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The map label for this gene is phbA [H]

Identifier: 15893057

GI number: 15893057

Start: 1048361

End: 1049125

Strand: Reverse

Name: phbA [H]

Synonym: RC1134

Alternate gene names: 15893057

Gene position: 1049125-1048361 (Counterclockwise)

Preceding gene: 15893058

Following gene: 15893055

Centisome position: 82.69

GC content: 40.92

Gene sequence:

>765_bases
ATGGTTGATCTAATGCAGTATGACGGATTAACCGATGTATTTTCAGGAGTATTTATGGGTATTACAGCCGAAAATATCTC
GAAACAGTTTAATATTAGCAGACAACAGCAGGACGAGTTTGCCTTAAGCTCTCACAAGAAAGCAGCTAAAGCACAGCTAG
CAGGAGTTTTTAAAGATGAAATCTTACCTGTCGAAGTAACGATTAAAAAAACTACTAGTTTGTTTGATCATGATGAAACA
GTAAGACCTGATATCAGCCTTGAAATTCTGAGTAAATTACGTCCTGCTTTTGATAAAAACGGTGTAGTTACAGCGGGTAA
TGCTTCCTCTATTAATGACGGTGCGGCATGTCTTATGGTAGTTTCCGAAGAAGCTTTGAAAAAGCATAATTTAACGCCGC
TAGCTCGTATTGTTTCTTATGCTTCAGCCGGTGTTGATCCAAGTATTATGGGTACTGCCCCTGTTCCTGCATCCAAAAAA
GCTTTAAGTAAAGCAGGTTGGAGCGTTAATGATTTGGAAGTTATCGAGGTTAATGAGGCGTTTGCCGCTCAAAGTATTTA
TGTAAACCGTGAAATGAAATGGGATATGGAGAAGGTTAATGTTAACGGTGGAGCAATAGCCATCGGTCATCCGATCGGGG
CAAGCGGCGGACGTGTACTTATTACTCTGATACACGGCTTACGCAGAGCTAAAGCTAAAAAAGGCTTAGTTACTTTATGT
ATCGGTGGCGGTATGGGTATGGCTATGTGCGTTGAAGCGGTTTAA

Upstream 100 bases:

>100_bases
TGATGGGTGATAATGCAATAGTTATAGCAGGTGGGCAGGAGAATATGTCGCTCTGTACGTTAGCTATATCAGAGCAGGAG
CTAAATTCGGCGATATTAAA

Downstream 100 bases:

>100_bases
ATGTGCATTTGACTATATAGGCATTCATTGCTTTATTTGCTAAAGAAGAAAGTTGTATTCATCTGAATTAACTATAGTTC
ATTGTAATATATATCTGATC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MVDLMQYDGLTDVFSGVFMGITAENISKQFNISRQQQDEFALSSHKKAAKAQLAGVFKDEILPVEVTIKKTTSLFDHDET
VRPDISLEILSKLRPAFDKNGVVTAGNASSINDGAACLMVVSEEALKKHNLTPLARIVSYASAGVDPSIMGTAPVPASKK
ALSKAGWSVNDLEVIEVNEAFAAQSIYVNREMKWDMEKVNVNGGAIAIGHPIGASGGRVLITLIHGLRRAKAKKGLVTLC
IGGGMGMAMCVEAV

Sequences:

>Translated_254_residues
MVDLMQYDGLTDVFSGVFMGITAENISKQFNISRQQQDEFALSSHKKAAKAQLAGVFKDEILPVEVTIKKTTSLFDHDET
VRPDISLEILSKLRPAFDKNGVVTAGNASSINDGAACLMVVSEEALKKHNLTPLARIVSYASAGVDPSIMGTAPVPASKK
ALSKAGWSVNDLEVIEVNEAFAAQSIYVNREMKWDMEKVNVNGGAIAIGHPIGASGGRVLITLIHGLRRAKAKKGLVTLC
IGGGMGMAMCVEAV
>Mature_254_residues
MVDLMQYDGLTDVFSGVFMGITAENISKQFNISRQQQDEFALSSHKKAAKAQLAGVFKDEILPVEVTIKKTTSLFDHDET
VRPDISLEILSKLRPAFDKNGVVTAGNASSINDGAACLMVVSEEALKKHNLTPLARIVSYASAGVDPSIMGTAPVPASKK
ALSKAGWSVNDLEVIEVNEAFAAQSIYVNREMKWDMEKVNVNGGAIAIGHPIGASGGRVLITLIHGLRRAKAKKGLVTLC
IGGGMGMAMCVEAV

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=254, Percent_Identity=50, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI167614485, Length=244, Percent_Identity=50, Blast_Score=249, Evalue=1e-66,
Organism=Homo sapiens, GI4501853, Length=255, Percent_Identity=44.3137254901961, Blast_Score=217, Evalue=8e-57,
Organism=Homo sapiens, GI4557237, Length=251, Percent_Identity=41.0358565737052, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI4504327, Length=256, Percent_Identity=36.71875, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI194353979, Length=238, Percent_Identity=36.1344537815126, Blast_Score=131, Evalue=5e-31,
Organism=Escherichia coli, GI1788554, Length=250, Percent_Identity=54.8, Blast_Score=278, Evalue=2e-76,
Organism=Escherichia coli, GI87082165, Length=252, Percent_Identity=52.7777777777778, Blast_Score=278, Evalue=3e-76,
Organism=Escherichia coli, GI1787663, Length=236, Percent_Identity=49.5762711864407, Blast_Score=234, Evalue=4e-63,
Organism=Escherichia coli, GI48994986, Length=247, Percent_Identity=46.5587044534413, Blast_Score=212, Evalue=2e-56,
Organism=Escherichia coli, GI1788683, Length=258, Percent_Identity=38.3720930232558, Blast_Score=147, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=250, Percent_Identity=47.6, Blast_Score=244, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI25147385, Length=252, Percent_Identity=39.2857142857143, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17535921, Length=254, Percent_Identity=38.1889763779528, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17551802, Length=258, Percent_Identity=34.8837209302326, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17535917, Length=195, Percent_Identity=31.7948717948718, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322031, Length=231, Percent_Identity=44.5887445887446, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6325229, Length=259, Percent_Identity=40.9266409266409, Blast_Score=188, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24655093, Length=252, Percent_Identity=49.2063492063492, Blast_Score=267, Evalue=4e-72,
Organism=Drosophila melanogaster, GI17648125, Length=248, Percent_Identity=49.5967741935484, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24640423, Length=253, Percent_Identity=39.9209486166008, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17137578, Length=257, Percent_Identity=36.1867704280156, Blast_Score=140, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 27045; Mature: 27045

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLMQYDGLTDVFSGVFMGITAENISKQFNISRQQQDEFALSSHKKAAKAQLAGVFKDE
CCCCHHCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
ILPVEVTIKKTTSLFDHDETVRPDISLEILSKLRPAFDKNGVVTAGNASSINDGAACLMV
EEEEEEEEECHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEE
VSEEALKKHNLTPLARIVSYASAGVDPSIMGTAPVPASKKALSKAGWSVNDLEVIEVNEA
ECHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECHH
FAAQSIYVNREMKWDMEKVNVNGGAIAIGHPIGASGGRVLITLIHGLRRAKAKKGLVTLC
HHHHEEEECCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEE
IGGGMGMAMCVEAV
ECCCCCHHHHEECC
>Mature Secondary Structure
MVDLMQYDGLTDVFSGVFMGITAENISKQFNISRQQQDEFALSSHKKAAKAQLAGVFKDE
CCCCHHCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
ILPVEVTIKKTTSLFDHDETVRPDISLEILSKLRPAFDKNGVVTAGNASSINDGAACLMV
EEEEEEEEECHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEE
VSEEALKKHNLTPLARIVSYASAGVDPSIMGTAPVPASKKALSKAGWSVNDLEVIEVNEA
ECHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECHH
FAAQSIYVNREMKWDMEKVNVNGGAIAIGHPIGASGGRVLITLIHGLRRAKAKKGLVTLC
HHHHEEEECCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEE
IGGGMGMAMCVEAV
ECCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7582015; 11481430 [H]