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The map label for this gene is hisD

Identifier: 15897514

GI number: 15897514

Start: 523517

End: 524713

Strand: Direct

Name: hisD

Synonym: SSO0599

Alternate gene names: 15897514

Gene position: 523517-524713 (Clockwise)

Preceding gene: 15897513

Following gene: 15897515

Centisome position: 17.5

GC content: 36.93

Gene sequence:

>1197_bases
GTGATTTCCTATAGTCTGCCAAATGAGAGACCGAACGATTTTAGCAGAGTAATCCCAGTAGTCAAGGATATTATTGAGTC
TGTTAAGACCAAGGGAGATAACGCGTTATATGAGCTAACTGAGAAATTAGATAAAGTTAAGATAGATAACATCAAGGCAA
GGGAAGAGGAACTAAAAACACAAGCTTCTAAGTTGGATCCCAAAGTTAAGCAAGCTATAGATACAGCCTATGAACAATTA
AAGGCATTCCATGAAATGCTAGTTCCGCCTAATATCGGAGGGGGCTATCAAGGTATATCCTTTGGAGTAATTTGGAGAAG
TATAGAGAAGATCGGAATATATGTCCCTTCCGGTAAATATTCCTATCCATCGACCTTACTAATGGCTGGAATACCAGCAA
AAGTAGCTAAGGTAAAGGAAATTTACGTAGCCTCTCCTCCTACTCAAGAAGGAACCGTAAATCCAGCTTTAGCTTATGTT
GCAATTAAGCTAGGAGTAAATGAGGTTTATAAGATTGGTGGTGCACAAGCAATAGCTGCTTTAGCTTTTGGTACTGAGAG
TGTAAAGAAAGTTTACAAGATTGTAGGACCAGGAAATGTCTATGTTCAAGCCGCTAAGTACCTAGTGAGTAGCGTTGTTG
GAATTGATGGAATTGAGGGACCAACTGAATTAGTTATAATAGCAGATGAGACTGCAAAGGCCGAGTATGTGGCTCTAGAT
ATGAAGGCACAAGCTGAACATGGTCCAGATACGTATATAGTGCTCTTATCTAATGATGATGAACTGATTAGGAGAGTCGA
AGAGAAAATAAAGAATGATAAAAAAATATATTATATAATAAAAACTAAAAATTTAGATGAAGCTATAGAAATTGCAAACA
AAATTGCCCCAGAACATCTATCTTTATATGTTAAAGACGCATATACCTTAATGGATAAAATAGTAAATGCAGGCGCGATA
AGCCTAGGAAACACACCTCCAGCAATAATAGATTATGTAGCTGGTCCTAATCACATTTTACCTACTAATGGTTGGGCTAA
AATTAGGGGAGGCATTACTGTTTACGATTTTATAAAACCAACAATGTACGCTAATGTCCGTGATATAAATAAACAGCTAC
TTGAAGCATCTATTTCCTTAGCAAACTATGAGGGATTCATAATTCATGGTAAAAGTATAGGTGCACGATATGAGTAA

Upstream 100 bases:

>100_bases
AGGCCGACGCAGCGTTAGCTGCTGGCATATTCCATGATGGAATAATTAAAATAAAAGACTTGAAGTCGTATTTAAGCCAG
AAAGGCATCGAGGTGAGAAT

Downstream 100 bases:

>100_bases
TGAAATAGTAGATGAATTATACAAAATCATACTTGATAGGATAGAAAAGAGGCCGACTGGTAGTTACACTGCTGAGATTG
TAAATAAGGGAAAACCATAC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MISYSLPNERPNDFSRVIPVVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKTQASKLDPKVKQAIDTAYEQL
KAFHEMLVPPNIGGGYQGISFGVIWRSIEKIGIYVPSGKYSYPSTLLMAGIPAKVAKVKEIYVASPPTQEGTVNPALAYV
AIKLGVNEVYKIGGAQAIAALAFGTESVKKVYKIVGPGNVYVQAAKYLVSSVVGIDGIEGPTELVIIADETAKAEYVALD
MKAQAEHGPDTYIVLLSNDDELIRRVEEKIKNDKKIYYIIKTKNLDEAIEIANKIAPEHLSLYVKDAYTLMDKIVNAGAI
SLGNTPPAIIDYVAGPNHILPTNGWAKIRGGITVYDFIKPTMYANVRDINKQLLEASISLANYEGFIIHGKSIGARYE

Sequences:

>Translated_398_residues
MISYSLPNERPNDFSRVIPVVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKTQASKLDPKVKQAIDTAYEQL
KAFHEMLVPPNIGGGYQGISFGVIWRSIEKIGIYVPSGKYSYPSTLLMAGIPAKVAKVKEIYVASPPTQEGTVNPALAYV
AIKLGVNEVYKIGGAQAIAALAFGTESVKKVYKIVGPGNVYVQAAKYLVSSVVGIDGIEGPTELVIIADETAKAEYVALD
MKAQAEHGPDTYIVLLSNDDELIRRVEEKIKNDKKIYYIIKTKNLDEAIEIANKIAPEHLSLYVKDAYTLMDKIVNAGAI
SLGNTPPAIIDYVAGPNHILPTNGWAKIRGGITVYDFIKPTMYANVRDINKQLLEASISLANYEGFIIHGKSIGARYE
>Mature_398_residues
MISYSLPNERPNDFSRVIPVVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKTQASKLDPKVKQAIDTAYEQL
KAFHEMLVPPNIGGGYQGISFGVIWRSIEKIGIYVPSGKYSYPSTLLMAGIPAKVAKVKEIYVASPPTQEGTVNPALAYV
AIKLGVNEVYKIGGAQAIAALAFGTESVKKVYKIVGPGNVYVQAAKYLVSSVVGIDGIEGPTELVIIADETAKAEYVALD
MKAQAEHGPDTYIVLLSNDDELIRRVEEKIKNDKKIYYIIKTKNLDEAIEIANKIAPEHLSLYVKDAYTLMDKIVNAGAI
SLGNTPPAIIDYVAGPNHILPTNGWAKIRGGITVYDFIKPTMYANVRDINKQLLEASISLANYEGFIIHGKSIGARYE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=399, Percent_Identity=35.5889724310777, Blast_Score=244, Evalue=9e-66,
Organism=Saccharomyces cerevisiae, GI6319819, Length=409, Percent_Identity=36.1858190709046, Blast_Score=232, Evalue=9e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_SULSO (O33775)

Other databases:

- EMBL:   U82227
- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   F90206
- RefSeq:   NP_342119.1
- ProteinModelPortal:   O33775
- GeneID:   1454876
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0599
- NMPDR:   fig|273057.1.peg.542
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   SSOL273057:SSO0599-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 43636; Mature: 43636

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 298-298 ACT_SITE 299-299 BINDING 114-114 BINDING 176-176 BINDING 199-199 BINDING 222-222 BINDING 244-244 BINDING 247-247 BINDING 299-299 BINDING 331-331 BINDING 384-384 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISYSLPNERPNDFSRVIPVVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCHHHHHHHHH
QASKLDPKVKQAIDTAYEQLKAFHEMLVPPNIGGGYQGISFGVIWRSIEKIGIYVPSGKY
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCC
SYPSTLLMAGIPAKVAKVKEIYVASPPTQEGTVNPALAYVAIKLGVNEVYKIGGAQAIAA
CCCCHHEECCCCHHHHHHHHEEEECCCCCCCCCCHHHEEEEEHHCHHHHHHCCCHHHHHH
LAFGTESVKKVYKIVGPGNVYVQAAKYLVSSVVGIDGIEGPTELVIIADETAKAEYVALD
HHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEE
MKAQAEHGPDTYIVLLSNDDELIRRVEEKIKNDKKIYYIIKTKNLDEAIEIANKIAPEHL
EEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHCCCHHH
SLYVKDAYTLMDKIVNAGAISLGNTPPAIIDYVAGPNHILPTNGWAKIRGGITVYDFIKP
EEHHHHHHHHHHHHHCCCEEECCCCCHHHEEECCCCCEEECCCCCEEEECCEEEEEHHCC
TMYANVRDINKQLLEASISLANYEGFIIHGKSIGARYE
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MISYSLPNERPNDFSRVIPVVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCHHHHHHHHH
QASKLDPKVKQAIDTAYEQLKAFHEMLVPPNIGGGYQGISFGVIWRSIEKIGIYVPSGKY
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCC
SYPSTLLMAGIPAKVAKVKEIYVASPPTQEGTVNPALAYVAIKLGVNEVYKIGGAQAIAA
CCCCHHEECCCCHHHHHHHHEEEECCCCCCCCCCHHHEEEEEHHCHHHHHHCCCHHHHHH
LAFGTESVKKVYKIVGPGNVYVQAAKYLVSSVVGIDGIEGPTELVIIADETAKAEYVALD
HHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEE
MKAQAEHGPDTYIVLLSNDDELIRRVEEKIKNDKKIYYIIKTKNLDEAIEIANKIAPEHL
EEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHCCCHHH
SLYVKDAYTLMDKIVNAGAISLGNTPPAIIDYVAGPNHILPTNGWAKIRGGITVYDFIKP
EEHHHHHHHHHHHHHCCCEEECCCCCHHHEEECCCCCEEECCCCCEEEECCEEEEEHHCC
TMYANVRDINKQLLEASISLANYEGFIIHGKSIGARYE
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9209067; 10701121; 11427726