Click here to switch to the map view.

The map label for this gene is lysS

Identifier: 15897053

GI number: 15897053

Start: 71195

End: 72679

Strand: Reverse

Name: lysS

Synonym: SSO0090

Alternate gene names: 15897053

Gene position: 72679-71195 (Counterclockwise)

Preceding gene: 15897054

Following gene: 15897051

Centisome position: 2.43

GC content: 34.68

Gene sequence:

>1485_bases
TTGTTGATGAATTGGGACGAAAGAAGAGTAAAAATCGTTGAAGAATTAAGAAAAAATGGCATTGAGCCATATCCTCATAA
ATACGAAGTAACTCATCTGATTAAAGATATTAAGCTAATTGCCAAATCACAAGGTAATAAATCCCATGAGCCGTTCATGT
TTAACATATCTACAGCAGGACGCGTCGCTAATATAAGAAGGCATGGAAAGGCATCCTTTGTAGATATATTTGATGAAGGT
GAGAAATTGCAATTATATATGAGAGTTGACGAACTTAAAGAAAAATATGATAAATTCTTTATATATGTTGGAAGAGGGGA
TATAATAGGTGTAAAAGGTGATTTGTTTTATACGATGAAAGGTGAGTTAAGCCTCCTTGTAAAGGATTACCAACTACTAT
CGAAAGCCCTTATAGAACCTCCAGATTGGTCAAAGCTTTCCCCAGAATTTAGATATGCGCATAGATATGTGGATTTCCTC
TATAACGATAATGCGAGGAAGGCTATGGAAATAAGGTATACAATTATAAGAGAAATTAGGGAGTTTCTTTATTCCAAAGG
CTTTATTGAAGTTGAAACGCCAATAGTTCAACCAGTATATGGTGGGGCATTAGCGAAACCTTTTAAAACACATGTAAATT
ACTTAAATGAAGATTGGTACTTAAGAATAGCATTAGAATTATACCTAAAAAGGTATATAATAGGTGGATTTAACAAAGTT
TTCGAGATAGGTAAGGTATTTAGAAATGAAGATATCGATGTAACTCATAATCCTGAGTTTACTCTCTTAGAGCTCTATTG
GGCATACGCCGATTACAACGATATAATGAATTTAACTGAAGATCTACTTAAGAGTGTAGTCAAGAAGGTTACAAATAGTA
CAAAAATAGTATATGGAAAGTACGAAATAGACTTTGAAGGTCCGTTCAAGAGAATTAGTATGTATGATTCTTTATCTGAA
ATTTTAGGTAAGGATGTTGAAAGTATGAGTGACAATGAGCTTAAGGAGTTAATGAAAAAATACAATCTAACTCCAAGAGG
AAACCAGTATGTTAGAGGGTTGATGATAGAGAAATTGTTCGATAAACTAGTCACACCCACCTTAACTAACCCAACCTTCA
TTACTGATTACCCAATAGAGACTACACCACTTTGTAAACCACATAGGAATAAACCGGGACTAGTCGAAAGATTTGAGATG
TTCATAGCTGGTATGGAGGTTGCAAACGCATACACGGAGTTGAACGACCCTATATTGCAAGATAAATTATTTAGAGAAGA
ACAAGAGATGTTCAGAAGAGGAGACGAGGAGGCTCATCCTTACGATAAGGATTTTGTAAGAGCCTTAAGTTATGGAATGC
CACCCACTGGAGGTTTAGGTATTGGTATAGACAGAATAGTTATGTTAGTAACAAATAATTACAGTATCAAAGAAGTTATT
CCTTTCCCCATGATAAGTAGTAAGGTTATCCTAGAGGACGATTAG

Upstream 100 bases:

>100_bases
CTGGAGAGGAGAGACCCAGTGGTCGCGGGTTCGAGTCCCGCCGGGCCCATACATCTAAACGAGAGAGAAGATAGGCTTTA
ATTTCTGCCGACCTATCTAA

Downstream 100 bases:

>100_bases
ATAGAAATATTGCGAATATAAAGATCAAAAGGAATAGTGACTGCAAGTAATATGAAATTTTTTCGCCGTTGCTCTCGCCT
AGCATTCTCTTTAATAATTC

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MLMNWDERRVKIVEELRKNGIEPYPHKYEVTHLIKDIKLIAKSQGNKSHEPFMFNISTAGRVANIRRHGKASFVDIFDEG
EKLQLYMRVDELKEKYDKFFIYVGRGDIIGVKGDLFYTMKGELSLLVKDYQLLSKALIEPPDWSKLSPEFRYAHRYVDFL
YNDNARKAMEIRYTIIREIREFLYSKGFIEVETPIVQPVYGGALAKPFKTHVNYLNEDWYLRIALELYLKRYIIGGFNKV
FEIGKVFRNEDIDVTHNPEFTLLELYWAYADYNDIMNLTEDLLKSVVKKVTNSTKIVYGKYEIDFEGPFKRISMYDSLSE
ILGKDVESMSDNELKELMKKYNLTPRGNQYVRGLMIEKLFDKLVTPTLTNPTFITDYPIETTPLCKPHRNKPGLVERFEM
FIAGMEVANAYTELNDPILQDKLFREEQEMFRRGDEEAHPYDKDFVRALSYGMPPTGGLGIGIDRIVMLVTNNYSIKEVI
PFPMISSKVILEDD

Sequences:

>Translated_494_residues
MLMNWDERRVKIVEELRKNGIEPYPHKYEVTHLIKDIKLIAKSQGNKSHEPFMFNISTAGRVANIRRHGKASFVDIFDEG
EKLQLYMRVDELKEKYDKFFIYVGRGDIIGVKGDLFYTMKGELSLLVKDYQLLSKALIEPPDWSKLSPEFRYAHRYVDFL
YNDNARKAMEIRYTIIREIREFLYSKGFIEVETPIVQPVYGGALAKPFKTHVNYLNEDWYLRIALELYLKRYIIGGFNKV
FEIGKVFRNEDIDVTHNPEFTLLELYWAYADYNDIMNLTEDLLKSVVKKVTNSTKIVYGKYEIDFEGPFKRISMYDSLSE
ILGKDVESMSDNELKELMKKYNLTPRGNQYVRGLMIEKLFDKLVTPTLTNPTFITDYPIETTPLCKPHRNKPGLVERFEM
FIAGMEVANAYTELNDPILQDKLFREEQEMFRRGDEEAHPYDKDFVRALSYGMPPTGGLGIGIDRIVMLVTNNYSIKEVI
PFPMISSKVILEDD
>Mature_494_residues
MLMNWDERRVKIVEELRKNGIEPYPHKYEVTHLIKDIKLIAKSQGNKSHEPFMFNISTAGRVANIRRHGKASFVDIFDEG
EKLQLYMRVDELKEKYDKFFIYVGRGDIIGVKGDLFYTMKGELSLLVKDYQLLSKALIEPPDWSKLSPEFRYAHRYVDFL
YNDNARKAMEIRYTIIREIREFLYSKGFIEVETPIVQPVYGGALAKPFKTHVNYLNEDWYLRIALELYLKRYIIGGFNKV
FEIGKVFRNEDIDVTHNPEFTLLELYWAYADYNDIMNLTEDLLKSVVKKVTNSTKIVYGKYEIDFEGPFKRISMYDSLSE
ILGKDVESMSDNELKELMKKYNLTPRGNQYVRGLMIEKLFDKLVTPTLTNPTFITDYPIETTPLCKPHRNKPGLVERFEM
FIAGMEVANAYTELNDPILQDKLFREEQEMFRRGDEEAHPYDKDFVRALSYGMPPTGGLGIGIDRIVMLVTNNYSIKEVI
PFPMISSKVILEDD

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=503, Percent_Identity=41.351888667992, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI194272210, Length=503, Percent_Identity=41.351888667992, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI45439306, Length=459, Percent_Identity=23.5294117647059, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI226491502, Length=362, Percent_Identity=24.3093922651934, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790571, Length=483, Percent_Identity=42.2360248447205, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1789256, Length=482, Percent_Identity=40.6639004149378, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI87082379, Length=321, Percent_Identity=29.9065420560748, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788173, Length=244, Percent_Identity=23.7704918032787, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17535925, Length=496, Percent_Identity=40.3225806451613, Blast_Score=348, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17535927, Length=496, Percent_Identity=40.3225806451613, Blast_Score=348, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI71994340, Length=496, Percent_Identity=40.3225806451613, Blast_Score=347, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI17551876, Length=471, Percent_Identity=22.7176220806794, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32566633, Length=253, Percent_Identity=25.6916996047431, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320242, Length=513, Percent_Identity=40.5458089668616, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6324256, Length=473, Percent_Identity=33.4038054968288, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6323011, Length=379, Percent_Identity=24.0105540897098, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640849, Length=501, Percent_Identity=42.1157684630739, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640851, Length=501, Percent_Identity=42.1157684630739, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI17136276, Length=462, Percent_Identity=23.5930735930736, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24584738, Length=188, Percent_Identity=27.1276595744681, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_SULSO (P95970)

Other databases:

- EMBL:   Y08257
- EMBL:   AE006641
- PIR:   S75398
- RefSeq:   NP_341658.1
- ProteinModelPortal:   P95970
- SMR:   P95970
- GeneID:   1453276
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0090
- NMPDR:   fig|273057.1.peg.81
- HOGENOM:   HBG631383
- OMA:   GHPQMMS
- PhylomeDB:   P95970
- ProtClustDB:   PRK00484
- BioCyc:   SSOL273057:SSO0090-MONOMER
- BRENDA:   6.1.1.6
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 57801; Mature: 57801

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMNWDERRVKIVEELRKNGIEPYPHKYEVTHLIKDIKLIAKSQGNKSHEPFMFNISTAG
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
RVANIRRHGKASFVDIFDEGEKLQLYMRVDELKEKYDKFFIYVGRGDIIGVKGDLFYTMK
HHHHHHHCCCCCEEEEECCCCEEEEEEEHHHHHHHHCEEEEEECCCCEEEECCCEEEEEC
GELSLLVKDYQLLSKALIEPPDWSKLSPEFRYAHRYVDFLYNDNARKAMEIRYTIIREIR
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EFLYSKGFIEVETPIVQPVYGGALAKPFKTHVNYLNEDWYLRIALELYLKRYIIGGFNKV
HHHHHCCCEEECCCCCCCCCCCHHCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCHHHH
FEIGKVFRNEDIDVTHNPEFTLLELYWAYADYNDIMNLTEDLLKSVVKKVTNSTKIVYGK
HHHHHHHCCCCCCEECCCCEEEEEEHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
YEIDFEGPFKRISMYDSLSEILGKDVESMSDNELKELMKKYNLTPRGNQYVRGLMIEKLF
EEECCCCCHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
DKLVTPTLTNPTFITDYPIETTPLCKPHRNKPGLVERFEMFIAGMEVANAYTELNDPILQ
HHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
DKLFREEQEMFRRGDEEAHPYDKDFVRALSYGMPPTGGLGIGIDRIVMLVTNNYSIKEVI
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHEEEEEECCCCHHHCC
PFPMISSKVILEDD
CCCCCCCEEEEECC
>Mature Secondary Structure
MLMNWDERRVKIVEELRKNGIEPYPHKYEVTHLIKDIKLIAKSQGNKSHEPFMFNISTAG
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
RVANIRRHGKASFVDIFDEGEKLQLYMRVDELKEKYDKFFIYVGRGDIIGVKGDLFYTMK
HHHHHHHCCCCCEEEEECCCCEEEEEEEHHHHHHHHCEEEEEECCCCEEEECCCEEEEEC
GELSLLVKDYQLLSKALIEPPDWSKLSPEFRYAHRYVDFLYNDNARKAMEIRYTIIREIR
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EFLYSKGFIEVETPIVQPVYGGALAKPFKTHVNYLNEDWYLRIALELYLKRYIIGGFNKV
HHHHHCCCEEECCCCCCCCCCCHHCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCHHHH
FEIGKVFRNEDIDVTHNPEFTLLELYWAYADYNDIMNLTEDLLKSVVKKVTNSTKIVYGK
HHHHHHHCCCCCCEECCCCEEEEEEHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
YEIDFEGPFKRISMYDSLSEILGKDVESMSDNELKELMKKYNLTPRGNQYVRGLMIEKLF
EEECCCCCHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
DKLVTPTLTNPTFITDYPIETTPLCKPHRNKPGLVERFEMFIAGMEVANAYTELNDPILQ
HHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
DKLFREEQEMFRRGDEEAHPYDKDFVRALSYGMPPTGGLGIGIDRIVMLVTNNYSIKEVI
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHEEEEEECCCCHHHCC
PFPMISSKVILEDD
CCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726