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The map label for this gene is adh-1 [H]

Identifier: 15897400

GI number: 15897400

Start: 406507

End: 407622

Strand: Reverse

Name: adh-1 [H]

Synonym: SSO0472

Alternate gene names: 15897400

Gene position: 407622-406507 (Counterclockwise)

Preceding gene: 15897403

Following gene: 15897398

Centisome position: 13.62

GC content: 37.81

Gene sequence:

>1116_bases
ATGATTATACTGTACCTTATACTAATGAAAGGAGCAATATTGTATAAATATAATGAGCCATTAATTATTGAGGATAATAT
TCAAATAGATGAACCTAAGGTAGGTGAAACAAAGATTAGAATTGAGGCAACTGGCTTATGTCATTCAGATGTAAATGTAT
TTGAAGGAAAAACTCCAGTCCCTCCACCAGTCATTGCGGGACATGAAATAGCTGGTGTTATAGAGGAGGTAGGAAATAAC
GTTACAGACTTTAAACCTGGCGATAGGGTTATATCAGCATTTATTCATCCCTGCGGTAAATGCAAAAATTGTATAACGGG
AAAGGAGAATTTATGTGAAGTCTTTGCGAAAAATAGACTAAATGGGACATTACTAGATGGTACAACTAGATTACACTTTA
AGGATGGAACTCCGATAAGGGCATTTTTAGGAGGAGGATTTGCAGAATACGCAATGGTACCTTATACTGCATTAACTAAA
GTTCCGGAAGATTTGGATTTAAGAAAGGTTGCAGTATTGGGTTGTGCAGGTTTAACTGCTTATGGTGCTGTAAATTCCGC
TAAAATAGAGCCTGGTGAAACAGTTGCTGTAATTGGAGTTGGCGGTGTAGGATTGTCTGTGATACAGATGTTAAAGATTG
CTGGTGCCGGAAGGATAATAGCAGTCGGGACTAGAAAATGGAAATTGGAAAAGGCGTTAGAGCTAGGAGCTAGTGATGTA
GTTAACTCTAAAGAGACTGATGTTGTTAGAGCTGTTAAGAATATTACTGGAGGAGGGCCGGATGTTGTAATAGAAGTAGC
AGGAACTACGGAAACAGTGAAAATGTCTTTAGATATGGTTAGAATAGGAGGAAAGGTAGTACTAGTGGGATTACCTCCAA
CTACTGCTGAAATTCCAATTAGGATAGCAAGTATAGTTAGAGGGGGTATTAAAATCATAGGAGACTATGGAGGGAGGCCT
AGAGTAGATATGCCTAGACTTATTGAACTTGTAAAATTGGGAAAATATGACCCTACTGCGTTAGTGACTGGAAAGTTCAG
ATTAGAAGAAATTAACGAGGCAGTAAAATTATTGGAGCAAGGAGAGGCAATAAGAAGTTTAATAATTCCTAACTAA

Upstream 100 bases:

>100_bases
AAAATCGGATAGTAATAAACATTTAAAGTATCGTAATCGTACCACGATATAATGAATAGTTTTCGCAGTTATAAAGGGAG
ATGTTTAGAAATGTTTAAAT

Downstream 100 bases:

>100_bases
AATGGAGCTCTGGTAGTTTTTCTTCCAATTATAAACATTATTAAATAGATGATTAACATTATTATGGTAAATACAACACC
TACTATAATTAGGTTACTTA

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MIILYLILMKGAILYKYNEPLIIEDNIQIDEPKVGETKIRIEATGLCHSDVNVFEGKTPVPPPVIAGHEIAGVIEEVGNN
VTDFKPGDRVISAFIHPCGKCKNCITGKENLCEVFAKNRLNGTLLDGTTRLHFKDGTPIRAFLGGGFAEYAMVPYTALTK
VPEDLDLRKVAVLGCAGLTAYGAVNSAKIEPGETVAVIGVGGVGLSVIQMLKIAGAGRIIAVGTRKWKLEKALELGASDV
VNSKETDVVRAVKNITGGGPDVVIEVAGTTETVKMSLDMVRIGGKVVLVGLPPTTAEIPIRIASIVRGGIKIIGDYGGRP
RVDMPRLIELVKLGKYDPTALVTGKFRLEEINEAVKLLEQGEAIRSLIIPN

Sequences:

>Translated_371_residues
MIILYLILMKGAILYKYNEPLIIEDNIQIDEPKVGETKIRIEATGLCHSDVNVFEGKTPVPPPVIAGHEIAGVIEEVGNN
VTDFKPGDRVISAFIHPCGKCKNCITGKENLCEVFAKNRLNGTLLDGTTRLHFKDGTPIRAFLGGGFAEYAMVPYTALTK
VPEDLDLRKVAVLGCAGLTAYGAVNSAKIEPGETVAVIGVGGVGLSVIQMLKIAGAGRIIAVGTRKWKLEKALELGASDV
VNSKETDVVRAVKNITGGGPDVVIEVAGTTETVKMSLDMVRIGGKVVLVGLPPTTAEIPIRIASIVRGGIKIIGDYGGRP
RVDMPRLIELVKLGKYDPTALVTGKFRLEEINEAVKLLEQGEAIRSLIIPN
>Mature_371_residues
MIILYLILMKGAILYKYNEPLIIEDNIQIDEPKVGETKIRIEATGLCHSDVNVFEGKTPVPPPVIAGHEIAGVIEEVGNN
VTDFKPGDRVISAFIHPCGKCKNCITGKENLCEVFAKNRLNGTLLDGTTRLHFKDGTPIRAFLGGGFAEYAMVPYTALTK
VPEDLDLRKVAVLGCAGLTAYGAVNSAKIEPGETVAVIGVGGVGLSVIQMLKIAGAGRIIAVGTRKWKLEKALELGASDV
VNSKETDVVRAVKNITGGGPDVVIEVAGTTETVKMSLDMVRIGGKVVLVGLPPTTAEIPIRIASIVRGGIKIIGDYGGRP
RVDMPRLIELVKLGKYDPTALVTGKFRLEEINEAVKLLEQGEAIRSLIIPN

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=39.7849462365591, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=38.9784946236559, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI4501929, Length=372, Percent_Identity=38.1720430107527, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=36.2666666666667, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=35.230352303523, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=35.230352303523, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=36.0433604336043, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI156523966, Length=372, Percent_Identity=34.4086021505376, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=34.5205479452055, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI156627571, Length=351, Percent_Identity=27.0655270655271, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI194239674, Length=290, Percent_Identity=27.5862068965517, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI13236495, Length=290, Percent_Identity=27.5862068965517, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI194239676, Length=312, Percent_Identity=25.3205128205128, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI22538446, Length=164, Percent_Identity=33.5365853658537, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI22538444, Length=164, Percent_Identity=33.5365853658537, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=35.792349726776, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87081918, Length=362, Percent_Identity=32.0441988950276, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788073, Length=336, Percent_Identity=30.3571428571429, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1787863, Length=359, Percent_Identity=27.2980501392758, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790045, Length=339, Percent_Identity=24.7787610619469, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=30.6629834254144, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786825, Length=366, Percent_Identity=29.2349726775956, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=25.7790368271955, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790718, Length=327, Percent_Identity=24.1590214067278, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1786518, Length=363, Percent_Identity=27.5482093663912, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788407, Length=290, Percent_Identity=26.8965517241379, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI226510992, Length=326, Percent_Identity=27.3006134969325, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87082401, Length=338, Percent_Identity=24.8520710059172, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=33.8666666666667, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=33.42175066313, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17565904, Length=334, Percent_Identity=33.8323353293413, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17562876, Length=372, Percent_Identity=27.9569892473118, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17562584, Length=363, Percent_Identity=28.9256198347107, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562582, Length=330, Percent_Identity=28.1818181818182, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=358, Percent_Identity=27.6536312849162, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=369, Percent_Identity=29.5392953929539, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=34.8773841961853, Blast_Score=212, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6324486, Length=366, Percent_Identity=30.0546448087432, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323961, Length=359, Percent_Identity=31.1977715877437, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=368, Percent_Identity=30.1630434782609, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6319621, Length=366, Percent_Identity=29.5081967213115, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322619, Length=348, Percent_Identity=28.448275862069, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=348, Percent_Identity=28.448275862069, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323099, Length=343, Percent_Identity=26.8221574344023, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=401, Percent_Identity=24.1895261845387, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=301, Percent_Identity=26.578073089701, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737895, Length=372, Percent_Identity=38.7096774193548, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI17137530, Length=342, Percent_Identity=27.4853801169591, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17737897, Length=340, Percent_Identity=25.8823529411765, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39594; Mature: 39594

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILYLILMKGAILYKYNEPLIIEDNIQIDEPKVGETKIRIEATGLCHSDVNVFEGKTPV
CCEEEEEHHCCEEEEEECCCEEEECCCEECCCCCCCEEEEEEEECCEECCCCEECCCCCC
PPPVIAGHEIAGVIEEVGNNVTDFKPGDRVISAFIHPCGKCKNCITGKENLCEVFAKNRL
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCC
NGTLLDGTTRLHFKDGTPIRAFLGGGFAEYAMVPYTALTKVPEDLDLRKVAVLGCAGLTA
CCEEECCEEEEEECCCCCEEHHHCCCHHHHHHCCHHHHHCCCCCCCHHHEEEHHHCCHHH
YGAVNSAKIEPGETVAVIGVGGVGLSVIQMLKIAGAGRIIAVGTRKWKLEKALELGASDV
HCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCHHHH
VNSKETDVVRAVKNITGGGPDVVIEVAGTTETVKMSLDMVRIGGKVVLVGLPPTTAEIPI
CCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEEEEECCEEEEEECCCCCCCCCH
RIASIVRGGIKIIGDYGGRPRVDMPRLIELVKLGKYDPTALVTGKFRLEEINEAVKLLEQ
HHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHH
GEAIRSLIIPN
CHHHHHHCCCC
>Mature Secondary Structure
MIILYLILMKGAILYKYNEPLIIEDNIQIDEPKVGETKIRIEATGLCHSDVNVFEGKTPV
CCEEEEEHHCCEEEEEECCCEEEECCCEECCCCCCCEEEEEEEECCEECCCCEECCCCCC
PPPVIAGHEIAGVIEEVGNNVTDFKPGDRVISAFIHPCGKCKNCITGKENLCEVFAKNRL
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCC
NGTLLDGTTRLHFKDGTPIRAFLGGGFAEYAMVPYTALTKVPEDLDLRKVAVLGCAGLTA
CCEEECCEEEEEECCCCCEEHHHCCCHHHHHHCCHHHHHCCCCCCCHHHEEEHHHCCHHH
YGAVNSAKIEPGETVAVIGVGGVGLSVIQMLKIAGAGRIIAVGTRKWKLEKALELGASDV
HCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCHHHH
VNSKETDVVRAVKNITGGGPDVVIEVAGTTETVKMSLDMVRIGGKVVLVGLPPTTAEIPI
CCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEEEEECCEEEEEECCCCCCCCCH
RIASIVRGGIKIIGDYGGRPRVDMPRLIELVKLGKYDPTALVTGKFRLEEINEAVKLLEQ
HHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHH
GEAIRSLIIPN
CHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]