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The map label for this gene is eif2G

Identifier: 15897345

GI number: 15897345

Start: 359364

End: 360611

Strand: Direct

Name: eif2G

Synonym: SSO0412

Alternate gene names: 15897345

Gene position: 359364-360611 (Clockwise)

Preceding gene: 15897344

Following gene: 15897346

Centisome position: 12.01

GC content: 37.66

Gene sequence:

>1248_bases
TTGGCATGGCCTAAAGTTCAACCAGAAGTTAATATAGGTGTAGTTGGTCATGTAGATCATGGTAAGACTACACTAGTTCA
AGCAATAACGGGAATTTGGACATCAAAACATTCCGAAGAATTAAAAAGAGGTATGACAATAAAACTGGGTTACGCAGAGA
CTAATATAGGTGTTTGTGAAAGTTGTAAAAAACCTGAGGCATATGTAACTGAACCCTCATGTAAATCTTGTGGATCAGAT
GATGAGCCCAAGTTTCTGAGACGAATTTCCTTTATTGATGCCCCGGGCCATGAAGTTCTAATGGCTACAATGTTATCTGG
AGCTGCATTAATGGATGGCGCAATTCTAGTCGTTGCTGCAAATGAACCTTTTCCGCAACCTCAGACTAGAGAACATTTCG
TAGCATTAGGTATAATAGGAGTGAAAAACCTAATTATAGTTCAAAATAAGGTAGACGTAGTCTCCAAAGAGGAAGCGTTA
TCGCAGTATAGGCAAATAAAGCAGTTTACGAAGGGAACTTGGGCTGAAAATGTACCTATAATCCCAGTAAGTGCACTTCA
TAAGATTAATATAGATTCTCTAATCGAAGGTATAGAAGAGTATATAAAAACTCCTTACAGGGATCTCTCACAAAAACCTG
TTATGCTTGTGATAAGAAGTTTTGACGTTAATAAGCCCGGTACCCAATTCAATGAGTTGAAGGGTGGTGTAATAGGTGGC
AGTATTATACAAGGTTTGTTTAAAGTTGACCAAGAAATAAAAGTATTACCGGGCTTAAGAGTGGAAAAACAAGGTAAAGT
ATCTTATGAACCTATTTTCACAAAGATTTCGTCCATAAGGTTTGGAGATGAGGAATTTAAAGAGGCTAAACCAGGAGGTT
TAGTTGCAATAGGTACATATTTAGATCCCTCATTGACTAAAGCTGATAATTTGCTTGGCAGTATTATTACCTTAGCTGAT
GCTGAAGTTCCAGTTTTATGGAACATTAGAATAAAGTATAATCTCCTAGAACGTGTAGTTGGAGCTAAGGAAATGTTAAA
GGTAGATCCCATAAGAGCTAAGGAAACTTTAATGTTGTCTGTAGGTTCATCGACGACTTTGGGTATCGTTACCTCTGTAA
AGAAGGATGAGATTGAAGTGGAGTTAAGGAGACCTGTGGCAGTATGGTCTAATAATATTAGAACTGTCATAAGTAGGCAA
ATAGCTGGTAGGTGGAGAATGATAGGATGGGGTTTAGTAGAGATCTAA

Upstream 100 bases:

>100_bases
CGAATGAAAATGGAGAAAGAAGAAGAAAAACTATACGAGGAAATACAATTAGCCAGGAAATAGTTCAAATTAATACCATA
ATAGTAAGGTGAAGTAGTTT

Downstream 100 bases:

>100_bases
AAGTACTAGTTGATACTAATATTTTATTGTACGTGTATGATGGTTTAGATCCATTTAATAAGGTATTAGAATTTCTAGAT
TATAAACCGTCTTTTTTTAT

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MAWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSD
DEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEAL
SQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGG
SIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLAD
AEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQ
IAGRWRMIGWGLVEI

Sequences:

>Translated_415_residues
MAWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSD
DEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEAL
SQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGG
SIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLAD
AEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQ
IAGRWRMIGWGLVEI
>Mature_414_residues
AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDD
EPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALS
QYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGS
IIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADA
EVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQI
AGRWRMIGWGLVEI

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasmic, and membrane-associated [C]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily

Homologues:

Organism=Homo sapiens, GI4503507, Length=425, Percent_Identity=43.5294117647059, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI34147630, Length=267, Percent_Identity=31.4606741573034, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI54607086, Length=297, Percent_Identity=26.9360269360269, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1790412, Length=307, Percent_Identity=29.6416938110749, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1789737, Length=307, Percent_Identity=29.6416938110749, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI2367247, Length=240, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789108, Length=290, Percent_Identity=25.1724137931034, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17509919, Length=423, Percent_Identity=42.080378250591, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17556456, Length=329, Percent_Identity=29.1793313069909, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25141371, Length=303, Percent_Identity=28.7128712871287, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17506081, Length=272, Percent_Identity=25.3676470588235, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320863, Length=423, Percent_Identity=43.0260047281324, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6324761, Length=305, Percent_Identity=31.8032786885246, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647046, Length=423, Percent_Identity=41.8439716312057, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24647048, Length=421, Percent_Identity=42.0427553444181, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI19921738, Length=288, Percent_Identity=32.2916666666667, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI281363316, Length=294, Percent_Identity=29.2517006802721, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17864358, Length=294, Percent_Identity=29.2517006802721, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922690, Length=283, Percent_Identity=31.4487632508834, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: 20568 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): IF2G_SULSO (Q980A5)

Other databases:

- EMBL:   AE006641
- PIR:   E90185
- RefSeq:   NP_341950.1
- PDB:   2AHO
- PDB:   2PLF
- PDB:   2PMD
- PDB:   2QMU
- PDB:   2QN6
- PDB:   3CW2
- PDB:   3I1F
- PDBsum:   2AHO
- PDBsum:   2PLF
- PDBsum:   2PMD
- PDBsum:   2QMU
- PDBsum:   2QN6
- PDBsum:   3CW2
- PDBsum:   3I1F
- ProteinModelPortal:   Q980A5
- SMR:   Q980A5
- DIP:   DIP-29031N
- GeneID:   1455550
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0412
- NMPDR:   fig|273057.1.peg.373
- HOGENOM:   HBG307581
- OMA:   IAANEPC
- PhylomeDB:   Q980A5
- ProtClustDB:   PRK04000
- BioCyc:   SSOL273057:SSO0412-MONOMER
- HAMAP:   MF_00119
- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- PRINTS:   PR00315
- TIGRFAMs:   TIGR03680

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; SSF50465 Elong_init_C; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 45793; Mature: 45662

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCE
CCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHCCCEEEEEEEECCCCHHH
SCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAA
CCCCCCCEEECCCHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCEEEEEEC
NEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPI
CCCCCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGG
EEHHHHHCCCHHHHHHHHHHHHHCCHHHCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCH
SIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTY
HHHHHHHHHCCHHEECCCCEECCCCCCCCCHHHHHHHHCCCCCHHHHHCCCCCEEEEECC
LDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLS
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHCHHHHHCCCCCCCCEEEEEE
VGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI
ECCCCEEEEEEECCCCCEEEEECCCHHHHCCCHHHHHHHHHCCCEEEEECEEECC
>Mature Secondary Structure 
AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCE
CCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHCCCEEEEEEEECCCCHHH
SCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAA
CCCCCCCEEECCCHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCEEEEEEC
NEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPI
CCCCCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGG
EEHHHHHCCCHHHHHHHHHHHHHCCHHHCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCH
SIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTY
HHHHHHHHHCCHHEECCCCEECCCCCCCCCHHHHHHHHCCCCCHHHHHCCCCCEEEEECC
LDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLS
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHCHHHHHCCCCCCCCEEEEEE
VGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI
ECCCCEEEEEEECCCCCEEEEECCCHHHHCCCHHHHHHHHHCCCEEEEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11427726