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The map label for this gene is glyS [H]

Identifier: 15897373

GI number: 15897373

Start: 382601

End: 384325

Strand: Reverse

Name: glyS [H]

Synonym: SSO0444

Alternate gene names: 15897373

Gene position: 384325-382601 (Counterclockwise)

Preceding gene: 15897375

Following gene: 15897372

Centisome position: 12.84

GC content: 35.3

Gene sequence:

>1725_bases
GTGAGTGAAGTAATAGATAAAGTGTTGGACTTAGCTAAAAGAAGAGGGATATTTTGGTTATCGTATGAAATTTACGGAGG
AGTTGCGGGATTCTACGACATAGGACCAGTAGGTGTAAGGATTAAAAATAGAATAGTAGAGCTATGGCGAAAATATTTCG
TGAAGGATAATGGCGATTTTGTAGTAGAAATAGAAAGTCCAATGATAGGACCAGCTAAAGTGTTTGAAGCTAGTGGGCAT
GTAGAAAGTTTTACAGATCCTATCGTGGAGTGTAATAATTGCAAAAGAATATATAGGGCTGACCATTTAATCGAAGACAT
ATTAAAGAAAAGCGTAGAGGGTCTTAAGCCAGAAGAACTAACGAGGATAATAAAAGAAAACAACATAAGATGCCAATATT
GTGGGGGCGAGTTGGGAGAAGTAAGATTGTTTAATTTACTTTTTACCACTAACATAGGTCCTTATACTGGTAATTTAGGT
TACATTAGACCAGAGACTGCTCAAGGGATGTTCACTGCATTTAAACGCGTATACGAGGCTACTAGGCAAAGATTACCTAT
TGGAATAGCTCAAATAGGGAAAGTAGGTAGAAATGAAATCTCACCTAGACAAGGACTAATAAGAATGAGGGAGTTCACCA
TAATGGAGATTGAGTTTTTCATAGACCCAGAGGATAATAATATTGAAAATATACCGTTGTATAGATTTAAGGATACTAAG
CTCAATATTTTGACTGCAAGTGAAAAGGAAAAAGATGGTAAACCACAAGAGTTCAAGTTAGAAGAGAGCGTAAGAGAAAA
AATCATTATCCAGCCTTGGATGGCATATTGGATGGCTGTAGCATCGAGTTTTGTCAAGGCGTTAGGTATTAATGAATTTT
ATTTTGAGGAAAAGTTACCTTACGAAAGAGCACATTATTCTAAACAGACTTTCGACCAAATAGCTGTAATTAATGGTATA
AAGGTTGAGATTTCTGGTCATGCATATAGAGGAGATTATGATTTATCAAGACATATGAAATATAGTGGACAAGATTTGAC
TATTTTCAGAAAATATAAAGAACCTAAAATGATTAAAAAGAAGACTGTTATAGTTAACAATACTAAATTAAAGGATAAGG
AACTAAGAAAAAAGATCATGGAACTGTTAAATGGGAAATCCGCCGAGGAAATTGAACAAATGATTAGAAACAACGTGATG
ATAGATGACAAACCTTTAAGTGAGTTCATAAATATTGTTGAGAGAGAAGAGAAGGTTCACGGTGAGCACTTCATACCACA
TGTTGTAGAGCCTTCATTCGGTGTGGAAAGGACATTATTCTTAACGATATTAAGTGCATACAAGGAAAAAGAGGGCAGAG
TTTTACTATCCTTACCTAGACATCTGGCTCCTTATGACATTGCAGTTTTTCCACTACTGGAGAGAGAAGAACTAATTAGA
AAATCAGTGGAAATACGAGAAAGTCTTTCCGAAAAATATGAAGTGTTATACGACGATTCTGGAAGTATTGGAAGAAGATA
TGCCAGAGCTGATGAGATTGGTATACCTTTTGCTATTACAGTTGATCCTCAGACACTAGTAGATAACAGCGTAACAATAA
GGGATAGGGATAGCTGGAAGCAAGTTAGAGTTAAAATAGATGATCTTAAGATTTCTCTAGAAAAGTTATTTAGAGGGGAA
GCCTTTAATAAGATTGGAATTGAGGTGAATGATAGTAATGAGTAG

Upstream 100 bases:

>100_bases
AAATTTCCTACTATTCTCATTTAAATAAAGTAATCTTCCATCGCTCACTCGTTAATCTTGGTCATAGAACTTTATAAACT
TGTTGTAATGTTAGAGAGTT

Downstream 100 bases:

>100_bases
TAACGAGAATGAAAAGGAAGAGGAGAAAAAGGTTGATATAAAAACCCTTGTTAGTGTTATACCTCCAGCTTCAGCATTAA
AGGGGAACAAAGCCCCACCA

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MSEVIDKVLDLAKRRGIFWLSYEIYGGVAGFYDIGPVGVRIKNRIVELWRKYFVKDNGDFVVEIESPMIGPAKVFEASGH
VESFTDPIVECNNCKRIYRADHLIEDILKKSVEGLKPEELTRIIKENNIRCQYCGGELGEVRLFNLLFTTNIGPYTGNLG
YIRPETAQGMFTAFKRVYEATRQRLPIGIAQIGKVGRNEISPRQGLIRMREFTIMEIEFFIDPEDNNIENIPLYRFKDTK
LNILTASEKEKDGKPQEFKLEESVREKIIIQPWMAYWMAVASSFVKALGINEFYFEEKLPYERAHYSKQTFDQIAVINGI
KVEISGHAYRGDYDLSRHMKYSGQDLTIFRKYKEPKMIKKKTVIVNNTKLKDKELRKKIMELLNGKSAEEIEQMIRNNVM
IDDKPLSEFINIVEREEKVHGEHFIPHVVEPSFGVERTLFLTILSAYKEKEGRVLLSLPRHLAPYDIAVFPLLEREELIR
KSVEIRESLSEKYEVLYDDSGSIGRRYARADEIGIPFAITVDPQTLVDNSVTIRDRDSWKQVRVKIDDLKISLEKLFRGE
AFNKIGIEVNDSNE

Sequences:

>Translated_574_residues
MSEVIDKVLDLAKRRGIFWLSYEIYGGVAGFYDIGPVGVRIKNRIVELWRKYFVKDNGDFVVEIESPMIGPAKVFEASGH
VESFTDPIVECNNCKRIYRADHLIEDILKKSVEGLKPEELTRIIKENNIRCQYCGGELGEVRLFNLLFTTNIGPYTGNLG
YIRPETAQGMFTAFKRVYEATRQRLPIGIAQIGKVGRNEISPRQGLIRMREFTIMEIEFFIDPEDNNIENIPLYRFKDTK
LNILTASEKEKDGKPQEFKLEESVREKIIIQPWMAYWMAVASSFVKALGINEFYFEEKLPYERAHYSKQTFDQIAVINGI
KVEISGHAYRGDYDLSRHMKYSGQDLTIFRKYKEPKMIKKKTVIVNNTKLKDKELRKKIMELLNGKSAEEIEQMIRNNVM
IDDKPLSEFINIVEREEKVHGEHFIPHVVEPSFGVERTLFLTILSAYKEKEGRVLLSLPRHLAPYDIAVFPLLEREELIR
KSVEIRESLSEKYEVLYDDSGSIGRRYARADEIGIPFAITVDPQTLVDNSVTIRDRDSWKQVRVKIDDLKISLEKLFRGE
AFNKIGIEVNDSNE
>Mature_573_residues
SEVIDKVLDLAKRRGIFWLSYEIYGGVAGFYDIGPVGVRIKNRIVELWRKYFVKDNGDFVVEIESPMIGPAKVFEASGHV
ESFTDPIVECNNCKRIYRADHLIEDILKKSVEGLKPEELTRIIKENNIRCQYCGGELGEVRLFNLLFTTNIGPYTGNLGY
IRPETAQGMFTAFKRVYEATRQRLPIGIAQIGKVGRNEISPRQGLIRMREFTIMEIEFFIDPEDNNIENIPLYRFKDTKL
NILTASEKEKDGKPQEFKLEESVREKIIIQPWMAYWMAVASSFVKALGINEFYFEEKLPYERAHYSKQTFDQIAVINGIK
VEISGHAYRGDYDLSRHMKYSGQDLTIFRKYKEPKMIKKKTVIVNNTKLKDKELRKKIMELLNGKSAEEIEQMIRNNVMI
DDKPLSEFINIVEREEKVHGEHFIPHVVEPSFGVERTLFLTILSAYKEKEGRVLLSLPRHLAPYDIAVFPLLEREELIRK
SVEIRESLSEKYEVLYDDSGSIGRRYARADEIGIPFAITVDPQTLVDNSVTIRDRDSWKQVRVKIDDLKISLEKLFRGEA
FNKIGIEVNDSNE

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=596, Percent_Identity=32.2147651006711, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI32564541, Length=596, Percent_Identity=34.5637583892617, Blast_Score=328, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI17554996, Length=596, Percent_Identity=34.5637583892617, Blast_Score=327, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6325338, Length=593, Percent_Identity=31.8718381112985, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6319597, Length=619, Percent_Identity=30.8562197092084, Blast_Score=270, Evalue=5e-73,
Organism=Drosophila melanogaster, GI21357965, Length=580, Percent_Identity=35.1724137931034, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24664462, Length=580, Percent_Identity=35.1724137931034, Blast_Score=323, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022960
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 66540; Mature: 66408

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVIDKVLDLAKRRGIFWLSYEIYGGVAGFYDIGPVGVRIKNRIVELWRKYFVKDNGDF
CHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCE
VVEIESPMIGPAKVFEASGHVESFTDPIVECNNCKRIYRADHLIEDILKKSVEGLKPEEL
EEEECCCCCCHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
TRIIKENNIRCQYCGGELGEVRLFNLLFTTNIGPYTGNLGYIRPETAQGMFTAFKRVYEA
HHHHHHCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
TRQRLPIGIAQIGKVGRNEISPRQGLIRMREFTIMEIEFFIDPEDNNIENIPLYRFKDTK
HHHHCCCCHHHHCCCCCCCCCHHHHHHHHHCEEEEEEEEEECCCCCCCCCCCEEEEECCE
LNILTASEKEKDGKPQEFKLEESVREKIIIQPWMAYWMAVASSFVKALGINEFYFEEKLP
EEEEECCCCCCCCCCCCEEHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCC
YERAHYSKQTFDQIAVINGIKVEISGHAYRGDYDLSRHMKYSGQDLTIFRKYKEPKMIKK
HHHHHCCHHHHHHHHEECCEEEEECCEEECCCCCHHHHCCCCCCCEEEEEECCCCCHHHH
KTVIVNNTKLKDKELRKKIMELLNGKSAEEIEQMIRNNVMIDDKPLSEFINIVEREEKVH
EEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHC
GEHFIPHVVEPSFGVERTLFLTILSAYKEKEGRVLLSLPRHLAPYDIAVFPLLEREELIR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCHHHHHHHH
KSVEIRESLSEKYEVLYDDSGSIGRRYARADEIGIPFAITVDPQTLVDNSVTIRDRDSWK
HHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCEEEEECCHHHHCCCEEEECCCCCE
QVRVKIDDLKISLEKLFRGEAFNKIGIEVNDSNE
EEEEEEEHHHHHHHHHHCCCCCCEEEEEECCCCC
>Mature Secondary Structure 
SEVIDKVLDLAKRRGIFWLSYEIYGGVAGFYDIGPVGVRIKNRIVELWRKYFVKDNGDF
HHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCE
VVEIESPMIGPAKVFEASGHVESFTDPIVECNNCKRIYRADHLIEDILKKSVEGLKPEEL
EEEECCCCCCHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
TRIIKENNIRCQYCGGELGEVRLFNLLFTTNIGPYTGNLGYIRPETAQGMFTAFKRVYEA
HHHHHHCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
TRQRLPIGIAQIGKVGRNEISPRQGLIRMREFTIMEIEFFIDPEDNNIENIPLYRFKDTK
HHHHCCCCHHHHCCCCCCCCCHHHHHHHHHCEEEEEEEEEECCCCCCCCCCCEEEEECCE
LNILTASEKEKDGKPQEFKLEESVREKIIIQPWMAYWMAVASSFVKALGINEFYFEEKLP
EEEEECCCCCCCCCCCCEEHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCC
YERAHYSKQTFDQIAVINGIKVEISGHAYRGDYDLSRHMKYSGQDLTIFRKYKEPKMIKK
HHHHHCCHHHHHHHHEECCEEEEECCEEECCCCCHHHHCCCCCCCEEEEEECCCCCHHHH
KTVIVNNTKLKDKELRKKIMELLNGKSAEEIEQMIRNNVMIDDKPLSEFINIVEREEKVH
EEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHC
GEHFIPHVVEPSFGVERTLFLTILSAYKEKEGRVLLSLPRHLAPYDIAVFPLLEREELIR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCHHHHHHHH
KSVEIRESLSEKYEVLYDDSGSIGRRYARADEIGIPFAITVDPQTLVDNSVTIRDRDSWK
HHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCEEEEECCHHHHCCCEEEECCCCCE
QVRVKIDDLKISLEKLFRGEAFNKIGIEVNDSNE
EEEEEEEHHHHHHHHHHCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]