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The map label for this gene is hisS [H]

Identifier: 15897222

GI number: 15897222

Start: 237076

End: 238356

Strand: Reverse

Name: hisS [H]

Synonym: SSO0279

Alternate gene names: 15897222

Gene position: 238356-237076 (Counterclockwise)

Preceding gene: 15897223

Following gene: 15897221

Centisome position: 7.97

GC content: 31.85

Gene sequence:

>1281_bases
ATGGTAAAGTTTGAAACAGTAAGAGGCATGAAAGATTATATTGGAATCGATGCAGAAAAAATTAGATACTTGGAATCTAC
CTTTAGAGACTTAGCAAAAAAATATGGATATTCTGAAATTATAACGCCAGTAGTAGAAGAATTTAAACTGTTTGAGTTGA
AGGGTGGGGAGGAACTAAGACAAACGATGTATGTGTTTAAGGACAAGGCAGATAGAGAGATATCGTTACGACCTGAAATA
ACACCAAGTGTAGCAAGAGCATACATACAAAATTTACAGAGTTCGCCAAAGCCGATAAGGCTATTTTACTTTGGTACCGT
TTATAGGTATGACGAACCCCAGTACGGCAGATATAGAGAGTTCAGACAAGCCGGAATAGAAATGATAGGTGATTCTTCCA
TCTTAGCTGATGTAGAAGTATTAGATTTATTGTACAATTTTTATGATAAGCTTAATCTTTCTAAGGATATAACAATTAAA
ATAAATAACATTGGTATATTTAGAAAAATAATGGATAAATATAATATCGAAGATAATCTACAAGAGCATGTTCTGCATTT
AATAGATAAGAATAAGGTTGACGAAGCTTTAGTTATTCTTGAAAAAAATATAAAGAATAAGGATATAATGGACTTTTTAA
ATATGATCCTTACTAAAAAAGAGGCAAAACTAGAAGATATAGAATCCTTAGCTGAATTAGAGGAAGTTTCAAAATTAGAT
ATTAAAAACGAATTTGAATATCTACTTCGATTATCTAGAATTTTAAGCAGCTTAAATGTAAAATTTAAGGTTGACCTAGG
TTTTGTAAGAGGATTAGCTTATTATACTGGACTAATATTTGAGGTTCTTCATCCCTCTGTTCAGTTTAGCATTGCTGGAG
GAGGAAGATATGATAAACTTATAGAGCTCTATGGTGGCTTACCCTCACCAGCAATAGGATTCGCTATAGGAGTTGAGAGA
ACTTTATTAGTAATTAAAGATCTGAAAGTTGAAGAACCAATAAATGTGATAGTAGTAGGCATCTCAGAGGAGGCAATACC
AGCTATGTTTACGGTATCCAGAATGTTAAGAAAGGAAGAATATAAGGTAGTAATAAATACTAAAGATCAGCCTCTCTCTA
AACTATTACCTTATTATGCTTCCCAAGGATTTAAACTCGCAATAATAATAGGTAAACAAGAACTTGAGAAAAATATGATA
ACAGTTAGAAATTTAATTACACGAAAACAGATTTCTATCCCACTAGAGAACGTTCTAGATGCAATAAAACAAACGTTATA
A

Upstream 100 bases:

>100_bases
AAAATCAATGAATTTAGAACTTTATCTTTCAATTGTAGATAAATATGGAGATGTAACGTATTATACTCTATCTGAGATAA
AAATGTCAAAGTGACTGGAT

Downstream 100 bases:

>100_bases
ATGGCATTTATAAGTATATTATGGGTAAACTAGCATGGAAGAATTACCTGCAACTGCTGTTGGTTTGAAGGTAAATGATG
GAATCGTATTAGCTTCTGAG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MVKFETVRGMKDYIGIDAEKIRYLESTFRDLAKKYGYSEIITPVVEEFKLFELKGGEELRQTMYVFKDKADREISLRPEI
TPSVARAYIQNLQSSPKPIRLFYFGTVYRYDEPQYGRYREFRQAGIEMIGDSSILADVEVLDLLYNFYDKLNLSKDITIK
INNIGIFRKIMDKYNIEDNLQEHVLHLIDKNKVDEALVILEKNIKNKDIMDFLNMILTKKEAKLEDIESLAELEEVSKLD
IKNEFEYLLRLSRILSSLNVKFKVDLGFVRGLAYYTGLIFEVLHPSVQFSIAGGGRYDKLIELYGGLPSPAIGFAIGVER
TLLVIKDLKVEEPINVIVVGISEEAIPAMFTVSRMLRKEEYKVVINTKDQPLSKLLPYYASQGFKLAIIIGKQELEKNMI
TVRNLITRKQISIPLENVLDAIKQTL

Sequences:

>Translated_426_residues
MVKFETVRGMKDYIGIDAEKIRYLESTFRDLAKKYGYSEIITPVVEEFKLFELKGGEELRQTMYVFKDKADREISLRPEI
TPSVARAYIQNLQSSPKPIRLFYFGTVYRYDEPQYGRYREFRQAGIEMIGDSSILADVEVLDLLYNFYDKLNLSKDITIK
INNIGIFRKIMDKYNIEDNLQEHVLHLIDKNKVDEALVILEKNIKNKDIMDFLNMILTKKEAKLEDIESLAELEEVSKLD
IKNEFEYLLRLSRILSSLNVKFKVDLGFVRGLAYYTGLIFEVLHPSVQFSIAGGGRYDKLIELYGGLPSPAIGFAIGVER
TLLVIKDLKVEEPINVIVVGISEEAIPAMFTVSRMLRKEEYKVVINTKDQPLSKLLPYYASQGFKLAIIIGKQELEKNMI
TVRNLITRKQISIPLENVLDAIKQTL
>Mature_426_residues
MVKFETVRGMKDYIGIDAEKIRYLESTFRDLAKKYGYSEIITPVVEEFKLFELKGGEELRQTMYVFKDKADREISLRPEI
TPSVARAYIQNLQSSPKPIRLFYFGTVYRYDEPQYGRYREFRQAGIEMIGDSSILADVEVLDLLYNFYDKLNLSKDITIK
INNIGIFRKIMDKYNIEDNLQEHVLHLIDKNKVDEALVILEKNIKNKDIMDFLNMILTKKEAKLEDIESLAELEEVSKLD
IKNEFEYLLRLSRILSSLNVKFKVDLGFVRGLAYYTGLIFEVLHPSVQFSIAGGGRYDKLIELYGGLPSPAIGFAIGVER
TLLVIKDLKVEEPINVIVVGISEEAIPAMFTVSRMLRKEEYKVVINTKDQPLSKLLPYYASQGFKLAIIIGKQELEKNMI
TVRNLITRKQISIPLENVLDAIKQTL

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=426, Percent_Identity=27.6995305164319, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI15029520, Length=433, Percent_Identity=27.4826789838337, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1788861, Length=441, Percent_Identity=28.5714285714286, Blast_Score=189, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71993693, Length=468, Percent_Identity=25.4273504273504, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71993686, Length=468, Percent_Identity=25.4273504273504, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6325290, Length=459, Percent_Identity=26.5795206971678, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24643061, Length=441, Percent_Identity=24.9433106575964, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643059, Length=426, Percent_Identity=24.6478873239437, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 49145; Mature: 49145

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKFETVRGMKDYIGIDAEKIRYLESTFRDLAKKYGYSEIITPVVEEFKLFELKGGEELR
CCCCHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCHHHH
QTMYVFKDKADREISLRPEITPSVARAYIQNLQSSPKPIRLFYFGTVYRYDEPQYGRYRE
HHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCHHHH
FRQAGIEMIGDSSILADVEVLDLLYNFYDKLNLSKDITIKINNIGIFRKIMDKYNIEDNL
HHHHCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCH
QEHVLHLIDKNKVDEALVILEKNIKNKDIMDFLNMILTKKEAKLEDIESLAELEEVSKLD
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
IKNEFEYLLRLSRILSSLNVKFKVDLGFVRGLAYYTGLIFEVLHPSVQFSIAGGGRYDKL
HHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
IELYGGLPSPAIGFAIGVERTLLVIKDLKVEEPINVIVVGISEEAIPAMFTVSRMLRKEE
HHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
YKVVINTKDQPLSKLLPYYASQGFKLAIIIGKQELEKNMITVRNLITRKQISIPLENVLD
CEEEEECCCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AIKQTL
HHHHCC
>Mature Secondary Structure
MVKFETVRGMKDYIGIDAEKIRYLESTFRDLAKKYGYSEIITPVVEEFKLFELKGGEELR
CCCCHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCHHHH
QTMYVFKDKADREISLRPEITPSVARAYIQNLQSSPKPIRLFYFGTVYRYDEPQYGRYRE
HHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCHHHH
FRQAGIEMIGDSSILADVEVLDLLYNFYDKLNLSKDITIKINNIGIFRKIMDKYNIEDNL
HHHHCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCH
QEHVLHLIDKNKVDEALVILEKNIKNKDIMDFLNMILTKKEAKLEDIESLAELEEVSKLD
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
IKNEFEYLLRLSRILSSLNVKFKVDLGFVRGLAYYTGLIFEVLHPSVQFSIAGGGRYDKL
HHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
IELYGGLPSPAIGFAIGVERTLLVIKDLKVEEPINVIVVGISEEAIPAMFTVSRMLRKEE
HHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
YKVVINTKDQPLSKLLPYYASQGFKLAIIIGKQELEKNMITVRNLITRKQISIPLENVLD
CEEEEECCCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AIKQTL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA