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The map label for this gene is gdS-1

Identifier: 15897028

GI number: 15897028

Start: 51207

End: 52205

Strand: Reverse

Name: gdS-1

Synonym: SSO0061

Alternate gene names: 15897028

Gene position: 52205-51207 (Counterclockwise)

Preceding gene: 15897029

Following gene: 15897027

Centisome position: 1.74

GC content: 34.83

Gene sequence:

>999_bases
ATGAGTAGTGATGATCTAAGTTTATATTTTAACGAGATAGTTAACAATGTAAATTTTCGGATAAAAAATTTTGTAAAGAG
CAATTTTAAGACGCTTGAGGAAGCATCATTTCATTTATTTACAGCAGGAGGTAAAAGACTTAGACCATTAGTGTTGGTTT
CATCTTCAGACTTAATTGGCGGGGACAGAGAAAGGGCATACAAGGCAGCTGCAGCCGTAGAAATTCTTCACAATTTTACT
CTAGTCCACGATGATATTATGGACAACGATGGTCTGAGAAGAGGATTACCAACTGTTCATGTAAAGTGGGGTGAACCAAT
GGCAATACTTGCGGGGGATTACTTACACGCAAAGGCTTTTGAAGCCTTAAATGAGGCACTAAAGGGTCTTGACGGCAATA
CTTTTTATAAGGCATTTTCTATATTTATCACTTCTATTGAGATAATATCTGAAGGTCAAGCAATGGATATGTCATTTGAG
AACAGACTTGACGTAACTGAGGAAGAGTATATACAAATGATAAAAGGAAAGACCGCGATGCTGTTTTCATGCTCTGCAGC
GTTAGGTGGTATAATTAATAAGGCTAATGATGATGTGGTTAAAAAATTAACCGAATATGGATTAAATTTGGGTATATCGT
TCCAAATAGTAGATGATATCCTAGGAATTATTGGAGATGAAAAGGAACTAGGGAAACCGATTTATAGTGATATTAGGGAA
GGTAAGAAGACAATTCTAGTTATAAAAACTTTAAGTGAAGCTACTGAAGATGAGAAGAAAATTCTGGTTTCAACACTTGG
TAACAAGGAAGCTAAAAAAGAAGATCTAGAAAGAGCCTCGGAAATAATAAGAAAACATTCATTACAATATGCATACGATT
TAGCTAAAAAATACTCGGATCTTGCAATAGAAAACTTACGTGAAATTCCTGTTTCTAATAAAACTGCTGAAAAGGCTTTA
AAGTATCTAGCACAGTTTACCATTCAAAGGAGAAAGTAA

Upstream 100 bases:

>100_bases
AAGAGGAGTAGTATTGTAATTTTGGGTAAACTTAAAGAGTGGGCTGAATATAGGGGGATAAATTTATCTATATACGAGAA
AGTTAGAAAGAGAGAATAAA

Downstream 100 bases:

>100_bases
ATGAGAATACTTGCAATACTACTCCCAATTTTAATTTCCTTTTTCATAAGCTATATTACAACGGTCTGGGTAATAAGACA
AGCTAAAAAGAGTAGATTCG

Product: geranylgeranyl pyrophosphate synthetase (gdS-1)

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSSDDLSLYFNEIVNNVNFRIKNFVKSNFKTLEEASFHLFTAGGKRLRPLVLVSSSDLIGGDRERAYKAAAAVEILHNFT
LVHDDIMDNDGLRRGLPTVHVKWGEPMAILAGDYLHAKAFEALNEALKGLDGNTFYKAFSIFITSIEIISEGQAMDMSFE
NRLDVTEEEYIQMIKGKTAMLFSCSAALGGIINKANDDVVKKLTEYGLNLGISFQIVDDILGIIGDEKELGKPIYSDIRE
GKKTILVIKTLSEATEDEKKILVSTLGNKEAKKEDLERASEIIRKHSLQYAYDLAKKYSDLAIENLREIPVSNKTAEKAL
KYLAQFTIQRRK

Sequences:

>Translated_332_residues
MSSDDLSLYFNEIVNNVNFRIKNFVKSNFKTLEEASFHLFTAGGKRLRPLVLVSSSDLIGGDRERAYKAAAAVEILHNFT
LVHDDIMDNDGLRRGLPTVHVKWGEPMAILAGDYLHAKAFEALNEALKGLDGNTFYKAFSIFITSIEIISEGQAMDMSFE
NRLDVTEEEYIQMIKGKTAMLFSCSAALGGIINKANDDVVKKLTEYGLNLGISFQIVDDILGIIGDEKELGKPIYSDIRE
GKKTILVIKTLSEATEDEKKILVSTLGNKEAKKEDLERASEIIRKHSLQYAYDLAKKYSDLAIENLREIPVSNKTAEKAL
KYLAQFTIQRRK
>Mature_331_residues
SSDDLSLYFNEIVNNVNFRIKNFVKSNFKTLEEASFHLFTAGGKRLRPLVLVSSSDLIGGDRERAYKAAAAVEILHNFTL
VHDDIMDNDGLRRGLPTVHVKWGEPMAILAGDYLHAKAFEALNEALKGLDGNTFYKAFSIFITSIEIISEGQAMDMSFEN
RLDVTEEEYIQMIKGKTAMLFSCSAALGGIINKANDDVVKKLTEYGLNLGISFQIVDDILGIIGDEKELGKPIYSDIREG
KKTILVIKTLSEATEDEKKILVSTLGNKEAKKEDLERASEIIRKHSLQYAYDLAKKYSDLAIENLREIPVSNKTAEKALK
YLAQFTIQRRK

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family

Homologues:

Organism=Homo sapiens, GI50659086, Length=311, Percent_Identity=28.9389067524116, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4758430, Length=231, Percent_Identity=29.4372294372294, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI83700220, Length=231, Percent_Identity=29.4372294372294, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI209571582, Length=249, Percent_Identity=30.9236947791165, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4503685, Length=249, Percent_Identity=30.9236947791165, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI209571584, Length=249, Percent_Identity=30.9236947791165, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789578, Length=318, Percent_Identity=28.9308176100629, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786623, Length=273, Percent_Identity=31.1355311355311, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17505681, Length=334, Percent_Identity=29.0419161676647, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6319475, Length=304, Percent_Identity=27.9605263157895, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6325188, Length=218, Percent_Identity=26.605504587156, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24651612, Length=342, Percent_Identity=26.0233918128655, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17137582, Length=249, Percent_Identity=27.3092369477912, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281365769, Length=239, Percent_Identity=28.4518828451883, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24660002, Length=239, Percent_Identity=28.4518828451883, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GGPS_SULSO (P95999)

Other databases:

- EMBL:   Y08257
- EMBL:   AE006641
- PIR:   H90145
- PIR:   S75427
- RefSeq:   NP_341633.1
- ProteinModelPortal:   P95999
- SMR:   P95999
- GeneID:   1455314
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0061
- NMPDR:   fig|273057.1.peg.56
- HOGENOM:   HBG732667
- OMA:   TFQIQDD
- PhylomeDB:   P95999
- ProtClustDB:   CLSK802541
- BioCyc:   SSOL273057:SSO0061-MONOMER
- BRENDA:   2.5.1.1
- BRENDA:   2.5.1.10
- BRENDA:   2.5.1.29
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949
- Gene3D:   G3DSA:1.10.600.10
- PANTHER:   PTHR12001

Pfam domain/function: PF00348 polyprenyl_synt; SSF48576 Terpenoid_synth

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10

Molecular weight: Translated: 37228; Mature: 37097

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00723 POLYPRENYL_SYNTHASE_1; PS00444 POLYPRENYL_SYNTHASE_2

Important sites: BINDING 45-45 BINDING 48-48 BINDING 77-77 BINDING 93-93 BINDING 94-94 BINDING 177-177 BINDING 178-178 BINDING 215-215 BINDING 232-232 BINDING 242-242

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDDLSLYFNEIVNNVNFRIKNFVKSNFKTLEEASFHLFTAGGKRLRPLVLVSSSDLIG
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCCCC
GDRERAYKAAAAVEILHNFTLVHDDIMDNDGLRRGLPTVHVKWGEPMAILAGDYLHAKAF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEECCCCEEEEECCHHHHHHH
EALNEALKGLDGNTFYKAFSIFITSIEIISEGQAMDMSFENRLDVTEEEYIQMIKGKTAM
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEECCCHHCCCCCCHHHHHHHHCCCHHE
LFSCSAALGGIINKANDDVVKKLTEYGLNLGISFQIVDDILGIIGDEKELGKPIYSDIRE
EEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHEEHHHHHHHCCCCHHHCCHHHHHHHC
GKKTILVIKTLSEATEDEKKILVSTLGNKEAKKEDLERASEIIRKHSLQYAYDLAKKYSD
CCCEEEEEEEHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIENLREIPVSNKTAEKALKYLAQFTIQRRK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSDDLSLYFNEIVNNVNFRIKNFVKSNFKTLEEASFHLFTAGGKRLRPLVLVSSSDLIG
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCCCC
GDRERAYKAAAAVEILHNFTLVHDDIMDNDGLRRGLPTVHVKWGEPMAILAGDYLHAKAF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEECCCCEEEEECCHHHHHHH
EALNEALKGLDGNTFYKAFSIFITSIEIISEGQAMDMSFENRLDVTEEEYIQMIKGKTAM
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEECCCHHCCCCCCHHHHHHHHCCCHHE
LFSCSAALGGIINKANDDVVKKLTEYGLNLGISFQIVDDILGIIGDEKELGKPIYSDIRE
EEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHEEHHHHHHHCCCCHHHCCHHHHHHHC
GKKTILVIKTLSEATEDEKKILVSTLGNKEAKKEDLERASEIIRKHSLQYAYDLAKKYSD
CCCEEEEEEEHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIENLREIPVSNKTAEKALKYLAQFTIQRRK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726