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The map label for this gene is tmk [H]

Identifier: 15892970

GI number: 15892970

Start: 971957

End: 972568

Strand: Reverse

Name: tmk [H]

Synonym: RC1047

Alternate gene names: 15892970

Gene position: 972568-971957 (Counterclockwise)

Preceding gene: 15892972

Following gene: 15892969

Centisome position: 76.66

GC content: 32.19

Gene sequence:

>612_bases
ATGAATAATTTGAAACAAGGAAAGTTTATTACATTTGAGGGAGGGGAAGGGATAGGCAAATCTACTCAATCTCAAATGCT
CTATGAATATTTACAATCTCAAAATACTCCCGTTATTTTAACTCGTGAAGTCGGTGGTACTATTGTAGCCGAAAAAATGC
GTGAAATTCTAGTACATGAAGAATTACTACCCATGTCCGAGCTATTACAAGCTATGGCAGCACGTTATGATCATATGGCA
CGGAAAATTATACCAGCTCTACAAGAGGGACATATTGTAATATGTGATAGGTTTATTGAATCAACTGTATGTTATCAAGG
ATTAGAGCTAGAAAACGGCATAGATTTAGTTTATAATCTGCACAAAACTTTAATGCCTTCTCTTATGCCGGATATTACGT
TTTTTATTGACGTAGAGCCGGATACTGCTATTAAGAGAGTCAATTCACGAAATATGAACAATAAATTTGACATAAGAGGT
ATAGATTTTTATAAAAAAATCTATTATTGCTTTAAAGAATTAAGTAATAGATTTCCTGAGAGAATAAAAACAATTAAAGC
TTCAGATTTAAGTCCACTTGAAGTACATGAGTTAATAAAAAAGCATTTATGA

Upstream 100 bases:

>100_bases
GCGCTTCGTTTTGTAGGAGTATATGAGTATGTAATCTTCCTTGTAAATATTTTTTTAAGAGATATGATTATAAAGTTATA
GCTTAAAGTAATTGTAATGA

Downstream 100 bases:

>100_bases
ACAATACTTACTACATTACTACCCCTATATATTACGTTAACGATATTCCCCATATCGGTCATGCTTATACTAGCGTTGCA
AGTGACGTAATCGCTCGTTT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MNNLKQGKFITFEGGEGIGKSTQSQMLYEYLQSQNTPVILTREVGGTIVAEKMREILVHEELLPMSELLQAMAARYDHMA
RKIIPALQEGHIVICDRFIESTVCYQGLELENGIDLVYNLHKTLMPSLMPDITFFIDVEPDTAIKRVNSRNMNNKFDIRG
IDFYKKIYYCFKELSNRFPERIKTIKASDLSPLEVHELIKKHL

Sequences:

>Translated_203_residues
MNNLKQGKFITFEGGEGIGKSTQSQMLYEYLQSQNTPVILTREVGGTIVAEKMREILVHEELLPMSELLQAMAARYDHMA
RKIIPALQEGHIVICDRFIESTVCYQGLELENGIDLVYNLHKTLMPSLMPDITFFIDVEPDTAIKRVNSRNMNNKFDIRG
IDFYKKIYYCFKELSNRFPERIKTIKASDLSPLEVHELIKKHL
>Mature_203_residues
MNNLKQGKFITFEGGEGIGKSTQSQMLYEYLQSQNTPVILTREVGGTIVAEKMREILVHEELLPMSELLQAMAARYDHMA
RKIIPALQEGHIVICDRFIESTVCYQGLELENGIDLVYNLHKTLMPSLMPDITFFIDVEPDTAIKRVNSRNMNNKFDIRG
IDFYKKIYYCFKELSNRFPERIKTIKASDLSPLEVHELIKKHL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=199, Percent_Identity=32.6633165829146, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23458; Mature: 23458

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLKQGKFITFEGGEGIGKSTQSQMLYEYLQSQNTPVILTREVGGTIVAEKMREILVHE
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHH
ELLPMSELLQAMAARYDHMARKIIPALQEGHIVICDRFIESTVCYQGLELENGIDLVYNL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHHH
HKTLMPSLMPDITFFIDVEPDTAIKRVNSRNMNNKFDIRGIDFYKKIYYCFKELSNRFPE
HHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHH
RIKTIKASDLSPLEVHELIKKHL
HHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNNLKQGKFITFEGGEGIGKSTQSQMLYEYLQSQNTPVILTREVGGTIVAEKMREILVHE
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHH
ELLPMSELLQAMAARYDHMARKIIPALQEGHIVICDRFIESTVCYQGLELENGIDLVYNL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHHH
HKTLMPSLMPDITFFIDVEPDTAIKRVNSRNMNNKFDIRGIDFYKKIYYCFKELSNRFPE
HHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHH
RIKTIKASDLSPLEVHELIKKHL
HHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA