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The map label for this gene is tyrS [H]

Identifier: 15892746

GI number: 15892746

Start: 777919

End: 779154

Strand: Reverse

Name: tyrS [H]

Synonym: RC0823

Alternate gene names: 15892746

Gene position: 779154-777919 (Counterclockwise)

Preceding gene: 15892747

Following gene: 15892745

Centisome position: 61.41

GC content: 38.27

Gene sequence:

>1236_bases
ATGCGCTTTATAGAAGAATTTATAAATAAAGGATATTTCCATCAATGTACCGATTTGGATCGGTTAACTGCTATAACGAA
AGAAACAAAAATAGCTGCGTATATAGGTTTTGACTGTACTGCTACATCACTCCATATCGGTAGTTTAATGCAGATAATGA
TTCTGCGATTGCTTCAGCAGCACGGGCATAAGCCTATTGTAATTATCGGTGGCGGTACGAGTAAAATCGGTGATCCTACT
TGGAAAGACGAAGTGCGCAAAATTTTAAGCAAAGAAGATATAGCTAAAAATGCCGAAGGTATTAAAAAATCTTTGTCGAA
GTTTATCAAATTCGGTGACGGTAAAAGTGATGCTATTATGCTGGATAACGCAGAGTGGTTAGATTCGTTCAATTATCTAG
ATTTTCTACGGGATTTCGGTAGCTATTTCTCGGTAAACCGTATGCTGACTATGGATTCGGTAAAACTAAGGCTTGAGCGT
GAGCAGCATTTAAGCTTCTTAGAATTTAACTATATGTTATTGCAGGCCTATGATTTTTACTATTTAAGCAAGCATTACAA
TTGCAGCTTGCAGCTTGGCGGTAGTGATCAGTGGGGCAATATCGTAATGGGAGCGGATTTAATTCGTAAAATAAGCGGCA
AAGAAGTATTCGGGATGACGACACCGCTACTTACGACTAGCTCTGGTGCTAAGATGGGCAAGACTGCTGCGGGAGCGGTA
TGGCTTAATGAAGATTTGTTAAGCCCGTATGATTATTACCAATATTGGCGTAACTGCGAAGATGCCGACATAGTTAGATT
TGCCAAATTATATAGCGAGTTCACTCAAGAAGAGCTTAATAGGTTTGAGAGTTTAGCGGCAGAAGATATTAATGCAGCTA
AAAAACAGCTTGCTTATGAGCTAACTAAGCTTTGTCACTCGGAGCAGGCAGCAAAATCAGCTCTAGAAACTGCAGTAAAG
ATATTTGAAGAAGGACAAATCGATGAGAATTTACCTACCGTTGTTTTAGAGCAGGAAGTATTACAAGCAGGTATTAGTGC
ATATGAATTATTTCATGAAGCAGGGCTTGCTACTTCTAAATCGGAAGCACGCAAGCTTATAAGAGGGAATGGTGCTAAGA
TAAATGATAGATTAGTCGAAGATGAAAATATGATAATTAACACTAATTTCTTACTCGATAAAAAAGTTATAAAGCTCTCT
GCCGGTAAGAAAAAACATATATTGGTTAGGGTTTGA

Upstream 100 bases:

>100_bases
AGTACTTTATATAAAAGGTGATAAAGATGTTATTTTCCTTAACACTTTATTTCCTAGCAGAAAAGCAAAAAAGGAATTTT
TAAAAAATAAGAAATAATAT

Downstream 100 bases:

>100_bases
ATATTTTGCTAGATTACCATGTTCCCTTCAGTTGCAGCATTATTGTATGGCTCAAATATATTATGTCTAATTGAAACTGT
AACTTTCAATTAGACAAATT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MRFIEEFINKGYFHQCTDLDRLTAITKETKIAAYIGFDCTATSLHIGSLMQIMILRLLQQHGHKPIVIIGGGTSKIGDPT
WKDEVRKILSKEDIAKNAEGIKKSLSKFIKFGDGKSDAIMLDNAEWLDSFNYLDFLRDFGSYFSVNRMLTMDSVKLRLER
EQHLSFLEFNYMLLQAYDFYYLSKHYNCSLQLGGSDQWGNIVMGADLIRKISGKEVFGMTTPLLTTSSGAKMGKTAAGAV
WLNEDLLSPYDYYQYWRNCEDADIVRFAKLYSEFTQEELNRFESLAAEDINAAKKQLAYELTKLCHSEQAAKSALETAVK
IFEEGQIDENLPTVVLEQEVLQAGISAYELFHEAGLATSKSEARKLIRGNGAKINDRLVEDENMIINTNFLLDKKVIKLS
AGKKKHILVRV

Sequences:

>Translated_411_residues
MRFIEEFINKGYFHQCTDLDRLTAITKETKIAAYIGFDCTATSLHIGSLMQIMILRLLQQHGHKPIVIIGGGTSKIGDPT
WKDEVRKILSKEDIAKNAEGIKKSLSKFIKFGDGKSDAIMLDNAEWLDSFNYLDFLRDFGSYFSVNRMLTMDSVKLRLER
EQHLSFLEFNYMLLQAYDFYYLSKHYNCSLQLGGSDQWGNIVMGADLIRKISGKEVFGMTTPLLTTSSGAKMGKTAAGAV
WLNEDLLSPYDYYQYWRNCEDADIVRFAKLYSEFTQEELNRFESLAAEDINAAKKQLAYELTKLCHSEQAAKSALETAVK
IFEEGQIDENLPTVVLEQEVLQAGISAYELFHEAGLATSKSEARKLIRGNGAKINDRLVEDENMIINTNFLLDKKVIKLS
AGKKKHILVRV
>Mature_411_residues
MRFIEEFINKGYFHQCTDLDRLTAITKETKIAAYIGFDCTATSLHIGSLMQIMILRLLQQHGHKPIVIIGGGTSKIGDPT
WKDEVRKILSKEDIAKNAEGIKKSLSKFIKFGDGKSDAIMLDNAEWLDSFNYLDFLRDFGSYFSVNRMLTMDSVKLRLER
EQHLSFLEFNYMLLQAYDFYYLSKHYNCSLQLGGSDQWGNIVMGADLIRKISGKEVFGMTTPLLTTSSGAKMGKTAAGAV
WLNEDLLSPYDYYQYWRNCEDADIVRFAKLYSEFTQEELNRFESLAAEDINAAKKQLAYELTKLCHSEQAAKSALETAVK
IFEEGQIDENLPTVVLEQEVLQAGISAYELFHEAGLATSKSEARKLIRGNGAKINDRLVEDENMIINTNFLLDKKVIKLS
AGKKKHILVRV

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=412, Percent_Identity=33.495145631068, Blast_Score=232, Evalue=5e-61,
Organism=Escherichia coli, GI1787925, Length=424, Percent_Identity=38.6792452830189, Blast_Score=293, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI25145802, Length=302, Percent_Identity=35.4304635761589, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25145805, Length=239, Percent_Identity=32.6359832635983, Blast_Score=125, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6325160, Length=437, Percent_Identity=31.8077803203661, Blast_Score=210, Evalue=4e-55,
Organism=Drosophila melanogaster, GI20130383, Length=436, Percent_Identity=32.3394495412844, Blast_Score=227, Evalue=1e-59,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 46624; Mature: 46624

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFIEEFINKGYFHQCTDLDRLTAITKETKIAAYIGFDCTATSLHIGSLMQIMILRLLQQ
CCHHHHHHCCCCCHHHCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
HGHKPIVIIGGGTSKIGDPTWKDEVRKILSKEDIAKNAEGIKKSLSKFIKFGDGKSDAIM
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
LDNAEWLDSFNYLDFLRDFGSYFSVNRMLTMDSVKLRLEREQHLSFLEFNYMLLQAYDFY
ECCHHHHHCCHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YLSKHYNCSLQLGGSDQWGNIVMGADLIRKISGKEVFGMTTPLLTTSSGAKMGKTAAGAV
EEECCCCEEEEECCCCCCCCEEECHHHHHHHCCCEEECCCCCCEECCCCCCCCCCCCCEE
WLNEDLLSPYDYYQYWRNCEDADIVRFAKLYSEFTQEELNRFESLAAEDINAAKKQLAYE
EECHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTKLCHSEQAAKSALETAVKIFEEGQIDENLPTVVLEQEVLQAGISAYELFHEAGLATSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SEARKLIRGNGAKINDRLVEDENMIINTNFLLDKKVIKLSAGKKKHILVRV
HHHHHHHHCCCCCCCCEEECCCCEEEECCEEECHHHHEECCCCCCEEEEEC
>Mature Secondary Structure
MRFIEEFINKGYFHQCTDLDRLTAITKETKIAAYIGFDCTATSLHIGSLMQIMILRLLQQ
CCHHHHHHCCCCCHHHCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
HGHKPIVIIGGGTSKIGDPTWKDEVRKILSKEDIAKNAEGIKKSLSKFIKFGDGKSDAIM
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
LDNAEWLDSFNYLDFLRDFGSYFSVNRMLTMDSVKLRLEREQHLSFLEFNYMLLQAYDFY
ECCHHHHHCCHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YLSKHYNCSLQLGGSDQWGNIVMGADLIRKISGKEVFGMTTPLLTTSSGAKMGKTAAGAV
EEECCCCEEEEECCCCCCCCEEECHHHHHHHCCCEEECCCCCCEECCCCCCCCCCCCCEE
WLNEDLLSPYDYYQYWRNCEDADIVRFAKLYSEFTQEELNRFESLAAEDINAAKKQLAYE
EECHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTKLCHSEQAAKSALETAVKIFEEGQIDENLPTVVLEQEVLQAGISAYELFHEAGLATSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SEARKLIRGNGAKINDRLVEDENMIINTNFLLDKKVIKLSAGKKKHILVRV
HHHHHHHHCCCCCCCCEEECCCCEEEECCEEECHHHHEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA