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The map label for this gene is ubiB [H]

Identifier: 15892959

GI number: 15892959

Start: 961495

End: 962931

Strand: Reverse

Name: ubiB [H]

Synonym: RC1036

Alternate gene names: 15892959

Gene position: 962931-961495 (Counterclockwise)

Preceding gene: 15892960

Following gene: 15892958

Centisome position: 75.9

GC content: 36.81

Gene sequence:

>1437_bases
ATGATAAGTAATTTTTTTAATTTAATACGTATTTTTCGTATCATCAGTAAAAAGCAAATCTTAATTGATTCAAGAAGCCC
TAAATATTGCAGGTTTATCGGTTATATATTAGCCTTATTTTTTGCTCCGGTCTCGTTAATAAAAAAATCACGGGAAGATT
ACGGCAAACGCTTAATAGATTGTTTAAGTGATCTTGGACCTATTTATATAAAATTTGGACAAACTCTTTCGACAAGAGCC
GATTTAGTAGGAACAGAGATAGCAGGTTATTTAAGGTTACTGCAAGATAAGCTACCTCCGTTTGATGGTGGGGTGGCGAG
AAGGTTGATAACGTCATTGCGAGGAGACATTTATGTCGACGAAGCAATCTCAGCAAGCAAACAAAAGATTGCCACGCAGT
CTATGACTGTGAGCCATGACGCCCTCCCTTTCTTACACCTCGACGATACCCCCATCGCTGCCGCATCAATTTCGCAGGTA
CATAAAGCACAACTTATAACCGGTGAATATGTTGCGGTAAAAATTTTGCGTCCGGGTATTCATAAAAAATATAACAGAGA
TATTAAGCTGCTATATTTTCTTGCAAAAATTATCTCAAAATTTTCTAAAGCAAAAAGGCTCAAACCGATTAAAGTAGTCG
ATAAATTTCATGAAACTATGAAATTTGAGCTTGATTTACGTTTAGAGGCGGCAGCAGCTTCTGAGCTTACGGATAATATG
CGAAATGATATTAACGTGATAATCCCTAAAATATATTGGGATTTAACATCAGAAAATATACTAACCACCGAGTGGTTAGA
CGGCACTTCTATATATGATACTTTGCTACTAAAGGAAATGGGGTTAGAACCTGCAAAAATATCTCAGGATTTTGCCGTAA
TGTTTTTCAATCAAGCCTATAGAGACGGATTTTTTCATGCTGATTTACATGCAGGGAATATTTTAGTGAATAAGCAAGGT
AAAATAATTTTACTTGATTTCGGTATTATGGGCAGACTTAAGGAAAAAGATCGTTTAGCCGTTGCCGAAAGTCTATTTGG
CTTTTTAAGGCGTGATTATAAATTAGTTGCTAAAGTACATTTAAGAGCCGGCTATATCCCATCAAATACCGATTTAGCTT
TATTTGCTCAAAGTTGTAGAGCAGTTACCGAGCCTATAGTAGGGACGCCCATAAAAAATATTTCCATAGGTAAGCTGCTT
GCACATTTATTTAAAATCACGGAAGATTTCGGCATGGAAGTACAACCGGAGTTGTTGTTATTGCAAAAGACTTTAATAAT
GGTGGAAGGGATAGGCAGACAGTTAGACGGTAATGTTAATATGTGGCAGCTCGCCGAACCTTGGATTAAAAAATGGGCCG
TGAAAAATCTAAGCCCTGAAGCGAAGTTGTTACGATTGGTAAAGCATGACCTAGATAGTCTAGAGGATATTATTTGA

Upstream 100 bases:

>100_bases
TATTAAGTATACGCTCCGTTCCTCGACTTGTGAACTCCTTGCTCTTTTTGAAGTTGATCTTCGTATACTATTCTTTATTT
TACTTCGGAGTATATAATAG

Downstream 100 bases:

>100_bases
CATATAAAAAATTAGCCTTATATATTAAGAAATTTTTTATTATTAAACTAAAAGATTTATTTATTAAATATCCTATTACT
ACTCCTTTTTTGGTTGATTG

Product: ubiquinone biosynthesis protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MISNFFNLIRIFRIISKKQILIDSRSPKYCRFIGYILALFFAPVSLIKKSREDYGKRLIDCLSDLGPIYIKFGQTLSTRA
DLVGTEIAGYLRLLQDKLPPFDGGVARRLITSLRGDIYVDEAISASKQKIATQSMTVSHDALPFLHLDDTPIAAASISQV
HKAQLITGEYVAVKILRPGIHKKYNRDIKLLYFLAKIISKFSKAKRLKPIKVVDKFHETMKFELDLRLEAAAASELTDNM
RNDINVIIPKIYWDLTSENILTTEWLDGTSIYDTLLLKEMGLEPAKISQDFAVMFFNQAYRDGFFHADLHAGNILVNKQG
KIILLDFGIMGRLKEKDRLAVAESLFGFLRRDYKLVAKVHLRAGYIPSNTDLALFAQSCRAVTEPIVGTPIKNISIGKLL
AHLFKITEDFGMEVQPELLLLQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSPEAKLLRLVKHDLDSLEDII

Sequences:

>Translated_478_residues
MISNFFNLIRIFRIISKKQILIDSRSPKYCRFIGYILALFFAPVSLIKKSREDYGKRLIDCLSDLGPIYIKFGQTLSTRA
DLVGTEIAGYLRLLQDKLPPFDGGVARRLITSLRGDIYVDEAISASKQKIATQSMTVSHDALPFLHLDDTPIAAASISQV
HKAQLITGEYVAVKILRPGIHKKYNRDIKLLYFLAKIISKFSKAKRLKPIKVVDKFHETMKFELDLRLEAAAASELTDNM
RNDINVIIPKIYWDLTSENILTTEWLDGTSIYDTLLLKEMGLEPAKISQDFAVMFFNQAYRDGFFHADLHAGNILVNKQG
KIILLDFGIMGRLKEKDRLAVAESLFGFLRRDYKLVAKVHLRAGYIPSNTDLALFAQSCRAVTEPIVGTPIKNISIGKLL
AHLFKITEDFGMEVQPELLLLQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSPEAKLLRLVKHDLDSLEDII
>Mature_478_residues
MISNFFNLIRIFRIISKKQILIDSRSPKYCRFIGYILALFFAPVSLIKKSREDYGKRLIDCLSDLGPIYIKFGQTLSTRA
DLVGTEIAGYLRLLQDKLPPFDGGVARRLITSLRGDIYVDEAISASKQKIATQSMTVSHDALPFLHLDDTPIAAASISQV
HKAQLITGEYVAVKILRPGIHKKYNRDIKLLYFLAKIISKFSKAKRLKPIKVVDKFHETMKFELDLRLEAAAASELTDNM
RNDINVIIPKIYWDLTSENILTTEWLDGTSIYDTLLLKEMGLEPAKISQDFAVMFFNQAYRDGFFHADLHAGNILVNKQG
KIILLDFGIMGRLKEKDRLAVAESLFGFLRRDYKLVAKVHLRAGYIPSNTDLALFAQSCRAVTEPIVGTPIKNISIGKLL
AHLFKITEDFGMEVQPELLLLQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSPEAKLLRLVKHDLDSLEDII

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=392, Percent_Identity=27.8061224489796, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI217035081, Length=336, Percent_Identity=28.8690476190476, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI41393593, Length=294, Percent_Identity=29.2517006802721, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI34147522, Length=195, Percent_Identity=29.2307692307692, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI2367309, Length=404, Percent_Identity=38.1188118811881, Blast_Score=280, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17559152, Length=323, Percent_Identity=27.8637770897833, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32565180, Length=190, Percent_Identity=30, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=446, Percent_Identity=22.6457399103139, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6321319, Length=225, Percent_Identity=28.8888888888889, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24662575, Length=304, Percent_Identity=30.9210526315789, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI22024280, Length=293, Percent_Identity=24.9146757679181, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 54209; Mature: 54209

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISNFFNLIRIFRIISKKQILIDSRSPKYCRFIGYILALFFAPVSLIKKSREDYGKRLID
CCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLSDLGPIYIKFGQTLSTRADLVGTEIAGYLRLLQDKLPPFDGGVARRLITSLRGDIYVD
HHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEH
EAISASKQKIATQSMTVSHDALPFLHLDDTPIAAASISQVHKAQLITGEYVAVKILRPGI
HHHHHHHHHHHHHHEEECCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCH
HKKYNRDIKLLYFLAKIISKFSKAKRLKPIKVVDKFHETMKFELDLRLEAAAASELTDNM
HHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEEEHHHHHHHHHHHH
RNDINVIIPKIYWDLTSENILTTEWLDGTSIYDTLLLKEMGLEPAKISQDFAVMFFNQAY
HCCCEEEEEHHEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHH
RDGFFHADLHAGNILVNKQGKIILLDFGIMGRLKEKDRLAVAESLFGFLRRDYKLVAKVH
HCCCEEEEECCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRAGYIPSNTDLALFAQSCRAVTEPIVGTPIKNISIGKLLAHLFKITEDFGMEVQPELLL
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
LQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSPEAKLLRLVKHDLDSLEDII
HHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MISNFFNLIRIFRIISKKQILIDSRSPKYCRFIGYILALFFAPVSLIKKSREDYGKRLID
CCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLSDLGPIYIKFGQTLSTRADLVGTEIAGYLRLLQDKLPPFDGGVARRLITSLRGDIYVD
HHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEH
EAISASKQKIATQSMTVSHDALPFLHLDDTPIAAASISQVHKAQLITGEYVAVKILRPGI
HHHHHHHHHHHHHHEEECCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCH
HKKYNRDIKLLYFLAKIISKFSKAKRLKPIKVVDKFHETMKFELDLRLEAAAASELTDNM
HHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEEEHHHHHHHHHHHH
RNDINVIIPKIYWDLTSENILTTEWLDGTSIYDTLLLKEMGLEPAKISQDFAVMFFNQAY
HCCCEEEEEHHEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHH
RDGFFHADLHAGNILVNKQGKIILLDFGIMGRLKEKDRLAVAESLFGFLRRDYKLVAKVH
HCCCEEEEECCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRAGYIPSNTDLALFAQSCRAVTEPIVGTPIKNISIGKLLAHLFKITEDFGMEVQPELLL
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
LQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSPEAKLLRLVKHDLDSLEDII
HHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]