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The map label for this gene is pyrG

Identifier: 15897152

GI number: 15897152

Start: 174323

End: 175930

Strand: Reverse

Name: pyrG

Synonym: SSO0201

Alternate gene names: 15897152

Gene position: 175930-174323 (Counterclockwise)

Preceding gene: 15897155

Following gene: 15897150

Centisome position: 5.88

GC content: 34.45

Gene sequence:

>1608_bases
GTGCCAAACAAGTACATAGTCGTTACAGGTGGAGTTTTGTCAAGTGTTGGTAAAGGTACGTTAGTTGCCTCTATTGGCAT
GCTACTCAAAAGAAGAGGATATAATGTAACTGCAGTAAAAATAGATCCATATATTAATGTCGATGCAGGTACAATGAATC
CTTATATGCATGGTGAAGTATTTGTAACTGAGGATGGGGCCGAGACAGATTTAGATTTAGGTCATTATGAGAGATTTATG
GATGTTAATATGACAAAGTACAATAATATAACAGCAGGCAAGGTATATTTCGAGGTTATAAAAAAGGAAAGAGAAGGTAA
ATATCTAGGTCAAACCGTACAAATTATTCCCCACGTTACGGATCAGATAAAGGATATGATAAGATATGCGAGTAAGATAA
ATAACGCAGAAATTACCTTAGTAGAAATAGGTGGCACGGTAGGTGATATAGAAAGCTTACCATTCCTAGAAGCTGTTAGG
CAACTTAAACTAGAAGAAGGTGAGGATAATGTTATTTTTGTGCATATAGCTTTAGTAGAATATTTGTCTGTAACTGGAGA
ACTGAAAACGAAACCATTGCAGCATAGTGTACAAGAATTAAGAAGAATTGGAATACAACCAGATTTCATTGTAGGTAGAG
CAACACTGCCCTTAGATGATGAAACCAGACGTAAAATTGCTCTGTTTACTAACGTTAAGGTAGATCATATAGTTTCTAGC
TACGATGTAGAAACATCTTATGAAGTGCCCATTATCCTAGAAAGCCAGAAATTGGTTTCTAAGATACTTAGTAGGCTTAA
ATTAGAGGATAGACAAGTAGACTTGACAGATTGGATAAGCTTTGTCAATAATATAAAAGGAATTAATAGCAAAAAGACTA
TTAATATCGCATTAGTTGGAAAATATACAAAACTAAAGGATAGTTATATTAGTATCAAGGAAGCAATTTATCATGCTTCA
GCCTATATAGGAGTAAGGCCTAAACTTATATGGATAGAATCAACTGATCTAGAAAGTGATACCAAGAATTTAAATGAGAT
CTTAGGAAATGTAAATGGAATAATAGTTTTACCTGGATTTGGAAGTAGAGGAGCTGAAGGTAAAATTAAGGCTATAAAGT
ACGCTAGAGAACATAATATACCATTCTTGGGTATATGCTTCGGTTTTCAATTATCTATTGTTGAATTTGCTAGAGATGTT
TTAGGTCTGAGTGAAGCCAATTCAACTGAAATTAATCCAAATACTAAAGATCCGGTTATCACACTGCTAGACGAACAAAA
AAATGTAACTCAACTTGGAGGGACTATGAGACTAGGGGCTCAGAAGATTATATTAAAAGAAGGAACGATTGCCTATCAAC
TATATGGTAAAAAGGTCGTATATGAAAGGCATAGGCATAGATATGAAGTAAATCCTAAATATGTAGATATACTAGAAGAT
GCAGGATTAGTAGTTTCTGGTATCAGTGAAAATGGATTGGTTGAAATTATAGAATTGCCATCTAATAAGTTCTTCGTAGC
TACCCAAGCTCATCCAGAATTCAAGAGTAGGCCAACGAATCCATCTCCGATATATTTAGGGTTCATTAGAGCTGTTGCTA
GTCTTTAA

Upstream 100 bases:

>100_bases
CCTCTCTCATTTAAGGTAAATATGTGCTTTAAAAGTACTTAAAGTAATTGACAGTGACTTTTTATTTTATAGCAGTAAAG
GCAAATTACTGTGGATATTA

Downstream 100 bases:

>100_bases
AACTATTATAATTTTATCATATTTAGCTTTTATAATCTTTTTTATACCTTTTATTCCATTCTGGTACTCAACTTCAACTA
GACCTAGATTTTCAAGCTCA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPNKYIVVTGGVLSSVGKGTLVASIGMLLKRRGYNVTAVKIDPYINVDAGTMNPYMHGEVFVTEDGAETDLDLGHYERFM
DVNMTKYNNITAGKVYFEVIKKEREGKYLGQTVQIIPHVTDQIKDMIRYASKINNAEITLVEIGGTVGDIESLPFLEAVR
QLKLEEGEDNVIFVHIALVEYLSVTGELKTKPLQHSVQELRRIGIQPDFIVGRATLPLDDETRRKIALFTNVKVDHIVSS
YDVETSYEVPIILESQKLVSKILSRLKLEDRQVDLTDWISFVNNIKGINSKKTINIALVGKYTKLKDSYISIKEAIYHAS
AYIGVRPKLIWIESTDLESDTKNLNEILGNVNGIIVLPGFGSRGAEGKIKAIKYAREHNIPFLGICFGFQLSIVEFARDV
LGLSEANSTEINPNTKDPVITLLDEQKNVTQLGGTMRLGAQKIILKEGTIAYQLYGKKVVYERHRHRYEVNPKYVDILED
AGLVVSGISENGLVEIIELPSNKFFVATQAHPEFKSRPTNPSPIYLGFIRAVASL

Sequences:

>Translated_535_residues
MPNKYIVVTGGVLSSVGKGTLVASIGMLLKRRGYNVTAVKIDPYINVDAGTMNPYMHGEVFVTEDGAETDLDLGHYERFM
DVNMTKYNNITAGKVYFEVIKKEREGKYLGQTVQIIPHVTDQIKDMIRYASKINNAEITLVEIGGTVGDIESLPFLEAVR
QLKLEEGEDNVIFVHIALVEYLSVTGELKTKPLQHSVQELRRIGIQPDFIVGRATLPLDDETRRKIALFTNVKVDHIVSS
YDVETSYEVPIILESQKLVSKILSRLKLEDRQVDLTDWISFVNNIKGINSKKTINIALVGKYTKLKDSYISIKEAIYHAS
AYIGVRPKLIWIESTDLESDTKNLNEILGNVNGIIVLPGFGSRGAEGKIKAIKYAREHNIPFLGICFGFQLSIVEFARDV
LGLSEANSTEINPNTKDPVITLLDEQKNVTQLGGTMRLGAQKIILKEGTIAYQLYGKKVVYERHRHRYEVNPKYVDILED
AGLVVSGISENGLVEIIELPSNKFFVATQAHPEFKSRPTNPSPIYLGFIRAVASL
>Mature_534_residues
PNKYIVVTGGVLSSVGKGTLVASIGMLLKRRGYNVTAVKIDPYINVDAGTMNPYMHGEVFVTEDGAETDLDLGHYERFMD
VNMTKYNNITAGKVYFEVIKKEREGKYLGQTVQIIPHVTDQIKDMIRYASKINNAEITLVEIGGTVGDIESLPFLEAVRQ
LKLEEGEDNVIFVHIALVEYLSVTGELKTKPLQHSVQELRRIGIQPDFIVGRATLPLDDETRRKIALFTNVKVDHIVSSY
DVETSYEVPIILESQKLVSKILSRLKLEDRQVDLTDWISFVNNIKGINSKKTINIALVGKYTKLKDSYISIKEAIYHASA
YIGVRPKLIWIESTDLESDTKNLNEILGNVNGIIVLPGFGSRGAEGKIKAIKYAREHNIPFLGICFGFQLSIVEFARDVL
GLSEANSTEINPNTKDPVITLLDEQKNVTQLGGTMRLGAQKIILKEGTIAYQLYGKKVVYERHRHRYEVNPKYVDILEDA
GLVVSGISENGLVEIIELPSNKFFVATQAHPEFKSRPTNPSPIYLGFIRAVASL

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=548, Percent_Identity=46.1678832116788, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI28559085, Length=549, Percent_Identity=45.7194899817851, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI28559083, Length=549, Percent_Identity=45.7194899817851, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI221316689, Length=549, Percent_Identity=45.7194899817851, Blast_Score=491, Evalue=1e-139,
Organism=Escherichia coli, GI1789142, Length=546, Percent_Identity=47.985347985348, Blast_Score=501, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI25148299, Length=602, Percent_Identity=37.375415282392, Blast_Score=422, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319432, Length=563, Percent_Identity=44.0497335701599, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322563, Length=564, Percent_Identity=43.2624113475177, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24664469, Length=548, Percent_Identity=46.3503649635037, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI21357815, Length=493, Percent_Identity=44.2190669371197, Blast_Score=422, Evalue=1e-118,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_SULSO (Q980S6)

Other databases:

- EMBL:   AE006641
- PIR:   D90161
- RefSeq:   NP_341757.1
- PDB:   3NVA
- PDBsum:   3NVA
- ProteinModelPortal:   Q980S6
- SMR:   Q980S6
- GeneID:   1455357
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0201
- NMPDR:   fig|273057.1.peg.180
- HOGENOM:   HBG597806
- OMA:   NIKIDPY
- PhylomeDB:   Q980S6
- ProtClustDB:   PRK05380
- BioCyc:   SSOL273057:SSO0201-MONOMER
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59761; Mature: 59630

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 386-386 ACT_SITE 511-511 ACT_SITE 513-513

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNKYIVVTGGVLSSVGKGTLVASIGMLLKRRGYNVTAVKIDPYINVDAGTMNPYMHGEV
CCCCEEEEECHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCCEE
FVTEDGAETDLDLGHYERFMDVNMTKYNNITAGKVYFEVIKKEREGKYLGQTVQIIPHVT
EEECCCCCCCCCHHHHHHHHCCCCEECCCEEHHHHHHHHHHHHHCCCHHCCHHEEHHHHH
DQIKDMIRYASKINNAEITLVEIGGTVGDIESLPFLEAVRQLKLEEGEDNVIFVHIALVE
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEHHHH
YLSVTGELKTKPLQHSVQELRRIGIQPDFIVGRATLPLDDETRRKIALFTNVKVDHIVSS
HHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCCHHHHHHH
YDVETSYEVPIILESQKLVSKILSRLKLEDRQVDLTDWISFVNNIKGINSKKTINIALVG
CCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEE
KYTKLKDSYISIKEAIYHASAYIGVRPKLIWIESTDLESDTKNLNEILGNVNGIIVLPGF
CCHHHCHHHHHHHHHHHHHHEEEECCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCC
GSRGAEGKIKAIKYAREHNIPFLGICFGFQLSIVEFARDVLGLSEANSTEINPNTKDPVI
CCCCCCCCEEEEEEHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
TLLDEQKNVTQLGGTMRLGAQKIILKEGTIAYQLYGKKVVYERHRHRYEVNPKYVDILED
EEECCCCCHHHCCCEEEECCEEEEEECCCEEEEEECCHHHHHHHCCCEECCCCEEEEECC
AGLVVSGISENGLVEIIELPSNKFFVATQAHPEFKSRPTNPSPIYLGFIRAVASL
CCEEEECCCCCCCEEEEECCCCEEEEEEECCCCHHCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PNKYIVVTGGVLSSVGKGTLVASIGMLLKRRGYNVTAVKIDPYINVDAGTMNPYMHGEV
CCCEEEEECHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCCEE
FVTEDGAETDLDLGHYERFMDVNMTKYNNITAGKVYFEVIKKEREGKYLGQTVQIIPHVT
EEECCCCCCCCCHHHHHHHHCCCCEECCCEEHHHHHHHHHHHHHCCCHHCCHHEEHHHHH
DQIKDMIRYASKINNAEITLVEIGGTVGDIESLPFLEAVRQLKLEEGEDNVIFVHIALVE
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEHHHH
YLSVTGELKTKPLQHSVQELRRIGIQPDFIVGRATLPLDDETRRKIALFTNVKVDHIVSS
HHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCCHHHHHHH
YDVETSYEVPIILESQKLVSKILSRLKLEDRQVDLTDWISFVNNIKGINSKKTINIALVG
CCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEE
KYTKLKDSYISIKEAIYHASAYIGVRPKLIWIESTDLESDTKNLNEILGNVNGIIVLPGF
CCHHHCHHHHHHHHHHHHHHEEEECCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCC
GSRGAEGKIKAIKYAREHNIPFLGICFGFQLSIVEFARDVLGLSEANSTEINPNTKDPVI
CCCCCCCCEEEEEEHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
TLLDEQKNVTQLGGTMRLGAQKIILKEGTIAYQLYGKKVVYERHRHRYEVNPKYVDILED
EEECCCCCHHHCCCEEEECCEEEEEECCCEEEEEECCHHHHHHHCCCEECCCCEEEEECC
AGLVVSGISENGLVEIIELPSNKFFVATQAHPEFKSRPTNPSPIYLGFIRAVASL
CCEEEECCCCCCCEEEEECCCCEEEEEEECCCCHHCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726