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The map label for this gene is purA [H]

Identifier: 15897188

GI number: 15897188

Start: 210097

End: 211104

Strand: Direct

Name: purA [H]

Synonym: SSO0242

Alternate gene names: 15897188

Gene position: 210097-211104 (Clockwise)

Preceding gene: 15897187

Following gene: 15897189

Centisome position: 7.02

GC content: 37.5

Gene sequence:

>1008_bases
ATGCTAGAATTAATTATTGGAGGATTTTTTGGTGATGAAGGAAAGGGAAAAGTAGCGGCATATTTGGGTATTAAAGATAG
ACCAAAATTAAGCGTGAGGACGGGATCTATTAATGCCGGGCATACCGTTACATATTCAGGGAGGATATGGAAGCTAAGGA
TCATCCCATCTGCATTTATAAATAAATCTACCGAATTAGCTCTAGGTCCTGGGGCGCTCACATCGTTAGACGCCCTATTT
AAAGAGATGAGGGAAACAGAAACTTATGATAGATTATATATTGATTCTCATGTTGGAATTATAACCGAAGATGAGATAAG
AGATGAGAAAAACGACCCTTATCTTATGAATGTAATTGGAAGCACTGGCCAAGGCGTCGGTTATGCAGAGAGCAAAAGAA
TATTAAGAAAATTAAAGTTAGCAAAAGATTATAAAGAACTTGAAAAGTTTATCATAGATGTTCCTAATAAAATATTGGAT
TACTTAGATAATGGTCATAATATTCTTATAGAAGGAACGCAAGGACACTATTTAAGTCTGTACCATGGCGAATATCCATA
CGTAACTAGTAGAAACACTACTGCATCAGGGGTATTAAGCGAGGCTGGAATAGGACCAAAATATGTGGATCACATAATAA
TTACCTTCAAGAGTTACGTTACCAGAGTAGGAAAAGGTCCACTGGAAGGTGAGTTAACAGAAGAAGATGCAAAAAAACTC
GGTTTAACGGAATATGGTACCGTAACTGGAAGATTAAGAAGAGTAGCGCCATTTAACGTTAAACTTGCTAGGGAAGCAAT
CAGAATAAATTCAGCTACAATAGTTGCGATAACTAAACTAGACACCTTATTTAAGGACGCATATAGAGTAAGAGAATATG
AAAAATTACCTGCTGAGGCTAGGAAGTGGCTAGATGAATTAGAAGAAGAGCTAAAAACGCCTATTGGGCTTATTGGAACT
GGAGAGGACGCATATGACATGATAGATCTCAGAGAGGAGGTGGGGTAG

Upstream 100 bases:

>100_bases
ATTAAGAAGATGTTATCGAAGTATCTAGGTTTCTATAATGACAGATAAGGCATAGATATACTTAAATAAGATAAAGTAGA
GGTATACAAAACGGTGTTTA

Downstream 100 bases:

>100_bases
ATGAGCTCTTATGATGTTGTAATAATTGGAGGAGGGCCTGCAGGGCTATTTGCTGCATATGAACTAGCGGGTTTAGCTAA
AGATAACGTCTCTAACTATA

Product: adenylosuccinate synthetase

Products: NA

Alternate protein names: AMPSase; AdSS; IMP--aspartate ligase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MLELIIGGFFGDEGKGKVAAYLGIKDRPKLSVRTGSINAGHTVTYSGRIWKLRIIPSAFINKSTELALGPGALTSLDALF
KEMRETETYDRLYIDSHVGIITEDEIRDEKNDPYLMNVIGSTGQGVGYAESKRILRKLKLAKDYKELEKFIIDVPNKILD
YLDNGHNILIEGTQGHYLSLYHGEYPYVTSRNTTASGVLSEAGIGPKYVDHIIITFKSYVTRVGKGPLEGELTEEDAKKL
GLTEYGTVTGRLRRVAPFNVKLAREAIRINSATIVAITKLDTLFKDAYRVREYEKLPAEARKWLDELEEELKTPIGLIGT
GEDAYDMIDLREEVG

Sequences:

>Translated_335_residues
MLELIIGGFFGDEGKGKVAAYLGIKDRPKLSVRTGSINAGHTVTYSGRIWKLRIIPSAFINKSTELALGPGALTSLDALF
KEMRETETYDRLYIDSHVGIITEDEIRDEKNDPYLMNVIGSTGQGVGYAESKRILRKLKLAKDYKELEKFIIDVPNKILD
YLDNGHNILIEGTQGHYLSLYHGEYPYVTSRNTTASGVLSEAGIGPKYVDHIIITFKSYVTRVGKGPLEGELTEEDAKKL
GLTEYGTVTGRLRRVAPFNVKLAREAIRINSATIVAITKLDTLFKDAYRVREYEKLPAEARKWLDELEEELKTPIGLIGT
GEDAYDMIDLREEVG
>Mature_335_residues
MLELIIGGFFGDEGKGKVAAYLGIKDRPKLSVRTGSINAGHTVTYSGRIWKLRIIPSAFINKSTELALGPGALTSLDALF
KEMRETETYDRLYIDSHVGIITEDEIRDEKNDPYLMNVIGSTGQGVGYAESKRILRKLKLAKDYKELEKFIIDVPNKILD
YLDNGHNILIEGTQGHYLSLYHGEYPYVTSRNTTASGVLSEAGIGPKYVDHIIITFKSYVTRVGKGPLEGELTEEDAKKL
GLTEYGTVTGRLRRVAPFNVKLAREAIRINSATIVAITKLDTLFKDAYRVREYEKLPAEARKWLDELEEELKTPIGLIGT
GEDAYDMIDLREEVG

Specific function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP [H]

COG id: COG0104

COG function: function code F; Adenylosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylosuccinate synthetase family [H]

Homologues:

Organism=Homo sapiens, GI34577063, Length=425, Percent_Identity=26.5882352941176, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI22748717, Length=425, Percent_Identity=25.4117647058824, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI40316944, Length=395, Percent_Identity=24.8101265822785, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1790620, Length=433, Percent_Identity=30.0230946882217, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25146553, Length=423, Percent_Identity=28.3687943262411, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25146555, Length=423, Percent_Identity=28.3687943262411, Blast_Score=146, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324109, Length=437, Percent_Identity=27.2311212814645, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21356033, Length=423, Percent_Identity=25.0591016548463, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: 940 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001114 [H]

Pfam domain/function: PF00709 Adenylsucc_synt [H]

EC number: =6.3.4.4 [H]

Molecular weight: Translated: 37440; Mature: 37440

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS01266 ADENYLOSUCCIN_SYN_1 ; PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELIIGGFFGDEGKGKVAAYLGIKDRPKLSVRTGSINAGHTVTYSGRIWKLRIIPSAFI
CCEEEEEEEECCCCCCCEEEEECCCCCCCEEEEECCCCCCCEEEECCEEEEEEECCHHHH
NKSTELALGPGALTSLDALFKEMRETETYDRLYIDSHVGIITEDEIRDEKNDPYLMNVIG
CCCCCEEECCCHHHHHHHHHHHHHHCCHHHEEEEECCCCEEECHHHCCCCCCCEEEEEEC
STGQGVGYAESKRILRKLKLAKDYKELEKFIIDVPNKILDYLDNGHNILIEGTQGHYLSL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCCEEEE
YHGEYPYVTSRNTTASGVLSEAGIGPKYVDHIIITFKSYVTRVGKGPLEGELTEEDAKKL
EECCCCEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHC
GLTEYGTVTGRLRRVAPFNVKLAREAIRINSATIVAITKLDTLFKDAYRVREYEKLPAEA
CCCCCCCHHHHHEECCCCCHHHHHHHHEECCEEEEEEEHHHHHHHHHHHHHHHHCCCHHH
RKWLDELEEELKTPIGLIGTGEDAYDMIDLREEVG
HHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLELIIGGFFGDEGKGKVAAYLGIKDRPKLSVRTGSINAGHTVTYSGRIWKLRIIPSAFI
CCEEEEEEEECCCCCCCEEEEECCCCCCCEEEEECCCCCCCEEEECCEEEEEEECCHHHH
NKSTELALGPGALTSLDALFKEMRETETYDRLYIDSHVGIITEDEIRDEKNDPYLMNVIG
CCCCCEEECCCHHHHHHHHHHHHHHCCHHHEEEEECCCCEEECHHHCCCCCCCEEEEEEC
STGQGVGYAESKRILRKLKLAKDYKELEKFIIDVPNKILDYLDNGHNILIEGTQGHYLSL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCCEEEE
YHGEYPYVTSRNTTASGVLSEAGIGPKYVDHIIITFKSYVTRVGKGPLEGELTEEDAKKL
EECCCCEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHC
GLTEYGTVTGRLRRVAPFNVKLAREAIRINSATIVAITKLDTLFKDAYRVREYEKLPAEA
CCCCCCCHHHHHEECCCCCHHHHHHHHEECCEEEEEEEHHHHHHHHHHHHHHHHCCCHHH
RKWLDELEEELKTPIGLIGTGEDAYDMIDLREEVG
HHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA