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The map label for this gene is mvk [H]

Identifier: 15897316

GI number: 15897316

Start: 326885

End: 327829

Strand: Reverse

Name: mvk [H]

Synonym: SSO0383

Alternate gene names: 15897316

Gene position: 327829-326885 (Counterclockwise)

Preceding gene: 15897317

Following gene: 15897315

Centisome position: 10.96

GC content: 35.98

Gene sequence:

>945_bases
ATGATGGTTGAAGCTAAGGTTCCGTTGAAGCTGACATTATTTGGGGAACATGCTGTAGTTTACGATAGACCAGCAATCGC
AATGACTATTTCAGAAAGTTTAAAGGTAAAGGTAAGTGAAAACGACAAGTTCCTAATTATATCTCCATCCCTTAATATAA
AAGGGGTTAAGTTAGATTTAAATGAGATGAAAATTGAGAGCGATGAGGCTAAGAAAGTACTTAGATATGTATTTGAGGTG
TTGAACTATTTTGAAATGAAGAAGCCAGTTAAAATAGAAATAAATTCAACAGTCGAACCTTCTGTTGGATTAGGTACTAG
TGCTGCAGTTATTGTTGGCACTGTTGCTGCTTACTCTAAATATTTGGGTATTGATTTAAGCAGAGATGAAATAGCCAAAA
TCTCGCACAATATAGAGTTAAAGGTTCAAGGAATAGCCAGTAGGATGGATACTTATACTGAAACTTATGGTGGGCTAATT
TACTTTCCAGCTGGTGGAAAGGGATTTGAAAAAATAGATACCAATTTTGAACTGACTGCAGGATACATAAGGAGGAGTAT
GAGTACTGCTGATGTTTTATGGCGTGTTAGAACGCTTAAGGAGTCAAACAAGGAAGTCTTTGAGAACATATTAGATGTGA
TAGGCGAGATAACTAATAGGGCTAAATCTTTAATAGTCGAACAAAATTTCGAGGAATTAGGACTCTTAATGTACGTAAAT
CATGGATTATTGTTTTCATTAGGAATAACTTCACCAGAAGCTGATGAGATTGTTTCTAGAGCTAAACAATTGGGAATAAA
AGGTTGTAAGATCAGTGGGGGAGGGGCTGGGGGTTCCATAATATGTATAAAGTCCGTTGAGGCTGAAGTTCTTCTGAGGA
GTTACAACGCTAGAATAGTTAATTCTACACTAACTAAAGATGGTGTCATTTTTTCGATACTATAA

Upstream 100 bases:

>100_bases
ATTTTAAGAACGATTCTTACCAAACTGCTATATCGGAGAAGAAGCCTATCTAAAATACGTAAATGAACTTTATTATTTTA
AACCTAGACTTTTTCATGTA

Downstream 100 bases:

>100_bases
GGAAAAGTCTAATTTACCAGTGCTTAAAAGATAGATTAATGTGTGTGGAATTATAGGGATTGTGTCAAATAAGGAAAGTA
ATAGACTAGCTGAATTAGTA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MMVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVKVSENDKFLIISPSLNIKGVKLDLNEMKIESDEAKKVLRYVFEV
LNYFEMKKPVKIEINSTVEPSVGLGTSAAVIVGTVAAYSKYLGIDLSRDEIAKISHNIELKVQGIASRMDTYTETYGGLI
YFPAGGKGFEKIDTNFELTAGYIRRSMSTADVLWRVRTLKESNKEVFENILDVIGEITNRAKSLIVEQNFEELGLLMYVN
HGLLFSLGITSPEADEIVSRAKQLGIKGCKISGGGAGGSIICIKSVEAEVLLRSYNARIVNSTLTKDGVIFSIL

Sequences:

>Translated_314_residues
MMVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVKVSENDKFLIISPSLNIKGVKLDLNEMKIESDEAKKVLRYVFEV
LNYFEMKKPVKIEINSTVEPSVGLGTSAAVIVGTVAAYSKYLGIDLSRDEIAKISHNIELKVQGIASRMDTYTETYGGLI
YFPAGGKGFEKIDTNFELTAGYIRRSMSTADVLWRVRTLKESNKEVFENILDVIGEITNRAKSLIVEQNFEELGLLMYVN
HGLLFSLGITSPEADEIVSRAKQLGIKGCKISGGGAGGSIICIKSVEAEVLLRSYNARIVNSTLTKDGVIFSIL
>Mature_314_residues
MMVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVKVSENDKFLIISPSLNIKGVKLDLNEMKIESDEAKKVLRYVFEV
LNYFEMKKPVKIEINSTVEPSVGLGTSAAVIVGTVAAYSKYLGIDLSRDEIAKISHNIELKVQGIASRMDTYTETYGGLI
YFPAGGKGFEKIDTNFELTAGYIRRSMSTADVLWRVRTLKESNKEVFENILDVIGEITNRAKSLIVEQNFEELGLLMYVN
HGLLFSLGITSPEADEIVSRAKQLGIKGCKISGGGAGGSIICIKSVEAEVLLRSYNARIVNSTLTKDGVIFSIL

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323864, Length=349, Percent_Identity=26.647564469914, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI78707210, Length=349, Percent_Identity=23.4957020057307, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 34543; Mature: 34543

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVKVSENDKFLIISPSLNIKGVKLDL
CEEECCCCEEEEEECCEEEEEECCEEEEEECCCEEEEECCCCEEEEECCCCCEEEEEEEH
NEMKIESDEAKKVLRYVFEVLNYFEMKKPVKIEINSTVEPSVGLGTSAAVIVGTVAAYSK
HHEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
YLGIDLSRDEIAKISHNIELKVQGIASRMDTYTETYGGLIYFPAGGKGFEKIDTNFELTA
HHCCCCCHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCEEEEH
GYIRRSMSTADVLWRVRTLKESNKEVFENILDVIGEITNRAKSLIVEQNFEELGLLMYVN
HHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEC
HGLLFSLGITSPEADEIVSRAKQLGIKGCKISGGGAGGSIICIKSVEAEVLLRSYNARIV
CCEEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCHHHHHHHCCCEEE
NSTLTKDGVIFSIL
ECCCCCCCEEEEEC
>Mature Secondary Structure
MMVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVKVSENDKFLIISPSLNIKGVKLDL
CEEECCCCEEEEEECCEEEEEECCEEEEEECCCEEEEECCCCEEEEECCCCCEEEEEEEH
NEMKIESDEAKKVLRYVFEVLNYFEMKKPVKIEINSTVEPSVGLGTSAAVIVGTVAAYSK
HHEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
YLGIDLSRDEIAKISHNIELKVQGIASRMDTYTETYGGLIYFPAGGKGFEKIDTNFELTA
HHCCCCCHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCEEEEH
GYIRRSMSTADVLWRVRTLKESNKEVFENILDVIGEITNRAKSLIVEQNFEELGLLMYVN
HHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEC
HGLLFSLGITSPEADEIVSRAKQLGIKGCKISGGGAGGSIICIKSVEAEVLLRSYNARIV
CCEEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCHHHHHHHCCCEEE
NSTLTKDGVIFSIL
ECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA