrolase (hisI)

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 85; Mature: 85

Protein sequence:

>85_residues
MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTSLGPICHTGNYTCFYRSYDEL
VNSKS

Sequences:

>Translated_85_residues
MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTSLGPICHTGNYTCFYRSYDEL
VNSKS
>Mature_85_residues
MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTSLGPICHTGNYTCFYRSYDEL
VNSKS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=73, Percent_Identity=47.945205479452, Blast_Score=79, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_SULSO (O33778)

Other databases:

- EMBL:   U82227
- EMBL:   AE006641
- PIR:   A90207
- RefSeq:   NP_342122.1
- ProteinModelPortal:   O33778
- SMR:   O33778
- GeneID:   1454879
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO6227
- NMPDR:   fig|273057.1.peg.545
- HOGENOM:   HBG294308
- BioCyc:   SSOL273057:SSO6227-MONOMER
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 9766; Mature: 9766

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS
CCCCCCHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCEEEEEEECCCCCCCEEEEEECC
LGPICHTGNYTCFYRSYDELVNSKS
CCCEEECCCEEEEECCHHHHCCCCC
>Mature Secondary Structure
MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS
CCCCCCHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCEEEEEEECCCCCCCEEEEEECC
LGPICHTGNYTCFYRSYDELVNSKS
CCCEEECCCEEEEECCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9209067; 11427726