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The map label for this gene is ubiE [H]

Identifier: 15892960

GI number: 15892960

Start: 963079

End: 963825

Strand: Reverse

Name: ubiE [H]

Synonym: RC1037

Alternate gene names: 15892960

Gene position: 963825-963079 (Counterclockwise)

Preceding gene: 15892965

Following gene: 15892959

Centisome position: 75.97

GC content: 30.79

Gene sequence:

>747_bases
ATGAACCAAACAAATTTTGGCTTTAAAAAAGTAGACTACACTAAAAAACAAGGTTTAGTAAATAACGTTTTTTCTAATGT
CGCTGATAAGTATGATTTAATGAATGACTTAATGAGTTTGGGATTACATCGCTTATGGAAAGATGAATTTATTAGGCAAA
TTCCAAATCTTAACTCTCATATATTAGATGTTGCTAGCGGTAGCGGTGATATTGCTTTAAAACTTGCTAAAAAAGCAAGA
GATAGAGTTAATAATATCTCTTTAACTTTAAGTGATATTAATGAAGAAATGTTAAAGCAAGCTAAGAAAAAAGCAATAGA
TCTGAATTTATTTCAAAATCTTAAATTTACTGTAGCAAGTGCTGAAGAACTACCGTTTCCGGATGATAGTTTTGATTATT
ATACTATAGCATTCGGTATTAGAAACGTACCTGATATAAATAAGGCTTTAAAGGAAGCATGTAGGGTTTTAAAGCCAATG
GGTAAGTTTATATGTCTTGAGTTTTCAAAAGTAAAGGAAGGGTACATAAAAGATTTCTATAAATTCTACTCATTTAATAT
TATACCGAGTATTGGTCAAATGATAGCAGGTAATAAAGAGGCATATGAATATTTGGTCGAAAGTATAGATTTATTCCCCT
CACAAGACGAGTTTAGAATAATGATTAAAGACGCCGGTTTTGAGGAAGTCGGTTATAAAAATCTAAGTGGCGGAATAGTT
GCTATCCACAGTGCGTATATTCAATGA

Upstream 100 bases:

>100_bases
TTCTATAATAAGCCCGATTAGCTTATCTTTTAGAGAGTTTTTAAGAGTTTCTACTTCAGGAAGTTCCGGCATTTGATACT
AATATTTATAATAAAAAACT

Downstream 100 bases:

>100_bases
ACTTCAAAAATTGGCTACGTCGTTCTACAAGATCTGCGGTACTTACGTATTAAGTATACGCTCCGTTCCTCGACTTGTGA
ACTCCTTGCTCTTTTTGAAG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MNQTNFGFKKVDYTKKQGLVNNVFSNVADKYDLMNDLMSLGLHRLWKDEFIRQIPNLNSHILDVASGSGDIALKLAKKAR
DRVNNISLTLSDINEEMLKQAKKKAIDLNLFQNLKFTVASAEELPFPDDSFDYYTIAFGIRNVPDINKALKEACRVLKPM
GKFICLEFSKVKEGYIKDFYKFYSFNIIPSIGQMIAGNKEAYEYLVESIDLFPSQDEFRIMIKDAGFEEVGYKNLSGGIV
AIHSAYIQ

Sequences:

>Translated_248_residues
MNQTNFGFKKVDYTKKQGLVNNVFSNVADKYDLMNDLMSLGLHRLWKDEFIRQIPNLNSHILDVASGSGDIALKLAKKAR
DRVNNISLTLSDINEEMLKQAKKKAIDLNLFQNLKFTVASAEELPFPDDSFDYYTIAFGIRNVPDINKALKEACRVLKPM
GKFICLEFSKVKEGYIKDFYKFYSFNIIPSIGQMIAGNKEAYEYLVESIDLFPSQDEFRIMIKDAGFEEVGYKNLSGGIV
AIHSAYIQ
>Mature_248_residues
MNQTNFGFKKVDYTKKQGLVNNVFSNVADKYDLMNDLMSLGLHRLWKDEFIRQIPNLNSHILDVASGSGDIALKLAKKAR
DRVNNISLTLSDINEEMLKQAKKKAIDLNLFQNLKFTVASAEELPFPDDSFDYYTIAFGIRNVPDINKALKEACRVLKPM
GKFICLEFSKVKEGYIKDFYKFYSFNIIPSIGQMIAGNKEAYEYLVESIDLFPSQDEFRIMIKDAGFEEVGYKNLSGGIV
AIHSAYIQ

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=275, Percent_Identity=46.9090909090909, Blast_Score=249, Evalue=2e-66,
Organism=Escherichia coli, GI48994983, Length=245, Percent_Identity=44.0816326530612, Blast_Score=218, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17557039, Length=245, Percent_Identity=44.8979591836735, Blast_Score=216, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6323526, Length=253, Percent_Identity=47.0355731225296, Blast_Score=212, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24641702, Length=254, Percent_Identity=45.2755905511811, Blast_Score=238, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28260; Mature: 28260

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTNFGFKKVDYTKKQGLVNNVFSNVADKYDLMNDLMSLGLHRLWKDEFIRQIPNLNSH
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ILDVASGSGDIALKLAKKARDRVNNISLTLSDINEEMLKQAKKKAIDLNLFQNLKFTVAS
EEEECCCCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
AEELPFPDDSFDYYTIAFGIRNVPDINKALKEACRVLKPMGKFICLEFSKVKEGYIKDFY
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFYSFNIIPSIGQMIAGNKEAYEYLVESIDLFPSQDEFRIMIKDAGFEEVGYKNLSGGIV
HHHHCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHCCCCCCCCEE
AIHSAYIQ
EEHHHHCC
>Mature Secondary Structure
MNQTNFGFKKVDYTKKQGLVNNVFSNVADKYDLMNDLMSLGLHRLWKDEFIRQIPNLNSH
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ILDVASGSGDIALKLAKKARDRVNNISLTLSDINEEMLKQAKKKAIDLNLFQNLKFTVAS
EEEECCCCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
AEELPFPDDSFDYYTIAFGIRNVPDINKALKEACRVLKPMGKFICLEFSKVKEGYIKDFY
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFYSFNIIPSIGQMIAGNKEAYEYLVESIDLFPSQDEFRIMIKDAGFEEVGYKNLSGGIV
HHHHCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHCCCCCCCCEE
AIHSAYIQ
EEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA